ATE309338T1 - Antisense oligonucleotides zur inhibition der expression von type i procollagen - Google Patents

Antisense oligonucleotides zur inhibition der expression von type i procollagen

Info

Publication number: ATE309338T1
Authority: AT; Austria
Prior art keywords: expression; procollagen; inhibition; type; antisense oligonucleotides
Prior art date: 1999-12-15

Application number

AT00988966T

Other languages

English (en)

Inventor

Rajinder Beri

Original Assignee

Rahul Kumar Nath M D

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-15

Filing date

2000-12-12

Publication date

2005-11-15

2000-12-12 Application filed by Rahul Kumar Nath M D filed Critical Rahul Kumar Nath M D

2005-11-15 Application granted granted Critical

2005-11-15 Publication of ATE309338T1 publication Critical patent/ATE309338T1/de

Links

108020000948 Antisense Oligonucleotides Proteins 0.000 title 1
102100036213 Collagen alpha-2(I) chain Human genes 0.000 title 1
101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 title 1
239000000074 antisense oligonucleotide Substances 0.000 title 1
238000012230 antisense oligonucleotides Methods 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
108020004491 Antisense DNA Proteins 0.000 abstract 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
239000003816 antisense DNA Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Veterinary Medicine (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT00988966T 1999-12-15 2000-12-12 Antisense oligonucleotides zur inhibition der expression von type i procollagen ATE309338T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9929487.8A GB9929487D0 (en)	1999-12-15	1999-12-15	Antisense oligonucleotides
PCT/GB2000/004741 WO2001044455A2 (en)	1999-12-15	2000-12-12	Antisense oligonucleotides for the inhibition of expression of type i procollagen

Publications (1)

Publication Number	Publication Date
ATE309338T1 true ATE309338T1 (de)	2005-11-15

Family

ID=10866254

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT05024183T ATE410510T1 (de)	1999-12-15	2000-12-12	Antisense oligonukleotide zur expressionshemmung des typ i-prokollagens
AT00988966T ATE309338T1 (de)	1999-12-15	2000-12-12	Antisense oligonucleotides zur inhibition der expression von type i procollagen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT05024183T ATE410510T1 (de)	1999-12-15	2000-12-12	Antisense oligonukleotide zur expressionshemmung des typ i-prokollagens

Country Status (17)

Country	Link
US (1)	US7173122B2 (de)
EP (3)	EP1244781B1 (de)
JP (1)	JP2003516752A (de)
KR (1)	KR20020064936A (de)
CN (1)	CN1423695A (de)
AT (2)	ATE410510T1 (de)
AU (1)	AU2529701A (de)
BR (1)	BR0016347A (de)
CA (1)	CA2390674A1 (de)
DE (2)	DE60023943T2 (de)
GB (1)	GB9929487D0 (de)
IL (1)	IL149640A0 (de)
MX (1)	MXPA02005871A (de)
NO (1)	NO20022799L (de)
NZ (1)	NZ519008A (de)
WO (1)	WO2001044455A2 (de)
ZA (1)	ZA200203878B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7396823B2 (en) *	1999-12-15	2008-07-08	Nath Rahul K	Therapy inhalation involving antisense oligonucleotides for treating idiopathic pulmonary fibrosis
CN111378657B (zh) *	2018-12-28	2024-03-15	苏州瑞博生物技术股份有限公司	抑制COL1A1基因表达的siRNA、含有该siRNA的药物组合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993011149A1 (en)	1991-12-03	1993-06-10	Thomas Jefferson University	Methods of detecting a genetic predisposition for osteoporosis
US6265157B1 (en) *	1991-12-03	2001-07-24	Allegheny University Of The Health Sciences	Compositions and methods for detecting altered COL1A1 gene sequences
EP0674705A4 (de) *	1992-11-09	1997-11-26	Univ Jefferson	Antisense-oligonukleotide zur hemmung der expression mutierter gene und wildtypgene des collagens.
WO1994022487A1 (en) *	1993-03-26	1994-10-13	Thomas Jefferson University	Use of a col 1a1 mini-gene construct to inhibit collagen synthesis
ATE206131T1 (de) *	1995-03-13	2001-10-15	Aventis Pharma Gmbh	Phosphonomonoesternnukleinsäuren, verfahren zu ihrer herstellung und ihre verwendung
DE19508923A1 (de) *	1995-03-13	1996-09-19	Hoechst Ag	Phosphonomonoesternukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0736608A1 (de) *	1995-04-08	1996-10-09	Roche Diagnostics GmbH	Verfahren zur spezifischen Vervielfältigung und zum Nachweis von DNA bzw. RNA
EP0856579A1 (de)	1997-01-31	1998-08-05	BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH	Ein Verfahren zur Zubereitung von Antisense Oligonukleotiden
US6238921B1 (en)	1998-03-26	2001-05-29	Isis Pharmaceuticals, Inc.	Antisense oligonucleotide modulation of human mdm2 expression
US6007995A (en) *	1998-06-26	1999-12-28	Isis Pharmaceuticals Inc.	Antisense inhibition of TNFR1 expression
CN1285612C (zh) *	1999-11-12	2006-11-22	法布罗根股份有限公司	动物胶原和明胶

1999
- 1999-12-15 GB GBGB9929487.8A patent/GB9929487D0/en not_active Ceased
2000
- 2000-12-12 EP EP00988966A patent/EP1244781B1/de not_active Expired - Lifetime
- 2000-12-12 DE DE60023943T patent/DE60023943T2/de not_active Expired - Lifetime
- 2000-12-12 IL IL14964000A patent/IL149640A0/xx unknown
- 2000-12-12 KR KR1020027007591A patent/KR20020064936A/ko not_active Withdrawn
- 2000-12-12 CA CA002390674A patent/CA2390674A1/en not_active Abandoned
- 2000-12-12 US US10/149,352 patent/US7173122B2/en not_active Expired - Fee Related
- 2000-12-12 JP JP2001545532A patent/JP2003516752A/ja active Pending
- 2000-12-12 MX MXPA02005871A patent/MXPA02005871A/es unknown
- 2000-12-12 AT AT05024183T patent/ATE410510T1/de not_active IP Right Cessation
- 2000-12-12 NZ NZ519008A patent/NZ519008A/en unknown
- 2000-12-12 CN CN00817282A patent/CN1423695A/zh active Pending
- 2000-12-12 WO PCT/GB2000/004741 patent/WO2001044455A2/en not_active Ceased
- 2000-12-12 AU AU25297/01A patent/AU2529701A/en not_active Abandoned
- 2000-12-12 EP EP08017586A patent/EP2025752A3/de not_active Withdrawn
- 2000-12-12 AT AT00988966T patent/ATE309338T1/de not_active IP Right Cessation
- 2000-12-12 BR BR0016347-3A patent/BR0016347A/pt not_active Application Discontinuation
- 2000-12-12 DE DE60040495T patent/DE60040495D1/de not_active Expired - Lifetime
- 2000-12-12 EP EP05024183A patent/EP1698695B1/de not_active Expired - Lifetime
2002
- 2002-05-15 ZA ZA200203878A patent/ZA200203878B/xx unknown
- 2002-06-12 NO NO20022799A patent/NO20022799L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
GB9929487D0 (en)	2000-02-09
NO20022799D0 (no)	2002-06-12
MXPA02005871A (es)	2002-10-23
EP2025752A2 (de)	2009-02-18
JP2003516752A (ja)	2003-05-20
NO20022799L (no)	2002-06-12
EP1244781B1 (de)	2005-11-09
DE60023943T2 (de)	2006-08-03
CN1423695A (zh)	2003-06-11
BR0016347A (pt)	2002-09-10
NZ519008A (en)	2004-04-30
CA2390674A1 (en)	2001-06-21
ATE410510T1 (de)	2008-10-15
DE60040495D1 (de)	2008-11-20
EP1244781A2 (de)	2002-10-02
EP1698695B1 (de)	2008-10-08
WO2001044455A3 (en)	2002-01-10
ZA200203878B (en)	2003-08-15
US7173122B2 (en)	2007-02-06
WO2001044455A2 (en)	2001-06-21
AU2529701A (en)	2001-06-25
EP1698695A3 (de)	2007-02-14
US20030105050A1 (en)	2003-06-05
DE60023943D1 (de)	2005-12-15
KR20020064936A (ko)	2002-08-10
EP1698695A2 (de)	2006-09-06
IL149640A0 (en)	2002-11-10
EP2025752A3 (de)	2009-08-12

Legal Events

Date

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Title

Description

2006-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1244781

Country of ref document: EP

2011-09-15

REN

Ceased due to non-payment of the annual fee

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