ATE312076T1 - Thiol-modifizierte hyaluronan-derivate - Google Patents

Thiol-modifizierte hyaluronan-derivate

Info

Publication number
ATE312076T1
ATE312076T1 AT02721085T AT02721085T ATE312076T1 AT E312076 T1 ATE312076 T1 AT E312076T1 AT 02721085 T AT02721085 T AT 02721085T AT 02721085 T AT02721085 T AT 02721085T AT E312076 T1 ATE312076 T1 AT E312076T1
Authority
AT
Austria
Prior art keywords
derivatives
hyaluronan
thiol group
linked
pendant thiol
Prior art date
Application number
AT02721085T
Other languages
English (en)
Inventor
Paul C A Bulpitt
Charles H Sherwood
Khalid K Sadozai
Original Assignee
Anika Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23033860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE312076(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anika Therapeutics Inc filed Critical Anika Therapeutics Inc
Application granted granted Critical
Publication of ATE312076T1 publication Critical patent/ATE312076T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/37—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT02721085T 2001-02-22 2002-02-21 Thiol-modifizierte hyaluronan-derivate ATE312076T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27102301P 2001-02-22 2001-02-22
PCT/US2002/005081 WO2002068383A2 (en) 2001-02-22 2002-02-21 Thiol-modified hyaluronan

Publications (1)

Publication Number Publication Date
ATE312076T1 true ATE312076T1 (de) 2005-12-15

Family

ID=23033860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02721085T ATE312076T1 (de) 2001-02-22 2002-02-21 Thiol-modifizierte hyaluronan-derivate

Country Status (6)

Country Link
US (3) US6620927B2 (de)
EP (1) EP1368309B2 (de)
AT (1) ATE312076T1 (de)
CA (1) CA2437417C (de)
DE (1) DE60207831D1 (de)
WO (1) WO2002068383A2 (de)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1041209A1 (zh) 1999-01-13 2002-07-05 Meditech Research Limited 加強藥物療效的成份及方法
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
ATE312076T1 (de) 2001-02-22 2005-12-15 Anika Therapeutics Inc Thiol-modifizierte hyaluronan-derivate
CA2458856C (en) * 2001-08-27 2011-02-15 Meditech Research Limited Improved therapeutic protocols
EP1564220A4 (de) * 2002-11-21 2010-03-17 Chugai Pharmaceutical Co Ltd Retard-arzneistoffträger
US6982298B2 (en) * 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US20040167480A1 (en) * 2003-02-21 2004-08-26 Advanced Medical Optics, Inc. Administration of multiple viscoelastic solutions with a multi-compartment syringe
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8383158B2 (en) 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
JP4745826B2 (ja) * 2003-11-14 2011-08-10 中外製薬株式会社 架橋多糖微粒子およびその製造方法
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US7767656B2 (en) * 2005-04-25 2010-08-03 Molly S Shoichet Blends of temperature sensitive and anionic polymers for drug delivery
CA2616607C (en) 2005-07-27 2015-06-02 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
US20070031468A1 (en) * 2005-08-04 2007-02-08 Endomedix, Inc. Modified chitosan for vascular embolization
US20070031467A1 (en) * 2005-08-04 2007-02-08 Abrahams John M Composition and method for vascular embolization
EA013877B1 (ru) 2005-09-07 2010-08-30 Алкемиа Онколоджи Пти Лимитед Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения
US9492381B1 (en) 2005-11-10 2016-11-15 Reyn Pharma, Llc Method of administering hyaluronan formulation for preventing and ameliorating osteoarthritis
US8598144B1 (en) 2005-11-10 2013-12-03 Reyn Pharma, Llc Method of administering hyaluronan formulation for the amelioration of osteoarthritis
US20070202084A1 (en) 2005-12-14 2007-08-30 Anika Therapeutics, Inc. Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
WO2007070547A2 (en) 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid
US20070196342A1 (en) * 2005-12-14 2007-08-23 Sadozai Khalid K Meniscal implant of hyaluronic acid derivatives for treatment of meniscal defects
US20070140897A1 (en) * 2005-12-21 2007-06-21 Hongna Wang Ph stable biguanide composition and method of treatment and prevention of infections
US20070141091A1 (en) * 2005-12-21 2007-06-21 Erning Xia Biguanide ointment and method of treatment and prevention of infections
US20070142478A1 (en) * 2005-12-21 2007-06-21 Erning Xia Combination antimicrobial composition and method of use
US20070243130A1 (en) * 2006-04-18 2007-10-18 Weiliam Chen Biopolymer system for tissue sealing
US7854923B2 (en) 2006-04-18 2010-12-21 Endomedix, Inc. Biopolymer system for tissue sealing
US20080075657A1 (en) * 2006-04-18 2008-03-27 Abrahams John M Biopolymer system for tissue sealing
CN101511875A (zh) * 2006-07-11 2009-08-19 犹他大学研究基金会 硫醇化的大分子及其制备方法和应用
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US20080063617A1 (en) * 2006-09-07 2008-03-13 Abrahams John M Cosmetics formulations
KR100880891B1 (ko) * 2006-11-03 2009-01-30 한국전자통신연구원 플렉시블 태양전지를 이용한 차양 장치
US8741326B2 (en) 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
CN101200504B (zh) * 2006-12-11 2010-05-12 上海百瑞吉生物医药有限公司 高分子巯基化改性衍生物及其交联材料
RU2432181C2 (ru) * 2006-12-22 2011-10-27 Кромафарма Гезельшафт М.Б.Х. Применение полимеров
US20080161405A1 (en) * 2006-12-29 2008-07-03 Erning Xia Biguanide Composition and Method of Treatment and Prevention of Infections
US8784893B2 (en) 2007-02-05 2014-07-22 Carbylan Therapeutics, Inc. Polymer formulations for delivery of bioactive agents
TR201809112T4 (tr) * 2007-04-16 2018-07-23 Regentis Biomaterials Ltd İskele oluşturmak i̇çi̇n bi̇leşi̇mler ve yöntemler.
WO2009005790A2 (en) * 2007-06-29 2009-01-08 Carbylan Biosurgery, Inc. Sterile thiol-derivatized hyaluronic acid polymer compositions and uses thereof
ES2326721B1 (es) * 2008-01-04 2010-07-16 Endor Nanotechnologies, S.L. Conjugado de acido hialuronico para el tratamiento cosmetico y procedimiento de preparacion.
EP2249891B1 (de) 2008-02-13 2016-05-25 The Cleveland Clinic Foundation Molekulare verstärkung von extrazellulärer matrix und anwendungsverfahren
WO2009108100A1 (en) * 2008-02-29 2009-09-03 Ipr-Systems Sweden Ab Composition for the formation of gels
US8410180B2 (en) 2008-04-30 2013-04-02 The Cleveland Clinic Foundation Methods to treat urinary incontinence
US8163716B1 (en) 2008-06-30 2012-04-24 Smith James D Method of administering hyaluronan formulation for the amelioration of osteophytes
US8178511B1 (en) 2008-07-02 2012-05-15 Smith James D Method of administering hyaluronan formulation for the amelioration of osteopenia
CN101721349B (zh) 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 可注射原位交联水凝胶及其制备方法和用途
AU2010276574B2 (en) 2009-07-30 2015-08-20 Carbylan Therapeutics, Inc. Modified hyaluronic acid polymer compositions and related methods
WO2011067653A1 (en) * 2009-12-04 2011-06-09 Carlo Ghisalberti Oral compositions for use in the mercury intoxication from dental amalgam
WO2011072399A1 (en) 2009-12-18 2011-06-23 The Governing Council Of The University Of Toronto Injectable polymer composition for use as a cell delivery vehicle
ES2376680B8 (es) 2010-08-16 2013-04-30 Nylstar, S.A. Fibra textil cosmética, procedimiento de obtención y su empleo.
CN102399295B (zh) 2010-09-09 2013-11-06 常州百瑞吉生物医药有限公司 低巯基化改性度生物相容高分子巯基化衍生物及其交联材料和用途
US9644042B2 (en) 2010-12-17 2017-05-09 Carnegie Mellon University Electrochemically mediated atom transfer radical polymerization
US20140275420A1 (en) 2011-08-22 2014-09-18 Carnegie Mellon University Atom transfer radical polymerization under biologically compatible conditions
US20130108550A1 (en) 2011-10-26 2013-05-02 Abbott Cardiovasculr Systems, Inc. Bioabsorbable Co-Filler for Cerebrovascular Aneurysms
US9533297B2 (en) 2012-02-23 2017-01-03 Carnegie Mellon University Ligands designed to provide highly active catalyst complexes
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2897976A1 (en) 2013-01-11 2014-07-17 Carbylan Therapeutics, Inc. Stabilized compositions comprising hyaluronic acid
KR20200140929A (ko) 2013-02-08 2020-12-16 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
WO2014189835A2 (en) * 2013-05-20 2014-11-27 Yale University Anti-thrombogenic grafts
US9782345B2 (en) 2013-10-17 2017-10-10 Jade Therapeutics, Inc. Ocular composition and method
CN103755759A (zh) * 2014-01-26 2014-04-30 江西科技师范大学 一种合成核苷磷酰哌啶、磷酰吗啉及磷酰吡咯烷的方法
BR112016023625A2 (pt) 2014-04-10 2018-06-26 10X Genomics, Inc. dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
CA2953469A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
CA2957970A1 (en) * 2014-08-15 2016-02-18 The Johns Hopkins University Technology Ventures Composite material for tissue restoration
BR112017008877A2 (pt) 2014-10-29 2018-07-03 10X Genomics Inc métodos e composições para sequenciamento de ácido nucleico-alvo
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
JP6769969B2 (ja) 2015-01-12 2020-10-14 １０エックス ジェノミクス， インコーポレイテッド 核酸配列決定ライブラリーを作製するためのプロセス及びシステム、並びにこれらを使用して作製したライブラリー
US9982070B2 (en) 2015-01-12 2018-05-29 Carnegie Mellon University Aqueous ATRP in the presence of an activator regenerator
MX2017010857A (es) 2015-02-24 2017-12-11 10X Genomics Inc Metodos para la cobertura de secuencia de acidos nucleicos seleccionados como diana.
EP3262407B1 (de) 2015-02-24 2023-08-30 10X Genomics, Inc. Partitionsverarbeitungsverfahren und -systeme
CN104910569B (zh) * 2015-06-03 2017-03-01 西安交通大学 一种可生物还原的透明质酸/聚(Nε‑丙烯酰基‑L‑赖氨酸)双网络水凝胶及其制备方法
JP6954899B2 (ja) 2015-12-04 2021-10-27 １０エックス ゲノミクス，インコーポレイテッド 核酸の解析のための方法及び組成物
US11104641B2 (en) 2016-03-31 2021-08-31 Dow Global Technologies Llc Biscarbodiimides and polycarbodiimides and method for their preparation
CA3021764C (en) 2016-04-27 2021-01-19 Anika Therapeutics, Inc. Compositions for use in treating tendon degeneration via intra-osteotendinous injection
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018124970A1 (en) * 2016-12-30 2018-07-05 Agency For Science, Technology And Research A nanocomplex
WO2018132582A1 (en) 2017-01-12 2018-07-19 Carnegie Mellon University Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes
EP4029939B1 (de) 2017-01-30 2023-06-28 10X Genomics, Inc. Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
AR111190A1 (es) 2017-03-22 2019-06-12 Genentech Inc Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados
EP3445876B1 (de) 2017-05-26 2023-07-05 10X Genomics, Inc. Einzelzellenanalyse von transposasezugänglichem chromatin
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
WO2018231882A1 (en) 2017-06-12 2018-12-20 Biotime, Inc. Implants, methods for making implants and methods of treating lipoatrophy defects therewith
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
EP3735204B1 (de) 2018-01-02 2023-09-06 Cartiheal (2009) Ltd. Implantationswerkzeug für optimierte solide substrate zur förderung von zell- und gewebewachstum
CN110294696B (zh) * 2018-03-24 2021-07-02 复旦大学 巯乙基脲/硫脲类二聚体衍生物及其制备方法和药用用途
CN112262218B (zh) 2018-04-06 2024-11-08 10X基因组学有限公司 用于单细胞处理中的质量控制的系统和方法
IL307979B2 (en) 2018-05-09 2025-08-01 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
EP3790602A1 (de) 2018-05-09 2021-03-17 The Johns Hopkins University Nanofaserhydrogel-verbundstoffe für zell- und gewebefreisetzung
WO2019238954A1 (en) 2018-06-15 2019-12-19 Croma-Pharma Gmbh Hydrogel composition comprising a crosslinked polymer
ES3061777T3 (en) 2018-06-15 2026-04-07 Croma Pharma Gmbh Hydrogel composition comprising a crosslinked polymer
WO2020106703A1 (en) 2018-11-19 2020-05-28 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
US10517988B1 (en) 2018-11-19 2019-12-31 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
KR102649858B1 (ko) * 2019-05-03 2024-03-20 아이게이트 파마슈티칼스, 인코포레이티드 안질환의 치료를 위한 조성물 및 방법
CN110279610B (zh) 2019-06-26 2021-06-11 常州百瑞吉生物医药有限公司 一种透明质酸皮肤保护组合物及其制备方法和应用
CN110229357B (zh) * 2019-06-28 2022-03-11 浙江科技学院 一种交联透明质酸凝胶的制备方法
US11795320B2 (en) * 2019-09-20 2023-10-24 Bausch + Lomb Ireland Limited Grafted polymer and use thereof
EP4077402B1 (de) 2019-12-19 2024-05-01 Croma-Pharma GmbH Thiolmodifiziertes hyaluronan und hydrogel mit dem vernetzten hyaluronan
CN111892668B (zh) * 2020-07-03 2022-07-12 广东工业大学 一种化合物及其制备方法、荧光探针和抗肿瘤药物
CN113683779B (zh) * 2021-09-09 2023-02-24 苏州快乐猩球生物科技有限公司 一种透明质酸光诱导载体、制备方法及应用
CN114478829B (zh) * 2021-12-31 2023-07-28 常州百瑞吉生物医药有限公司 一种透明质酸交联活性材料组合物、制备方法及应用
CN115078718B (zh) * 2022-07-22 2024-11-12 福建师范大学 一种基于表面增强拉曼技术检测透明质酸酶的方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2832756A (en) 1955-04-15 1958-04-29 Rohm & Haas Monomeric polymerizable ureido and thioureido compounds, methods for producing them and polymers thereof
US2946819A (en) 1958-04-14 1960-07-26 Gen Aniline & Film Corp Process of producing carbodimides
DE1156401B (de) 1960-05-24 1963-10-31 Bayer Ag Verfahren zur Herstellung von Carbodiimiden
DE1149712B (de) 1961-11-14 1963-06-06 Bayer Ag Verfahren zur Herstellung von Carbodiimiden
US3644456A (en) 1964-08-12 1972-02-22 Upjohn Co Di((isocyanatobenzyl)-phenyl) carbodiimides and preparation of organic carbodiimides
US3972933A (en) 1974-05-28 1976-08-03 Monsanto Company Preparation of carbodiimides from ureas by dehydration
GB1476088A (en) 1975-04-03 1977-06-10 Ici Ltd Carbodiimides
US4280954A (en) 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
DE2556760A1 (de) 1975-12-17 1977-06-30 Hoechst Ag Verfahren zur herstellung von carbodiimiden
GB1584153A (en) 1976-09-22 1981-02-04 Ici Ltd Carbodimides
US4066629A (en) 1976-10-28 1978-01-03 Celanese Corporation Process for preparing carbodiimides utilizing a phosphonium salt catalyst
US4098973A (en) 1977-01-31 1978-07-04 The Upjohn Company Compounds and process
JPS5835991B2 (ja) 1980-06-23 1983-08-05 大内新興化学工業株式会社 Ｎ−置換ビスアニリノジスルフィド誘導体及びその誘導体の製造方法
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
MX163953B (es) 1984-03-27 1992-07-03 Univ New Jersey Med Procedimiento para preparar una matriz biodegradable a base de colageno
SE456346B (sv) 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US5099013A (en) * 1985-03-12 1992-03-24 Biomatrix, Inc, Hylan preparation and method of recovery thereof from animal tissues
IT1215344B (it) * 1987-01-27 1990-02-08 Dessy S R L Ora Recordati Farm Procedimento per la preparazione di composti ad attivita' anti-ulcera.
US5527893A (en) 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US4937270A (en) 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5017229A (en) 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
SE8900422D0 (sv) 1989-02-08 1989-02-08 Pharmacia Ab Tvaerbundna hyaluronatgeler samt foerfarande foer framstaellning av dessa
EP0416250A3 (en) † 1989-08-01 1991-08-28 The Research Foundation Of State University Of New York N-acylurea and o-acylisourea derivatives of hyaluronic acid
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5616568A (en) † 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5690961A (en) 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
US6096728A (en) 1996-02-09 2000-08-01 Amgen Inc. Composition and method for treating inflammatory diseases
US6350527B1 (en) 1998-08-27 2002-02-26 Eidgenossische Technische Hochschule Zurich Gels and multilayer surface structures from boronic acid containing polymers
AT406054B (de) † 1998-11-04 2000-02-25 Andreas Bernkop-Schnuerch Verfahren zur verbesserung der mucoadhäsion von polymeren sowie deren herstellung und verwendung
JP2000191538A (ja) * 1998-12-28 2000-07-11 Maruha Corp 白血球―血管内皮細胞接着抑制剤
CA2416126C (en) 2000-07-28 2011-07-05 Anika Therapeutics, Inc. Bioabsorbable composites of derivatized hyaluronic acid
ATE312076T1 (de) 2001-02-22 2005-12-15 Anika Therapeutics Inc Thiol-modifizierte hyaluronan-derivate

Also Published As

Publication number Publication date
DE60207831D1 (de) 2006-01-12
CA2437417A1 (en) 2002-09-06
US6884788B2 (en) 2005-04-26
US6620927B2 (en) 2003-09-16
CA2437417C (en) 2016-07-26
US20050222083A1 (en) 2005-10-06
EP1368309A2 (de) 2003-12-10
WO2002068383A2 (en) 2002-09-06
WO2002068383A3 (en) 2003-02-27
EP1368309B1 (de) 2005-12-07
US20040038934A1 (en) 2004-02-26
US20020128512A1 (en) 2002-09-12
EP1368309B2 (de) 2014-10-01

Similar Documents

Publication Publication Date Title
DE60207831D1 (de) Thiol-modifizierte hyaluronan-derivate
US20220233579A1 (en) Hydrogen sulfide releasing polymer compounds
BR0309868A (pt) Conjugados de derivados de caliqueamicina - veìculo
BRPI0408690A (pt) composto, método para tratamento de uma doença, composição farmacêutica, e, uso de um composto
ATE234634T1 (de) Feste pharmazeutische formulierungen enthaltend eine physische mischung aus sulphoalkylethercyclodextrin und einem therapeutischen wirkstoff
BR0214757A (pt) Formulações farmacêuticas de derivados de platina
BR0016012A (pt) Implante farmacêutico contendo componentes de liberação imediata e de liberação prolongada, além de processo de administração
DK0939627T3 (da) Pentaflourbenzensulfonamider og analoger
BRPI0416752A (pt) composição farmacêutica, uso de um ou mais compostos, método para a prevenção ou tratamento de distúrbios, compostos, e, processo para a preparação de uma composição farmacêutica
JP2010270126A (ja) ヒアルロン酸の組成物および使用方法
SV2002000245A (es) Oxazolidinonas substituidas y su uso ref. lea 34122-sv
TR200100894T2 (tr) Aril ikameli propanolamin türevleri, imalat yöntemleri, ilaç maddeleri, kullanımları.
BRPI0418245B8 (pt) composto derivado de nitróxi de prostaglandina, processo para preparar dito composto, composição farmacêutica compreendendo dito composto e usos destes
DE69724964D1 (de) Zielgerichte arzneimittel abgabe für zulphonamide-derivate
ATE422356T1 (de) Pharmazeutische zubereitungen
DE60204620D1 (de) Nasenspray enthaltend Ondansetron-hydrochlorid
TR200101163T2 (tr) Safra suyu ikameli fenil-alkenoilguanidinler, üretim yöntemleri, kullanımları
BR0013793A (pt) Medicamentos profiláticos e terapêuticos para doenças oftálmicas
TW200501963A (en) Pharmaceutical compositions comprising epinastine for the treatment of skin diseases
ATE440838T1 (de) Pharmazeutisch aktive sulfonylaminosäurederivate
DE60106953D1 (de) Adenosinderivate und deren verwendung
DE60233276D1 (de) Verfahren zur Herstellung der Natrium Salze von Retinoylderivaten
EP1544216A3 (de) Thio-modifizierte Hyaluronan-Derivate
TR200100896T2 (tr) İkameli propanol türevleri, imalat yöntemleri, bileşimleri içeren ilaçlar, kullanımları
BR0013283A (pt) Agente farmacêutico que compreende um derivado de benzamida como ingrediente ativo

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties