ATE556060T1 - Monocyclische anilidspirohydantoine als cgrp- rezeptorantagonisten - Google Patents
Monocyclische anilidspirohydantoine als cgrp- rezeptorantagonistenInfo
- Publication number
- ATE556060T1 ATE556060T1 AT04719323T AT04719323T ATE556060T1 AT E556060 T1 ATE556060 T1 AT E556060T1 AT 04719323 T AT04719323 T AT 04719323T AT 04719323 T AT04719323 T AT 04719323T AT E556060 T1 ATE556060 T1 AT E556060T1
- Authority
- AT
- Austria
- Prior art keywords
- spirohydantoins
- anilide
- monocyclic
- receptor antagonists
- cgrp receptor
- Prior art date
Links
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title abstract 2
- 150000003931 anilides Chemical class 0.000 title 1
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 abstract 2
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 abstract 2
- 102000014468 Calcitonin Gene-Related Peptide Receptors Human genes 0.000 abstract 1
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45494403P | 2003-03-14 | 2003-03-14 | |
| PCT/US2004/007678 WO2004083187A1 (en) | 2003-03-14 | 2004-03-10 | Monocyclic anilide spirohydantoin cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE556060T1 true ATE556060T1 (de) | 2012-05-15 |
Family
ID=33029931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04719323T ATE556060T1 (de) | 2003-03-14 | 2004-03-10 | Monocyclische anilidspirohydantoine als cgrp- rezeptorantagonisten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7192954B2 (de) |
| EP (1) | EP1606264B1 (de) |
| JP (1) | JP4673295B2 (de) |
| AT (1) | ATE556060T1 (de) |
| AU (1) | AU2004221891B2 (de) |
| CA (1) | CA2518852A1 (de) |
| WO (1) | WO2004083187A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| WO2004082605A2 (en) * | 2003-03-14 | 2004-09-30 | Merck & Co. Inc. | Bicyclic anilide spirohydantoin cgrp receptor antagonists |
| US7205293B2 (en) * | 2003-03-14 | 2007-04-17 | Merck & Co., Inc. | Benodiazepine spirohydantoin CGRP receptor antagonists |
| ATE516803T1 (de) * | 2003-03-14 | 2011-08-15 | Merck Sharp & Dohme | Aryl-spirohydantoin-cgrp-rezeptor-antagonisten |
| US7569578B2 (en) | 2003-12-05 | 2009-08-04 | Bristol-Meyers Squibb Company | Heterocyclic anti-migraine agents |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| US7659300B2 (en) * | 2004-09-08 | 2010-02-09 | Merck Sharp & Dohme Corp. | Monocyclic anilide spirolactam CGRP receptor antagonists |
| JP2008512456A (ja) | 2004-09-09 | 2008-04-24 | メルク エンド カムパニー インコーポレーテッド | 三環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬 |
| ATE537153T1 (de) * | 2004-09-09 | 2011-12-15 | Merck Sharp & Dohme | Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors |
| ATE518852T1 (de) * | 2004-09-13 | 2011-08-15 | Merck Sharp & Dohme | Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten |
| ATE464305T1 (de) | 2004-09-13 | 2010-04-15 | Merck Sharp & Dohme | Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| ES2433251T5 (es) | 2005-11-14 | 2020-03-13 | Teva Pharmaceuticals Int Gmbh | Anticuerpos antagonistas dirigidos contra un péptido relacionado con el gen de la calcitonina y procedimientos que utilizan los mismos |
| EP1951042B1 (de) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Spirolactam tricyclische cgrp-rezeptor-antagonisten |
| WO2007061694A2 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirohydantoin tricyclic cgrp receptor antagonists |
| EP1951228B1 (de) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Bicyclische spirohydantoin cgrp-rezeptor-antagonisten |
| WO2007061677A2 (en) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirolactam aryl cgrp receptor antagonists |
| US8071770B2 (en) | 2005-11-18 | 2011-12-06 | Merck Sharp & Dohme Corp. | Spirohydantoin aryl CGRP receptor antagonists |
| BRPI0711352A2 (pt) * | 2006-05-09 | 2011-09-27 | Merck & Co Inc | composto, composição farmacêutica, e, métodos para o antagonismo de atividade receptora de cgrp em um mamìfero, e para, tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca , ou cefaléia vascular |
| DE102006024024A1 (de) * | 2006-05-23 | 2007-11-29 | Bayer Healthcare Aktiengesellschaft | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
| CA2658573A1 (en) * | 2006-07-21 | 2008-01-24 | Vertex Pharmaceuticals Incorporated | Cgrp receptor antagonists |
| EP2091533B1 (de) * | 2006-12-08 | 2012-11-28 | Merck Sharp & Dohme Corp. | Eingeschränkte spirocyclische verbindungen als cgrp-rezeptor-antagonisten |
| US8148390B2 (en) | 2007-03-12 | 2012-04-03 | Merck, Sharp & Dohme, Corp. | Monocyclic anilide spirolactam CGRP receptor antagonists |
| AU2008239754A1 (en) * | 2007-04-11 | 2008-10-23 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups |
| WO2008130524A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Aryl heterocyclic cgrp receptor antagonists |
| JP2010524931A (ja) * | 2007-04-16 | 2010-07-22 | メルク・シャープ・エンド・ドーム・コーポレイション | 二環式アニリドヘテロ環式ｃｇｒｐ受容体アンタゴニスト |
| EP2161996B1 (de) * | 2007-06-05 | 2014-07-16 | Merck Sharp & Dohme Corp. | Heterocyclische carboxamid-cgrp-rezeptorantagonisten |
| JP2010529120A (ja) * | 2007-06-07 | 2010-08-26 | メルク・シャープ・エンド・ドーム・コーポレイション | 三環式アニリド複素環ｃｇｒｐ受容体アンタゴニスト |
| WO2009109911A1 (en) | 2008-03-04 | 2009-09-11 | Pfizer Limited | Methods of treating chronic pain |
| WO2010027927A1 (en) * | 2008-09-08 | 2010-03-11 | Merck Sharp & Dohme Corp. | Monocyclic amide cgrp receptor antagonists |
| CA2738657A1 (en) * | 2008-10-03 | 2010-04-08 | Merck Sharp & Dohme Corp. | Cgrp receptor antagonists |
| DE102008060967A1 (de) | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylsulfonyltriazolone und ihre Verwendung |
| DE102010001064A1 (de) * | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| ES2912569T3 (es) | 2009-08-28 | 2022-05-26 | Teva Pharmaceuticals Int Gmbh | Métodos para tratar el dolor visceral administrando anticuerpos antagonistas dirigidos contra el péptido relacionado con el gen de la calcitonina |
| PL2539326T3 (pl) | 2010-02-27 | 2017-10-31 | Bayer Ip Gmbh | Połączone bis-arylem arylotriazolony i ich zastosowanie |
| DE102010040187A1 (de) | 2010-09-02 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung |
| DE102010040924A1 (de) | 2010-09-16 | 2012-03-22 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung |
| SG10201604040PA (en) | 2011-05-20 | 2016-07-28 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
| NZ732875A (en) | 2011-05-20 | 2022-08-26 | H Lundbeck As | Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea |
| RS66303B1 (sr) | 2011-05-20 | 2025-01-31 | H Lundbeck As | Upotreba anti-cgrp antitela i fragmenata antitela za sprečavanje ili inhibiranje fotofobije ili odbojnosti prema svetlu kod subjekata kojima je to potrebno, naročito kod subjekata koji pate od migrene |
| US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| MX378344B (es) | 2014-03-21 | 2025-03-10 | Teva Pharmaceuticals Int Gmbh | Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos. |
| KR20170081178A (ko) | 2014-11-03 | 2017-07-11 | 바이엘 파마 악티엔게젤샤프트 | 히드록시알킬-치환된 페닐트리아졸 유도체 및 그의 용도 |
| FR3030521B1 (fr) * | 2014-12-23 | 2019-07-26 | Galderma Research & Development | Nouveaux composes heterocycliques et leur utilisation en medecine ainsi qu'en cosmetique |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| AU2017331593B2 (en) | 2016-09-23 | 2022-04-28 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
| EP3366286A1 (de) | 2017-02-22 | 2018-08-29 | Johannes Keller | Verbindungen zur behandlung von sepsis |
| PE20211707A1 (es) | 2019-01-08 | 2021-09-01 | H Lundbeck As | Tratamiento agudo y tratamiento rapido de la cefalea usando anticuerpos anticgrp |
| KR20210124867A (ko) | 2020-04-06 | 2021-10-15 | 하. 룬드벡 아크티에셀스카브 | 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772632A (en) * | 1987-02-24 | 1988-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Antineoplastic, system - L specific amino acid nitrogen mustards |
| JP3449084B2 (ja) * | 1995-12-25 | 2003-09-22 | 富士レビオ株式会社 | ヒダントイン誘導体 |
-
2004
- 2004-03-10 US US10/547,082 patent/US7192954B2/en not_active Expired - Lifetime
- 2004-03-10 JP JP2006507138A patent/JP4673295B2/ja not_active Expired - Fee Related
- 2004-03-10 AT AT04719323T patent/ATE556060T1/de active
- 2004-03-10 CA CA002518852A patent/CA2518852A1/en not_active Abandoned
- 2004-03-10 AU AU2004221891A patent/AU2004221891B2/en not_active Ceased
- 2004-03-10 EP EP04719323A patent/EP1606264B1/de not_active Expired - Lifetime
- 2004-03-10 WO PCT/US2004/007678 patent/WO2004083187A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006520387A (ja) | 2006-09-07 |
| EP1606264A1 (de) | 2005-12-21 |
| CA2518852A1 (en) | 2004-09-30 |
| AU2004221891A1 (en) | 2004-09-30 |
| WO2004083187A1 (en) | 2004-09-30 |
| AU2004221891B2 (en) | 2009-11-19 |
| EP1606264A4 (de) | 2009-02-18 |
| EP1606264B1 (de) | 2012-05-02 |
| JP4673295B2 (ja) | 2011-04-20 |
| US7192954B2 (en) | 2007-03-20 |
| US20060148779A1 (en) | 2006-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE394400T1 (de) | Bicyclische anilidspirohydantoine als cgrp- rezeptorantagonisten | |
| ATE535514T1 (de) | Carboxamid-spirohydantoin-cgrp-rezeptor- antagonisten | |
| ATE509019T1 (de) | Benzodiazepinspirohydantoine als cgrp- rezeptorantagonisten | |
| EP1606264A4 (de) | Monocyclische anilidspirohydantoine als cgrp-rezeptorantagonisten | |
| EP1605936A4 (de) | Aryl-spirohydantoin-cgrp-rezeptor-antagonisten | |
| JO2355B1 (en) | Hereditary calcitonin polypeptide receptor antagonists | |
| ATE464305T1 (de) | Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors | |
| NO20072435L (no) | CGRP-reseptorantagonister | |
| DE602005020655D1 (de) | Carboxamid-spirolactam-cgrp-rezeptor-antagonisten | |
| WO2006029153A3 (en) | Monocyclic anilide spirolactam cgrp receptor antagonists | |
| ATE537170T1 (de) | Cgrp-rezeptorantagonisten | |
| EP1641423A4 (de) | Benzodiazepin-cgrp-rezeptor-antagonisten | |
| ATE466860T1 (de) | Cgrp-rezeptorantagonisten | |
| NO20092470L (no) | Substituerte diazepanforbindelser som orexinreseptorantagonister | |
| ATE463245T1 (de) | Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten | |
| ATE537153T1 (de) | Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors | |
| ATE493412T1 (de) | Spirohydantoin-aryl-cgrp-rezeptorantagonisten | |
| WO2005000807A3 (en) | Benzodiazepine cgrp receptor antagonists | |
| WO2008112159A3 (en) | Monocyclic anilide spirolactam cgrp receptor antagonists | |
| EP1794146A4 (de) | Tricyclische anilid-spirohydantoin-cgrp-rezeptorantagonisten | |
| DE602005027230D1 (de) | Cgrp-rezeptorantagonisten | |
| WO2007016087A3 (en) | Heterocyclic benzodiazepine cgrp receptor antagonists | |
| DE602005027870D1 (de) | Cgrp-rezeptorantagonisten | |
| ATE466853T1 (de) | Cgrp-rezeptorantagonisten |