ATE308239T1 - Verfahren und vorrichtungen zur extrakorporealen organperfusion - Google Patents

Verfahren und vorrichtungen zur extrakorporealen organperfusion

Info

Publication number
ATE308239T1
ATE308239T1 AT00915294T AT00915294T ATE308239T1 AT E308239 T1 ATE308239 T1 AT E308239T1 AT 00915294 T AT00915294 T AT 00915294T AT 00915294 T AT00915294 T AT 00915294T AT E308239 T1 ATE308239 T1 AT E308239T1
Authority
AT
Austria
Prior art keywords
organ
liver
devices
organs
blood flow
Prior art date
Application number
AT00915294T
Other languages
English (en)
Inventor
Peter Friend
Andrew Butler
Michael Rees
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation filed Critical Isis Innovation
Application granted granted Critical
Publication of ATE308239T1 publication Critical patent/ATE308239T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
AT00915294T 1999-04-12 2000-04-05 Verfahren und vorrichtungen zur extrakorporealen organperfusion ATE308239T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9908335.4A GB9908335D0 (en) 1999-04-12 1999-04-12 Methods and means for extracorporeal organ perfusion
PCT/GB2000/001271 WO2000060936A1 (en) 1999-04-12 2000-04-05 Methods and means for extracorporeal organ perfusion

Publications (1)

Publication Number Publication Date
ATE308239T1 true ATE308239T1 (de) 2005-11-15

Family

ID=10851385

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00915294T ATE308239T1 (de) 1999-04-12 2000-04-05 Verfahren und vorrichtungen zur extrakorporealen organperfusion

Country Status (9)

Country Link
US (1) US7410474B1 (de)
EP (1) EP1168913B1 (de)
AT (1) ATE308239T1 (de)
AU (1) AU3665800A (de)
CA (1) CA2369159C (de)
DE (1) DE60023672T2 (de)
ES (1) ES2250119T3 (de)
GB (1) GB9908335D0 (de)
WO (1) WO2000060936A1 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6977140B1 (en) * 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US7572622B2 (en) 2002-08-14 2009-08-11 Transmedic, Inc. Heart preservation chamber
NL1024022C2 (nl) 2003-07-30 2005-02-01 Technologiestichting Stw Draagbare preservatie-inrichting voor een donororgaan.
DE10340487B4 (de) * 2003-09-03 2007-07-12 Technische Universität Dresden Perfusionskreislauf
US8741555B2 (en) * 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
CN103931605B (zh) 2004-10-07 2015-11-18 特兰斯迈迪茨公司 用于活体外器官护理的系统和方法
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US10176887B1 (en) 2005-11-14 2019-01-08 Organ Recovery Systems, Inc. Ex vivo methods for drug discovery, development and testing
EP2131650B1 (de) 2007-03-01 2017-11-29 Lifeline Scientific, Inc. Perfusionsregulierung
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8771930B2 (en) * 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
US8765364B2 (en) * 2007-05-18 2014-07-01 Lifeline Scientific, Inc. Ex vivo methods for validating substance testing with human organs and/or tissues
US8420380B2 (en) 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
EP2278874B1 (de) * 2008-04-22 2019-03-20 The Board of Regents of The University of Texas System Auf fluidströmung basierende organkonservierungsvorrichtung mit pulsierender perfusion
US20130323708A1 (en) 2009-07-01 2013-12-05 Massachusetts Institute Of Technology Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
WO2011038251A1 (en) * 2009-09-25 2011-03-31 Board Of Regents, The University Of Texas System Fluidics based pulsatile perfusion preservation device and method
FR2951927A1 (fr) * 2009-11-05 2011-05-06 Centre Nat Rech Scient Dispositif de prelevement de liquide corporel et procede de mise en oeuvre.
US10575515B2 (en) 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
US12096765B1 (en) 2011-03-15 2024-09-24 Paragonix Technologies, Inc. System for hypothermic transport of samples
US8835158B2 (en) 2011-03-15 2014-09-16 Paragonix Technologics, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US12279610B2 (en) 2011-03-15 2025-04-22 Paragonix Technonogies, Inc. System for hypothermic transport of samples
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US20130011823A1 (en) 2011-04-14 2013-01-10 Hassanein Waleed H Organ care solution for ex-vivo machine perfusion of donor lungs
EP2750499B1 (de) 2011-09-02 2016-07-20 Organ Assist B.V. Vorrichtung, system und verfahren zur kühlung und erhaltung eines organs von einem spender
GB201119420D0 (en) 2011-11-10 2011-12-21 Organox Ltd Oxygen supply for organ perfusion systems
ES2681229T3 (es) 2011-11-10 2018-09-12 Organox Limited Sistema de perfusión de órganos
WO2013068752A2 (en) 2011-11-10 2013-05-16 Organox Limited Organ perfusion systems
EP2633755A1 (de) 2012-03-02 2013-09-04 Rodos BioTarget GmbH Organperfusionssystem
US10602740B2 (en) * 2012-07-10 2020-03-31 Lifeline Scientific, Inc. Organ perfusion apparatus with downstream flow control
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
CN102813559B (zh) * 2012-08-27 2014-11-05 山东大学 一种全自动灌流装置
JP6336392B2 (ja) * 2012-09-08 2018-06-06 株式会社オーガンテクノロジーズ 移植のための臓器又は組織の長期維持方法
US9629358B2 (en) * 2013-03-15 2017-04-25 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids
US10918102B2 (en) 2014-03-13 2021-02-16 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
JP2017518301A (ja) 2014-06-02 2017-07-06 トランスメディクス， インク．Ｔｒａｎｓｍｅｄｉｃｓ， Ｉｎｃ． ｅｘ−ｖｉｖｏでの臓器管理システム
USD765874S1 (en) 2014-10-10 2016-09-06 Paragonix Technologies, Inc. Transporter for a tissue transport system
CA3155169A1 (en) 2014-12-12 2016-06-16 Tevosol, Inc. Apparatus and method for organ perfusion
CA2997267A1 (en) 2015-09-09 2017-03-16 Transmedics, Inc. Aortic cannula for ex vivo organ care system
US10091986B2 (en) 2016-05-09 2018-10-09 Xor-Labs Toronto Inc. Organ perfusion device and method
US20190141988A1 (en) * 2016-05-20 2019-05-16 SCREEN Holdings Co., Ltd. Perfusion device for liver graft, and liver removal method and liver transplantation method using the device
ES2968062T3 (es) 2016-05-30 2024-05-07 Transmedics Inc Aparato y método de ventilación pulmonar ex vivo con presión exterior variable
WO2018013849A1 (en) * 2016-07-13 2018-01-18 The Trustees Of Columbia University In The City Of New York Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs
JP2019525776A (ja) 2016-07-22 2019-09-12 エー・テー・ハー・チューリッヒＥｔｈ Ｚｕｅｒｉｃｈ 体外で肝臓に潅流する潅流ループアセンブリ及び肝臓チェンバーアセンブリ
WO2018037835A1 (ja) * 2016-08-25 2018-03-01 株式会社Ｓｃｒｅｅｎホールディングス 肝臓保存方法及び手術方法
CN106937671B (zh) * 2017-04-10 2018-05-29 青岛大学 一种新鲜动物肝脏的清洗、祛毒以及细胞组织保鲜的方法
CN106962804B (zh) * 2017-04-10 2018-08-03 青岛大学 祛毒动物肝脏食品及其加工方法
US20210400952A1 (en) 2017-06-07 2021-12-30 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
CA3066625A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
EP3638019A4 (de) 2017-06-14 2020-08-26 The General Hospital Corporation Kryokonservierung mit temperaturen weit unter dem nullpunkt
KR20240142604A (ko) * 2017-08-25 2024-09-30 말린크로트 파마슈티칼스 아일랜드 리미티드 기관 생존력을 개선시키는 방법
EP3513653A1 (de) 2018-01-19 2019-07-24 ETH Zürich Perfusionsschlaufenanordnung für eine ex-vivo-leberperfusion und verfahren für eine ex-vivo-leberperfusion
EP3740067B1 (de) 2018-01-19 2024-11-06 ETH Zürich Perfusionskreislaufanordnung für eine ex-vivo-leberperfusion und verfahren für eine ex-vivo-leberperfusion
US12167729B2 (en) 2018-05-30 2024-12-17 The General Hospital Corporation Cryopreservation of tissues and organs
EP3982725A4 (de) 2019-06-11 2023-07-19 Paragonix Technologies Inc. Organtransportbehälter mit antiviraler therapie
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
JP2021143128A (ja) * 2020-03-10 2021-09-24 株式会社Ｓｃｒｅｅｎホールディングス 灌流装置
RU2741219C1 (ru) * 2020-06-18 2021-01-22 федеральное государственное бюджетное образовательное учреждение высшего образования «Омский государственный медицинский университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО ОмГМУ Минздрава России) Устройство для консервации донорских органов
CN112155841B (zh) * 2020-09-04 2022-03-22 深圳市医思美科技有限公司 一种热灌注治疗设备的控制系统和控制方法
GB202018460D0 (en) 2020-11-24 2021-01-06 Organox Ltd Precision oxygen flow control for organ perfusion systems
US12439910B2 (en) 2021-06-28 2025-10-14 John M. Brassil Apparatus and method for sustaining and evaluating isolated organs
JP2024029908A (ja) * 2022-08-23 2024-03-07 株式会社Ｓｃｒｅｅｎホールディングス 接続配管、灌流装置の準備方法、および灌流方法
USD1031028S1 (en) 2022-09-08 2024-06-11 Paragonix Technologies, Inc. Tissue suspension adaptor
US20250064674A1 (en) 2023-08-25 2025-02-27 Paragonix Technologies, Inc. Methods and systems for cyclically inflating and deflating a lung ex-vivo
US12410408B2 (en) 2024-02-02 2025-09-09 Paragonix Technologies, Inc. Method for hypothermic transport of biological samples
US20260087945A1 (en) * 2024-05-03 2026-03-26 Maximum Fidelity Surgical Simulations, Inc. Surgical simulation systems and methods with selective perfusion
USD1087382S1 (en) 2025-01-30 2025-08-05 Paragonix Technologies, Inc. Device for transporting a biological sample

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666425A (en) * 1985-12-17 1987-05-19 The Dis Corporation Device for perfusing an animal head
AU633280B2 (en) * 1988-10-26 1993-01-28 Michael Kaye A device for transportation of human organs used for transplantation
US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US6331658B1 (en) * 1993-04-20 2001-12-18 Integris Baptist Medical Center, Inc. Genetically engineered mammals for use as organ donors
DE9422008U1 (de) * 1993-06-07 1997-08-28 Mayer, Berndt, Priv.-Doz. Dr.med., 10585 Berlin Vorrichtung zur Konservierung von Organen, Extremitäten und Gewebelappen
US5807737A (en) * 1996-07-26 1998-09-15 Schill Enterprises, Inc. Heart and lung support assembly
US6642045B1 (en) * 1997-04-14 2003-11-04 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US6100082A (en) * 1997-09-23 2000-08-08 Hassanein; Waleed H. Perfusion apparatus and method including chemical compositions for maintaining an organ
CA2304598C (en) * 1997-09-23 2009-03-10 Waleed H. Hassanein Compositions, methods and devices for maintaining an organ

Also Published As

Publication number Publication date
EP1168913A1 (de) 2002-01-09
DE60023672T2 (de) 2006-07-20
US7410474B1 (en) 2008-08-12
AU3665800A (en) 2000-11-14
DE60023672D1 (de) 2005-12-08
GB9908335D0 (en) 1999-06-09
WO2000060936A1 (en) 2000-10-19
ES2250119T3 (es) 2006-04-16
CA2369159C (en) 2011-11-29
EP1168913B1 (de) 2005-11-02
CA2369159A1 (en) 2000-10-19

Similar Documents

Publication Publication Date Title
ATE308239T1 (de) Verfahren und vorrichtungen zur extrakorporealen organperfusion
DE602004030941D1 (de) Kreislauf für die extrakorporale blutbehandlung und dabei verwendete fluss-umkehr-vorrichtung
Wolff et al. Free flap transplantation using an extracorporeal perfusion device: First three cases
US20030212357A1 (en) Method and apparatus for treating wounds with oxygen and reduced pressure
JP2004505660A (ja) 増強した化学的デブリドマンのためのシステム
MXPA05009455A (es) Sistema para monitoreo de paciente y suministro de farmaco y metodo de uso.
ATE298259T1 (de) Vorrichtung zur lokalen verabreichung einer arznei in einer körperhöhle
DE60036811D1 (de) Zugangsöffnung mit klip und verwendungsverfahren
ATE439887T1 (de) System zur freisetzung eines heilmittels
ATE534426T1 (de) Intravaskuläres abgabesystem für therapeutische mittel
DE60139077D1 (de) System zur endotrachealen/ösophagischen stimulation vor und während eines medizinischen verfahrens
WO2008008340A3 (en) System and method for a low profile vibrating plate
ATE332668T1 (de) Medizinische vorrichtung zur blutstromsteuerung
WO2004101024A3 (en) Method for treating glandular diseases and malignancies
Wolff et al. In vivo perfusion of free skin flaps using extracorporeal membrane oxygenation
DE602004022521D1 (de) System zur behandlung von harnwegserkrankungen
SE0202172D0 (sv) Device and method for cirkulatory isolation and treatment of a part of a body
RU2237473C1 (ru) Способ лечения ран
MX348034B (es) Dispositivo y método para conectar una bomba de sangre sin atrapar burbujas de aire.
Frühauf et al. A bioartificial liver support system using primary hepatocytes: a preclinical study in a new porcine hepatectomy model
Chua Patel et al. Vacuum-assisted wound closure
Khin et al. Hypertensive extracorporeal limb perfusion for critical limb ischemia
Ichai et al. Treatment of patients with hepatic failure: the difficult place of liver support systems
RU2680935C1 (ru) Способ комбинированной аутопластики
RU2113175C1 (ru) Способ лечения гнойного холангита и холангиогенных абсцессов печени

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties