ATE309341T1 - Identifizierung von eukaryotischen internal ribosome entry site elementen (ires) - Google Patents
Identifizierung von eukaryotischen internal ribosome entry site elementen (ires)Info
- Publication number
- ATE309341T1 ATE309341T1 AT02776971T AT02776971T ATE309341T1 AT E309341 T1 ATE309341 T1 AT E309341T1 AT 02776971 T AT02776971 T AT 02776971T AT 02776971 T AT02776971 T AT 02776971T AT E309341 T1 ATE309341 T1 AT E309341T1
- Authority
- AT
- Austria
- Prior art keywords
- ires
- gene
- ires element
- potential
- translation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10143238A DE10143238A1 (de) | 2001-09-04 | 2001-09-04 | Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente |
| PCT/EP2002/009844 WO2003020928A2 (en) | 2001-09-04 | 2002-09-03 | Identification of eukaryotic internal ribosome entry site (ires) elements |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309341T1 true ATE309341T1 (de) | 2005-11-15 |
Family
ID=7697618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02776971T ATE309341T1 (de) | 2001-09-04 | 2002-09-03 | Identifizierung von eukaryotischen internal ribosome entry site elementen (ires) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8257945B2 (de) |
| EP (1) | EP1423516B1 (de) |
| JP (1) | JP2005502348A (de) |
| AT (1) | ATE309341T1 (de) |
| AU (1) | AU2002339478B2 (de) |
| CA (1) | CA2457038A1 (de) |
| DE (2) | DE10143238A1 (de) |
| MX (1) | MXPA04002097A (de) |
| WO (1) | WO2003020928A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10049587A1 (de) | 2000-10-06 | 2002-05-02 | Icon Genetics Ag | Vektorsystem für Pflanzen |
| DE10061150A1 (de) | 2000-12-08 | 2002-06-13 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| DE10102389A1 (de) | 2001-01-19 | 2002-08-01 | Icon Genetics Ag | Verfahren und Vektoren zur Plastidentransformation höherer Pflanzen |
| DE10114209A1 (de) * | 2001-03-23 | 2002-12-05 | Icon Genetics Ag | Ortsgerichtete Transformation durch Verwendung von Amplifikationsvektoren |
| DE10115507A1 (de) * | 2001-03-29 | 2002-10-10 | Icon Genetics Ag | Verfahren zur Kodierung von Information in Nukleinsäuren eines genetisch veränderten Organismus |
| DE10121283B4 (de) | 2001-04-30 | 2011-08-11 | Icon Genetics GmbH, 80333 | Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen |
| DE10132780A1 (de) * | 2001-07-06 | 2003-01-16 | Icon Genetics Ag | Plastidäre Genexpression über autonom replizierende Vektoren |
| DE10143237A1 (de) * | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente) |
| DE10143238A1 (de) | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente |
| EP1608762B1 (de) * | 2003-03-20 | 2014-01-08 | Alphavax, Inc. | Verbesserte alphavirus replikons und helferkonstrukt |
| EP1807520B1 (de) | 2004-10-25 | 2012-07-25 | Devgen NV | Rna-konstrukte |
| ES2388003T3 (es) * | 2006-09-20 | 2012-10-05 | Genzyme Corporation | Un sistema basado en FACS y en la proteína indicadora para un desarrollo de alto rendimiento de proteínas terapéuticas |
| DK2947149T3 (en) * | 2007-06-21 | 2018-06-06 | Alphavax Inc | ALPHAVIRUS REPLICATION PARTICLES FOR USE IN VACCINATION |
| WO2009098717A2 (en) * | 2008-01-17 | 2009-08-13 | Polyclone Bioservices Pvt. Ltd. | A method to characterize a protein as rna binding protein |
| ES2746803T3 (es) | 2013-05-15 | 2020-03-06 | Robert Kruse | Traducción intracelular de ARN circular |
| IL258538B2 (en) | 2015-10-09 | 2023-04-01 | Genzyme Corp | Early isolation after the infection of cells (epic) for the production of biological material |
| ES3021241T3 (en) | 2016-10-07 | 2025-05-26 | Genzyme Corp | Early post-transfection isolation of cells (epic) for biologics production |
| CN110819707B (zh) * | 2019-11-24 | 2023-07-18 | 中南大学湘雅医院 | 一种针对多种来源细胞样本中内部核糖体结合位点元件的高通量鉴定方法 |
| KR20230028375A (ko) * | 2020-06-25 | 2023-02-28 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 원형 rna 번역을 구동하는 유전 요소와 이를 사용하는 방법 |
| AU2022221309A1 (en) * | 2021-02-09 | 2023-08-24 | Virginia Commonwealth University | Mini circular rna therapeutics and vaccines and methods of use thereof |
| CN115394376B (zh) * | 2022-09-28 | 2023-04-18 | 奥明(杭州)生物医药有限公司 | 一种预测环状rna ires的方法 |
