ATE312084T1 - Verfahren zur herstellung von rizatriptan - Google Patents

Verfahren zur herstellung von rizatriptan

Info

Publication number
ATE312084T1
ATE312084T1 AT03784405T AT03784405T ATE312084T1 AT E312084 T1 ATE312084 T1 AT E312084T1 AT 03784405 T AT03784405 T AT 03784405T AT 03784405 T AT03784405 T AT 03784405T AT E312084 T1 ATE312084 T1 AT E312084T1
Authority
AT
Austria
Prior art keywords
give
rizatriptan
reaction
hydrazone
viii
Prior art date
Application number
AT03784405T
Other languages
English (en)
Inventor
Barjoan Pere Dalmases
Asparo Montserrat Armengol
Original Assignee
Vita Cientifica S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Cientifica S L filed Critical Vita Cientifica S L
Application granted granted Critical
Publication of ATE312084T1 publication Critical patent/ATE312084T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03784405T 2002-08-07 2003-08-05 Verfahren zur herstellung von rizatriptan ATE312084T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200201874A ES2204303B2 (es) 2002-08-07 2002-08-07 Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
PCT/IB2003/003540 WO2004014877A1 (en) 2002-08-07 2003-08-05 Process for preparing rizatriptan

Publications (1)

Publication Number Publication Date
ATE312084T1 true ATE312084T1 (de) 2005-12-15

Family

ID=31502894

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03784405T ATE312084T1 (de) 2002-08-07 2003-08-05 Verfahren zur herstellung von rizatriptan

Country Status (11)

Country Link
US (1) US7279581B2 (de)
EP (1) EP1527053B8 (de)
KR (1) KR20050039749A (de)
AT (1) ATE312084T1 (de)
AU (1) AU2003250478A1 (de)
DE (1) DE60302671D1 (de)
ES (2) ES2204303B2 (de)
IS (1) IS7702A (de)
NO (1) NO20051155L (de)
TW (1) TW200404798A (de)
WO (1) WO2004014877A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04012923A (es) * 2002-06-27 2005-03-31 Sb Pharmco Inc Sales de fosfato de carvedilol y/o solvatos de las mismas, composiciones correspondientes y/o metodos de tratamiento.
ES2204302B2 (es) * 2002-08-07 2005-03-01 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
EP1709032A2 (de) 2004-01-09 2006-10-11 Ratiopharm GmbH Kristalline formen von rizatriptanbenzoat
US7786156B2 (en) * 2004-01-28 2010-08-31 Ratiopharm Gmbh Synthesis methods and intermediates for the manufacture of Rizatriptan
WO2007054979A1 (en) * 2005-11-14 2007-05-18 Matrix Laboratories Ltd Process for the large scale production of rizatriptan benzoate
ATE510836T1 (de) * 2006-01-19 2011-06-15 Matrix Lab Ltd Umwandlung eines aromatischen diazoniumsalzes in ein arylhydrazin
WO2017130141A1 (en) 2016-01-27 2017-08-03 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
CN115353492A (zh) * 2022-08-26 2022-11-18 浙江野风药业股份有限公司 一种连续合成1-(4-肼基苯基)甲基-1,2,4-三氮唑的方法
CN115417859B (zh) * 2022-09-19 2024-02-02 陕西师范大学 一种苯甲酸利扎曲坦的合成方法
CN116283924B (zh) * 2023-01-16 2024-07-26 四川效佳科技有限公司 一种药用级纯度的苯甲酸利扎曲普坦的重结晶方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
ES2033577B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de la 2-carboxi-3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida y sus esteres alquilicos inferiores.
ES2033578B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida.
GB9215526D0 (en) * 1992-07-22 1992-09-02 Merck Sharp & Dohme Chemical process
US5567824A (en) * 1994-05-24 1996-10-22 Merck & Co., Inc. Palladium catalyzed ring closure of triazolyltryptamine
WO1998006725A1 (en) * 1996-08-13 1998-02-19 Merck & Co., Inc. Palladium catalyzed indolization
US5998438A (en) * 1996-11-26 1999-12-07 Allelix Biopharmaceuticals, Inc. 5-cyclo indole compounds
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process

Also Published As

Publication number Publication date
TW200404798A (en) 2004-04-01
ES2204303B2 (es) 2004-12-16
EP1527053A1 (de) 2005-05-04
US7279581B2 (en) 2007-10-09
EP1527053B8 (de) 2006-03-08
ES2254982T3 (es) 2006-06-16
IS7702A (is) 2005-02-21
ES2204303A1 (es) 2004-04-16
AU2003250478A1 (en) 2004-02-25
EP1527053B1 (de) 2005-12-07
WO2004014877A1 (en) 2004-02-19
DE60302671D1 (de) 2006-01-12
KR20050039749A (ko) 2005-04-29
NO20051155L (no) 2005-03-03
US20050148778A1 (en) 2005-07-07

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