ATE309326T1 - Verfahren zur konservierung eukariotischen zellen und dadurch hergestellte zusammensetzungen - Google Patents

Verfahren zur konservierung eukariotischen zellen und dadurch hergestellte zusammensetzungen

Info

Publication number
ATE309326T1
ATE309326T1 AT97947793T AT97947793T ATE309326T1 AT E309326 T1 ATE309326 T1 AT E309326T1 AT 97947793 T AT97947793 T AT 97947793T AT 97947793 T AT97947793 T AT 97947793T AT E309326 T1 ATE309326 T1 AT E309326T1
Authority
AT
Austria
Prior art keywords
preserving
cells
produced therefrom
compositions produced
storage
Prior art date
Application number
AT97947793T
Other languages
English (en)
Inventor
Alan G Tunnacliffe
David T Welsh
Bruce Joseph Roser
Kamaljit S Dhaliwal
Camilo Colaco
Original Assignee
Quadrant Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadrant Drug Delivery Ltd filed Critical Quadrant Drug Delivery Ltd
Application granted granted Critical
Publication of ATE309326T1 publication Critical patent/ATE309326T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Microbiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT97947793T 1996-12-05 1997-12-05 Verfahren zur konservierung eukariotischen zellen und dadurch hergestellte zusammensetzungen ATE309326T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3242396P 1996-12-05 1996-12-05
PCT/GB1997/003375 WO1998024882A1 (en) 1996-12-05 1997-12-05 Methods of preserving prokaryotic cells and compositions obtained thereby

Publications (1)

Publication Number Publication Date
ATE309326T1 true ATE309326T1 (de) 2005-11-15

Family

ID=21864890

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97947793T ATE309326T1 (de) 1996-12-05 1997-12-05 Verfahren zur konservierung eukariotischen zellen und dadurch hergestellte zusammensetzungen

Country Status (10)

Country Link
US (2) US6468782B1 (de)
EP (1) EP0946710B1 (de)
JP (1) JP2001505431A (de)
CN (1) CN1239997A (de)
AT (1) ATE309326T1 (de)
AU (1) AU721391B2 (de)
CA (1) CA2272821A1 (de)
DE (1) DE69734600T2 (de)
WO (1) WO1998024882A1 (de)
ZA (1) ZA9710974B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0679088T3 (da) * 1992-09-29 2002-10-28 Inhale Therapeutic Syst Pulmonal levering af aktive fragmenter af parathyreoideaea hormon
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
DE69535897D1 (de) 1994-03-07 2009-01-22 Nektar Therapeutics Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6468782B1 (en) * 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US7569342B2 (en) 1997-12-10 2009-08-04 Sierra Molecular Corp. Removal of molecular assay interferences
EP1402003A4 (de) * 1999-08-19 2004-07-14 Universal Preservation Technologies Inc Konservierung von bakteriellen Zellen unter Raumtemperaturen
GB9919732D0 (en) * 1999-08-19 1999-10-20 Colaco Camilo Trehalose producing cells as vaccines
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US6653062B1 (en) 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
US20040110267A1 (en) * 2000-12-15 2004-06-10 Stratagene Room temperature stable competent cells
ATE329008T1 (de) * 2001-02-02 2006-06-15 Suntory Ltd Verfahren zur herstellung von aktiver trockenhefe
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
EP1937800A4 (de) * 2005-09-26 2009-11-18 Aeras Global Tb Vaccine Found Verfahren zur stabilisierung von bakterienzellen
GB2430880A (en) * 2005-10-04 2007-04-11 Cambridge Biostability Ltd Pharmaceutical compositions stabilized in glassy particles
GB0523638D0 (en) * 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
WO2007079147A2 (en) 2005-12-28 2007-07-12 Advanced Bionutrition Corporation A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
JP5285617B2 (ja) 2006-12-18 2013-09-11 アドバンスド バイオニュートリション コーポレーション 生きたプロバイオティクスを含む乾燥食物製品
DK2148923T3 (da) * 2007-05-18 2012-12-03 Medimmune Llc Konservering af biologisk aktive materialer med frysetørret skum
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
US9801818B2 (en) 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
ES2578522T3 (es) 2008-01-03 2016-07-27 Proterro, Inc Microorganismos fotosintéticos transgénicos y fotobiorreactor
GB0900350D0 (en) 2009-01-09 2009-02-11 Cambridge Entpr Ltd Formulations of viable bacteria for oral delivery
EP3266448B1 (de) 2009-03-27 2022-02-16 Intervet International B.V. Impfstoffe in mikropartikelform zur oralen oder nasalen impfung und stärkung von tieren einschliesslich fischen
SG176253A1 (en) 2009-05-26 2011-12-29 Advanced Bionutrition Corp Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
WO2011089391A1 (en) 2010-01-21 2011-07-28 Cambridge Enterprise Limited Mammalian cell preservation methods
NZ601017A (en) 2010-01-28 2014-07-25 Advanced Bionutrition Corp Dry glassy composition comprising a bioactive material
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
CL2011001984A1 (es) 2010-08-13 2012-06-29 Advanced Bionutrition Corp Composicion seca estabilizadora para material biologico que comprende carbohidrato, proteinas hidrolizadas de animal o de planta y un componente de acido carboxilico; metodo de preparacion; y formulacion de entrega oral que comprende la composicion seca estabilizadora.
US8512679B2 (en) 2011-03-04 2013-08-20 Elwha Llc Glassy compositions
WO2013082139A1 (en) * 2011-11-28 2013-06-06 Rui Zhang Thermal cycling using phase changing fluids
EP3328215B1 (de) 2015-07-29 2021-07-07 Advanced BioNutrition Corp. Stabile trockene probiotische zusammensetzungen für spezielle diätverwendungen
US12558395B2 (en) 2015-07-29 2026-02-24 Advanced Bionutrition Corp. Stable dry probiotic compositions for special dietary uses
US20170204357A1 (en) * 2016-01-19 2017-07-20 Bassam El-Fahmawi Method and device for maintaining mammalian and microbial cells viable and intact during ambient temperature transport and storage
US10843244B2 (en) 2016-08-23 2020-11-24 Bulldog Green Remediation, Inc. Methods for bioremediation of hydrocarbon-contaminated media
EP3839039A1 (de) * 2019-12-16 2021-06-23 4D Pharma Research Limited Herstellung von bakterieller biomasse mit verbesserter lagerstabilität
KR20220146614A (ko) * 2020-02-28 2022-11-01 업카라 인코포레이티드 모세관 보조 유리화 방법 및 생물학적 시료의 보존을 위한 물질
CN116064360A (zh) * 2022-11-18 2023-05-05 上海理工大学 一种提高菌株冷冻干燥存活率的方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2246013A1 (de) 1972-09-20 1974-03-28 Boehringer Mannheim Gmbh Verfahren zur herstellung von poroesen tabletten
FR2238476A1 (en) 1973-07-23 1975-02-21 Aries Robert Double esters of zeranol and natural hormones - and their implants for livestock, have protein anabolism props
JPS54140710A (en) 1978-03-10 1979-11-01 Mitsui Toatsu Chem Inc Anti-tumor substance and its preparation
US4436728A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
JPS58216695A (ja) 1982-06-07 1983-12-16 Otsuka Shokuhin Kogyo Kk トレハロ−スの製造方法
DE3484951D1 (de) 1983-10-14 1991-09-26 Sumitomo Pharma Verlaengerte praeparate mit verzoegerter abgabe.
US5171568A (en) 1984-04-06 1992-12-15 Chiron Corporation Recombinant herpes simplex gb-gd vaccine
US4620847A (en) 1984-06-01 1986-11-04 Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov Device for administering powdered substances
JPS60258195A (ja) 1984-06-05 1985-12-20 Ss Pharmaceut Co Ltd α．α―トレハロース脂肪酸ジエステル誘導体
GB8508173D0 (en) 1985-03-28 1985-05-01 Standard Telephones Cables Ltd Controlled delivery device
JPH0779694B2 (ja) 1985-07-09 1995-08-30 カドラント バイオリソ−シズ リミテツド 蛋白質および同類品の保護
JPS62174094A (ja) 1985-12-16 1987-07-30 Ss Pharmaceut Co Ltd α．α―トレハロース誘導体
GB8604983D0 (en) 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
US5387431A (en) 1991-10-25 1995-02-07 Fuisz Technologies Ltd. Saccharide-based matrix
US4855326A (en) 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
GB8715238D0 (en) 1987-06-29 1987-08-05 Quadrant Bioresources Ltd Food process
GB8801338D0 (en) 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
US5045446A (en) 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US5077284A (en) 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response
US5407684A (en) 1988-12-30 1995-04-18 Virginia Commonwealth University Use of DHEA as a medicinal
AU5414990A (en) 1989-04-12 1990-11-05 Aberdeen University Slow release vitreous systems
US5312909A (en) * 1990-03-28 1994-05-17 Gist Brocades, N.V. Recombinant DNA encoding neutral trehalase
ATE147990T1 (de) 1990-05-10 1997-02-15 Dana Farber Cancer Inst Inc Erhöhung der assoziation exogener peptide mit mhci-molekülen auf zellen des immunsystems
IT1246350B (it) 1990-07-11 1994-11-17 Eurand Int Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili
AU650045B2 (en) * 1990-09-12 1994-06-09 Lifecell Corporation Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions
GB9105992D0 (en) 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccine
WO1993002834A1 (de) 1991-07-31 1993-02-18 Farros Blatter Ag Schleifgerät zum schleifen einer zylindrischen oder sphärischen oberfläche einer walze, insbesondere einer walze einer papiermaschine
GB9125695D0 (en) 1991-12-03 1992-01-29 Mastavac Limited Medical preparations
EP0615438B1 (de) 1991-12-05 1996-07-24 Mallinckrodt Veterinary, Inc. Glasartige kohlenhydratenmatrize zur verabreichung von heilmitteln mit verzögerter wirkstoffabgabe
NL9200844A (nl) 1992-05-13 1993-12-01 De Wijdeven Gijsbertus G P Van Inrichting en werkwijze voor het injecteren met een vaste stof.
US5380473A (en) 1992-10-23 1995-01-10 Fuisz Technologies Ltd. Process for making shearform matrix
DK0686045T3 (da) 1993-02-23 2001-03-05 Genentech Inc Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof
TW404844B (en) 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
WO1995006126A1 (en) 1993-08-24 1995-03-02 Mogen International N.V. Production of trehalose in plants
GB9314886D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Production of a biological control agent
US5565341A (en) 1993-08-13 1996-10-15 Kureha Chemical Industry Co., Ltd. Process for producing trehalose
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5512547A (en) 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
JPH08157491A (ja) 1994-11-30 1996-06-18 Hayashibara Biochem Lab Inc トレハロース誘導体の製造方法
CN1245957C (zh) 1995-06-07 2006-03-22 廓德伦特控股剑桥有限公司 将物质稳定掺入干燥泡沫玻璃基质中的方法以及由此制得的组合物
US5766520A (en) * 1996-07-15 1998-06-16 Universal Preservation Technologies, Inc. Preservation by foam formation
US6468782B1 (en) * 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby

Also Published As

Publication number Publication date
EP0946710B1 (de) 2005-11-09
EP0946710A1 (de) 1999-10-06
DE69734600D1 (de) 2005-12-15
AU721391B2 (en) 2000-06-29
US6468782B1 (en) 2002-10-22
US20030113900A1 (en) 2003-06-19
ZA9710974B (en) 1998-12-28
CA2272821A1 (en) 1998-06-11
AU5403498A (en) 1998-06-29
CN1239997A (zh) 1999-12-29
WO1998024882A1 (en) 1998-06-11
JP2001505431A (ja) 2001-04-24
DE69734600T2 (de) 2006-07-20

Similar Documents

Publication Publication Date Title
DE69734600D1 (de) Verfahren zur konservierung eukariotischen zellen und dadurch hergestellte zusammensetzungen
DE69929445D1 (de) Methoden und reagenzien zur erhaltung der rna in zellen und geweben
NO975773D0 (no) Fremgangsmåter for stabil innarbeiding av stoffer i törre, skummede glass-grunnmasser, og sammensetninger oppnådd derved
DK0809110T3 (da) Makromolekylære mikropartikler og fremgangsmåder til fremstilling
DK0804163T3 (da) Forbedret fremgangsmåde til stabilisering af biologiske stoffer under tørring og efterfølgende opbevaring samt præparater deraf
ATE110412T1 (de) Translation von mrna.
DK59691D0 (da) Fremgangsmaade til fremstilling af liposomer med forbedret stabilitet under toerring
DE60035125D1 (de) Konservierung von empfindlichem biologischen material
DE69431903D1 (de) Verbesserung der lebensfähigkeit von getrockneten bakterienzellen
WO2000001231A3 (en) Improved methods for storing neural cells
DE69524121D1 (de) Verfahren zur herstellung von komprimiertem und teilweise dehydratisiertem gemüse
ATE237373T1 (de) Epithelzellen enthaltendes biomaterial und ihre verwendung als transplantat
DE60213852D1 (de) Herstellung von zellsuspensionen
BR8601513A (pt) Processo para a preservacao de bacterias produtoras de acidos,suspensao de bacterias assim preparada e composicao
DE60107718T8 (de) Konservierung von zellen
ES2007950A6 (es) Procedimiento para obtener productos inhibidores de levaduras y mohos.
DE60102147D1 (de) Anti-gefrier proteine, deren herstellung und verwendung
WO2004110372A3 (en) Room temperature storage of organs
ATE218377T1 (de) Verfahren zur präparation von knochenmaterial
Tan et al. Freeze-drying fungi using a shelf-freeze drier
Mandelstam Isolation of lysozyme-soluble mucopeptides from the cells wall of Escherichia coli
NO911902D0 (no) Fremgangsmaate for fremstilling av dehydrerte sammenpressede naeringsmidler med utgangspunkt i frysetoerkede og/eller toerkede produkter av vegetabilsk eller animalsk opprinnelse, og naeringsmidler oppnaadd saaledes.
DK0536252T3 (da) Phosphortrilactamer og fremgangsmåde til deres fremstilling
ATE251655T1 (de) Wassergeschäumte polystyrolpartikel
FR2657020B1 (fr) Diffuseur de parfum d'ambiance, destine notamment a impregner une fleur ou une plante artificielle ou une composition florale, et fleur ou plante artificielle ou composition florale ainsi parfumee.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0946710

Country of ref document: EP

REN Ceased due to non-payment of the annual fee