ATE311832T1 - Verkalkungswiderstandsfähiges bioprothetisches gewebe und herstellungsverfahren - Google Patents

Verkalkungswiderstandsfähiges bioprothetisches gewebe und herstellungsverfahren

Info

Publication number
ATE311832T1
ATE311832T1 AT95938792T AT95938792T ATE311832T1 AT E311832 T1 ATE311832 T1 AT E311832T1 AT 95938792 T AT95938792 T AT 95938792T AT 95938792 T AT95938792 T AT 95938792T AT E311832 T1 ATE311832 T1 AT E311832T1
Authority
AT
Austria
Prior art keywords
tissue
crosslinked
calcification
production method
bioprosthetic tissue
Prior art date
Application number
AT95938792T
Other languages
English (en)
Inventor
Robert J Levy
Eyal Lerner
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Application granted granted Critical
Publication of ATE311832T1 publication Critical patent/ATE311832T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
    • Y10S623/921—Blood vessel

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT95938792T 1994-10-21 1995-10-20 Verkalkungswiderstandsfähiges bioprothetisches gewebe und herstellungsverfahren ATE311832T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32735994A 1994-10-21 1994-10-21
PCT/US1995/013443 WO1996013227A1 (en) 1994-10-21 1995-10-20 Calcification-resistant bioprosthetic tissue and methods of making same

Publications (1)

Publication Number Publication Date
ATE311832T1 true ATE311832T1 (de) 2005-12-15

Family

ID=23276227

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95938792T ATE311832T1 (de) 1994-10-21 1995-10-20 Verkalkungswiderstandsfähiges bioprothetisches gewebe und herstellungsverfahren

Country Status (14)

Country Link
US (1) US5674298A (de)
EP (1) EP0786970B1 (de)
JP (1) JPH10507673A (de)
CN (1) CN1200655C (de)
AT (1) ATE311832T1 (de)
AU (1) AU713605B2 (de)
BR (1) BR9509473A (de)
CA (1) CA2202247A1 (de)
DE (1) DE69534671T2 (de)
IL (1) IL115708A (de)
NO (1) NO971744D0 (de)
NZ (1) NZ296283A (de)
WO (1) WO1996013227A1 (de)
ZA (1) ZA958900B (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE40570E1 (en) 1994-07-29 2008-11-11 Edwards Lifesciences Corporation Apparatuses and methods for treating biological tissue to mitigate calcification
US5931969A (en) 1994-07-29 1999-08-03 Baxter International Inc. Methods and apparatuses for treating biological tissue to mitigate calcification
DE69523074T2 (de) * 1994-07-29 2002-06-06 Edwards Lifesciences Corp., Irvine Verfahren zur behandlung von implantierbaren biologischen geweben zur verringerung von verkalkung
US6468300B1 (en) * 1997-09-23 2002-10-22 Diseno Y Desarrollo Medico, S.A. De C.V. Stent covered heterologous tissue
US6254627B1 (en) * 1997-09-23 2001-07-03 Diseno Y Desarrollo Medico S.A. De C.V. Non-thrombogenic stent jacket
US6008292A (en) * 1997-12-02 1999-12-28 Baxter International Inc. Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6214054B1 (en) 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
CA2345799C (en) 1998-09-30 2010-01-05 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
US6106555A (en) * 1998-12-15 2000-08-22 Av Healing Llc Method for tissue fixation
AU5639700A (en) * 1999-07-01 2001-01-22 Biomedical Design, Inc. Targeted anticalcification treatment
US6712812B2 (en) 1999-08-05 2004-03-30 Broncus Technologies, Inc. Devices for creating collateral channels
US7422563B2 (en) 1999-08-05 2008-09-09 Broncus Technologies, Inc. Multifunctional tip catheter for applying energy to tissue and detecting the presence of blood flow
US6749606B2 (en) 1999-08-05 2004-06-15 Thomas Keast Devices for creating collateral channels
US7022088B2 (en) 1999-08-05 2006-04-04 Broncus Technologies, Inc. Devices for applying energy to tissue
US7175644B2 (en) 2001-02-14 2007-02-13 Broncus Technologies, Inc. Devices and methods for maintaining collateral channels in tissue
US7815590B2 (en) 1999-08-05 2010-10-19 Broncus Technologies, Inc. Devices for maintaining patency of surgically created channels in tissue
US7462162B2 (en) 2001-09-04 2008-12-09 Broncus Technologies, Inc. Antiproliferative devices for maintaining patency of surgically created channels in a body organ
AU6530800A (en) * 1999-08-05 2001-03-05 Broncus Technologies, Inc. Methods and devices for creating collateral channels in the lungs
US6471723B1 (en) * 2000-01-10 2002-10-29 St. Jude Medical, Inc. Biocompatible prosthetic tissue
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
US20020177223A1 (en) * 2001-03-12 2002-11-28 Ogle Mathew F. Methods and compositions for crosslinking tissue
US7078163B2 (en) * 2001-03-30 2006-07-18 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
CA2452040C (en) * 2001-06-29 2011-03-22 Cook Biotech Incorporated Porous sponge matrix medical devices and methods
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US7708712B2 (en) * 2001-09-04 2010-05-04 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in a body organ
US20050060041A1 (en) * 2001-09-04 2005-03-17 Broncus Technologies, Inc. Methods and devices for maintaining surgically created channels in a body organ
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
EP1471921B1 (de) * 2002-01-07 2009-03-11 The Children's Hospital of Philadelphia Entgegenwirken bioprothetischer kalzifizierung
US8002740B2 (en) 2003-07-18 2011-08-23 Broncus Technologies, Inc. Devices for maintaining patency of surgically created channels in tissue
US8308682B2 (en) 2003-07-18 2012-11-13 Broncus Medical Inc. Devices for maintaining patency of surgically created channels in tissue
US7955788B2 (en) * 2003-10-30 2011-06-07 Medtronic, Inc. Bioprosthetic tissue preparation with synthetic hydrogels
US7258434B2 (en) * 2003-11-24 2007-08-21 Lexmark International, Inc. Inkjet printheads having multiple label placement positions for air diffusion vents
US20050266390A1 (en) * 2004-06-01 2005-12-01 Yuichiro Ueda Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction
US8409167B2 (en) 2004-07-19 2013-04-02 Broncus Medical Inc Devices for delivering substances through an extra-anatomic opening created in an airway
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US7579381B2 (en) 2005-03-25 2009-08-25 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US8007992B2 (en) 2006-10-27 2011-08-30 Edwards Lifesciences Corporation Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C1-C3 alcohol
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
CA2683193A1 (en) 2007-05-15 2008-11-20 Jenavalve Technology Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
BR112012021347A2 (pt) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente
US20100119605A1 (en) * 2008-11-12 2010-05-13 Isenburg Jason C Compositions for tissue stabilization
US20100292779A1 (en) 2009-05-15 2010-11-18 Helmut Straubinger Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system
WO2011044455A1 (en) * 2009-10-09 2011-04-14 Vatrix Medical, Inc. In vivo chemical stabilization of vulnerable plaque
US9211361B2 (en) * 2010-03-15 2015-12-15 Kemal Schankereli Thin collagen tissue for medical device applications
BR122014006876B1 (pt) 2010-03-23 2020-09-29 Edwards Lifesciences Corporation Método para preparar material de membrana de tecido bioprotético
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
CA2799459A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
CN102946916B (zh) 2010-06-17 2015-03-18 爱德华兹生命科学公司 通过化学修饰抗原性碳水化合物稳定生物假体组织的方法
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
CN102172338B (zh) * 2011-02-28 2013-03-20 上海微创医疗器械(集团)有限公司 梯度浸没式化学改性人工生物瓣的装置
US8709034B2 (en) 2011-05-13 2014-04-29 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
WO2012158553A2 (en) 2011-05-13 2012-11-22 Broncus Technologies, Inc. Methods and devices for excision of tissue
US9358107B2 (en) 2011-06-30 2016-06-07 Edwards Lifesciences Corporation Systems, dies, and methods for processing pericardial tissue
JP6005168B2 (ja) 2011-10-21 2016-10-12 イエナバルブ テクノロジー インク 患者の身体への拡張型心臓弁ステント導入用カテーテルシステム、カテーテルシステムを備えた挿入システムおよび心臓弁欠陥治療用医療機器
WO2013078235A1 (en) 2011-11-23 2013-05-30 Broncus Medical Inc Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
EP2849678B1 (de) 2012-05-16 2022-08-10 JenaValve Technology, Inc. Katheterverabreichungssystem zur einführung einer dehnbaren herzklappenprothese sowie medizinische vorrichtung zur behandlung eines herzklappendefekts
CN102727935B (zh) * 2012-07-19 2014-04-23 陕西佰傲再生医学有限公司 硬脑/脊膜移植替代物的制备方法及其装置
CN102793593B (zh) * 2012-09-03 2015-06-10 于好勇 用于后巩膜加固术的异种巩膜片及其制备方法
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
CN104130437B (zh) * 2014-07-31 2017-05-31 苏州正海生物技术有限公司 一种硬脑/脊膜生物补片材料及其制备方法和应用
EP4353203B1 (de) 2015-03-20 2026-08-19 JenaValve Technology, Inc. Herzklappenprotheseneinführungssystem
EP3632378B1 (de) 2015-05-01 2024-05-29 JenaValve Technology, Inc. Vorrichtung mit reduzierter herzschrittmacherrate bei herzklappenersatz
CN104990882B (zh) * 2015-07-22 2018-05-01 杭州启明医疗器械有限公司 体外生物瓣钙化评价的方法及抗钙化因子溶液
WO2017195125A1 (en) 2016-05-13 2017-11-16 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
EP3573579B1 (de) 2017-01-27 2023-12-20 JenaValve Technology, Inc. Herzklappennachahmung
CN110678590B (zh) 2017-05-31 2022-07-19 爱德华兹生命科学公司 胶原纤维和由其形成的制品
AU2019212059A1 (en) 2018-01-23 2020-05-21 Edwards Lifesciences Corporation Method for pre-stretching implantable biocompatible materials, and materials and devices produced thereby
CN113164258B (zh) 2018-11-01 2024-08-27 爱德华兹生命科学公司 经导管再生肺动脉瓣
CA3143206A1 (en) 2019-12-09 2021-06-17 Edwards Lifesciences Corporation Bioprosthetic tissue preparation
RU2741224C1 (ru) * 2019-12-18 2021-01-22 Общество с ограниченной ответственностью "Ангиолайн Ресерч" Способ обработки биологической ткани для имплантируемого биопротеза
WO2024102411A1 (en) 2022-11-09 2024-05-16 Jenavalve Technology, Inc. Catheter system for sequential deployment of an expandable implant

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282322A (en) * 1975-11-24 1981-08-04 Merck & Co., Inc. Process for enzymatic deacylation of antibiotics
US4283494A (en) * 1978-04-26 1981-08-11 Meito Sangyo Kabushiki Kaisha Microbial lipase, process for its preparation and microbiologically pure culture therefor
US4446122A (en) * 1979-12-28 1984-05-01 Research Corporation Purified human prostate antigen
US4885005A (en) * 1982-11-12 1989-12-05 Baxter International Inc. Surfactant treatment of implantable biological tissue to inhibit calcification
JPH0611305B2 (ja) * 1985-07-29 1994-02-16 株式会社高研 抗血栓性材料の製造方法
JP2529112B2 (ja) * 1987-08-31 1996-08-28 株式会社 高研 生体弁
US4976733A (en) * 1988-02-03 1990-12-11 Biomedical Design, Inc. Prevention of prosthesis calcification
EP0559819A1 (de) * 1990-11-28 1993-09-15 Baxter International Inc. Verfahren zur sterilisation mit hilfe einer flüssigkeit
US5314874A (en) * 1991-04-19 1994-05-24 Koken Co., Ltd. Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen
US5436291A (en) * 1992-07-09 1995-07-25 University Of Michigan, The Board Of . . . Calcification-resistant synthetic biomaterials
US5296583A (en) * 1992-07-09 1994-03-22 University Of Michigan Calcification-resistant synthetic biomaterials
WO1994017841A1 (en) * 1993-02-01 1994-08-18 Baxter International Inc. Biological grafts having regionalized differences in cross-link density and their methods of manufacture

Also Published As

Publication number Publication date
IL115708A0 (en) 1996-08-04
DE69534671D1 (de) 2006-01-12
CN1200655C (zh) 2005-05-11
AU4003795A (en) 1996-05-23
CN1162252A (zh) 1997-10-15
IL115708A (en) 2000-11-21
NO971744L (no) 1997-04-16
EP0786970B1 (de) 2005-12-07
EP0786970A1 (de) 1997-08-06
JPH10507673A (ja) 1998-07-28
CA2202247A1 (en) 1996-05-09
AU713605B2 (en) 1999-12-09
NZ296283A (en) 1999-11-29
WO1996013227A1 (en) 1996-05-09
NO971744D0 (no) 1997-04-16
US5674298A (en) 1997-10-07
ZA958900B (en) 1997-04-15
EP0786970A4 (de) 2000-04-05
DE69534671T2 (de) 2006-07-13
BR9509473A (pt) 1997-09-30

Similar Documents

Publication Publication Date Title
DE69534671D1 (de) Verkalkungswiderstandsfähiges bioprothetisches gewebe und herstellungsverfahren
ES2153455T3 (es) Sistema de intercambio de datos que incluye unidades portatiles de procesamiento de datos.
BRPI0115730B8 (pt) método de preparação de um material compreendendo um polímero hidrofílico, anfótero ou aniônico que possui atividade antimicrobiana
CA2351216A1 (en) Method for tissue fixation using epoxides
AR021674A1 (es) Una fibra de polimero hidrofobico que tiene un recubrimiento cationicamente cargado sobre el mismo, un filtro fibroso que comprende fibras y un metodo parapreparar dicho filtro
DK1035877T3 (da) Fremgangsmåde til forhindring af forkalkning af aldehyd-fikserede bioprotesematerialer
FI970918A7 (fi) Yhdisteet ja menetelmät syövän hoitamiseksi
CL2003002786A1 (es) Composicion liofilizada que comprende i) una epotilona y ii) manitol o una ciclodextrina y composicion liofilizada que los comprende reconstituida con solvente, util como citotoxico en el tratamiento de tumores.
BR9900604A (pt) Agente desinfetante aquoso contendo ácido perfómico e ácido peracético, processo para produção e uso do mesmo
RU2011107877A (ru) Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты
ES2000015A4 (es) Superficies polimericas modificadas y metodo de preparacion de las mismas.
ES2060548B1 (es) Derivados 1-hidrocarbiloxi-2,2,6,6,-tetrametil-piperidinicos de 1,3,5 triazinas, no migrantes, como estabilizadores de polimeros.
DK0738106T3 (da) Sterilisering med pereddikesyre
ATE114156T1 (de) Herstellung von proteinen in aktiver form.
ATE476870T1 (de) Biologisch abbaubarer faserträger zum mulchen von böden
MY104050A (en) Preserving agents for wood and their application.
NO910511L (no) Lusedrepende sjampo.
DK1028628T3 (da) Pesticid mod plantepatogene mikroorganismer
NO881470L (no) Anvendelse av vandige, kationiske plastdispersjoner for impregnering og grunning av absorberende substrater.
NO871177D0 (no) Trebeskyttelsesmiddel.
DE59708046D1 (de) Verfahren zur Herstellung von Celluloselösungen in wasserhaltigem Aminoxid
EE200100287A (et) Puidukaitsevahendite lahused
ATE360664T1 (de) Vernetzungsmittel auf basis einer polyallyletherverbindung
SE9903418D0 (sv) Metod för att modifiera cellulosabaserade fibermaterial
ATE431876T1 (de) Verfahren zum beschleunigten abbau von mulchpapier, und mulchpapier

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties