ATE308046T1 - Kardiovaskulares sicherheitstestverfahren - Google Patents
Kardiovaskulares sicherheitstestverfahrenInfo
- Publication number
- ATE308046T1 ATE308046T1 AT02762316T AT02762316T ATE308046T1 AT E308046 T1 ATE308046 T1 AT E308046T1 AT 02762316 T AT02762316 T AT 02762316T AT 02762316 T AT02762316 T AT 02762316T AT E308046 T1 ATE308046 T1 AT E308046T1
- Authority
- AT
- Austria
- Prior art keywords
- test procedure
- safety test
- cardiovascular safety
- kits
- cardiotoxicity
- Prior art date
Links
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000011076 safety test Methods 0.000 title 1
- 206010048610 Cardiotoxicity Diseases 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 2
- 231100000259 cardiotoxicity Toxicity 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101001047090 Homo sapiens Potassium voltage-gated channel subfamily H member 2 Proteins 0.000 abstract 1
- 102100022807 Potassium voltage-gated channel subfamily H member 2 Human genes 0.000 abstract 1
- GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 abstract 1
- 229960004754 astemizole Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202689 | 2001-07-13 | ||
| PCT/EP2002/007364 WO2003006988A1 (en) | 2001-07-13 | 2002-07-02 | Cardiovascular safety assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE308046T1 true ATE308046T1 (de) | 2005-11-15 |
Family
ID=8180635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02762316T ATE308046T1 (de) | 2001-07-13 | 2002-07-02 | Kardiovaskulares sicherheitstestverfahren |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20040161805A1 (de) |
| EP (1) | EP1410019B1 (de) |
| JP (1) | JP4570870B2 (de) |
| CN (1) | CN1276254C (de) |
| AT (1) | ATE308046T1 (de) |
| AU (1) | AU2002328312B8 (de) |
| CA (1) | CA2450581C (de) |
| DE (1) | DE60206923T2 (de) |
| DK (1) | DK1410019T3 (de) |
| ES (1) | ES2252505T3 (de) |
| IL (2) | IL159819A0 (de) |
| NZ (1) | NZ529496A (de) |
| WO (1) | WO2003006988A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302775D0 (sv) * | 2003-10-20 | 2003-10-20 | Astrazeneca Ab | Chemical compound and assay |
| US7396524B2 (en) * | 2005-08-02 | 2008-07-08 | Main Line Health Heart Center | Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy |
| US9820888B2 (en) | 2006-09-26 | 2017-11-21 | Smith & Nephew, Inc. | Wound dressing |
| GB0902368D0 (en) | 2009-02-13 | 2009-04-01 | Smith & Nephew | Wound packing |
| WO2012106590A2 (en) | 2011-02-04 | 2012-08-09 | University Of Massachusetts | Negative pressure wound closure device |
| US9421132B2 (en) | 2011-02-04 | 2016-08-23 | University Of Massachusetts | Negative pressure wound closure device |
| MX2014014265A (es) | 2012-05-22 | 2015-06-23 | Smith & Nephew | Dispositivo para cierre de heridas. |
| CN104661601B (zh) | 2012-05-22 | 2018-06-22 | 史密夫及内修公开有限公司 | 用于伤口治疗的设备和方法 |
| CN104736110B (zh) | 2012-05-24 | 2019-05-31 | 史密夫和内修有限公司 | 用于利用负压来处理和封闭伤口的装置和方法 |
| RU2015104581A (ru) | 2012-07-16 | 2016-09-10 | Смит Энд Нефью, Инк. | Устройство для закрытия раны с использованием отрицательного давления |
| WO2014165275A1 (en) | 2013-03-13 | 2014-10-09 | Smith & Nephew Inc. | Negative pressure wound closure device and systems and methods of use in treating wounds with negative pressure |
| RU2015142877A (ru) | 2013-03-14 | 2017-04-18 | СМИТ ЭНД НЕФЬЮ ПиЭлСи | Сжимаемые наполнители раны и системы и способы их применения в лечении ран с применением отрицательного давления |
| AU2014340232B2 (en) | 2013-10-21 | 2019-07-11 | Smith & Nephew Inc. | Negative pressure wound closure device |
| EP4209201A1 (de) | 2015-04-29 | 2023-07-12 | Smith & Nephew, Inc. | Unterdruckwundverschlussvorrichtung |
| US10814049B2 (en) | 2015-12-15 | 2020-10-27 | University Of Massachusetts | Negative pressure wound closure devices and methods |
| US10575991B2 (en) | 2015-12-15 | 2020-03-03 | University Of Massachusetts | Negative pressure wound closure devices and methods |
| JP6940920B2 (ja) * | 2017-02-04 | 2021-09-29 | アナバイオス コーポレーション | 医薬誘発性の変力作用および不整脈誘発のリスクを予測するためのシステムおよび方法 |
| WO2020124038A1 (en) | 2018-12-13 | 2020-06-18 | University Of Massachusetts | Negative pressure wound closure devices and methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| WO2000070079A1 (en) * | 1999-05-13 | 2000-11-23 | Ortho-Mcneil Pharmaceutical, Inc. | High throughput assay for modulators of nuclear receptors |
| US20030013136A1 (en) * | 2000-10-30 | 2003-01-16 | Balser Jeffrey R. | Human KCR1 regulation of HERG potassium channel block |
-
2002
- 2002-07-02 ES ES02762316T patent/ES2252505T3/es not_active Expired - Lifetime
- 2002-07-02 JP JP2003512705A patent/JP4570870B2/ja not_active Expired - Fee Related
- 2002-07-02 CN CNB02813995XA patent/CN1276254C/zh not_active Expired - Fee Related
- 2002-07-02 EP EP02762316A patent/EP1410019B1/de not_active Expired - Lifetime
- 2002-07-02 IL IL15981902A patent/IL159819A0/xx unknown
- 2002-07-02 AU AU2002328312A patent/AU2002328312B8/en not_active Ceased
- 2002-07-02 DK DK02762316T patent/DK1410019T3/da active
- 2002-07-02 NZ NZ529496A patent/NZ529496A/en not_active IP Right Cessation
- 2002-07-02 US US10/483,617 patent/US20040161805A1/en not_active Abandoned
- 2002-07-02 WO PCT/EP2002/007364 patent/WO2003006988A1/en not_active Ceased
- 2002-07-02 CA CA2450581A patent/CA2450581C/en not_active Expired - Lifetime
- 2002-07-02 DE DE60206923T patent/DE60206923T2/de not_active Expired - Lifetime
- 2002-07-02 AT AT02762316T patent/ATE308046T1/de not_active IP Right Cessation
-
2004
- 2004-01-12 IL IL159819A patent/IL159819A/en active IP Right Grant
-
2006
- 2006-11-06 US US11/593,399 patent/US7820453B2/en not_active Expired - Fee Related
-
2010
- 2010-08-20 US US12/860,387 patent/US20110076696A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1541334A (zh) | 2004-10-27 |
| EP1410019B1 (de) | 2005-10-26 |
| JP2005501037A (ja) | 2005-01-13 |
| DK1410019T3 (da) | 2006-03-06 |
| DE60206923T2 (de) | 2006-07-20 |
| US7820453B2 (en) | 2010-10-26 |
| CN1276254C (zh) | 2006-09-20 |
| HK1070693A1 (en) | 2005-06-24 |
| IL159819A0 (en) | 2004-06-20 |
| AU2002328312B2 (en) | 2006-12-14 |
| AU2002328312B8 (en) | 2007-02-15 |
| NZ529496A (en) | 2005-09-30 |
| US20080193924A1 (en) | 2008-08-14 |
| WO2003006988A1 (en) | 2003-01-23 |
| AU2002328312A1 (en) | 2003-01-29 |
| EP1410019A1 (de) | 2004-04-21 |
| IL159819A (en) | 2010-05-31 |
| US20110076696A1 (en) | 2011-03-31 |
| DE60206923D1 (de) | 2005-12-01 |
| JP4570870B2 (ja) | 2010-10-27 |
| CA2450581A1 (en) | 2003-01-23 |
| CA2450581C (en) | 2010-11-02 |
| ES2252505T3 (es) | 2006-05-16 |
| US20040161805A1 (en) | 2004-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |