ATE312087T1 - Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen - Google Patents

Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen

Info

Publication number: ATE312087T1
Authority: AT; Austria
Prior art keywords: vitamin; compounds; cyclic ether; epi; 1alfa
Prior art date: 1997-05-16

Application number

AT98922374T

Other languages

English (en)

Inventor

Satyanarayana G Reddy

Original Assignee

Woman & Infants Hospital

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-16

Filing date

1998-05-15

Publication date

2005-12-15

1998-05-15 Application filed by Woman & Infants Hospital filed Critical Woman & Infants Hospital

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE312087T1 publication Critical patent/ATE312087T1/de

Links

QYSXJUFSXHHAJI-YHJXBONMSA-N (1r,3z)-3-[(2e)-2-[(1r,3as,7ar)-7a-methyl-1-[(2r)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@H](O)CCC1=C QYSXJUFSXHHAJI-YHJXBONMSA-N 0.000 title abstract 3
-1 CYCLIC ETHER VITAMIN D3 COMPOUNDS Chemical class 0.000 title abstract 2
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 3
150000004292 cyclic ethers Chemical group 0.000 abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000006345 epimerization reaction Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000037353 metabolic pathway Effects 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
235000005282 vitamin D3 Nutrition 0.000 abstract 1
239000011647 vitamin D3 Substances 0.000 abstract 1
229940021056 vitamin d3 Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Hematology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Nutrition Science (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT98922374T 1997-05-16 1998-05-15 Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen ATE312087T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4669097P	1997-05-16	1997-05-16
PCT/US1998/010062 WO1998051678A1 (en)	1997-05-16	1998-05-15	CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF

Publications (1)

Publication Number	Publication Date
ATE312087T1 true ATE312087T1 (de)	2005-12-15

Family

ID=21944848

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98922374T ATE312087T1 (de)	1997-05-16	1998-05-15	Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen

Country Status (8)

Country	Link
US (5)	US6100294A (de)
EP (1)	EP0981523B1 (de)
JP (1)	JP2002505668A (de)
AT (1)	ATE312087T1 (de)
AU (1)	AU743514B2 (de)
CA (1)	CA2289209C (de)
DE (1)	DE69832699T2 (de)
WO (1)	WO1998051678A1 (de)

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DE19619036A1 (de) *	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
CA2289209C (en)	1997-05-16	2006-07-25	Women & Infants Hospital	Cyclic ether vitamin d3 compounds, 1.alpha. (oh) 3-epi-vitamin d3 compounds and uses thereof
US20010007907A1 (en) *	1997-05-16	2001-07-12	Women And Infants Hospital	3-epi compounds of vitamin d3 and uses thereof
CA2303248A1 (en) *	1997-09-08	1999-03-18	F. Hoffmann-La Roche Ag	1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
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US20020045606A1 (en)	1999-12-02	2002-04-18	Reddy Satyanarayana G.	Esters of vitamin D3 and uses thereof
US6358939B1 (en) *	1999-12-21	2002-03-19	Northern Lights Pharmaceuticals, Llc	Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en)	1999-12-21	2006-01-24	Wisconsin Alumni Research Foundation	Treating vitamin D responsive diseases
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US20060171983A1 (en) *	2003-07-30	2006-08-03	Jin Tian	Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease
US20050209203A1 (en) *	2003-07-30	2005-09-22	Jin Tian	Use of vitamin Ds or vitamin D analogs to treat cardiovascular disease
WO2005027928A1 (en) *	2003-09-19	2005-03-31	Pfizer Products Inc.	2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
BRPI0404050A (pt) *	2003-09-24	2005-06-14	Bioxell Spa	Uso de um composto ou de um seu sal ou éster farmaceuticamente aceitável, formulação farmacêutica, formulação acondicionada, composto, e, método para prevenir e/ou tratar hiperplasia benigna da próstata em pacientes em necessidade de tal prevenção ou tratamento
JP4921794B2 (ja) *	2004-02-06	2012-04-25	中外製薬株式会社	Ｅｄ−７１製剤
JP2007525533A (ja)	2004-03-01	2007-09-06	ビオエクセルエスピーエー	間質性膀胱炎の治療方法、並びに関連化合物及び組成物
WO2005101022A2 (en) *	2004-04-15	2005-10-27	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with vitamin d (1,25-dihydroxyvitamin d3) receptor 1 (vdr1)
EP1797033A4 (de) *	2004-09-24	2010-04-28	Bioxell Spa	20-cycloalkyl-26,27-alkyl/halogenalkyl-vitamin-d3-verbindungen und verfahren zu deren anwendung
CA2586679A1 (en)	2004-11-12	2006-05-18	Bioxell Spa	Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US20080069814A1 (en) *	2005-01-05	2008-03-20	Novacea, Inc.	Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof
WO2006100285A1 (en) *	2005-03-23	2006-09-28	Bioxell Spa	Use of vitamin d compounds to treat endometriosis
JP2008538580A (ja) *	2005-04-22	2008-10-30	ノバセアインコーポレイティッド	活性ビタミンｄ化合物またはその模倣体による、化学療法または放射線療法と関連する肺疾患の治療、予防、および改善
EP1777220A1 (de)	2005-09-28	2007-04-25	Centre National de la Recherche Scientifique	Vitamin D-Derivate mit Vitamin D nuklear Rezeptor Aktivität, deren Herstellung und deren Verwendung
WO2008131267A2 (en) *	2007-04-18	2008-10-30	Johns Hopkins University	Low calcemic, highly antiproliferative, analogs of calcitriol
WO2009115398A1 (en) *	2008-03-18	2009-09-24	INSERM (Institut National de la Santé et de la Recherche Médicale)	Vitamin d compounds for the treatment of biliary diseases
US8716334B2 (en) *	2008-06-17	2014-05-06	Ben Gurion University Of The Negev Research And Development Authority	Substituted cyclohexylidene-ethylidene-octahydro-indene compounds
ES2331289B2 (es) *	2008-06-27	2010-06-25	Universidade De Santiago De Compostela	Compuestos de la vitamina d deuterados.
US9290447B2 (en)	2011-05-03	2016-03-22	Wisconsin Alumni Research Foundation	(20R) and (20S)-24-(p-toluenesulfonyloxy)-25,26,27-trinorvitamin D3 analogs and their uses
US9416102B2 (en) *	2013-01-23	2016-08-16	Wisconsin Alumni Research Foundation	(22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs
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GB202016614D0 (en)	2020-10-20	2020-12-02	King S College London	Compounds
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1998
- 1998-05-15 CA CA002289209A patent/CA2289209C/en not_active Expired - Fee Related
- 1998-05-15 AU AU74936/98A patent/AU743514B2/en not_active Ceased
- 1998-05-15 WO PCT/US1998/010062 patent/WO1998051678A1/en not_active Ceased
- 1998-05-15 DE DE69832699T patent/DE69832699T2/de not_active Expired - Fee Related
- 1998-05-15 AT AT98922374T patent/ATE312087T1/de not_active IP Right Cessation
- 1998-05-15 JP JP54963098A patent/JP2002505668A/ja not_active Ceased
- 1998-05-15 US US09/079,942 patent/US6100294A/en not_active Expired - Fee Related
- 1998-05-15 EP EP98922374A patent/EP0981523B1/de not_active Expired - Lifetime
1999
- 1999-09-30 US US09/410,223 patent/US6121312A/en not_active Expired - Fee Related
2000
- 2000-07-17 US US09/617,881 patent/US6479538B1/en not_active Expired - Fee Related
2002
- 2002-07-01 US US10/188,320 patent/US20030125309A1/en not_active Abandoned
2003
- 2003-12-30 US US10/750,570 patent/US20080188548A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2002505668A (ja)	2002-02-19
US6100294A (en)	2000-08-08
US20080188548A1 (en)	2008-08-07
AU7493698A (en)	1998-12-08
US20030125309A1 (en)	2003-07-03
US6121312A (en)	2000-09-19
EP0981523B1 (de)	2005-12-07
CA2289209A1 (en)	1998-11-19
DE69832699D1 (de)	2006-01-12
WO1998051678A1 (en)	1998-11-19
EP0981523A1 (de)	2000-03-01
DE69832699T2 (de)	2006-08-24
CA2289209C (en)	2006-07-25
AU743514B2 (en)	2002-01-24
US6479538B1 (en)	2002-11-12

Legal Events

Date	Code	Title	Description
2006-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE312087T1 (de)	2005-12-15	Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen
IL136249A0 (en)	2001-05-20	Suppository containing an acid-labile active compound
BG105564A (en)	2002-01-31	Galantamine-containing composition with controlled release
MY122383A (en)	2006-04-29	Cyclic boroproline compounds
BG103664A (en)	2000-03-31	Pharmaceutical forms containing ammoxycillin and clavulanate
NZ227131A (en)	1991-09-25	Compositions for improving cognitive function by administering 1,2-oxazole derivatives
BG104819A (en)	2001-05-31	Substituted indolealkanoic acids
MXPA02000973A (es)	2002-07-30	Benzofurilpiperazinas y benzofurilhomopiperazinas: agonistas de serotonina.
TR200102800T2 (tr)	2002-01-21	Yeni bileşikler.
YU19499A (sh)	2001-09-28	Benzonaftiridini kao bronhijalni terapeutici
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