ATE312812T1 - Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung - Google Patents

Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung

Info

Publication number
ATE312812T1
ATE312812T1 AT00905438T AT00905438T ATE312812T1 AT E312812 T1 ATE312812 T1 AT E312812T1 AT 00905438 T AT00905438 T AT 00905438T AT 00905438 T AT00905438 T AT 00905438T AT E312812 T1 ATE312812 T1 AT E312812T1
Authority
AT
Austria
Prior art keywords
vanilloid
analogues
receptor agonists
analgesics
compositions
Prior art date
Application number
AT00905438T
Other languages
English (en)
Inventor
Jeewoo Lee
Uhtaek Oh
Young-Ger Suh
Hyeung-Geun Park
Hee-Doo Kim
Original Assignee
Pacific Corp
Digital Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Corp, Digital Biotech Co Ltd filed Critical Pacific Corp
Application granted granted Critical
Publication of ATE312812T1 publication Critical patent/ATE312812T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00905438T 1999-02-22 2000-02-21 Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung ATE312812T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19990005751 1999-02-22
PCT/KR2000/000137 WO2000050387A1 (en) 1999-02-22 2000-02-21 Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof

Publications (1)

Publication Number Publication Date
ATE312812T1 true ATE312812T1 (de) 2005-12-15

Family

ID=36578904

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00905438T ATE312812T1 (de) 1999-02-22 2000-02-21 Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung

Country Status (12)

Country Link
US (1) US6476076B1 (de)
EP (1) EP1154989B1 (de)
JP (1) JP3727851B2 (de)
CN (1) CN1210254C (de)
AT (1) ATE312812T1 (de)
AU (1) AU763824B2 (de)
CA (1) CA2363531C (de)
DE (1) DE60024785T2 (de)
ES (1) ES2253208T3 (de)
HK (1) HK1042472B (de)
MX (1) MXPA01008403A (de)
WO (1) WO2000050387A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100348819B1 (ko) * 1999-02-22 2002-08-17 주식회사 태평양 레시니페라톡신 약리기를 함유하여 강력한 바닐로이드수용체의 효현제 및 진통제로서 사용하는 바닐로이드동족체 및 이를 함유하는 약학적 조성물
JP3501775B2 (ja) * 2000-05-31 2004-03-02 ファイザー株式会社 ヒトバニロイド受容体様タンパク質
AU8066701A (en) * 2000-07-20 2002-02-05 Neurogen Corp Capsaicin receptor ligands
KR100564902B1 (ko) 2000-08-21 2006-03-30 주식회사 태평양 신규 티오우레아 유도체 및 이를 함유하는 약제학적 조성물
JP2004506714A (ja) * 2000-08-21 2004-03-04 パシフィック　コーポレーション 新規チオ尿素化合物及びこれを含有する薬学的組成物
US20040146590A1 (en) 2001-03-22 2004-07-29 Iadarola Michael J Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin
CA2442049C (en) * 2001-03-22 2010-06-01 Michael J. Iadarola Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist
WO2003014064A1 (en) * 2001-07-31 2003-02-20 Bayer Healthcare Ag Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists
PE20030417A1 (es) 2001-09-13 2003-08-06 Smithkline Beecham Plc Derivados de urea como antagonistas del receptor vainilloide
US6872748B2 (en) * 2001-09-27 2005-03-29 Digital Biotech Co., Ltd. Simplified resiniferatoxin analogues as vanilloid receptor agonist showing excellent analgesic activity and the pharmaceutical compositions containing the same
US20040259912A1 (en) * 2001-09-28 2004-12-23 Takahiro Matsumoto Benzine derivatives, process for preparing the same and use thereof
EP1461311A2 (de) * 2001-12-26 2004-09-29 Bayer HealthCare AG Harnstoff-derivate als vr1-antagonisten
RS63204A (sr) * 2002-01-17 2006-10-27 Neurogen Corporation Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
CA2476936A1 (en) * 2002-02-20 2003-08-28 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
ATE371641T1 (de) * 2002-05-08 2007-09-15 Bayer Healthcare Ag Hydroxy-tetrahydro-naphtalenylharnstoff-derivat
DE10224107A1 (de) * 2002-05-29 2003-12-11 Gruenenthal Gmbh Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz
DK1569896T3 (da) 2002-12-06 2007-12-10 Xention Ltd Tetrahydronaphthalenderivater
US7544716B2 (en) 2002-12-09 2009-06-09 Xention Limited Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
EP1438942A1 (de) * 2003-01-17 2004-07-21 Schering Oy Medikamentenabgabevorrichtung für das Mittelohr und Nase
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
WO2004072020A1 (en) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Hydroxy-tetrahydro-naphthalenylurea derivatives
US20040202735A1 (en) * 2003-04-08 2004-10-14 Moore Bob M. Method and kit for controlling bleeding
US7943166B2 (en) 2003-04-10 2011-05-17 Neurogesx, Inc. Methods and compositions for administration of TRPV1 agonists
KR100707123B1 (ko) * 2003-07-02 2007-04-16 그뤼넨탈 게엠베하 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물
US7615557B2 (en) 2003-10-01 2009-11-10 Xention Limited Tetrahydro-naphthalene and urea derivatives
JP4935073B2 (ja) 2003-10-14 2012-05-23 味の素株式会社 エーテル誘導体
EP1685112B1 (de) 2003-11-08 2011-07-20 Bayer Schering Pharma Aktiengesellschaft Tetrahydrochinolinylharnstoffderivate
WO2005044786A1 (en) * 2003-11-08 2005-05-19 Bayer Healthcare Ag Bicyclic amide, carbamate or urea derivatives as vanilloid receptor modulators
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
GB0412769D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
WO2006098554A1 (en) * 2005-03-16 2006-09-21 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
EP1861357B1 (de) * 2005-03-19 2013-04-24 Amorepacific Corporation Neue verbindungen oder pharmazeutisch unbedenkliche salze davon als vanilloidrezeptorantagonist, und pharmazeutische zusammensetzungen, die diese enthalten
EP1946132B1 (de) * 2005-11-04 2010-04-14 Nxp B.V. Verfahren und testvorrichtung zur prüfung integrierter schaltungen
CN101541758A (zh) 2006-08-25 2009-09-23 艾博特公司 抑制trpv1的吲唑衍生物及其用途
WO2008079683A2 (en) 2006-12-20 2008-07-03 Abbott Laboratories N- (5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
CN102036969A (zh) 2008-03-20 2011-04-27 雅培制药有限公司 制造作为trpv1拮抗剂的中枢神经系统药剂的方法
WO2010119877A1 (ja) * 2009-04-13 2010-10-21 味の素株式会社 アミジン誘導体の製造方法
EP3295794A1 (de) 2010-07-27 2018-03-21 Flex Pharma, Inc. Verfahren und zusammensetzungen zur vorbeugung und linderung von muskelkrämpfen und zur erholung von neuromuskulärer reizbarkeit und erschöpfung nach dem training
US20120310140A1 (en) 2010-12-01 2012-12-06 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
US9956166B2 (en) 2013-09-18 2018-05-01 Sorrento Therapeutics, Inc. Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
WO2018136943A1 (en) 2017-01-23 2018-07-26 Flex Pharma, Inc. Compositions and methods affecting exercise performance

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021450A (en) * 1989-05-30 1991-06-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof
US5431914A (en) * 1992-04-17 1995-07-11 Adekunle; Michael Method of treating an internal condition by external application of capsaicin without the need for systemic absorption

Also Published As

Publication number Publication date
JP3727851B2 (ja) 2005-12-21
HK1042472B (zh) 2005-12-09
AU763824B2 (en) 2003-07-31
JP2002537373A (ja) 2002-11-05
CN1342138A (zh) 2002-03-27
CA2363531C (en) 2007-07-31
MXPA01008403A (es) 2003-06-06
HK1042472A1 (en) 2002-08-16
DE60024785T2 (de) 2006-09-14
EP1154989A1 (de) 2001-11-21
US6476076B1 (en) 2002-11-05
DE60024785D1 (de) 2006-01-19
ES2253208T3 (es) 2006-06-01
WO2000050387A1 (en) 2000-08-31
EP1154989B1 (de) 2005-12-14
AU2697600A (en) 2000-09-14
CA2363531A1 (en) 2000-08-31
CN1210254C (zh) 2005-07-13

Similar Documents

Publication Publication Date Title
ATE312812T1 (de) Vanilloid-analoge die resiniferatoxin- pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung
AR002267A1 (es) Compuestos de imidazol utiles para el tratamiento de patologias mediadas por citoquinas; composicion farmaceutica que los contiene; proceso para preparar dichos compuestos; uso del mismo para preparar dichas composiciones; compuestos intermediarios y procesos para su preparacion.
DE602004013563D1 (de) Rantagonisten
EP1606264A4 (de) Monocyclische anilidspirohydantoine als cgrp-rezeptorantagonisten
JO2355B1 (en) Hereditary calcitonin polypeptide receptor antagonists
MY137535A (en) New pyrrolidinium derivatives
IL182317A0 (en) Cgrp receptor antagonists
ATE464304T1 (de) Carboxamid-spirolactam-cgrp-rezeptor-antagonist n
ATE535514T1 (de) Carboxamid-spirohydantoin-cgrp-rezeptor- antagonisten
WO2004087649A3 (en) Benodiazepine spirohydantoin cgrp receptor antagonists
ATE490244T1 (de) Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren
ATE466860T1 (de) Cgrp-rezeptorantagonisten
CL2008000762A1 (es) Compuestos derivados de pirimidinas; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de la psoriasis, diabetes, artritis reumatoide, entre otras enfermedades ( divisional solicitud 1147-02).
ATE516803T1 (de) Aryl-spirohydantoin-cgrp-rezeptor-antagonisten
CL2004000778A1 (es) Compuestos derivados de heterociclos de 5 miembros, inhibidores de la porteina tirosina fosfatasa 1b (ptp1b); composiciones farmaceuticas, utiles para tratar hipertension, obesidad, diabetes, hiperlipidemia.
NO20026064D0 (no) Nye forbindelser
HRP941000B9 (hr) Morfolin i tiomorfolin antagonisti receptora tahikinina
GT199800042A (es) Nuevos derivados del acido hexanoico.
BR0206595A (pt) Composto, composição farmacêutica, e uso de um composto
CL2003002611A1 (es) Compuestos derivados del acido tiofeno hidroxamico, 2-hidroxamida-5-[(aril o heteroaril)-disutituido-metil]-amida del acido tiofeno-2,5-dicarboxilico enantiomeros, composicion farmaceutica, procedimiento de preparacion, y su uso para el tratamiento d
DE60237528D1 (de) Neue aminoazetidin-, aminopyrrolidin- und aminopiperidinderivative
TW200716584A (en) Dihydrobenzofuran derivatives and uses thereof
WO2006099268A3 (en) Cgrp receptor antagonists
DE602004031123D1 (de) Umsetzungsprodukte von mercaptobenzothiazolen, mercaptothiazolinen und mercaptobenzimidazolen mit epoxiden als schmiermitteladditive
WO2006047196A3 (en) Cgrp receptor antagonists

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties