IT1271301B - Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono - Google Patents

Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono

Info

Publication number
IT1271301B
IT1271301B ITMI942568A ITMI942568A IT1271301B IT 1271301 B IT1271301 B IT 1271301B IT MI942568 A ITMI942568 A IT MI942568A IT MI942568 A ITMI942568 A IT MI942568A IT 1271301 B IT1271301 B IT 1271301B
Authority
IT
Italy
Prior art keywords
uterus
pct
breast
esters
natural
Prior art date
Application number
ITMI942568A
Other languages
English (en)
Inventor
Ezio Bombardelli
Monache Franco Delle
Salvatore Mancuso
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI942568A0 publication Critical patent/ITMI942568A0/it
Priority to ITMI942568A priority Critical patent/IT1271301B/it
Priority to RU97112461/14A priority patent/RU2181284C2/ru
Priority to AU43019/96A priority patent/AU689357B2/en
Priority to ES95941665T priority patent/ES2181806T3/es
Priority to PT95941665T priority patent/PT800387E/pt
Priority to PCT/EP1995/004770 priority patent/WO1996019209A1/en
Priority to PL95320787A priority patent/PL183772B1/pl
Priority to DE69527980T priority patent/DE69527980T2/de
Priority to HU9702094A priority patent/HU225501B1/hu
Priority to CN95196940A priority patent/CN1087609C/zh
Priority to SK781-97A priority patent/SK282259B6/sk
Priority to CZ19971869A priority patent/CZ288043B6/cs
Priority to FI972641A priority patent/FI972641A7/fi
Priority to EP95941665A priority patent/EP0800387B1/en
Priority to KR1019970704130A priority patent/KR100264369B1/ko
Priority to SI9520139A priority patent/SI9520139B/sl
Priority to CA002208351A priority patent/CA2208351C/en
Priority to US08/849,767 priority patent/US5808137A/en
Priority to AT95941665T priority patent/ATE222756T1/de
Priority to DK95941665T priority patent/DK0800387T3/da
Publication of ITMI942568A1 publication Critical patent/ITMI942568A1/it
Application granted granted Critical
Publication of IT1271301B publication Critical patent/IT1271301B/it
Priority to NO972842A priority patent/NO307926B1/no
Priority to JP2003434456A priority patent/JP2004131509A/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
ITMI942568A 1994-12-20 1994-12-20 Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono IT1271301B (it)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ITMI942568A IT1271301B (it) 1994-12-20 1994-12-20 Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono
SK781-97A SK282259B6 (sk) 1994-12-20 1995-12-04 Estery chalkónov, ich komplexy, farmaceutické prostriedky s ich obsahom a ich použitie
FI972641A FI972641A7 (fi) 1994-12-20 1995-12-04 Kalkonit ja niiden esterit, joilla on antiproliferatiivinen vaikutus k ohtu-, munasarja- ja rintakasvaimiin
ES95941665T ES2181806T3 (es) 1994-12-20 1995-12-04 Chalconas y sus eteres con actividad antiproliferativa en los tumores de utero, ovario y mama.
PT95941665T PT800387E (pt) 1994-12-20 1995-12-04 Calconas e os seus esteres com actividade antiproliferativa em tumores do utero dos ovarios e da mama
PCT/EP1995/004770 WO1996019209A1 (en) 1994-12-20 1995-12-04 Chalcones and esters thereof with antiproliferative activity in uterus, ovary and breast tumours
PL95320787A PL183772B1 (pl) 1994-12-20 1995-12-04 Nowe estry związków chalkonowych, kompleksy związków chalkonowych i środki farmaceutyczne je zawierające
DE69527980T DE69527980T2 (de) 1994-12-20 1995-12-04 Chalcone und ihre ester mit antiproliferativer aktivität in gebärmutter, ovar- und brusttumoren
HU9702094A HU225501B1 (en) 1994-12-20 1995-12-04 Use of chalcone esters and complexes for producing pharmaceutical compositions against cancer and ii.typ estrogen receptor antagonist
CN95196940A CN1087609C (zh) 1994-12-20 1995-12-04 有抗子宫、卵巢和乳腺肿瘤增生活性的查耳酮及其酯
RU97112461/14A RU2181284C2 (ru) 1994-12-20 1995-12-04 Хальконы и их сложные эфиры с антипролиферативной активностью в отношении опухолей матки, яичника и молочной железы
CZ19971869A CZ288043B6 (cs) 1994-12-20 1995-12-04 Estery cordoinu, isocordoinu a příbuzných látek, jejich použití a farmaceutický prostředek
AU43019/96A AU689357B2 (en) 1994-12-20 1995-12-04 Chalcones and esters thereof with antiproliferative activityin uterus, ovary and breast tumours
EP95941665A EP0800387B1 (en) 1994-12-20 1995-12-04 Chalcones and esters thereof with antiproliferative activity in uterus, ovary and breast tumours
KR1019970704130A KR100264369B1 (ko) 1994-12-20 1995-12-04 자궁, 난소 및 유방암에 항증식작용을 갖는 천연 및 합성 찰콘류 및 그의 에스텔과 그들을 함유한 제제
SI9520139A SI9520139B (sl) 1994-12-20 1995-12-04 Halkoni in njihovi estri z antiproliferativno učinkovitostjo na tumorje maternice, jajčnikov in dojk
CA002208351A CA2208351C (en) 1994-12-20 1995-12-04 Chalcones and esters thereof with antiproliferative activity in uterus, ovary and breast tumours
US08/849,767 US5808137A (en) 1994-12-20 1995-12-04 Chalcones and esters thereof with antiproliferative activity in uterus, ovary and breast tumors
AT95941665T ATE222756T1 (de) 1994-12-20 1995-12-04 Chalcone und ihre ester mit antiproliferativer aktivität in gebärmutter, ovar- und brusttumoren
DK95941665T DK0800387T3 (da) 1994-12-20 1995-12-04 Chalconer og estere deraf med antiproliferativ aktivitet i uterus-, ovarie- og brysttumorer
NO972842A NO307926B1 (no) 1994-12-20 1997-06-19 Chalkoner og estere derav med antiproliferativ aktivitet i uterus, ovarie- og brysttumorer
JP2003434456A JP2004131509A (ja) 1994-12-20 2003-12-26 子宮、卵巣、及び乳腫瘍において抗増殖活性を有するカルコン複合体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942568A IT1271301B (it) 1994-12-20 1994-12-20 Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono

Publications (3)

Publication Number Publication Date
ITMI942568A0 ITMI942568A0 (it) 1994-12-20
ITMI942568A1 ITMI942568A1 (it) 1996-06-20
IT1271301B true IT1271301B (it) 1997-05-27

Family

ID=11370023

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942568A IT1271301B (it) 1994-12-20 1994-12-20 Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono

Country Status (22)

Country Link
US (1) US5808137A (it)
EP (1) EP0800387B1 (it)
JP (1) JP2004131509A (it)
KR (1) KR100264369B1 (it)
CN (1) CN1087609C (it)
AT (1) ATE222756T1 (it)
AU (1) AU689357B2 (it)
CA (1) CA2208351C (it)
CZ (1) CZ288043B6 (it)
DE (1) DE69527980T2 (it)
DK (1) DK0800387T3 (it)
ES (1) ES2181806T3 (it)
FI (1) FI972641A7 (it)
HU (1) HU225501B1 (it)
IT (1) IT1271301B (it)
NO (1) NO307926B1 (it)
PL (1) PL183772B1 (it)
PT (1) PT800387E (it)
RU (1) RU2181284C2 (it)
SI (1) SI9520139B (it)
SK (1) SK282259B6 (it)
WO (1) WO1996019209A1 (it)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423740B1 (en) 1997-06-19 2002-07-23 Indena S.P.A. Chalcones having antiproliferative activity
GB9712966D0 (en) * 1997-06-19 1997-08-27 Indena Spa Novel chalcones
US6239114B1 (en) * 1997-09-26 2001-05-29 Kgk Synergize Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols
GB9920908D0 (en) * 1999-09-03 1999-11-10 Indena Spa Chalcone coumarins
GB9920910D0 (en) * 1999-09-03 1999-11-10 Indena Spa Novel chalcones
WO2001098291A2 (en) 2000-06-20 2001-12-27 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat vcam-1 mediated disorders
WO2002040021A2 (en) 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
CN1596240A (zh) * 2001-12-19 2005-03-16 阿特罗吉尼克斯公司 查耳酮衍生物及其治疗疾病的用途
AU2003243594A1 (en) * 2002-06-13 2003-12-31 Johns Hopkins University Novel boronic chalcone derivatives and uses thereof
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
EP1702912A4 (en) * 2003-12-05 2007-10-24 Takara Bio Inc REMEDIES
US20060063828A1 (en) * 2004-06-28 2006-03-23 Weingarten M D 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
CN100336797C (zh) * 2005-08-19 2007-09-12 浙江大学 四取代查耳酮衍生物及制备方法和用途
GB0609386D0 (en) * 2006-05-11 2006-06-21 Active Botan Ltd Treating drug resistant cancers
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
ES2540457B2 (es) * 2013-06-19 2015-12-28 Universidad De Sevilla Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica
KR101731159B1 (ko) 2015-02-04 2017-04-28 계명대학교 산학협력단 2',4'-디하이드록시칼콘 화합물을 유효성분으로 포함하는 항진균용 조성물
CZ307046B6 (cs) * 2015-09-02 2017-12-13 Univerzita PalackĂ©ho v Olomouci Komplexy mědi s deriváty (E)-1-(2´-hydroxyfenyl)-3-fenylprop-2-en-1-onu a jejich použití jako léčiv v protinádorové terapii
CN111138264B (zh) * 2019-11-29 2023-08-04 温州医科大学 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
CN113564103B (zh) * 2021-05-17 2023-01-06 南京医科大学 4,4’-二甲氧基查耳酮在延缓卵母细胞体内外老化中的应用
CN119552068A (zh) * 2024-11-29 2025-03-04 华东理工大学 查尔酮类衍生物、其药物组合物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH593224A5 (it) * 1973-10-30 1977-11-30 Taisho Pharmaceutical Co Ltd
US5234951A (en) * 1986-12-12 1993-08-10 Tsumura Juntendo, Inc. Anti-ulcer agent comprising chalcone derivative
US5106871A (en) * 1986-12-12 1992-04-21 Tsumura & Co. Anti-ulcer agent comprising chalcone derivative as effective ingredient and novel chalcone derivative
JPH05509078A (ja) * 1990-05-17 1993-12-16 ベイラー カレッジ オブ メディシン 成長抑制因とガンおよび細胞増殖性疾患措置法
AU2393992A (en) * 1991-07-24 1993-02-23 Baylor College Of Medicine Combination therapy using bioflavonoid compounds with anti-cancer drugs

Also Published As

Publication number Publication date
ITMI942568A1 (it) 1996-06-20
ATE222756T1 (de) 2002-09-15
KR100264369B1 (ko) 2000-08-16
CA2208351C (en) 2002-06-25
NO307926B1 (no) 2000-06-19
CN1170362A (zh) 1998-01-14
HU225501B1 (en) 2007-01-29
DE69527980T2 (de) 2003-05-28
CZ288043B6 (cs) 2001-04-11
AU689357B2 (en) 1998-03-26
WO1996019209A1 (en) 1996-06-27
PL320787A1 (en) 1997-10-27
CZ186997A3 (en) 1997-11-12
DK0800387T3 (da) 2002-12-23
EP0800387B1 (en) 2002-08-28
ITMI942568A0 (it) 1994-12-20
EP0800387A1 (en) 1997-10-15
SI9520139A (en) 1997-10-31
AU4301996A (en) 1996-07-10
ES2181806T3 (es) 2003-03-01
NO972842D0 (no) 1997-06-19
SI9520139B (sl) 1999-02-28
FI972641L (fi) 1997-08-14
CA2208351A1 (en) 1996-06-27
FI972641A0 (fi) 1997-06-19
HUT77438A (hu) 1998-04-28
SK282259B6 (sk) 2001-12-03
PL183772B1 (pl) 2002-07-31
DE69527980D1 (de) 2002-10-02
NO972842L (no) 1997-06-19
PT800387E (pt) 2002-12-31
RU2181284C2 (ru) 2002-04-20
CN1087609C (zh) 2002-07-17
US5808137A (en) 1998-09-15
JP2004131509A (ja) 2004-04-30
SK78197A3 (en) 1997-12-10
FI972641A7 (fi) 1997-08-14

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971223