ATE312086T1 - Phenoxazinanaloge zur behandlung von amyloidose - Google Patents

Phenoxazinanaloge zur behandlung von amyloidose

Info

Publication number: ATE312086T1
Authority: AT; Austria
Prior art keywords: hydrogen; lower alkyl; amyloidose; phenoxazine; analogues
Prior art date: 2000-09-29

Application number

AT01122733T

Other languages

English (en)

Inventor

Corinne Elizab Augelli-Szafran

Yingije Lai

Tomoyuki Yasunaga

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-29

Filing date

2001-09-21

Publication date

2005-12-15

2001-09-21 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE312086T1 publication Critical patent/ATE312086T1/de

Links

TZMSYXZUNZXBOL-UHFFFAOYSA-N 10H-phenoxazine Chemical class C1=CC=C2NC3=CC=CC=C3OC2=C1 TZMSYXZUNZXBOL-UHFFFAOYSA-N 0.000 title 1
206010002022 amyloidosis Diseases 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
-1 cyano, carboxy Chemical group 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
208000037259 Amyloid Plaque Diseases 0.000 abstract 1
102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
238000004220 aggregation Methods 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
238000003384 imaging method Methods 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT01122733T 2000-09-29 2001-09-21 Phenoxazinanaloge zur behandlung von amyloidose ATE312086T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23696600P	2000-09-29	2000-09-29

Publications (1)

Publication Number	Publication Date
ATE312086T1 true ATE312086T1 (de)	2005-12-15

Family

ID=22891762

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01122733T ATE312086T1 (de)	2000-09-29	2001-09-21	Phenoxazinanaloge zur behandlung von amyloidose

Country Status (10)

Country	Link
US (1)	US20020143012A1 (de)
EP (1)	EP1193260B1 (de)
JP (1)	JP2002201186A (de)
AT (1)	ATE312086T1 (de)
BR (1)	BR0104344A (de)
CA (1)	CA2357450A1 (de)
DE (1)	DE60115569T2 (de)
DK (1)	DK1193260T3 (de)
ES (1)	ES2253315T3 (de)
MX (1)	MXPA01009768A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004262970B2 (en) *	2003-08-07	2010-03-18	Merck Sharp & Dohme Limited	Treatment for Alzheimer's disease and related conditions
WO2005016934A1 (en) *	2003-08-18	2005-02-24	Novartis Ag	3h-phenoxazine derivatives suitable as near-infrared imaging agents, preparation an use thereof
GB0410238D0 (en) *	2004-05-07	2004-06-09	Merck Sharp & Dohme	Therapeutic agents
CA2668744C (en) *	2006-11-17	2015-09-15	Queen's University At Kingston	Compounds and methods for treating protein folding disorders
DK2890700T3 (en)	2012-08-28	2018-03-12	Univ Tuebingen Medizinische Fakultaet	HALOGENATED BENZOXAZINES AND THEIR USE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9506197D0 (en) *	1995-03-27	1995-05-17	Hoffmann La Roche	Inhibition of tau-tau association.
YU86801A (sh) *	1999-06-10	2004-07-15	Warner-Lambert Company	Izoindol derivati korisni u inhibiciji agregacije amiloidnih proteina i snimanju amiloidnih naslaga
SK17632001A3 (sk) *	1999-06-10	2003-03-04	Warner-Lambert Company	Liečivo na liečbu Alzheimerovej choroby, inhibíciu agregácie amyloidového proteínu a spôsob na zobrazenie depozít amyloidu

2001
- 2001-09-19 CA CA002357450A patent/CA2357450A1/en not_active Abandoned
- 2001-09-21 ES ES01122733T patent/ES2253315T3/es not_active Expired - Lifetime
- 2001-09-21 AT AT01122733T patent/ATE312086T1/de not_active IP Right Cessation
- 2001-09-21 DK DK01122733T patent/DK1193260T3/da active
- 2001-09-21 EP EP01122733A patent/EP1193260B1/de not_active Expired - Lifetime
- 2001-09-21 DE DE60115569T patent/DE60115569T2/de not_active Expired - Fee Related
- 2001-09-27 MX MXPA01009768A patent/MXPA01009768A/es unknown
- 2001-09-27 US US09/966,534 patent/US20020143012A1/en not_active Abandoned
- 2001-09-28 JP JP2001301315A patent/JP2002201186A/ja not_active Abandoned
- 2001-09-28 BR BR0104344-7A patent/BR0104344A/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60115569D1 (de)	2006-01-12
DE60115569T2 (de)	2006-08-10
EP1193260A1 (de)	2002-04-03
EP1193260B1 (de)	2005-12-07
US20020143012A1 (en)	2002-10-03
BR0104344A (pt)	2003-03-05
DK1193260T3 (da)	2006-04-10
MXPA01009768A (es)	2004-08-12
JP2002201186A (ja)	2002-07-16
CA2357450A1 (en)	2002-03-29
ES2253315T3 (es)	2006-06-01

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2006-08-15

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