| CN121450687A (zh) * | 2024-07-31 | 2026-02-03 | 康码(上海)生态科技有限公司 | 增强蛋白质合成效率的串联rna元件 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0229174A1 (de) | 1985-07-16 | 1987-07-22 | The Salk Institute For Biological Studies | Genetische modifikation von pflanzen mittels retroviren |
| US6147278A (en) | 1985-10-25 | 2000-11-14 | Monsanto Company | Plant vectors |
| GB8626878D0 (en) | 1986-11-11 | 1986-12-10 | Ici Plc | Dna |
| US5922602A (en) | 1988-02-26 | 1999-07-13 | Biosource Technologies, Inc. | Cytoplasmic inhibition of gene expression |
| US6174700B1 (en) | 1988-07-08 | 2001-01-16 | University Of British Columbia | Purification of a polypeptide compound having a polysaccharide binding domain by affinity phase separation |
| FR2649518B1 (fr) | 1989-07-07 | 1991-10-18 | Bioprobe Systems Sa | Procede et dispositif de marquage crypte de haute securite pour la protection d'objets de valeur |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5877402A (en) | 1990-05-01 | 1999-03-02 | Rutgers, The State University Of New Jersey | DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein |
| US5474925A (en) | 1991-12-19 | 1995-12-12 | Agracetus, Inc. | Immobilized proteins in cotton fiber |
| AU694102B2 (en) | 1992-12-30 | 1998-07-16 | Kentucky Bioprocessing, Llc | Viral amplification of recombinant messenger RNA in transgenic plants |
| US5496934A (en) | 1993-04-14 | 1996-03-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acids encoding a cellulose binding domain |
| US5576198A (en) | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
| US5723765A (en) | 1994-08-01 | 1998-03-03 | Delta And Pine Land Co. | Control of plant gene expression |
| EP0795029A1 (de) | 1994-12-08 | 1997-09-17 | Pabio | Chemische markierung von gegenständen |
| US5910628A (en) | 1996-05-20 | 1999-06-08 | Iowa State University Research Foundation, Inc. | Cap-independent translation sequences derived from barley yellow dwarf virus |
| US6037525A (en) | 1996-08-01 | 2000-03-14 | North Carolina State University | Method for reducing expression variability of transgenes in plant cells |
| CA2264489A1 (en) | 1996-09-09 | 1998-03-12 | Loyola University Of Chicago | Plant retroviral polynucleotides and methods for use thereof |
| US5939541A (en) | 1997-03-28 | 1999-08-17 | University Of South Carolina | Method for enhancing expression of a foreign or endogenous gene product in plants |
| US6146845A (en) | 1997-04-02 | 2000-11-14 | Smithkline Beecham Corporation | Polynucleotides encoding a sialoadhesin family member-2 (SAF-2) |
| FI972293A7 (fi) | 1997-05-30 | 1998-12-01 | Timo Korpela | Useamman kuin yhden geenin yhteisekspressiomenetelmät |
| PT1034262E (pt) | 1997-11-18 | 2005-10-31 | Pioneer Hi Bred Int | Composicoes e metodos para a modificacao genetica de plantas |
| NZ504510A (en) | 1997-11-18 | 2002-10-25 | Pioneer Hi Bred Int | Methods and compositions for increasing efficiency of excision of a viral replicon from T-DNA that is transferred to a plant by agroinfection |
| EP1045899A2 (de) | 1998-01-16 | 2000-10-25 | Biosource Technologies, Inc. | Methode zur bestimmung der funktion von nukleinsäurensequenzen und davon kodierten proteine durch transfektion in einem gast |
| EP1115870A2 (de) | 1998-09-23 | 2001-07-18 | E.I. Du Pont De Nemours And Company | Binäres virales expressionssystem in pflanzen |
| GB9821303D0 (en) | 1998-10-01 | 1998-11-25 | Novartis Ag | Organic compounds |
| WO2000068391A1 (en) | 1998-10-23 | 2000-11-16 | University Of British Columbia | Expression of a mannan binding domain to alter plant morphology |
| EP1144665A1 (de) | 1998-11-25 | 2001-10-17 | Calgene LLC | Verfahren zur transformation von plastiden |
| EP1045037A1 (de) | 1999-04-12 | 2000-10-18 | Discovery Biotech., Inc. | System zu Identifizierung von Planzenzellen |
| AU4703300A (en) | 1999-05-06 | 2000-11-21 | Mount Sinai School Of Medicine Of The City University Of New York, The | Dna-based steganography |
| WO2000070019A2 (en) | 1999-05-17 | 2000-11-23 | Icon Genetics, Inc. | Process of rapid variety-independent plant transformation |
| US6331416B1 (en) | 1999-06-10 | 2001-12-18 | Cbd Technologies Ltd. | Process of expressing and isolating recombinant proteins and recombinant protein products from plants, plant derived tissues or cultured plant cells |
| JP2003503033A (ja) | 1999-06-24 | 2003-01-28 | メタボリックス，インコーポレイテッド | 植物多重遺伝子発現構築物 |
| CA2378787A1 (en) | 1999-08-05 | 2001-02-15 | Icon Genetics, Inc. | Method of making plant artificial chromosomes |
| WO2001055371A1 (en) | 2000-01-28 | 2001-08-02 | The Scripps Research Institute | Methods of identifying synthetic transcriptional and translational regulatory elements, and compositions relating to same |
| AU2001242360A1 (en) | 2000-02-10 | 2001-08-20 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Plant internal ribosome entry segment |
| EP1276884A2 (de) | 2000-04-20 | 2003-01-22 | Btg International Limited | Transgene pflanzen |
| WO2001081605A2 (en) | 2000-04-26 | 2001-11-01 | Monsanto Technology Llc | Method for the transformation of plant cell plastids |
| GB0019745D0 (en) | 2000-08-10 | 2000-09-27 | Univ Surrey | Gene expression element |
| DE10049587A1 (de) | 2000-10-06 | 2002-05-02 | Icon Genetics Ag | Vektorsystem für Pflanzen |
| DE10061150A1 (de) | 2000-12-08 | 2002-06-13 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| US20030049228A1 (en) * | 2001-01-09 | 2003-03-13 | Simon Santa-Cruz | Expression of foreign genes from plant virus vectors |
| DE10101276A1 (de) | 2001-01-12 | 2002-07-18 | Icon Genetics Ag | Verfahren und Vektoren zur Transformation von Plastiden |
| DE10102389A1 (de) | 2001-01-19 | 2002-08-01 | Icon Genetics Ag | Verfahren und Vektoren zur Plastidentransformation höherer Pflanzen |
| DE10109354A1 (de) | 2001-02-27 | 2002-09-05 | Icon Genetics Ag | Rekombinante virale Schaltersysteme |
| US6833254B2 (en) | 2001-03-01 | 2004-12-21 | The Regents Of The University Of California | Method to identify IRES elements |
| DE10114209A1 (de) | 2001-03-23 | 2002-12-05 | Icon Genetics Ag | Ortsgerichtete Transformation durch Verwendung von Amplifikationsvektoren |
| DE10115507A1 (de) | 2001-03-29 | 2002-10-10 | Icon Genetics Ag | Verfahren zur Kodierung von Information in Nukleinsäuren eines genetisch veränderten Organismus |
| DE10121283B4 (de) | 2001-04-30 | 2011-08-11 | Icon Genetics GmbH, 80333 | Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen |
| DE10129010A1 (de) | 2001-06-13 | 2002-12-19 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| EP1270741A1 (de) | 2001-06-22 | 2003-01-02 | Keygene N.V. | An Krankheitsresistenzen beteiligte Nukleotidsequenzen in Pflanzen |
| DE10131690A1 (de) | 2001-06-29 | 2003-01-16 | Icon Genetics Ag | Verfahren zum kontrollierten Umordnen von Chromosomenfragmenten für die Pflanzenzucht |
| DE10131680A1 (de) | 2001-06-29 | 2003-01-23 | Voith Paper Patent Gmbh | Auftragsvorrichtung |
| DE10132780A1 (de) | 2001-07-06 | 2003-01-16 | Icon Genetics Ag | Plastidäre Genexpression über autonom replizierende Vektoren |
| DE10143238A1 (de) | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente |
| DE10143237A1 (de) | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente) |
| DE10143205A1 (de) | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Verfahren zur Proteinproduktion in Pflanzen |
-
2001
- 2001-09-04 DE DE10143238A patent/DE10143238A1/de not_active Withdrawn
-
2002
- 2002-09-03 AT AT02776971T patent/ATE309341T1/de active
- 2002-09-03 EP EP02776971A patent/EP1423516B1/de not_active Expired - Lifetime
- 2002-09-03 CA CA002457038A patent/CA2457038A1/en not_active Abandoned
- 2002-09-03 US US10/489,136 patent/US8257945B2/en not_active Expired - Fee Related
- 2002-09-03 AU AU2002339478A patent/AU2002339478B2/en not_active Ceased
- 2002-09-03 MX MXPA04002097A patent/MXPA04002097A/es active IP Right Grant
- 2002-09-03 DE DE60207275T patent/DE60207275T2/de not_active Expired - Lifetime
- 2002-09-03 JP JP2003525631A patent/JP2005502348A/ja active Pending
- 2002-09-03 WO PCT/EP2002/009844 patent/WO2003020928A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04002097A (es) | 2005-02-17 |
| US20050014150A1 (en) | 2005-01-20 |
| EP1423516B1 (de) | 2005-11-09 |
| WO2003020928A3 (en) | 2003-10-09 |
| AU2002339478B2 (en) | 2007-08-23 |
| EP1423516A2 (de) | 2004-06-02 |
| JP2005502348A (ja) | 2005-01-27 |
| CA2457038A1 (en) | 2003-03-13 |
| US8257945B2 (en) | 2012-09-04 |
| DE10143238A1 (de) | 2003-03-20 |
| WO2003020928A2 (en) | 2003-03-13 |
| DE60207275T2 (de) | 2006-07-13 |
| DE60207275D1 (de) | 2005-12-15 |
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