ATE310100T1 - Screeningverfahren für modulatoren von methyltransferase abhängiger chromosomenstabilität - Google Patents

Screeningverfahren für modulatoren von methyltransferase abhängiger chromosomenstabilität

Info

Publication number
ATE310100T1
ATE310100T1 AT01940552T AT01940552T ATE310100T1 AT E310100 T1 ATE310100 T1 AT E310100T1 AT 01940552 T AT01940552 T AT 01940552T AT 01940552 T AT01940552 T AT 01940552T AT E310100 T1 ATE310100 T1 AT E310100T1
Authority
AT
Austria
Prior art keywords
modulators
methyltransferase
suv39h2
screening method
chromosome stability
Prior art date
Application number
AT01940552T
Other languages
English (en)
Inventor
Thomas Jenuwein
Stephen Rea
Frank Eisenhaber
Donal O'carroll
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00112479A external-priority patent/EP1162460A1/de
Priority claimed from EP00112345A external-priority patent/EP1162274A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of ATE310100T1 publication Critical patent/ATE310100T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875Nucleoproteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1003Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007Methyltransferases (general) (2.1.1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/91005Transferases (2.) transferring one-carbon groups (2.1)
    • G01N2333/91011Methyltransferases (general) (2.1.1.)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01940552T 2000-06-09 2001-06-07 Screeningverfahren für modulatoren von methyltransferase abhängiger chromosomenstabilität ATE310100T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00112479A EP1162460A1 (de) 2000-06-09 2000-06-09 Screeningverfahren für Modulatoren des Suv39h2 Methyltransferases und der männlichen Gametogenese
EP00112345A EP1162274A1 (de) 2000-06-09 2000-06-09 Verfahren zur Identifizierung von Verbindungen, die die Methyltransferase-abhängige Chromosomen-Stabilität beeinflussen
PCT/EP2001/006485 WO2001094620A1 (en) 2000-06-09 2001-06-07 Screening-method for modulators of methyltransferase-dependent chromosome stability

Publications (1)

Publication Number Publication Date
ATE310100T1 true ATE310100T1 (de) 2005-12-15

Family

ID=26071033

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01940552T ATE310100T1 (de) 2000-06-09 2001-06-07 Screeningverfahren für modulatoren von methyltransferase abhängiger chromosomenstabilität

Country Status (7)

Country Link
EP (2) EP1294927B1 (de)
JP (2) JP4896344B2 (de)
AT (1) ATE310100T1 (de)
AU (2) AU2001274088A1 (de)
DE (1) DE60115039T2 (de)
ES (1) ES2252240T3 (de)
WO (2) WO2001094620A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055506A1 (fr) * 2001-12-27 2003-07-10 Takeda Chemical Industries, Ltd. Medicaments pour la prevention et le traitement du cancer
GB0301450D0 (en) * 2003-01-22 2003-02-19 Medical Res Council Protein crystal structure
JP3913181B2 (ja) * 2003-02-06 2007-05-09 三菱重工業株式会社 カーボンナノファイバの製造方法及び製造装置
JP5451376B2 (ja) * 2007-03-15 2014-03-26 株式会社リバース・プロテオミクス研究所 血球系に特異的あるいは破骨細胞分化に特異的なバイオマーカー
WO2012164936A1 (en) * 2011-06-03 2012-12-06 Oncotherapy Science, Inc. Suv39h2 as a target gene for cancer therapy and diagnosis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362007B1 (en) * 1997-08-29 2002-03-26 Innogenetics N.V. Methylated, SMD homologous peptides, reactive with the antibodies from sera of living beings affected with systemic lupus erythematosus

Also Published As

Publication number Publication date
WO2001094621A1 (en) 2001-12-13
JP2003535596A (ja) 2003-12-02
DE60115039D1 (de) 2005-12-22
EP1294928A1 (de) 2003-03-26
DE60115039T2 (de) 2006-07-27
AU2001274088A1 (en) 2001-12-17
JP4896344B2 (ja) 2012-03-14
EP1294927A1 (de) 2003-03-26
EP1294927B1 (de) 2005-11-16
WO2001094620A1 (en) 2001-12-13
JP2003535595A (ja) 2003-12-02
AU2001266055A1 (en) 2001-12-17
ES2252240T3 (es) 2006-05-16

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