ATE312830T1 - 2,3-dihydro-1h-isoindol-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel) - Google Patents
2,3-dihydro-1h-isoindol-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)Info
- Publication number
- ATE312830T1 ATE312830T1 AT99953832T AT99953832T ATE312830T1 AT E312830 T1 ATE312830 T1 AT E312830T1 AT 99953832 T AT99953832 T AT 99953832T AT 99953832 T AT99953832 T AT 99953832T AT E312830 T1 ATE312830 T1 AT E312830T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- formula
- zero
- group
- antipsychotic agents
- Prior art date
Links
- 239000000164 antipsychotic agent Substances 0.000 title abstract 2
- 102000004073 Dopamine D3 Receptors Human genes 0.000 title 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 title 1
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical class C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9821978.5A GB9821978D0 (en) | 1998-10-08 | 1998-10-08 | Compounds |
| PCT/EP1999/007762 WO2000021950A1 (en) | 1998-10-08 | 1999-10-06 | 2,3-dihydro-1h-isoindole derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312830T1 true ATE312830T1 (de) | 2005-12-15 |
Family
ID=10840234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99953832T ATE312830T1 (de) | 1998-10-08 | 1999-10-06 | 2,3-dihydro-1h-isoindol-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel) |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6521638B1 (de) |
| EP (1) | EP1119562B1 (de) |
| JP (1) | JP2002527432A (de) |
| AT (1) | ATE312830T1 (de) |
| AU (1) | AU1038000A (de) |
| DE (1) | DE69928951D1 (de) |
| GB (1) | GB9821978D0 (de) |
| HK (1) | HK1040393A1 (de) |
| WO (1) | WO2000021950A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| DK1362039T3 (da) * | 2001-02-16 | 2006-05-08 | Aventis Pharma Inc | Heterocykliske, substituerede carbonylderivater og deres anvendelse som dopamin D3-receptorligander |
| GB0117577D0 (en) | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| GB0330043D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them |
| GB0330042D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them |
| US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| JP5701213B2 (ja) | 2008-10-10 | 2015-04-15 | インスティチュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ | 新規なドーパミンｄ３受容体リガンド、その調製及び使用 |
| US10870660B2 (en) | 2016-07-28 | 2020-12-22 | Shionogi & Co., Ltd. | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect |
| KR20200112910A (ko) | 2018-01-26 | 2020-10-05 | 시오노기 앤드 컴파니, 리미티드 | 도파민 d3 수용체 길항 작용을 갖는 축환 화합물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047406A (en) * | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
| GB9305644D0 (en) | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| CZ363298A3 (cs) * | 1996-05-11 | 1999-06-16 | Smithkline Beecham P. L. C. | Tetrahydroizochinolinové deriváty jako modulátory receptorů dopaminu D3 |
| AU4204697A (en) | 1996-08-14 | 1998-03-06 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives and their pharmaceutical use |
| JP2002501506A (ja) | 1997-05-03 | 2002-01-15 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ドーパミンｄ▲下３▼受容体のモジュレーターとしてのテトラヒドロイソキノリン誘導体 |
-
1998
- 1998-10-08 GB GBGB9821978.5A patent/GB9821978D0/en not_active Ceased
-
1999
- 1999-10-06 JP JP2000575856A patent/JP2002527432A/ja active Pending
- 1999-10-06 EP EP99953832A patent/EP1119562B1/de not_active Expired - Lifetime
- 1999-10-06 DE DE69928951T patent/DE69928951D1/de not_active Expired - Lifetime
- 1999-10-06 HK HK02100619.9A patent/HK1040393A1/zh unknown
- 1999-10-06 AU AU10380/00A patent/AU1038000A/en not_active Abandoned
- 1999-10-06 WO PCT/EP1999/007762 patent/WO2000021950A1/en not_active Ceased
- 1999-10-06 US US09/806,894 patent/US6521638B1/en not_active Expired - Fee Related
- 1999-10-06 AT AT99953832T patent/ATE312830T1/de not_active IP Right Cessation
-
2002
- 2002-12-03 US US10/308,708 patent/US20030158222A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HK1040393A1 (zh) | 2002-06-07 |
| DE69928951D1 (de) | 2006-01-19 |
| EP1119562A1 (de) | 2001-08-01 |
| GB9821978D0 (en) | 1998-12-02 |
| EP1119562B1 (de) | 2005-12-14 |
| JP2002527432A (ja) | 2002-08-27 |
| WO2000021950A1 (en) | 2000-04-20 |
| US6521638B1 (en) | 2003-02-18 |
| AU1038000A (en) | 2000-05-01 |
| US20030158222A1 (en) | 2003-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |