ATE312821T1 - 2-amino-pyridin zwischenprodukte für beta3- adrenergischer rezeptor-agoniste - Google Patents
2-amino-pyridin zwischenprodukte für beta3- adrenergischer rezeptor-agonisteInfo
- Publication number
- ATE312821T1 ATE312821T1 AT99307987T AT99307987T ATE312821T1 AT E312821 T1 ATE312821 T1 AT E312821T1 AT 99307987 T AT99307987 T AT 99307987T AT 99307987 T AT99307987 T AT 99307987T AT E312821 T1 ATE312821 T1 AT E312821T1
- Authority
- AT
- Austria
- Prior art keywords
- adrenergic receptor
- beta3
- amino
- receptor agonists
- pyridine intermediate
- Prior art date
Links
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 title 2
- 239000000048 adrenergic agonist Substances 0.000 title 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 title 1
- 102000016959 beta-3 Adrenergic Receptors Human genes 0.000 title 1
- 108010014502 beta-3 Adrenergic Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 3
- 229940126158 β3 adrenergic receptor agonist Drugs 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10437598P | 1998-10-15 | 1998-10-15 | |
| US14546099P | 1999-07-23 | 1999-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312821T1 true ATE312821T1 (de) | 2005-12-15 |
Family
ID=26801476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99307987T ATE312821T1 (de) | 1998-10-15 | 1999-10-11 | 2-amino-pyridin zwischenprodukte für beta3- adrenergischer rezeptor-agoniste |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6090942A (de) |
| EP (1) | EP0994105B1 (de) |
| JP (1) | JP2000128864A (de) |
| KR (1) | KR20000029108A (de) |
| CN (1) | CN1256276A (de) |
| AT (1) | ATE312821T1 (de) |
| BR (1) | BR9904689A (de) |
| CA (1) | CA2285914C (de) |
| DE (1) | DE69928890D1 (de) |
| HU (1) | HUP9903602A2 (de) |
| ID (1) | ID23360A (de) |
| IL (1) | IL132269A0 (de) |
| PL (1) | PL336053A1 (de) |
| TR (1) | TR199902565A2 (de) |
| YU (1) | YU51599A (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1153919A4 (de) | 1999-02-16 | 2002-10-02 | Kaneka Corp | Substituierte acetylpyridin-derivate und ein verfahren zur herstellung von intermediaten für optisch aktive beta3 agonsitenmittels ihrer verwendung |
| US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| ES2228413T3 (es) | 1999-07-23 | 2005-04-16 | Pfizer Products Inc. | Productos intermedios y un procedimiento para producir agonistas de receptores beta-adrenergicos. |
| US6864268B2 (en) | 2002-02-27 | 2005-03-08 | Pfizer Inc. | β3 adrenergic receptor agonists |
| MXPA04008298A (es) | 2002-02-27 | 2004-11-26 | Pfizer Prod Inc | Procesos e intermedios utiles en la preparacion de agonistas de receptor beta-3 adrenergico. |
| AU2003209527A1 (en) | 2002-02-27 | 2003-09-09 | Pfizer Products Inc. | Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol |
| EP1477167A1 (de) * | 2003-05-15 | 2004-11-17 | Pfizer Limited | [(2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethylamino)-propyl] phenyl derivative als beta2 agonist |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2220538A1 (en) * | 1995-05-10 | 1996-11-14 | Pfizer Inc. | .beta.-adrenergic agonists |
| EP0824519A1 (de) * | 1995-05-10 | 1998-02-25 | Pfizer Inc. | Beta-adrenergische agonisten |
| GB2305665A (en) * | 1995-09-26 | 1997-04-16 | Merck & Co Inc | Selective ß3 agonists for the treatment of diabetes aand obesity |
| EA199900375A1 (ru) * | 1996-11-14 | 1999-12-29 | Пфайзер Инк. | Способ получения замещенных пиридинов |
| US6001856A (en) * | 1997-06-13 | 1999-12-14 | Pfizer Inc. | β-adrenergic agonists to reduce a wasting condition |
| EP0920864A1 (de) * | 1997-12-03 | 1999-06-09 | Pfizer Products Inc. | Kombinationstherapie durch einen spezifischen beta-3 Agonisten und einen Appetithemmer |
-
1999
- 1999-09-29 US US09/408,998 patent/US6090942A/en not_active Expired - Fee Related
- 1999-10-07 IL IL13226999A patent/IL132269A0/xx unknown
- 1999-10-08 YU YU51599A patent/YU51599A/sh unknown
- 1999-10-11 AT AT99307987T patent/ATE312821T1/de not_active IP Right Cessation
- 1999-10-11 EP EP99307987A patent/EP0994105B1/de not_active Expired - Lifetime
- 1999-10-11 DE DE69928890T patent/DE69928890D1/de not_active Expired - Lifetime
- 1999-10-13 CA CA002285914A patent/CA2285914C/en not_active Expired - Fee Related
- 1999-10-13 ID IDP990951D patent/ID23360A/id unknown
- 1999-10-14 TR TR1999/02565A patent/TR199902565A2/xx unknown
- 1999-10-14 HU HU9903602A patent/HUP9903602A2/hu unknown
- 1999-10-15 BR BR9904689-0A patent/BR9904689A/pt not_active IP Right Cessation
- 1999-10-15 CN CN99125439A patent/CN1256276A/zh active Pending
- 1999-10-15 PL PL99336053A patent/PL336053A1/xx not_active Application Discontinuation
- 1999-10-15 KR KR1019990044778A patent/KR20000029108A/ko not_active Ceased
- 1999-10-15 JP JP11293733A patent/JP2000128864A/ja active Pending
-
2000
- 2000-01-20 US US09/488,245 patent/US6124457A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0994105B1 (de) | 2005-12-14 |
| TR199902565A2 (xx) | 2000-05-22 |
| HU9903602D0 (en) | 1999-12-28 |
| EP0994105A3 (de) | 2000-05-24 |
| KR20000029108A (ko) | 2000-05-25 |
| CA2285914C (en) | 2003-06-03 |
| EP0994105A2 (de) | 2000-04-19 |
| PL336053A1 (en) | 2000-04-25 |
| DE69928890D1 (de) | 2006-01-19 |
| BR9904689A (pt) | 2000-11-14 |
| ID23360A (id) | 2000-04-20 |
| CN1256276A (zh) | 2000-06-14 |
| YU51599A (sh) | 2001-03-07 |
| HUP9903602A2 (en) | 2001-03-28 |
| US6090942A (en) | 2000-07-18 |
| CA2285914A1 (en) | 2000-04-15 |
| IL132269A0 (en) | 2001-03-19 |
| JP2000128864A (ja) | 2000-05-09 |
| US6124457A (en) | 2000-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |