DK1771208T3 - Anvendelse af thioflavin radiomarkerede derivater i amyloid billeddannelse til vurdering af anti-amyloide terapier - Google Patents

Anvendelse af thioflavin radiomarkerede derivater i amyloid billeddannelse til vurdering af anti-amyloide terapier

Info

Publication number: DK1771208T3
Authority: DK; Denmark
Prior art keywords: amyloid; thioflavin; assessment; radio; image
Prior art date: 2004-07-02

Application number

DK05787557.7T

Other languages

English (en)

Inventor

William E Klunk

Chester A Mathis Jr

Original Assignee

Univ Pittsburgh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-02

Filing date

2005-07-01

Publication date

2013-09-02

2005-07-01 Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh

2013-09-02 Application granted granted Critical

2013-09-02 Publication of DK1771208T3 publication Critical patent/DK1771208T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Radiology & Medical Imaging (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Psychology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Rheumatology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK05787557.7T 2004-07-02 2005-07-01 Anvendelse af thioflavin radiomarkerede derivater i amyloid billeddannelse til vurdering af anti-amyloide terapier DK1771208T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58448704P	2004-07-02	2004-07-02
PCT/US2005/023617 WO2006014381A2 (en)	2004-07-02	2005-07-01	Use of thioflavin radiolabeled derivatives in amyloid imaging gor assessing anti-amyloid therapies

Publications (1)

Publication Number	Publication Date
DK1771208T3 true DK1771208T3 (da)	2013-09-02

Family

ID=35504952

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05787557.7T DK1771208T3 (da)	2004-07-02	2005-07-01	Anvendelse af thioflavin radiomarkerede derivater i amyloid billeddannelse til vurdering af anti-amyloide terapier

Country Status (16)

Country	Link
US (4)	US8147798B2 (da)
EP (1)	EP1771208B1 (da)
JP (1)	JP2008505115A (da)
CN (2)	CN102973954A (da)
AU (1)	AU2005270026A1 (da)
BR (1)	BRPI0512893B8 (da)
CA (2)	CA2587248C (da)
CY (1)	CY1114644T1 (da)
DK (1)	DK1771208T3 (da)
ES (1)	ES2427963T3 (da)
NO (1)	NO339187B1 (da)
PL (1)	PL1771208T3 (da)
PT (1)	PT1771208E (da)
RU (1)	RU2007104107A (da)
SI (1)	SI1771208T1 (da)
WO (1)	WO2006014381A2 (da)

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TWI239847B (en)	1997-12-02	2005-09-21	Elan Pharm Inc	N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20080050367A1 (en)	1998-04-07	2008-02-28	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
US7270800B2 (en) *	2000-08-24	2007-09-18	University Of Pittsburgh	Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
RU2324686C2 (ru) *	2000-08-24	2008-05-20	Юнивесити Оф Питсбэг	ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
MY139983A (en)	2002-03-12	2009-11-30	Janssen Alzheimer Immunotherap	Humanized antibodies that recognize beta amyloid peptide
KR20050118669A (ko) *	2003-02-01	2005-12-19	뉴랄랩 리미티드	가용성 ａ-베타에 대한 항체를 생성하기 위한 능동 면역화
US8236282B2 (en)	2003-08-22	2012-08-07	University of Pittsburgh—of the Commonwealth System of Higher Education	Benzothiazole derivative compounds, compositions and uses
EP1838348B1 (en)	2004-12-15	2013-06-26	Janssen Alzheimer Immunotherapy	Humanized amyloid beta antibodies for use in improving cognition
GB0516564D0 (en) *	2005-08-12	2005-09-21	Ge Healthcare Ltd	Fluorination process
EP1937260A2 (en) *	2005-09-16	2008-07-02	University of Pittsburgh	In-vivo and in-vitro method for detecting amyloid deposits having at least one amyloidogenic protein
US8784810B2 (en)	2006-04-18	2014-07-22	Janssen Alzheimer Immunotherapy	Treatment of amyloidogenic diseases
EP2023919A4 (en)	2006-05-08	2010-12-22	Molecular Neuroimaging Llc	COMPOUNDS AND AMYLOID PROBES FOR THERAPY AND IMAGING USES
TW200813035A (en)	2006-06-19	2008-03-16	Astrazeneca Ab	Novel heteroaryl substituted benzoxazoles
CN101293878B (zh) *	2007-04-25	2010-12-15	中国科学院上海应用物理研究所	苯并噻唑苯胺类化合物及其制备方法和应用
ES2498040T3 (es) *	2007-07-27	2014-09-24	Janssen Alzheimer Immunotherapy	Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
US8916131B2 (en) *	2007-08-30	2014-12-23	Ge Healthcare Limited	Radiopharmaceutical composition
JO3076B1 (ar)	2007-10-17	2017-03-15	Janssen Alzheimer Immunotherap	نظم العلاج المناعي المعتمد على حالة apoe
US8557222B2 (en)	2008-04-04	2013-10-15	Avid Radiopharmaceuticals, Inc.	Radiopharmaceutical imaging of neurodegenerative diseases
MX2011002647A (es)	2008-09-23	2011-04-07	Wista Lab Ltd	Ligandos para moleculas tau agregadas.
US9067981B1 (en)	2008-10-30	2015-06-30	Janssen Sciences Ireland Uc	Hybrid amyloid-beta antibodies
KR101155403B1 (ko) *	2008-11-06	2013-12-20	서울대학교산학협력단	플루오린이 도입된 벤조타이아졸 유도체, 이의 제조방법 및 이를 이용한 알츠하이머 질환 진단용 영상화제
WO2011106732A1 (en) *	2010-02-25	2011-09-01	Wyeth Llc	Pet monitoring of ab-directed immunotherapy
US20150157744A1 (en) *	2012-06-27	2015-06-11	Geoffrey B. Johnson	Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives
US9422286B2 (en)	2014-01-27	2016-08-23	Washington University	Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's disease
JP7114074B2 (ja)	2015-08-18	2022-08-08	ザリージェンツオブザユニバーシティオブカリフォルニア	画像化のためのニトロキシドを含むアミロイド結合剤およびその治療的使用
EP3426653B1 (en) *	2016-03-11	2021-12-15	AC Immune SA	Bicyclic compounds for diagnosis and therapy
US20230158178A1 (en) *	2020-03-16	2023-05-25	Emory University	Radionuclide Tracers of 1-Amino-3,4-Difluorocyclopentane-1-Carboxylic Acid, Derivatives, and Uses Thereof
CN116953008B (zh) *	2023-06-14	2024-10-22	汕头大学医学院第二附属医院	基于磁共振成像的β淀粉样蛋白浓度检测方法及系统

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US20030092003A1 (en) *	1999-12-29	2003-05-15	Ribozyme Pharmaceuticals, Inc.	Method and reagent for the treatment of Alzheimer's disease
US7270800B2 (en) *	2000-08-24	2007-09-18	University Of Pittsburgh	Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
RU2324686C2 (ru)	2000-08-24	2008-05-20	Юнивесити Оф Питсбэг	ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
CA2444214A1 (en)	2001-04-23	2002-10-31	The Trustees Of The University Of Pennsylvania	Amyloid plaque aggregation inhibitors and diagnostic imaging agents
GB0130305D0 (en) *	2001-12-19	2002-02-06	Amersham Plc	Compounds for imaging alzheimers disease
EP1474178A1 (en)	2002-02-13	2004-11-10	Amersham plc	Benzothiazole derivatives for in vivo imaging of amyloid plaques
CA2438032C (en)	2003-03-14	2013-05-07	University Of Pittsburgh	Benzothiazole derivative compounds, compositions and uses
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2005
- 2005-07-01 DK DK05787557.7T patent/DK1771208T3/da active
- 2005-07-01 RU RU2007104107/04A patent/RU2007104107A/ru not_active Application Discontinuation
- 2005-07-01 WO PCT/US2005/023617 patent/WO2006014381A2/en not_active Ceased
- 2005-07-01 PT PT57875577T patent/PT1771208E/pt unknown
- 2005-07-01 JP JP2007519500A patent/JP2008505115A/ja active Pending
- 2005-07-01 SI SI200531765T patent/SI1771208T1/sl unknown
- 2005-07-01 CA CA2587248A patent/CA2587248C/en not_active Expired - Lifetime
- 2005-07-01 ES ES05787557T patent/ES2427963T3/es not_active Expired - Lifetime
- 2005-07-01 US US11/666,083 patent/US8147798B2/en active Active
- 2005-07-01 EP EP05787557.7A patent/EP1771208B1/en not_active Expired - Lifetime
- 2005-07-01 AU AU2005270026A patent/AU2005270026A1/en not_active Abandoned
- 2005-07-01 CN CN2012104014697A patent/CN102973954A/zh active Pending
- 2005-07-01 CA CA2830939A patent/CA2830939C/en not_active Expired - Lifetime
- 2005-07-01 BR BRPI0512893A patent/BRPI0512893B8/pt active IP Right Grant
- 2005-07-01 CN CNA2005800263010A patent/CN101137397A/zh active Pending
- 2005-07-01 PL PL05787557T patent/PL1771208T3/pl unknown
2007
- 2007-01-31 NO NO20070593A patent/NO339187B1/no unknown
2012
- 2012-03-06 US US13/412,823 patent/US8343457B2/en not_active Expired - Lifetime
- 2012-10-23 US US13/658,483 patent/US8580229B2/en not_active Expired - Lifetime
2013
- 2013-09-10 CY CY20131100776T patent/CY1114644T1/el unknown
- 2013-10-09 US US14/050,018 patent/US20140105820A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN101137397A (zh)	2008-03-05
US20080219931A1 (en)	2008-09-11
BRPI0512893B8 (pt)	2021-07-27
WO2006014381A3 (en)	2007-01-18
NO20070593L (no)	2007-03-27
PT1771208E (pt)	2013-09-24
US20120177572A1 (en)	2012-07-12
US20140105820A1 (en)	2014-04-17
US8580229B2 (en)	2013-11-12
AU2005270026A1 (en)	2006-02-09
ES2427963T3 (es)	2013-11-05
CA2830939C (en)	2017-02-28
NO339187B1 (no)	2016-11-14
CY1114644T1 (el)	2016-10-05
CN102973954A (zh)	2013-03-20
EP1771208B1 (en)	2013-06-19
CA2587248C (en)	2014-01-07
SI1771208T1 (sl)	2013-10-30
CA2830939A1 (en)	2006-02-09
US20130045164A1 (en)	2013-02-21
RU2007104107A (ru)	2008-08-10
WO2006014381A2 (en)	2006-02-09
CA2587248A1 (en)	2006-02-09
JP2008505115A (ja)	2008-02-21
BRPI0512893B1 (pt)	2019-12-24
BRPI0512893A (pt)	2008-04-15
US8147798B2 (en)	2012-04-03
WO2006014381A9 (en)	2006-04-13
US8343457B2 (en)	2013-01-01
EP1771208A2 (en)	2007-04-11
PL1771208T3 (pl)	2013-11-29

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DE602005007983D1 (de)	2008-08-21	Photoempfindliches Bildaufzeichnungselement
DE602004019389D1 (de)	2009-03-26	Toner
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EP1779444A4 (en)	2011-01-05	TUNABLE PHOTONIC CRYSTAL
DE602005010938D1 (de)	2008-12-24	Genauguss
NL300998I2 (nl)	2019-08-28	Lusutrombopag of farmaceutisch aanvaardbare zouten of solvaten daarvan
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DE602006001604D1 (de)	2008-08-14	Tragbares metrologisches Bildaufnahmegerät
DK1928438T3 (da)	2013-04-22	Anvendelse af ibudilast til behandling af stofafhængighed
DE602005005527D1 (de)	2008-05-08	Verschlussdüse
DK2192933T3 (da)	2011-06-27	Materialer til oftalmologisk og ortorhinolaryngologisk anordning
DK2086932T3 (da)	2014-11-10	Substituerede aryl-indol forbindelser og deres kynurenin/kynuramin-lignende metabolitter som terapeutiske midler
DK1948607T3 (da)	2010-07-26	Cyclopropylaminer med histamin-H3-receptormodulatorer
DE502005007052D1 (de)	2009-05-20	Sitzbefestigungsvorrichtung
DE602005023094D1 (de)	2010-10-07	Entwickler und Bilderzeugungsmethode
DE602005003608D1 (de)	2008-01-17	Bilderzeugende Materialien
DE602005019525D1 (de)	2010-04-08	Verschlussdüse