ATE311475T1 - Verfahren zur identifizierung von punkt mutationen in einem genom - Google Patents
Verfahren zur identifizierung von punkt mutationen in einem genomInfo
- Publication number
- ATE311475T1 ATE311475T1 AT99965222T AT99965222T ATE311475T1 AT E311475 T1 ATE311475 T1 AT E311475T1 AT 99965222 T AT99965222 T AT 99965222T AT 99965222 T AT99965222 T AT 99965222T AT E311475 T1 ATE311475 T1 AT E311475T1
- Authority
- AT
- Austria
- Prior art keywords
- mutations
- point mutations
- genome
- population
- juveniles
- Prior art date
Links
- 230000035772 mutation Effects 0.000 title abstract 8
- 230000009286 beneficial effect Effects 0.000 abstract 2
- 230000002939 deleterious effect Effects 0.000 abstract 2
- 230000009931 harmful effect Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11145798P | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/029379 WO2000034652A2 (en) | 1998-12-09 | 1999-12-09 | Methods of identifying point mutations in a genome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE311475T1 true ATE311475T1 (de) | 2005-12-15 |
Family
ID=22338669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99965222T ATE311475T1 (de) | 1998-12-09 | 1999-12-09 | Verfahren zur identifizierung von punkt mutationen in einem genom |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1137811B1 (de) |
| JP (1) | JP2002531147A (de) |
| AT (1) | ATE311475T1 (de) |
| AU (1) | AU3118600A (de) |
| CA (1) | CA2354322A1 (de) |
| DE (1) | DE69928688T2 (de) |
| WO (1) | WO2000034652A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455692B1 (en) | 1998-08-04 | 2002-09-24 | Transgenomic, Inc. | Method of concentrating polynucleotides using MIPC |
| US6994962B1 (en) | 1998-12-09 | 2006-02-07 | Massachusetts Institute Of Technology | Methods of identifying point mutations in a genome |
| US7807447B1 (en) | 2000-08-25 | 2010-10-05 | Merck Sharp & Dohme Corp. | Compositions and methods for exon profiling |
| US20020132244A1 (en) | 2000-09-27 | 2002-09-19 | Xiao-Cheng Li-Sucholeiki | Methods for detecting rare polymorphic variants in genomic DNA sequences |
| JP2002153299A (ja) * | 2000-11-22 | 2002-05-28 | Sumikin Bioscience Kk | ヒト補体活性化レクチンＲａＲＦの構成成分ＭＡＳＰ−１の遺伝子多型 |
| EP1798291B1 (de) * | 2005-12-13 | 2011-05-18 | Institut Curie | Verfahren für die Detektion von Mutationen in Nukleinsaüren, und die Anwendung in der Diagnose von genetischen Krankheiten und Krebs |
| US8609338B2 (en) | 2006-02-28 | 2013-12-17 | University Of Louisville Research Foundation, Inc. | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| US20100184044A1 (en) | 2006-02-28 | 2010-07-22 | University Of Louisville Research Foundation | Detecting Genetic Abnormalities |
| EP2351858B1 (de) | 2006-02-28 | 2014-12-31 | University of Louisville Research Foundation | Erkennung von Chromosomabnormalitäten im Fötus mithilfe der Tandem-Einzelnukleotid-Polymorphismen |
| WO2014110549A1 (en) * | 2013-01-14 | 2014-07-17 | The General Hospital Corporation | Methods and assays relating to rnf216 |
| JP6700376B2 (ja) * | 2015-07-29 | 2020-05-27 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 有意性が未知のバリアントに優先順位をつけるシステム及び方法 |
| WO2018144782A1 (en) * | 2017-02-01 | 2018-08-09 | The Translational Genomics Research Institute | Methods of detecting somatic and germline variants in impure tumors |
| CN114517223B (zh) * | 2020-11-20 | 2023-09-12 | 福建和瑞基因科技有限公司 | 一种用于筛选snp位点的方法及其应用 |
| CN119498254B (zh) * | 2024-12-06 | 2025-10-24 | 北京肿瘤医院(北京大学肿瘤医院) | 小鼠胃癌自发瘤模型的构建方法与应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5045450A (en) * | 1989-07-13 | 1991-09-03 | Massachusetts Institute Of Technology | Determination of a mutational spectrum |
| US5633129A (en) * | 1989-07-13 | 1997-05-27 | Massachusetts Institute Of Technology | Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices |
-
1999
- 1999-12-09 EP EP99965222A patent/EP1137811B1/de not_active Expired - Lifetime
- 1999-12-09 AU AU31186/00A patent/AU3118600A/en not_active Abandoned
- 1999-12-09 WO PCT/US1999/029379 patent/WO2000034652A2/en not_active Ceased
- 1999-12-09 CA CA002354322A patent/CA2354322A1/en not_active Abandoned
- 1999-12-09 AT AT99965222T patent/ATE311475T1/de not_active IP Right Cessation
- 1999-12-09 DE DE69928688T patent/DE69928688T2/de not_active Expired - Fee Related
- 1999-12-09 JP JP2000587076A patent/JP2002531147A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69928688D1 (de) | 2006-01-05 |
| AU3118600A (en) | 2000-06-26 |
| WO2000034652A3 (en) | 2000-11-09 |
| WO2000034652A8 (en) | 2000-08-24 |
| EP1137811B1 (de) | 2005-11-30 |
| EP1137811A2 (de) | 2001-10-04 |
| CA2354322A1 (en) | 2000-06-15 |
| WO2000034652A2 (en) | 2000-06-15 |
| DE69928688T2 (de) | 2006-08-24 |
| JP2002531147A (ja) | 2002-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |