HUP0000729A2 - Új amidszármazékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Új amidszármazékok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0000729A2
HUP0000729A2 HU0000729A HUP0000729A HUP0000729A2 HU P0000729 A2 HUP0000729 A2 HU P0000729A2 HU 0000729 A HU0000729 A HU 0000729A HU P0000729 A HUP0000729 A HU P0000729A HU P0000729 A2 HUP0000729 A2 HU P0000729A2
Authority
HU
Hungary
Prior art keywords
group
oxygen
general formula
sulfur atom
formula
Prior art date
Application number
HU0000729A
Other languages
English (en)
Inventor
Toshiyuki Edano
Mitsuteru Hirata
Katsumi Kawamine
Takahiro Kitamura
Toru Miura
Tadaaki Ohgiya
Chiyoka Ozaki
Yukihiro Sato
Kimiyuki Shibuya
Original Assignee
Kowa Company, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Company, Ltd. filed Critical Kowa Company, Ltd.
Publication of HUP0000729A2 publication Critical patent/HUP0000729A2/hu
Publication of HUP0000729A3 publication Critical patent/HUP0000729A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány új, ACAT-gátló hatással rendelkező (I) általános képletűvegyületekre, azok sóira és szolvátjaira és a fenti vegyületek közüllegalább egyet tartalmazó gyógyszerkészítményre vonatkozik. Aképletben (A) általános képletű csoport jelentése adott esetben szubsztituáltkét vegyértékű csoport, így például fenil-, piridil-, ciklohexil- vagynaftil-, vagy (a) képletű csoport; Het jelentése 5-8 tagú szubsztituált vagy szubsztituálatlanheterociklusos csoport, amely heteroatomként legalább egy nitrogén-,oxigén- vagy kénatomot tartalmaz, így például monociklusos,policiklusos vagy kondenzált gyűrűs csoport; X jelentése -NH- csoport, oxigén- vagy kénatom; Y jelentése oxigén-, kénatom, -NR4- általános képletű csoport,szulfoxid- vagy szulfoncsoport; Z jelentése egyes kötés vagy -NR5- általános képletű csoport; R4 és R5 jelentése hidrogénatom, rövid szénláncú alkil-, aril- vagyadott esetben szubsztituált szilil-(rövid szénláncú alkil)-csoport; és n jelentése egész szám, melynek értéke 1-15 lehet. Ó
HU0000729A 1997-11-14 1998-11-16 Novel amide compounds and drugs containing the same HUP0000729A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33087797 1997-11-14
PCT/JP1998/005149 WO1999025712A1 (en) 1997-11-14 1998-11-16 Novel amide compounds and drugs containing the same

Publications (2)

Publication Number Publication Date
HUP0000729A2 true HUP0000729A2 (hu) 2001-04-28
HUP0000729A3 HUP0000729A3 (en) 2001-06-28

Family

ID=18237521

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000729A HUP0000729A3 (en) 1997-11-14 1998-11-16 Novel amide compounds and drugs containing the same

Country Status (10)

Country Link
EP (1) EP0979823B1 (hu)
JP (1) JP4402176B2 (hu)
AT (1) ATE321759T1 (hu)
AU (1) AU755654C (hu)
CA (1) CA2303781A1 (hu)
DE (1) DE69834052T2 (hu)
ES (1) ES2262248T3 (hu)
HU (1) HUP0000729A3 (hu)
TW (1) TW580498B (hu)
WO (1) WO1999025712A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969711B2 (en) 1997-05-26 2005-11-29 Kowa Company, Ltd. Cyclic diamine compounds and medicine containing the same
WO1998054153A1 (en) * 1997-05-26 1998-12-03 Kowa Company, Ltd. Novel cyclic diamine compounds and medicine containing the same
ATE257826T1 (de) 1999-06-28 2004-01-15 Fuji Photo Film Co Ltd Benzimidazolderivate und sie enthaltende medikamente
EP1201664B1 (en) 1999-06-30 2004-09-08 Fuji Photo Film Co., Ltd. Benzimidazole compounds and drugs containing the same
JP4624616B2 (ja) * 1999-07-07 2011-02-02 富士フイルム株式会社 ベンズイミダゾール化合物
AU2003243921B2 (en) 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
PT1723128E (pt) 2004-01-06 2013-02-27 Novo Nordisk As Heteroaril-ureias e o seu uso como activadores da glicoquinase
US8916550B2 (en) 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
AU2006244074B2 (en) * 2005-05-09 2012-12-13 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
KR20080024211A (ko) 2005-07-08 2008-03-17 노보 노르디스크 에이/에스 디시클로알킬 우레아 글루코키나제 활성제
JP2009500378A (ja) 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス グルコキナーゼ活性化剤としてのジシクロアルキルカルバモイル尿素
BRPI0612996A2 (pt) 2005-07-14 2010-12-14 Novo Nordisk As ativadores de urÉia glucocinase
US8138185B2 (en) 2007-01-09 2012-03-20 Novo Nordisk A/S Urea glucokinase activators
AU2008204530B2 (en) 2007-01-11 2013-08-01 Vtv Therapeutics Llc Urea glucokinase activators
AU2019287437A1 (en) 2018-06-12 2020-09-10 Vtv Therapeutics Llc Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
WO2021167840A1 (en) 2020-02-18 2021-08-26 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
CN116194442A (zh) 2020-06-08 2023-05-30 维特卫治疗有限责任公司 {2-[3-环己基-3-(反式-4-丙氧基-环己基)-脲基]-噻唑-5-基硫烷基}-乙酸的盐或共晶体及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116433B1 (hu) * 1968-04-01 1976-05-24 Fujisawa Pharmaceutical Co
JPS6242989A (ja) * 1986-08-04 1987-02-24 Sumitomo Pharmaceut Co Ltd 溶接電極の自動整形および交換装置
JPH04139172A (ja) * 1990-10-01 1992-05-13 Sankyo Co Ltd α―スルフィニル置換アセトアミド誘導体
US5358946A (en) * 1992-05-29 1994-10-25 The Du Pont Merck Pharmaceutical Company Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis
JP4191269B2 (ja) * 1996-05-17 2008-12-03 興和株式会社 新規なアニリド化合物及びこれを含有する医薬

Also Published As

Publication number Publication date
AU755654B2 (en) 2002-12-19
TW580498B (en) 2004-03-21
ATE321759T1 (de) 2006-04-15
JP4402176B2 (ja) 2010-01-20
EP0979823A1 (en) 2000-02-16
ES2262248T3 (es) 2006-11-16
CA2303781A1 (en) 1999-05-27
DE69834052T2 (de) 2006-11-02
AU755654C (en) 2007-03-29
HUP0000729A3 (en) 2001-06-28
AU1053899A (en) 1999-06-07
EP0979823B1 (en) 2006-03-29
DE69834052D1 (de) 2006-05-18
WO1999025712A1 (en) 1999-05-27
EP0979823A4 (en) 2002-10-30

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees