ATE311463T1 - Fusionsprotein mit multiplen epitopen - Google Patents

Fusionsprotein mit multiplen epitopen

Info

Publication number: ATE311463T1
Authority: AT; Austria
Prior art keywords: epitopes; epitope; amino acid; acid sequence; sequences
Prior art date: 1996-05-24

Application number

AT97927767T

Other languages

English (en)

Inventor

Pablo D T Valenzuela

David Ying Chien

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-24

Filing date

1997-05-23

Publication date

2005-12-15

1996-05-24 Priority claimed from US08/653,226 external-priority patent/US6514731B1/en

1997-05-23 Application filed by Chiron Corp filed Critical Chiron Corp

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE311463T1 publication Critical patent/ATE311463T1/de

Links

108020001507 fusion proteins Proteins 0.000 title 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 4
108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
244000052769 pathogen Species 0.000 abstract 2
230000001717 pathogenic effect Effects 0.000 abstract 2
230000035945 sensitivity Effects 0.000 abstract 2
239000000758 substrate Substances 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
239000000427 antigen Substances 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
239000011248 coating agent Substances 0.000 abstract 1
238000000576 coating method Methods 0.000 abstract 1
230000007423 decrease Effects 0.000 abstract 1
238000001514 detection method Methods 0.000 abstract 1
238000003018 immunoassay Methods 0.000 abstract 1
230000000873 masking effect Effects 0.000 abstract 1
230000001131 transforming effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT97927767T 1996-05-24 1997-05-23 Fusionsprotein mit multiplen epitopen ATE311463T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/653,226 US6514731B1 (en)	1996-05-24	1996-05-24	Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
US08/859,524 US6428792B1 (en)	1996-05-24	1997-05-20	Hepatitis C virus multiple copy epitope fusion antigens
PCT/US1997/008950 WO1997044469A2 (en)	1996-05-24	1997-05-23	Multiple epitope fusion protein

Publications (1)

Publication Number	Publication Date
ATE311463T1 true ATE311463T1 (de)	2005-12-15

Family

ID=27096474

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97927767T ATE311463T1 (de)	1996-05-24	1997-05-23	Fusionsprotein mit multiplen epitopen

Country Status (11)

Country	Link
EP (1)	EP0935662B1 (de)
JP (2)	JP3945822B2 (de)
AT (1)	ATE311463T1 (de)
AU (1)	AU719929B2 (de)
CA (1)	CA2250723C (de)
DE (1)	DE69734776T2 (de)
DK (1)	DK0935662T3 (de)
ES (1)	ES2251028T3 (de)
IL (1)	IL126460A (de)
NZ (1)	NZ333431A (de)
WO (1)	WO1997044469A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0870830A3 (de) *	1997-02-10	2004-02-25	Advanced Life Science Institute, Inc.	Chimäres Hepatitis C-Virusantigen
DE69837155T2 (de) *	1997-09-22	2007-06-21	Novartis Vaccines and Diagnostics, Inc., Emeryville	Verfahren zum nachweiss von antikörpern in einer probe
AU9498098A (en)	1997-09-22	1999-04-12	Chiron Corporation	Buffers for stabilizing antigens
AU746258B2 (en) *	1998-01-30	2002-04-18	General Hospital Corporation, The	Genetic immunization with nonstructural proteins of hepatitis C virus
DK1071955T4 (da)	1998-04-17	2009-06-15	Innogenetics Nv	Forbedrede immundiagnostiske assays, som anvender reduktionsmidler
AU3714499A (en) *	1998-05-14	1999-11-29	Pasteur Merieux Serums Et Vaccins	Hepatitis c virus mimotopes
US7052696B2 (en) *	1998-07-10	2006-05-30	The United States Of America As Represented By The Department Of Health And Human Services	Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US6379903B1 (en) *	1999-10-08	2002-04-30	Sigma-Aldrich Co.	Purification of recombinant proteins fused to multiple epitopes
AU1236801A (en)	1999-10-27	2001-05-08	Chiron Corporation	Activation of hcv-specific t cells
EP1242108B1 (de) *	1999-12-28	2007-07-11	Pharmexa Inc.	Optimierte minigene und dadurch kodierte peptide
SI1354204T2 (sl) *	2000-06-15	2010-09-30	Novartis Vaccines & Diagnostic	Hcv antigen antitelo kombinacijska analiza
US7491808B2 (en)	2000-06-15	2009-02-17	Novartis Vaccines And Diagnostics, Inc.	HCV non-structural protein mutants and uses thereof
EP1829891B1 (de)	2000-06-15	2012-12-26	Novartis Vaccines and Diagnostics, Inc.	Immuntests für Anti-HCV-Antikörper
WO2003008537A2 (en) *	2001-04-06	2003-01-30	Mannkind Corporation	Epitope sequences
AR045702A1 (es)	2001-10-03	2005-11-09	Chiron Corp	Composiciones de adyuvantes.
ES2312806T3 (es)	2002-09-09	2009-03-01	Novartis Vaccines And Diagnostics, Inc.	Ensayo de vhc.
EP1576125A4 (de) *	2002-10-25	2008-09-03	Novartis Vaccines & Diagnostic	Aktivierung von hcv-spezifischen zellen
US7731967B2 (en)	2003-04-30	2010-06-08	Novartis Vaccines And Diagnostics, Inc.	Compositions for inducing immune responses
EP1802778B1 (de)	2004-08-27	2011-10-05	Novartis Vaccines and Diagnostics, Inc.	Hcv-antigene zur mehrfachen epitopfusion mit modifizierten proteolytischen spaltungsorten und verwendungen davon
WO2006133911A2 (en) *	2005-06-17	2006-12-21	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	Hepatitis c virus nucleic acid vaccine
ES2514316T3 (es)	2005-11-22	2014-10-28	Novartis Vaccines And Diagnostics, Inc.	Partículas similares a virus (VLPs) de Norovirus y Sapovirus
EP3067048B1 (de)	2007-12-07	2018-02-14	GlaxoSmithKline Biologicals SA	Zusammensetzungen zur induzierung von immunreaktionen
EP2646459B1 (de)	2010-12-02	2020-01-08	Bionor Immuno AS	Peptidgerüstentwurf
JP6294076B2 (ja)	2011-01-06	2018-03-14	ビオノールイミュノエーエスＢｉｏｎｏｒＩｍｍｕｎｏＡｓ	多量体ペプチド
EP3494989B1 (de) *	2012-01-26	2025-07-16	Longhorn Vaccines and Diagnostics, LLC	Zusammengesetzte antigensequenzen und impfstoffe
IN2014KN02769A (de)	2012-06-06	2015-05-08	Bionor Immuno As
US11867696B2 (en)	2015-02-06	2024-01-09	Cell Idx, Inc.	Antigen-coupled immunoreagents
CA2980718C (en)	2015-03-27	2021-06-01	Ortho-Clinical Diagnostics, Inc.	Hcv ns4a/modified ns3 polypeptides and uses thereof
CN109716130B (zh) *	2016-07-18	2023-05-23	赛尔伊迪克斯公司	抗原偶联的杂交试剂
KR101813586B1 (ko) *	2016-12-29	2018-01-30	고려대학교 산학협력단	다양한 질병마커 인지 에피토프와 연결된 단백질 나노입자 및 이를 이용한 고민감도 질병마커 검출방법
CN110996986B (zh)	2017-07-27	2024-07-19	豪夫迈·罗氏有限公司	Hcv抗原的多表位融合蛋白及其用途
KR101871985B1 (ko) *	2017-08-14	2018-06-27	고려대학교 산학협력단	3차원 단백질 나노입자 프로브 기반 복수 질환의 동시검출 방법 및 키트
CN108794636B (zh) *	2018-06-28	2020-05-22	中国人民解放军军事科学院军事医学研究院	一种表位多肽串联混合物在抗立氏立克次体的免疫保护中的应用
KR102100813B1 (ko) *	2018-11-08	2020-04-16	주식회사 보레다바이오텍	C형 간염바이러스 유래 융합 단백질 및 이를 포함하는 진단키트

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2188583T3 (es) *	1991-06-24	2003-07-01	Chiron Corp	Polipeptidos para el virus de la hepatitis c (hcv).
IL103456A (en) *	1991-10-16	2006-06-11	Merck Patent Gmbh	Isolated peptides having t-cell stimulating activity
US5683695A (en) *	1993-02-10	1997-11-04	United Biomedical, Inc.	Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains
US5744144A (en) *	1993-07-30	1998-04-28	University Of Pittsburgh University Patent Committee Policy And Procedures	Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
GB2294047A (en) *	1994-10-14	1996-04-17	Merck & Co Inc	Synthetic peptides for use as epitopes specific for HIV

1997
- 1997-05-23 NZ NZ333431A patent/NZ333431A/xx not_active IP Right Cessation
- 1997-05-23 WO PCT/US1997/008950 patent/WO1997044469A2/en not_active Ceased
- 1997-05-23 CA CA2250723A patent/CA2250723C/en not_active Expired - Lifetime
- 1997-05-23 JP JP54284897A patent/JP3945822B2/ja not_active Expired - Lifetime
- 1997-05-23 EP EP97927767A patent/EP0935662B1/de not_active Expired - Lifetime
- 1997-05-23 DE DE69734776T patent/DE69734776T2/de not_active Expired - Lifetime
- 1997-05-23 AU AU32143/97A patent/AU719929B2/en not_active Expired
- 1997-05-23 IL IL126460A patent/IL126460A/en not_active IP Right Cessation
- 1997-05-23 AT AT97927767T patent/ATE311463T1/de active
- 1997-05-23 DK DK97927767T patent/DK0935662T3/da active
- 1997-05-23 ES ES97927767T patent/ES2251028T3/es not_active Expired - Lifetime
2007
- 2007-02-06 JP JP2007027374A patent/JP2007127671A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DE69734776D1 (de)	2006-02-09
EP0935662A2 (de)	1999-08-18
CA2250723C (en)	2012-07-17
WO1997044469A2 (en)	1997-11-27
JP2007127671A (ja)	2007-05-24
IL126460A0 (en)	1999-08-17
IL126460A (en)	2007-07-04
NZ333431A (en)	2000-05-26
DE69734776T2 (de)	2006-08-17
AU719929B2 (en)	2000-05-18
ES2251028T3 (es)	2006-04-16
WO1997044469A3 (en)	1997-12-31
EP0935662B1 (de)	2005-11-30
JP3945822B2 (ja)	2007-07-18
DK0935662T3 (da)	2006-03-06
AU3214397A (en)	1997-12-09
JP2001500723A (ja)	2001-01-23
CA2250723A1 (en)	1997-11-27
WO1997044469A8 (en)	1999-07-22

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2006-10-15

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