ATE312817T1 - Cyclohept'bö indolderivate als spla2-inhibitoren - Google Patents

Cyclohept'bö indolderivate als spla2-inhibitoren

Info

Publication number
ATE312817T1
ATE312817T1 AT02756390T AT02756390T ATE312817T1 AT E312817 T1 ATE312817 T1 AT E312817T1 AT 02756390 T AT02756390 T AT 02756390T AT 02756390 T AT02756390 T AT 02756390T AT E312817 T1 ATE312817 T1 AT E312817T1
Authority
AT
Austria
Prior art keywords
cyclohept
indole derivatives
spla2 inhibitors
sub
compounds
Prior art date
Application number
AT02756390T
Other languages
English (en)
Inventor
Michael Dean Kinnick
Edward David Mihelich
John Michael Junior Morin
Daniel Jon Sall
Jason Scott Sawyer
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE312817T1 publication Critical patent/ATE312817T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02756390T 2001-08-09 2002-07-29 Cyclohept'bö indolderivate als spla2-inhibitoren ATE312817T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31127501P 2001-08-09 2001-08-09
PCT/US2002/021299 WO2003016277A1 (en) 2001-08-09 2002-07-29 Cyclohept`b!indole derivatives as spla2 inhibitors

Publications (1)

Publication Number Publication Date
ATE312817T1 true ATE312817T1 (de) 2005-12-15

Family

ID=23206182

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02756390T ATE312817T1 (de) 2001-08-09 2002-07-29 Cyclohept'bö indolderivate als spla2-inhibitoren

Country Status (7)

Country Link
US (1) US7109231B2 (de)
EP (1) EP1438290B1 (de)
JP (1) JP2005527466A (de)
AT (1) ATE312817T1 (de)
DE (1) DE60208065T2 (de)
ES (1) ES2252497T3 (de)
WO (1) WO2003016277A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2537837A1 (en) * 2003-09-11 2005-03-24 Xenoport, Inc. Treating and/or preventing urinary incontinence using prodrugs of gaba analogs
EP1811986B1 (de) 2004-11-04 2014-03-26 XenoPort, Inc. Orale darreichungsformen von gabapentin-prodrug mit verzögerter freisetzung
WO2008086492A1 (en) * 2007-01-11 2008-07-17 Xenoport, Inc. Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment
GB0905328D0 (en) 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
CN107233337A (zh) 2009-04-29 2017-10-10 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
US9220795B2 (en) 2011-09-22 2015-12-29 Ge Healthcare Limited Indole derivatives
RU2500670C1 (ru) * 2012-08-07 2013-12-10 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" ПРОИЗВОДНОЕ 1',2',3'-ТРИМЕТОКСИБЕНЗО[4',5':4,5]-6,7-ДИГИДРОЦИКЛОГЕПТА-[2,3-e]-1H-1-МЕТИЛИНДОЛА И ЕГО ПРИМЕНЕНИЕ
RU2500671C1 (ru) * 2012-08-07 2013-12-10 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" ПРОИЗВОДНОЕ 1',2',3'-ТРИМЕТОКСИБЕНЗО[4',5':4,5]-6,7-ДИГИДРОЦИКЛОГЕПТА-[3,2-f]-1H-1-МЕТИЛИНДОЛА И ЕГО ПРИМЕНЕНИЕ
CN104797559A (zh) 2012-11-30 2015-07-22 通用电气健康护理有限公司 卤化锌介导的环化过程得到三环吲哚
US10709798B2 (en) 2012-11-30 2020-07-14 Ge Healthcare Limited Crystallization process of tricyclic indole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID23219A (id) 1998-04-17 2000-03-30 Lilly Co Eli Trisiklik tersubstitusi
CA2338727A1 (en) * 1998-08-03 2000-02-17 Edward David Mihelich Indole spla2 inhibitors

Also Published As

Publication number Publication date
EP1438290B1 (de) 2005-12-14
WO2003016277A1 (en) 2003-02-27
US20040198801A1 (en) 2004-10-07
EP1438290A1 (de) 2004-07-21
DE60208065D1 (en) 2006-01-19
DE60208065T2 (de) 2006-07-13
JP2005527466A (ja) 2005-09-15
ES2252497T3 (es) 2006-05-16
US7109231B2 (en) 2006-09-19

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties