ATE312812T1 - Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung - Google Patents

Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung

Info

Publication number
ATE312812T1
ATE312812T1 AT00905438T AT00905438T ATE312812T1 AT E312812 T1 ATE312812 T1 AT E312812T1 AT 00905438 T AT00905438 T AT 00905438T AT 00905438 T AT00905438 T AT 00905438T AT E312812 T1 ATE312812 T1 AT E312812T1
Authority
AT
Austria
Prior art keywords
vanilloid
analogues
receptor agonists
analgesics
compositions
Prior art date
Application number
AT00905438T
Other languages
English (en)
Inventor
Jeewoo Lee
Uhtaek Oh
Young-Ger Suh
Hyeung-Geun Park
Hee-Doo Kim
Original Assignee
Pacific Corp
Digital Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Corp, Digital Biotech Co Ltd filed Critical Pacific Corp
Application granted granted Critical
Publication of ATE312812T1 publication Critical patent/ATE312812T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00905438T 1999-02-22 2000-02-21 Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung ATE312812T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19990005751 1999-02-22
PCT/KR2000/000137 WO2000050387A1 (en) 1999-02-22 2000-02-21 Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof

Publications (1)

Publication Number Publication Date
ATE312812T1 true ATE312812T1 (de) 2005-12-15

Family

ID=36578904

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00905438T ATE312812T1 (de) 1999-02-22 2000-02-21 Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung

Country Status (12)

Country Link
US (1) US6476076B1 (de)
EP (1) EP1154989B1 (de)
JP (1) JP3727851B2 (de)
CN (1) CN1210254C (de)
AT (1) ATE312812T1 (de)
AU (1) AU763824B2 (de)
CA (1) CA2363531C (de)
DE (1) DE60024785T2 (de)
ES (1) ES2253208T3 (de)
HK (1) HK1042472B (de)
MX (1) MXPA01008403A (de)
WO (1) WO2000050387A1 (de)

Families Citing this family (42)

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KR100348819B1 (ko) * 1999-02-22 2002-08-17 주식회사 태평양 레시니페라톡신 약리기를 함유하여 강력한 바닐로이드수용체의 효현제 및 진통제로서 사용하는 바닐로이드동족체 및 이를 함유하는 약학적 조성물
JP3501775B2 (ja) * 2000-05-31 2004-03-02 ファイザー株式会社 ヒトバニロイド受容体様タンパク質
WO2002008221A2 (en) * 2000-07-20 2002-01-31 Neurogen Corporation Capsaicin receptor ligands
DE60120421T2 (de) * 2000-08-21 2006-12-28 Pacific Corp. Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten
WO2002016318A1 (en) 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
US20040146590A1 (en) 2001-03-22 2004-07-29 Iadarola Michael J Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin
CA2442049C (en) * 2001-03-22 2010-06-01 Michael J. Iadarola Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist
CA2455754A1 (en) * 2001-07-31 2003-02-20 Bayer Healthcare Ag Amine derivatives
MY138086A (en) 2001-09-13 2009-04-30 Smithkline Beecham Plc Novel urea derivative as vanilloid receptor-1 antagonist
US6872748B2 (en) * 2001-09-27 2005-03-29 Digital Biotech Co., Ltd. Simplified resiniferatoxin analogues as vanilloid receptor agonist showing excellent analgesic activity and the pharmaceutical compositions containing the same
JPWO2003029199A1 (ja) * 2001-09-28 2005-01-13 武田薬品工業株式会社 ベンゼン誘導体、その製造法および用途
JP2005513154A (ja) * 2001-12-26 2005-05-12 バイエル・ヘルスケア・アクチェンゲゼルシャフト 尿素誘導体
CN1627944A (zh) * 2002-01-17 2005-06-15 神经能质公司 取代的喹唑啉－4－基胺类似物作为辣椒辣素调节剂
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
CA2476936A1 (en) * 2002-02-20 2003-08-28 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
CA2487238C (en) * 2002-05-08 2011-03-22 Bayer Healthcare Ag Hydroxy tetrahydro-naphthalenylurea derivatives
DE10224107A1 (de) * 2002-05-29 2003-12-11 Gruenenthal Gmbh Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz
WO2004052846A1 (en) 2002-12-06 2004-06-24 Bayer Healthcare Ag Tetrahydro-naphthalene derivatives
DK1572632T3 (da) 2002-12-09 2008-10-27 Xention Ltd Tetrahydro-naphthalenderivater som vanilloidreceptorantagonister
EP1438942A1 (de) * 2003-01-17 2004-07-21 Schering Oy Medikamentenabgabevorrichtung für das Mittelohr und Nase
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
JP4621654B2 (ja) * 2003-02-12 2011-01-26 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト ヒドロキシ−テトラヒドロ−ナフタレニル尿素誘導体
US20040202735A1 (en) * 2003-04-08 2004-10-14 Moore Bob M. Method and kit for controlling bleeding
EP1610742B1 (de) 2003-04-10 2015-01-21 Neurogesx, Inc. Verwendung und zusammensetzungen zur verabreichung von capsaicin
KR100707123B1 (ko) * 2003-07-02 2007-04-16 그뤼넨탈 게엠베하 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물
WO2005040119A1 (en) 2003-10-01 2005-05-06 Bayer Healthcare Ag Tetrahydro-naphthalene and urea derivatives
EP1679296A4 (de) 2003-10-14 2007-12-26 Ajinomoto Kk Etherderivat
US20080058377A1 (en) * 2003-11-08 2008-03-06 Bayer Healthcare Ag Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators
EP1685112B1 (de) 2003-11-08 2011-07-20 Bayer Schering Pharma Aktiengesellschaft Tetrahydrochinolinylharnstoffderivate
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
WO2006098554A1 (en) * 2005-03-16 2006-09-21 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
MX2007011466A (es) * 2005-03-19 2008-01-16 Amorepacific Corp Compuestos novedosos, isomeros de los mismos, o sales farmaceuticamente aceptables de los mismos como antagonistas de receptor de vaniloides, y composiciones farmaceuticas que contienen los mismos.
ATE464571T1 (de) * 2005-11-04 2010-04-15 Nxp Bv Verfahren und testvorrichtung zur prüfung integrierter schaltungen
TW200824687A (en) 2006-08-25 2008-06-16 Abbott Lab Compounds that inhibit TRPV1 and uses thereof
US8030504B2 (en) 2006-12-20 2011-10-04 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
MX2010010262A (es) 2008-03-20 2010-12-06 Abbott Lab Metodos para la elaboracion de agentes para el sistema nervioso central que son antagonistas del trpv1.
WO2010119877A1 (ja) * 2009-04-13 2010-10-21 味の素株式会社 アミジン誘導体の製造方法
WO2012015882A1 (en) 2010-07-27 2012-02-02 Bean Bruce P Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise
WO2012075337A2 (en) 2010-12-01 2012-06-07 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
US9956166B2 (en) 2013-09-18 2018-05-01 Sorrento Therapeutics, Inc. Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
US11253493B2 (en) 2017-01-23 2022-02-22 Cliff-Cartwright Corporation Compositions and methods affecting exercise performance

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021450A (en) * 1989-05-30 1991-06-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof
US5431914A (en) * 1992-04-17 1995-07-11 Adekunle; Michael Method of treating an internal condition by external application of capsaicin without the need for systemic absorption

Also Published As

Publication number Publication date
ES2253208T3 (es) 2006-06-01
MXPA01008403A (es) 2003-06-06
US6476076B1 (en) 2002-11-05
WO2000050387A1 (en) 2000-08-31
HK1042472A1 (en) 2002-08-16
EP1154989A1 (de) 2001-11-21
CN1342138A (zh) 2002-03-27
JP3727851B2 (ja) 2005-12-21
DE60024785D1 (de) 2006-01-19
HK1042472B (zh) 2005-12-09
AU2697600A (en) 2000-09-14
AU763824B2 (en) 2003-07-31
CN1210254C (zh) 2005-07-13
CA2363531C (en) 2007-07-31
EP1154989B1 (de) 2005-12-14
CA2363531A1 (en) 2000-08-31
JP2002537373A (ja) 2002-11-05
DE60024785T2 (de) 2006-09-14

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