ATE310736T1 - Verbindungen zur bilddarstellung der alzheimer- krankenheit - Google Patents

Verbindungen zur bilddarstellung der alzheimer- krankenheit

Info

Publication number
ATE310736T1
ATE310736T1 AT02785662T AT02785662T ATE310736T1 AT E310736 T1 ATE310736 T1 AT E310736T1 AT 02785662 T AT02785662 T AT 02785662T AT 02785662 T AT02785662 T AT 02785662T AT E310736 T1 ATE310736 T1 AT E310736T1
Authority
AT
Austria
Prior art keywords
disease
compounds
alzheimer
imaging alzheimer
imaging
Prior art date
Application number
AT02785662T
Other languages
English (en)
Inventor
Denis Raymond C Bouvet
Harry John Wadsworth
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE310736T1 publication Critical patent/ATE310736T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0419—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
AT02785662T 2001-12-19 2002-12-12 Verbindungen zur bilddarstellung der alzheimer- krankenheit ATE310736T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0130305.6A GB0130305D0 (en) 2001-12-19 2001-12-19 Compounds for imaging alzheimers disease
PCT/GB2002/005641 WO2003051859A1 (en) 2001-12-19 2002-12-12 Compounds for imaging alzheimer's disease

Publications (1)

Publication Number Publication Date
ATE310736T1 true ATE310736T1 (de) 2005-12-15

Family

ID=9927890

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02785662T ATE310736T1 (de) 2001-12-19 2002-12-12 Verbindungen zur bilddarstellung der alzheimer- krankenheit

Country Status (9)

Country Link
US (1) US7173061B2 (de)
EP (1) EP1463721B1 (de)
JP (1) JP4418237B2 (de)
AT (1) ATE310736T1 (de)
AU (1) AU2002350950A1 (de)
DE (1) DE60207612T2 (de)
ES (1) ES2254763T3 (de)
GB (1) GB0130305D0 (de)
WO (1) WO2003051859A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004100998A2 (en) 2003-05-07 2004-11-25 General Electric Company Compositions and methods for non-invasive imaging of soluble beta-amyloid
GB0416062D0 (en) * 2004-07-19 2004-08-18 Amersham Plc Improved N4 chelator conjugates
US7785566B2 (en) 2003-11-06 2010-08-31 Ge Healthcare, Inc. Pharmaceutical compounds
US7431914B2 (en) 2003-11-24 2008-10-07 Ge Healthcare As Contrast agent
ES2427963T3 (es) * 2004-07-02 2013-11-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Uso de derivados de tioflavina radiomarcados en formación de imágenes de amiloide para evaluación de las terapias antiamiloide
EP1945622B1 (de) 2005-10-11 2011-12-28 University of Pittsburgh - Of the Commonwealth System of Higher Education Isotopenmarkierte benzofuranverbindungen als bilddarstellende mittel für amyloidogene proteine
TW200736252A (en) 2006-01-27 2007-10-01 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
US7737183B2 (en) * 2006-10-17 2010-06-15 The Regents Of The University Of California β-amyloid and neurofibrillary tangle imaging agents
EP2081892A4 (de) * 2006-11-17 2014-03-05 Donald F Weaver Verbindungen und verfahren zur behandlung von proteinfaltungserkrankungen
MX2009006003A (es) * 2006-12-05 2009-06-17 Univ Nagasaki Composicion que contiene derivados de aurona con fines de diagnostico.
JP2008231102A (ja) * 2007-02-23 2008-10-02 Hiroaki Okuno アミロイドベータ凝集阻害作用を有するフェノール誘導体
TW200901998A (en) * 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
US8193363B2 (en) * 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4024273A (en) * 1974-06-20 1977-05-17 Smithkline Corporation Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
US5599951A (en) * 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
WO1995017382A1 (en) 1993-12-21 1995-06-29 Eli Lilly And Company Non-peptide tachykinin receptor antagonists

Also Published As

Publication number Publication date
AU2002350950A1 (en) 2003-06-30
US20050080130A1 (en) 2005-04-14
DE60207612D1 (de) 2005-12-29
US7173061B2 (en) 2007-02-06
ES2254763T3 (es) 2006-06-16
EP1463721A1 (de) 2004-10-06
EP1463721B1 (de) 2005-11-23
JP2005516935A (ja) 2005-06-09
WO2003051859A1 (en) 2003-06-26
JP4418237B2 (ja) 2010-02-17
GB0130305D0 (en) 2002-02-06
DE60207612T2 (de) 2006-08-03

Similar Documents

Publication Publication Date Title
DE60207612D1 (de) Verbindungen zur bilddarstellung der alzheimer-krankenheit
DE602004029580D1 (de) Substituierte indolderivate für eine pharmazeutische zusammensetzung zur behandlung von atemwegserkrankungen
NO20054640D0 (no) Fremgangsmater for behandling av Parkinsons sykdom
DK2157192T3 (da) Sammensætninger til diagnose og terapi af sygdomme forbundet med afvigende ekspression af futriner (R-spondiner)
TW200736252A (en) Novel heteroaryl substituted benzothiazoles
ATE343562T1 (de) Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
CY1112737T1 (el) Ισοτοπικα σεσημασμενες ενωσεις βενζοfuran σαν παραγοντες απεικονισης για πρωτεϊνες δημιουργιας αμυλοειδους (αμυloid)
DK0907379T3 (da) Bioaktiveret diagnostisk billeddannelseskontrastmiddel
EP1643986A4 (de) Phenylcarboxylat-beta-secretase-hemmer zur behandlung von morbus alzheimer
NO20026199L (no) Forbindelser for behandling av Alzheimers sykdom
DK1944040T3 (da) Analysefremgangsmåde for Alzheimers sygdom
EA200401114A3 (ru) Замещённые гидроксиэтиламины
EE200300216A (et) Radiofarmatseutilised ained Alzheimeri tõve diagnoosimiseks
DE602004016010D1 (de) Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungen
UA83691C2 (ru) Применение замещенных 2-аминотетралинов для упреждающего лечения болезни паркинсона
ATE376428T1 (de) Metallkomplexverbindungen
BR0011728A (pt) Método de inibir a agregação de proteìna amilóide e imagem de depósitos de amilóide
UY27287A1 (es) Sal citrato de 5,8,14-triazatetraciclo[10.3.1.0 2,11.0 4,9] hexadeca-2(11),3,5,7,9-pentaeno y composiciones farmaceuticas de la misma
ATE534736T1 (de) Identifizierungsverfahren und verbindungen für die behandlung degenerativer und entzündlicher erkrankungen
ATE522230T1 (de) Biphenyle als bilderzeugungsmittel bei der alzheimerschen krankheit
EP1573440A4 (de) Verfahren zur diagnose von akathisie
ZA200603178B (en) Quick test for the diagnosis of Alzheimer's disease
BR0211223A (pt) Derivados de 4-aminociclohexanol substituìdos
AU2003236714A8 (en) Diagnosis of alzheimer's disease based on the habeta42:habeta40 ratio
UY27570A1 (es) Sal de ácido cítrico de un compuesto terapéutico y composiciones farmacéuticas que la contienen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties