ATE281464T1 - Adenosinderivate und deren verwendung - Google Patents

Adenosinderivate und deren verwendung

Info

Publication number: ATE281464T1
Authority: AT; Austria
Prior art keywords: adenosine; hexyn; cyano; compounds; drugs
Prior art date: 2000-09-08

Application number

AT01963522T

Other languages

English (en)

Inventor

Takashi Konno

Iizakamachi Yuno

Kazuhiro Uemoto

Shinya Onuma

Yoshikazu Kato

Original Assignee

Toa Eiyo Ltd

Yamasa Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-08

Filing date

2001-09-07

Publication date

2004-11-15

2001-09-07 Application filed by Toa Eiyo Ltd, Yamasa Corp filed Critical Toa Eiyo Ltd

2001-09-07 Priority claimed from PCT/JP2001/007791 external-priority patent/WO2002020540A1/ja

2004-11-15 Application granted granted Critical

2004-11-15 Publication of ATE281464T1 publication Critical patent/ATE281464T1/de

Links

150000003835 adenosine derivatives Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
XESHLCLROHUHDE-IWCJZZDYSA-N 7-[6-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]hept-6-ynenitrile Chemical compound C1=NC=2C(N)=NC(C#CCCCCC#N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O XESHLCLROHUHDE-IWCJZZDYSA-N 0.000 abstract 1
206010018307 Glaucoma and ocular hypertension Diseases 0.000 abstract 1
XAIXEZHEHYNWQH-IWCJZZDYSA-N [(2r,3s,4r,5r)-5-[6-amino-2-(6-cyanohex-1-ynyl)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate Chemical compound C1=NC=2C(N)=NC(C#CCCCCC#N)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O XAIXEZHEHYNWQH-IWCJZZDYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000017531 blood circulation Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000001328 optic nerve Anatomy 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
210000001525 retina Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT01963522T 2000-09-08 2001-09-07 Adenosinderivate und deren verwendung ATE281464T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2000272979		2000-09-08
PCT/JP2001/006922 WO2002020539A1 (en)	2000-09-08	2001-08-10	Adenosine derivatives and use thereof
PCT/JP2001/007791 WO2002020540A1 (fr)	2000-09-08	2001-09-07	Dérivés d'adénosine et leurs applications

Publications (1)

Publication Number	Publication Date
ATE281464T1 true ATE281464T1 (de)	2004-11-15

Family

ID=18759008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01963522T ATE281464T1 (de)	2000-09-08	2001-09-07	Adenosinderivate und deren verwendung

Country Status (6)

Country	Link
US (2)	US6936596B2 (de)
JP (1)	JPWO2002020540A1 (de)
AT (1)	ATE281464T1 (de)
AU (1)	AU2001278708A1 (de)
DE (1)	DE60106953T2 (de)
WO (1)	WO2002020539A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7378400B2 (en) *	1999-02-01	2008-05-27	University Of Virginia Patent Foundation	Method to reduce an inflammatory response from arthritis
US6232297B1 (en) *	1999-02-01	2001-05-15	University Of Virginia Patent Foundation	Methods and compositions for treating inflammatory response
US7427606B2 (en) *	1999-02-01	2008-09-23	University Of Virginia Patent Foundation	Method to reduce inflammatory response in transplanted tissue
AU2002362443B2 (en) *	2001-10-01	2008-05-15	University Of Virginia Patent Foundation	2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
DE60318192T2 (de) *	2002-04-10	2008-04-30	The University Of Virginia Patent Foundation	Verwendung von a2a adenosin rezeptor agonisten und anti-pathogene mittel enthaltenden kombinationen zur behandlung von entzündungskrankheiten
EP1464708A1 (de) *	2003-04-03	2004-10-06	Pro. Bio. Sint. S.p.A.	Verfahren zur Herstellung von Fludarabinphosphat aus 2-Fluoroadenin
WO2006028618A1 (en) *	2004-08-02	2006-03-16	University Of Virginia Patent Foundation	2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
AU2005267706B2 (en) *	2004-08-02	2011-12-08	University Of Virginia Patent Foundation	2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
WO2006023272A1 (en) *	2004-08-02	2006-03-02	University Of Virginia Patent Foundation	2-polycyclic propynyl adenosine analogs having a2a agonist activity
US20080027022A1 (en) *	2006-02-08	2008-01-31	Linden Joel M	Method to treat gastric lesions
US8178509B2 (en)	2006-02-10	2012-05-15	University Of Virginia Patent Foundation	Method to treat sickle cell disease
US8188063B2 (en) *	2006-06-19	2012-05-29	University Of Virginia Patent Foundation	Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) *	2007-12-20	2011-11-15	University Of Virginia Patent Foundation	Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
NZ630760A (en) *	2013-03-15	2017-09-29	Inotek Pharmaceuticals Corp	A method of providing ocular neuroprotection

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57140716A (en)	1981-02-24	1982-08-31	Yamasa Shoyu Co Ltd	Antiallergic agent
JPH07106983B2 (ja)	1987-12-02	1995-11-15	三共株式会社	グリゼオール酸ジエステル誘導体
DE68916036T2 (de)	1988-11-15	1994-09-29	Toa Eiyo Ltd	Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.
US5039797A (en)	1989-10-13	1991-08-13	Yale University	2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate
US5189027A (en)	1990-11-30	1993-02-23	Yamasa Shoyu Kabushiki Kaisha	2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
JP3025557B2 (ja)	1991-06-28	2000-03-27	ヤマサ醤油株式会社	２‐アルキニルアデノシン誘導体
JP3053908B2 (ja) *	1991-06-28	2000-06-19	ヤマサ醤油株式会社	２‐アルキニルアデノシン誘導体
FR2685918B1 (fr)	1992-01-08	1995-06-23	Union Pharma Scient Appl	Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
IT1254915B (it) *	1992-04-24	1995-10-11	Gloria Cristalli	Derivati di adenosina ad attivita' a2 agonista
JP2002173427A (ja)	1998-09-01	2002-06-21	Yamasa Shoyu Co Ltd	眼疾患治療用医薬組成物
JP2003055395A (ja)	2001-08-10	2003-02-26	Toa Eiyo Ltd	アデノシン誘導体

2001
- 2001-08-10 WO PCT/JP2001/006922 patent/WO2002020539A1/ja not_active Ceased
- 2001-08-10 AU AU2001278708A patent/AU2001278708A1/en not_active Abandoned
- 2001-09-07 JP JP2002525161A patent/JPWO2002020540A1/ja active Pending
- 2001-09-07 DE DE60106953T patent/DE60106953T2/de not_active Expired - Fee Related
- 2001-09-07 AT AT01963522T patent/ATE281464T1/de not_active IP Right Cessation
- 2001-09-07 US US10/363,675 patent/US6936596B2/en not_active Expired - Fee Related
2005
- 2005-01-11 US US11/032,020 patent/US7132409B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE60106953T2 (de)	2005-04-28
AU2001278708A1 (en)	2002-03-22
US7132409B2 (en)	2006-11-07
US6936596B2 (en)	2005-08-30
US20050130930A1 (en)	2005-06-16
JPWO2002020540A1 (ja)	2004-01-15
DE60106953D1 (de)	2004-12-09
WO2002020539A1 (en)	2002-03-14
US20040053881A1 (en)	2004-03-18

Legal Events

Date	Code	Title	Description
2005-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE281464T1 (de)	2004-11-15	Adenosinderivate und deren verwendung
RU2324684C2 (ru)	2008-05-20	Пиримидиновые производные
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
AU2804400A (en)	2000-08-29	Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
BR0113757A (pt)	2004-03-02	Derivados de quinolinona como inibibores de tirosina quinase
MA27040A1 (fr)	2004-12-20	Nucleosides substitues en 4'
BRPI0408690A (pt)	2006-03-28	composto, método para tratamento de uma doença, composição farmacêutica, e, uso de um composto
TR200101499T1 (tr)	2002-09-23	Azepinoindol türevleri, hazırlanmaları ve kullanımları.
ATE312076T1 (de)	2005-12-15	Thiol-modifizierte hyaluronan-derivate
TR200100694T2 (tr)	2001-10-22	Opioid alıcı aktivitesine sahip 4,4-Biarilpiperidin türevleri
TR200000223T2 (tr)	2000-07-21	XA faktörünü engelleyen heterosiklik türevler
DE68906609D1 (de)	1993-06-24	Dopamin-vorlaeufer.
ATE319458T1 (de)	2006-03-15	Medizinische zusammensetzungen zur behandlung von augenerkrankungen
NO20072089L (no)	2007-06-15	Benzimidazolderivater, sammensetninger som inneholder dem, fremstilling derav og anvendelse derav
ES2108717T3 (es)	1998-01-01	Derivados de la tetrahidropirrolo(1,2-a)pirazina-4-espiro-3'-pirrolidina, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
BG100069A (bg)	1996-04-30	Амидинови производни,съдържащи хетероциклични групи,получаване и приложението им
SE9903997D0 (sv)	1999-11-03	New compounds
BR9914128A (pt)	2002-09-24	Composições antibióticas para tratamento do olho, ouvido e nariz
TR200101163T2 (tr)	2001-08-21	Safra suyu ikameli fenil-alkenoilguanidinler, üretim yöntemleri, kullanımları
DE60013126D1 (de)	2004-09-23	Ophthalmische histamin-enthaltende zusammensetzungen und deren verwendung
TR199800165T1 (xx)	1998-06-22	(R)-5-bromo-n-(1-etil-4-metil hekzahidro-1h-1,4-diazepin-6-il)-2-metoksi-6- metilamino-3-piridinkarboksamid, bunu haz�rlamaya mahsus y�ntem ve bu bile�i�i ihtiva eden farmas�tik terkip.
BR9814188A (pt)	2000-10-03	"agonistas de 5-ht1f"
ATE141796T1 (de)	1996-09-15	2',5'-oligoadenylat-derivate zur verwendung als heilmittel
ATE285771T1 (de)	2005-01-15	Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung
IT1306147B1 (it)	2001-05-30	Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali