ATE431396T1 - Für hcv-infektion geeignete zusammensetzungen und verfahren - Google Patents

Für hcv-infektion geeignete zusammensetzungen und verfahren

Info

Publication number
ATE431396T1
ATE431396T1 AT02753872T AT02753872T ATE431396T1 AT E431396 T1 ATE431396 T1 AT E431396T1 AT 02753872 T AT02753872 T AT 02753872T AT 02753872 T AT02753872 T AT 02753872T AT E431396 T1 ATE431396 T1 AT E431396T1
Authority
AT
Austria
Prior art keywords
compositions
hcv
methods
hcv infection
methods suitable
Prior art date
Application number
AT02753872T
Other languages
English (en)
Inventor
Ann Kwong
Randal Byrn
Lola Reid
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE431396T1 publication Critical patent/ATE431396T1/de

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0031—Serum-free culture media
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/46—Amines, e.g. putrescine
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    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/18—Liver cell growth factor (LCGF, Gly-His-Lys)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/335—Glucagon; Glucagon-like peptide [GLP]; Exendin
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/375—Thyroid stimulating hormone [TSH]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Semiconductor Lasers (AREA)
AT02753872T 2001-03-27 2002-03-27 Für hcv-infektion geeignete zusammensetzungen und verfahren ATE431396T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27917401P 2001-03-27 2001-03-27
PCT/US2002/009685 WO2002077206A1 (en) 2001-03-27 2002-03-27 Compositiona and methods useful for hcv infection

Publications (1)

Publication Number Publication Date
ATE431396T1 true ATE431396T1 (de) 2009-05-15

Family

ID=23067944

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02753872T ATE431396T1 (de) 2001-03-27 2002-03-27 Für hcv-infektion geeignete zusammensetzungen und verfahren

Country Status (14)

Country Link
US (3) US7879606B2 (de)
EP (1) EP1381673B1 (de)
JP (2) JP4499990B2 (de)
KR (1) KR100947911B1 (de)
CN (1) CN100362095C (de)
AT (1) ATE431396T1 (de)
CA (1) CA2441688C (de)
DE (1) DE60232322D1 (de)
ES (1) ES2328466T3 (de)
MX (1) MXPA03008882A (de)
NO (1) NO20034278L (de)
NZ (1) NZ528462A (de)
WO (1) WO2002077206A1 (de)
ZA (1) ZA200307373B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
EP1594975A4 (de) * 2002-12-04 2006-08-02 Applera Corp Multiplex-amplifikation von polynukleotiden
TW201127828A (en) 2003-09-05 2011-08-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
EP1689857A1 (de) * 2003-12-01 2006-08-16 Vertex Pharmaceuticals Incorporated Zusammensetzungen enthaltende fötale leberzellen und methoden zur hcv infektion
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
CA2643688A1 (en) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
US20070225297A1 (en) 2006-03-16 2007-09-27 Perni Robert B Deuterated hepatitis C protease inhibitors
EP2134717A2 (de) 2007-02-27 2009-12-23 Vertex Pharmceuticals Incorporated Serinprotease-hemmer
MX2009009182A (es) 2007-02-27 2009-09-04 Vertex Pharma Co-cristales y composiciones farmaceuticas que los comprenden.
NZ583699A (en) 2007-08-30 2012-04-27 Vertex Pharma Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
NZ585259A (en) * 2007-12-04 2011-12-22 Prionics Ag Method for detecting bovine viral diarrhea virus (bvdv) in tissue samples using collagenase
CN101906487A (zh) * 2010-08-05 2010-12-08 中国兽医药品监察所 一种猪瘟病毒核酸标准物质的制备方法
US9969979B2 (en) * 2012-08-31 2018-05-15 The Governors Of The University Of Alberta Methods for producing cells having a phenotype of a primary human hepatocytes and compositions
EP3289074B1 (de) * 2015-04-28 2023-10-04 Université de Strasbourg Klinisches gensignaturbasiertes zellkulturmodell und verwendungen davon

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5529920A (en) 1988-12-14 1996-06-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human liver epithelial cell line and culture media therefor
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
EP0597964A4 (de) 1991-08-07 1994-11-30 Einstein Coll Med Proliferation von vorläufern von hepatocyten.
US6069005A (en) 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
JPH09505206A (ja) 1993-11-19 1997-05-27 イェシバ・ユニバーシティ 肝芽細胞およびその単離方法
CN1122531C (zh) * 1995-08-01 2003-10-01 巴斯德梅诺血清和疫苗公司 抗日本脑炎疫苗的工业生产方法和所获得的疫苗
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
JP4492826B2 (ja) * 1996-11-20 2010-06-30 イントロジェン セラピューティクス，インコーポレイテッド アデノウイルスベクターの産生および精製のための改良された方法
US6133030A (en) * 1997-05-14 2000-10-17 The General Hospital Corporation Co-cultivation of cells in a micropatterned configuration
FR2775983B1 (fr) * 1998-03-13 2000-11-10 Pasteur Merieux Serums Vacc Milieu et procede de propagation et de multiplication virales
EP0972828A1 (de) 1998-06-24 2000-01-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Verfahren zur in vitro Replikation von HCV
DK1137798T3 (da) 1998-12-07 2009-04-14 Univ Duke Fremgangsmåde til isolering af stamceller
DK2048228T3 (en) 1999-01-19 2016-05-09 Univ North Carolina Human liver progenitors
US20020187133A1 (en) 1999-10-01 2002-12-12 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
IL150819A0 (en) 2000-01-19 2003-02-12 Univ North Carolina Liver tissue source
CN1258589C (zh) 2000-10-03 2006-06-07 北卡罗来纳大学 分离双能肝祖细胞的方法
JP2004510434A (ja) 2000-10-03 2004-04-08 ユニバーシティ　オブ　ノース　カロライナ 肝前駆細胞のクローン増殖方法
WO2002072776A2 (en) 2001-03-09 2002-09-19 The Regents Of The University Of California Cell culture system for synthesis of infectious hepatitis c virus
US20040167067A1 (en) * 2002-07-01 2004-08-26 David Griggs ESM-1 gene differentially expressed in angiogenesis, antagonists thereof, and methods of using the same

Also Published As

Publication number Publication date
US20020142449A1 (en) 2002-10-03
JP4499990B2 (ja) 2010-07-14
ES2328466T3 (es) 2009-11-13
CA2441688A1 (en) 2002-10-03
US8211696B2 (en) 2012-07-03
HK1063334A1 (en) 2004-12-24
NZ528462A (en) 2005-11-25
DE60232322D1 (de) 2009-06-25
US7879606B2 (en) 2011-02-01
KR20040012739A (ko) 2004-02-11
NO20034278D0 (no) 2003-09-25
JP2010142249A (ja) 2010-07-01
US20110229874A1 (en) 2011-09-22
CN1511190A (zh) 2004-07-07
EP1381673A1 (de) 2004-01-21
ZA200307373B (en) 2005-06-29
JP2004529637A (ja) 2004-09-30
NO20034278L (no) 2003-11-25
WO2002077206A1 (en) 2002-10-03
CA2441688C (en) 2014-01-21
CN100362095C (zh) 2008-01-16
US20130071834A1 (en) 2013-03-21
EP1381673B1 (de) 2009-05-13
EP1381673A4 (de) 2004-11-10
MXPA03008882A (es) 2003-12-08
KR100947911B1 (ko) 2010-03-17
WO2002077206A9 (en) 2004-02-19

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