ATE310512T1 - Verwendung von lipoxinen zur inhibierung von tnf- alpha initiierter gegenreaktion - Google Patents
Verwendung von lipoxinen zur inhibierung von tnf- alpha initiierter gegenreaktionInfo
- Publication number
- ATE310512T1 ATE310512T1 AT00917903T AT00917903T ATE310512T1 AT E310512 T1 ATE310512 T1 AT E310512T1 AT 00917903 T AT00917903 T AT 00917903T AT 00917903 T AT00917903 T AT 00917903T AT E310512 T1 ATE310512 T1 AT E310512T1
- Authority
- AT
- Austria
- Prior art keywords
- lipoxins
- initiated
- counterreaction
- alpha
- inhibit tnf
- Prior art date
Links
- 229930184725 Lipoxin Natural products 0.000 title 1
- 150000002639 lipoxins Chemical class 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 3
- IXAQOQZEOGMIQS-SSQFXEBMSA-M lipoxin A4(1-) Chemical compound CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC([O-])=O IXAQOQZEOGMIQS-SSQFXEBMSA-M 0.000 abstract 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12520599P | 1999-03-18 | 1999-03-18 | |
| PCT/US2000/006582 WO2000054767A1 (en) | 1999-03-18 | 2000-03-14 | Use of lipoxin compounds for inhibiting of tnf-(alfa) initiated neutrophil response |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE310512T1 true ATE310512T1 (de) | 2005-12-15 |
Family
ID=22418647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00917903T ATE310512T1 (de) | 1999-03-18 | 2000-03-14 | Verwendung von lipoxinen zur inhibierung von tnf- alpha initiierter gegenreaktion |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US6387953B1 (de) |
| EP (1) | EP1165066B1 (de) |
| JP (1) | JP4440481B2 (de) |
| AT (1) | ATE310512T1 (de) |
| AU (1) | AU775140B2 (de) |
| CA (3) | CA2367909C (de) |
| DE (1) | DE60024242T2 (de) |
| DK (1) | DK1165066T3 (de) |
| ES (1) | ES2249257T3 (de) |
| HK (1) | HK1043307B (de) |
| WO (1) | WO2000054767A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| AU775140B2 (en) * | 1999-03-18 | 2004-07-22 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of TNF-(alfa) initiated neutrophil response |
| DE60044335D1 (de) | 1999-03-18 | 2010-06-17 | Brigham & Womens Hospital | 16-phenoxy-lipoxin analoge zur medizinischen verwendung |
| ATE303355T1 (de) * | 1999-03-18 | 2005-09-15 | Brigham & Womens Hospital | Lipoxinverbindungen und ihre anwendung |
| ATE504557T1 (de) | 2000-02-16 | 2011-04-15 | Brigham & Womens Hospital | Aspirin-ausgelöste lipidmediatoren |
| EP1268393A2 (de) * | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxinanaloge und verfahren zur behandlung von periodontalen erkrankungen |
| GB2362140B (en) * | 2000-05-12 | 2003-03-05 | Autoliv Dev | Improvements in or relating to an apparatus for a method of folding an air-bag |
| US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
| ATE412448T1 (de) * | 2001-03-02 | 2008-11-15 | Brigham & Womens Hospital | Lipoxin analoge als neue inhibitoren der angiogenese |
| WO2003039533A1 (en) * | 2001-11-06 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| EP1911448B1 (de) * | 2001-11-06 | 2013-01-02 | The Brigham and Women's Hospital, Inc. | Aspirin-ausgelöste Lipoxine und ihre stabilen Analoga in der Behandlung von Asthma und entzündlichen Atemwegserkrankungen |
| JP2005513061A (ja) * | 2001-12-18 | 2005-05-12 | ザ ブライハム アンド ウイメンズ ホスピタル | グラム陰性感染に対する細胞防御を促進するためのリポキシンアナログの使用 |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| EP3584235A3 (de) * | 2002-08-12 | 2020-04-22 | Brigham and Women's Hospital | Resolvine: biovorlagen für neuartige therapeutische interventionen |
| WO2004078143A2 (en) | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| US7615212B2 (en) * | 2004-02-26 | 2009-11-10 | Baylor Research Institute | Compositions and methods for the systemic treatment of arthritis |
| EP1755537A4 (de) * | 2004-04-14 | 2009-12-09 | Univ Boston | Verfahren und zusammensetzungen zur prävention oder behandlung von periodontopathien |
| US8273792B2 (en) * | 2005-10-03 | 2012-09-25 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| US7906678B2 (en) | 2006-12-04 | 2011-03-15 | Bayer Schering Pharma Aktiengesellschaft | Crystalline potassium salt of lipoxin A4 analogs |
| WO2011050126A1 (en) * | 2009-10-21 | 2011-04-28 | University Of Medicine And Dentistry Of New Jersey | Method for treating sepsis or septic shock |
| JP2020507761A (ja) | 2017-01-31 | 2020-03-12 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 炎症系疾患の生化学的エンドタイプを定義するａｌｘ受容体リガンド |
| ES2986149T3 (es) | 2018-10-09 | 2024-11-08 | Univ Rochester | Tratamiento de trastornos vulvovaginales |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| EP0703897B1 (de) * | 1993-06-15 | 2008-08-20 | The Brigham And Women's Hospital, Inc. | Lipoxinverbindungen mit verlängerter halbwertszeit |
| US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| AU7215294A (en) | 1993-06-29 | 1995-01-24 | Brigham And Women's Hospital | Modulation of inflammation related to columnar epithelia |
| AU775140B2 (en) * | 1999-03-18 | 2004-07-22 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of TNF-(alfa) initiated neutrophil response |
| ATE303355T1 (de) * | 1999-03-18 | 2005-09-15 | Brigham & Womens Hospital | Lipoxinverbindungen und ihre anwendung |
| DE60044335D1 (de) * | 1999-03-18 | 2010-06-17 | Brigham & Womens Hospital | 16-phenoxy-lipoxin analoge zur medizinischen verwendung |
-
2000
- 2000-03-14 AU AU38806/00A patent/AU775140B2/en not_active Ceased
- 2000-03-14 CA CA002367909A patent/CA2367909C/en not_active Expired - Fee Related
- 2000-03-14 AT AT00917903T patent/ATE310512T1/de active
- 2000-03-14 WO PCT/US2000/006582 patent/WO2000054767A1/en not_active Ceased
- 2000-03-14 HK HK02104452.1A patent/HK1043307B/en not_active IP Right Cessation
- 2000-03-14 DE DE60024242T patent/DE60024242T2/de not_active Expired - Lifetime
- 2000-03-14 JP JP2000604843A patent/JP4440481B2/ja not_active Expired - Fee Related
- 2000-03-14 US US09/525,291 patent/US6387953B1/en not_active Expired - Fee Related
- 2000-03-14 DK DK00917903T patent/DK1165066T3/da active
- 2000-03-14 ES ES00917903T patent/ES2249257T3/es not_active Expired - Lifetime
- 2000-03-14 EP EP00917903A patent/EP1165066B1/de not_active Expired - Lifetime
- 2000-03-14 CA CA2615917A patent/CA2615917C/en not_active Expired - Fee Related
- 2000-03-14 CA CA2747376A patent/CA2747376A1/en not_active Abandoned
-
2002
- 2002-01-11 US US10/044,740 patent/US6710084B2/en not_active Expired - Fee Related
- 2002-01-11 US US10/044,499 patent/US6703423B2/en not_active Expired - Fee Related
-
2004
- 2004-03-05 US US10/794,153 patent/US7132451B2/en not_active Expired - Fee Related
-
2006
- 2006-09-14 US US11/531,921 patent/US20080312323A1/en not_active Abandoned
-
2007
- 2007-12-03 US US11/837,964 patent/US20080081838A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2367909C (en) | 2008-02-12 |
| US6387953B1 (en) | 2002-05-14 |
| EP1165066B1 (de) | 2005-11-23 |
| US20020143069A1 (en) | 2002-10-03 |
| CA2615917A1 (en) | 2000-09-21 |
| US6710084B2 (en) | 2004-03-23 |
| US20080081838A1 (en) | 2008-04-03 |
| US20040192785A1 (en) | 2004-09-30 |
| CA2747376A1 (en) | 2000-09-21 |
| US20020132847A1 (en) | 2002-09-19 |
| AU3880600A (en) | 2000-10-04 |
| DE60024242T2 (de) | 2006-12-14 |
| JP2002539159A (ja) | 2002-11-19 |
| DE60024242D1 (de) | 2005-12-29 |
| US7132451B2 (en) | 2006-11-07 |
| ES2249257T3 (es) | 2006-04-01 |
| HK1043307A1 (en) | 2002-09-13 |
| EP1165066A1 (de) | 2002-01-02 |
| US6703423B2 (en) | 2004-03-09 |
| CA2367909A1 (en) | 2000-09-21 |
| US20080312323A1 (en) | 2008-12-18 |
| HK1043307B (en) | 2006-02-03 |
| WO2000054767A1 (en) | 2000-09-21 |
| CA2615917C (en) | 2011-10-04 |
| DK1165066T3 (da) | 2006-03-06 |
| AU775140B2 (en) | 2004-07-22 |
| JP4440481B2 (ja) | 2010-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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