ATE312090T1 - 4-(piperidyl- und pyrrolidyl-alkyl-ureido)- chinoline als urotensin ii rezeptor antagonisten - Google Patents

4-(piperidyl- und pyrrolidyl-alkyl-ureido)- chinoline als urotensin ii rezeptor antagonisten

Info

Publication number
ATE312090T1
ATE312090T1 AT02791749T AT02791749T ATE312090T1 AT E312090 T1 ATE312090 T1 AT E312090T1 AT 02791749 T AT02791749 T AT 02791749T AT 02791749 T AT02791749 T AT 02791749T AT E312090 T1 ATE312090 T1 AT E312090T1
Authority
AT
Austria
Prior art keywords
urotensin
quinolines
pyrrolidyl
ureido
piperidyl
Prior art date
Application number
AT02791749T
Other languages
English (en)
Inventor
Aissaoui Hamed Dr
Christoph Binkert
Martine Clozel
Boris Mathys
Claus Mueller
Oliver Nayler
Scherz Michael Dr
Joerg Velker
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE312090T1 publication Critical patent/ATE312090T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02791749T 2001-12-04 2002-12-02 4-(piperidyl- und pyrrolidyl-alkyl-ureido)- chinoline als urotensin ii rezeptor antagonisten ATE312090T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0114195 2001-12-04
PCT/EP2002/013577 WO2003048154A1 (en) 2001-12-04 2002-12-02 4-(piperidyl- and pyrrolidyl-alkyl-ureido) -quinolines as urotensin ii receptor antagonists

Publications (1)

Publication Number Publication Date
ATE312090T1 true ATE312090T1 (de) 2005-12-15

Family

ID=8164711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02791749T ATE312090T1 (de) 2001-12-04 2002-12-02 4-(piperidyl- und pyrrolidyl-alkyl-ureido)- chinoline als urotensin ii rezeptor antagonisten

Country Status (18)

Country Link
US (1) US7375227B2 (de)
EP (1) EP1499607B1 (de)
CN (1) CN100424082C (de)
AT (1) ATE312090T1 (de)
AU (1) AU2002358071B2 (de)
CA (1) CA2473892C (de)
CY (1) CY1104993T1 (de)
DE (1) DE60207894T2 (de)
DK (1) DK1499607T3 (de)
ES (1) ES2254772T3 (de)
HU (1) HUP0402184A2 (de)
IL (1) IL162851A0 (de)
MX (1) MXPA04006599A (de)
NO (1) NO20042844L (de)
NZ (1) NZ534046A (de)
SI (1) SI1499607T1 (de)
WO (1) WO2003048154A1 (de)
ZA (1) ZA200405348B (de)

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RU2005111589A (ru) * 2002-09-17 2006-01-20 Актелион Фармасьютиклз Лтд. (Ch) Производные 1-пиридин-4-илмочевины
JP2006525273A (ja) * 2003-05-07 2006-11-09 アクテリオン　ファマシューティカルズ　リミテッド 新規なピペラジン誘導体
US20070010516A1 (en) * 2003-05-08 2007-01-11 Hamed Aissaoui Novel piperidine derivatives
BRPI0414777A (pt) * 2003-09-26 2006-11-21 Actelion Pharmaceuticals Ltd compostos, composições farmacêuticas, uso de um ou mais compostos, e, método de tratar um paciente que sofre de um distúrbio
DE10358539A1 (de) * 2003-12-15 2005-07-07 Merck Patent Gmbh Carbonsäureamidderivate
JP2008510755A (ja) 2004-08-25 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド ビシクロノネン誘導体
MX2007004293A (es) * 2004-10-12 2007-06-18 Actelion Pharmaceuticals Ltd 1[2-(4-bencil-4-hidroxi-piperidin-1-il)-etil]-3-(2-metil-quinolin -4-il)-urea como la sal de sulfato cristalina.
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
US20070043104A1 (en) * 2005-06-10 2007-02-22 Luthman Ingrid K UII-modulating compounds and their use
CN101384581B (zh) * 2006-02-17 2013-09-18 弗·哈夫曼-拉罗切有限公司 作为5ht2/d3调节剂的苯甲酰基-哌啶衍生物
EP1987019B1 (de) * 2006-02-17 2012-11-28 F. Hoffmann-La Roche AG Benzoylpiperidinderivate als 5ht2/d3-modulatoren
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118853A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
EP2079693B1 (de) 2006-10-31 2013-02-27 F. Hoffmann-La Roche AG Etherderivate als duale modulatoren der 5-ht2a- und d3-rezeptoren
US8399486B2 (en) 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
JP2010527367A (ja) 2007-05-15 2010-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウロテンシンｉｉ受容体アンタゴニスト
KR20100020487A (ko) * 2007-05-24 2010-02-22 와이어쓰 엘엘씨 히스타민-3 길항제로서 아자시클릴벤즈아미드 유도체
ES2609258T3 (es) * 2007-06-29 2017-04-19 Pfizer Inc. Derivados de bencimidazol
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US20090186567A1 (en) * 2008-01-17 2009-07-23 Xavier Orlhac Abrasive Tool With Mosaic Grinding Face
CN102757447B (zh) * 2011-07-05 2014-12-31 北京大学 一种尿素通道蛋白抑制剂及其制备方法与应用
KR101468207B1 (ko) 2013-02-14 2014-12-01 한국화학연구원 신규한 싸이에노[3,2-b]피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물
KR101508214B1 (ko) * 2013-03-07 2015-04-07 한국화학연구원 신규한 아졸-접합 피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물
FR3008619B1 (fr) * 2013-07-16 2018-04-20 Centre Hospitalier Universitaire De Rouen Antagonistes, agonistes partiels et agonistes inverses du recepteur de l'urotensine ii pour leur utilisation dans la prevention des deficits neurologiques consecutifs a une hemorragie sous-arachnoidienne
AU2016210544B2 (en) * 2015-01-23 2020-12-10 Gvk Biosciences Private Limited Inhibitors of TrkA kinase
CA2992054A1 (en) * 2015-07-29 2017-02-02 Laboratorios Del Dr. Esteve, S.A. Amide derivatives having multimodal activity against pain
CN109306151B (zh) * 2018-08-31 2020-08-14 大连理工大学 一种不含醚氧键型聚合物阴离子交换膜及其制备方法
CN112830897B (zh) * 2019-11-22 2022-09-09 石家庄以岭药业股份有限公司 含脲基苯并咪唑类衍生物及其制备方法和应用
CN116139140A (zh) * 2021-11-19 2023-05-23 中国医学科学院药物研究所 一种化合物在治疗糖皮质激素不良反应中的用途
CN115677551A (zh) * 2021-12-28 2023-02-03 武汉市振邦生物科技有限公司 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺

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AUPP003197A0 (en) 1997-09-03 1997-11-20 Fujisawa Pharmaceutical Co., Ltd. New heterocyclic compounds
WO2001009088A1 (en) 1999-07-28 2001-02-08 Kirin Beer Kabushiki Kaisha Urea derivatives as inhibitors of ccr-3 receptor
EP1246619B1 (de) * 1999-12-21 2004-10-20 Smithkline Beecham Corporation Urotensin-ii rezeptorantagonisten
JP2003518057A (ja) 1999-12-21 2003-06-03 スミスクライン・ビーチャム・コーポレイション ウロテンシン−ｉｉ受容体アンタゴニスト
WO2001045711A1 (en) * 1999-12-21 2001-06-28 Smithkline Beecham Corporation Urotensin-ii receptor antagonists
EP1262195A4 (de) 2000-03-07 2003-05-21 Takeda Chemical Industries Ltd Vasoaktieve agentia
US20040063699A1 (en) 2000-07-04 2004-04-01 Naoki Tarui Gpr14 antagonist
US20040039017A1 (en) 2000-12-11 2004-02-26 Dashyant Dhanak Urotensin-II receptor antagonists
JP2004524295A (ja) 2001-01-26 2004-08-12 スミスクライン・ビーチャム・コーポレイション ウロテンシン−ｉｉ受容体アンタゴニスト
JP2004525156A (ja) 2001-03-29 2004-08-19 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド
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Also Published As

Publication number Publication date
IL162851A0 (en) 2005-11-20
NO20042844L (no) 2004-08-23
ES2254772T3 (es) 2006-06-16
CA2473892A1 (en) 2003-06-12
MXPA04006599A (es) 2004-12-07
US20050043535A1 (en) 2005-02-24
ZA200405348B (en) 2005-12-28
NZ534046A (en) 2006-02-24
DE60207894T2 (de) 2006-07-20
AU2002358071A1 (en) 2003-06-17
DE60207894D1 (en) 2006-01-12
CN100424082C (zh) 2008-10-08
SI1499607T1 (sl) 2006-06-30
CY1104993T1 (el) 2010-03-03
CA2473892C (en) 2010-09-21
HUP0402184A2 (hu) 2005-02-28
EP1499607A1 (de) 2005-01-26
AU2002358071B2 (en) 2008-06-12
EP1499607B1 (de) 2005-12-07
DK1499607T3 (da) 2006-04-18
US7375227B2 (en) 2008-05-20
CN1617869A (zh) 2005-05-18
WO2003048154A1 (en) 2003-06-12

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