ATE312843T1 - Neues cyclosporin mit verbesserter wirkung - Google Patents

Neues cyclosporin mit verbesserter wirkung

Info

Publication number: ATE312843T1
Authority: AT; Austria
Prior art keywords: improved effects; new cyclosporin; cyclosporin; new; effects
Prior art date: 1998-07-01

Application number

AT99926684T

Other languages

English (en)

Inventor

Roland M Wenger

Manfred Mutter

Thomas Ruckle

Original Assignee

Debiopharm Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-01

Filing date

1999-06-30

Publication date

2005-12-15

1999-06-30 Application filed by Debiopharm Sa filed Critical Debiopharm Sa

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE312843T1 publication Critical patent/ATE312843T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 title abstract 2
108010036949 Cyclosporine Proteins 0.000 title abstract 2
229960001265 ciclosporin Drugs 0.000 title abstract 2
229930182912 cyclosporin Natural products 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT99926684T 1998-07-01 1999-06-30 Neues cyclosporin mit verbesserter wirkung ATE312843T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH140598		1998-07-01
PCT/IB1999/001232 WO2000001715A1 (fr)	1998-07-01	1999-06-30	Nouvelle cyclosporine ayant un profil d'activite ameliore

Publications (1)

Publication Number	Publication Date
ATE312843T1 true ATE312843T1 (de)	2005-12-15

Family

ID=4209677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99926684T ATE312843T1 (de)	1998-07-01	1999-06-30	Neues cyclosporin mit verbesserter wirkung

Country Status (14)

Country	Link
US (2)	US6927208B1 (de)
EP (1)	EP1091975B1 (de)
JP (1)	JP4350898B2 (de)
CN (1)	CN1218958C (de)
AT (1)	ATE312843T1 (de)
AU (1)	AU759480B2 (de)
BR (1)	BR9911724A (de)
CA (1)	CA2335903C (de)
DE (1)	DE69928938T2 (de)
DK (1)	DK1091975T3 (de)
ES (1)	ES2255275T3 (de)
MX (1)	MXPA00013019A (de)
PT (1)	PT1091975E (de)
WO (1)	WO2000001715A1 (de)

Families Citing this family (55)

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PT1091975E (pt)	1998-07-01	2006-05-31	Debiopharm Sa	Nova ciclosporina com um perfil de actividade melhorado
PT1150999E (pt)	1999-02-05	2006-10-31	Debiopharm Sa	Derivados da ciclosporina em que a sequencia peptidica contem pelo menos um aminoacido nao natural do tipo pseudo-prolina e metodo para preparacao dos mesmos
JP4588979B2 (ja)	2001-04-20	2010-12-01	オプタルモファーマアクチェンゲゼルシャフト	プロドラッグとして使用されうる修飾型シクロスポリン及びその使用
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US20060035821A1 (en) *	2004-08-16	2006-02-16	Hunt Kevin W	Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
JP2008514702A (ja) *	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
US7378391B2 (en)	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
US7196161B2 (en)	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
PT1802650E (pt) *	2004-10-01	2011-12-30	Scynexis Inc	Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c
ATE490778T1 (de) *	2004-10-01	2010-12-15	Debiopharm Sa	Verwendung von äd-mealaü3-äetvalü4-ciclosporin zur behandlung von hepatitis-c-infektion
WO2006041631A2 (en)	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
JP2008526816A (ja) *	2005-01-10	2008-07-24	デビオファームソシエテアノニム	心筋虚血状態の間の投与のための薬剤の製造のための環状ウンデカペプチドの使用
WO2007041632A2 (en)	2005-09-30	2007-04-12	Scynexis, Inc.	Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection
WO2007041631A1 (en) *	2005-09-30	2007-04-12	Scynexis, Inc.	ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION
KR101273681B1 (ko) *	2005-10-26	2013-06-25	아스텔라스세이야쿠 가부시키가이샤	신규 시클릭 펩티드 화합물
US7696166B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
CA2652662C (en)	2006-05-19	2015-11-03	Scynexis, Inc.	Methods for the treatment and prevention of ocular disorders
KR101089112B1 (ko) *	2006-06-02	2011-12-06	피씨 제스띠옹 에스.아.에스.	활성 전자 관리
CN101108178B (zh) *	2006-07-20	2010-09-15	复旦大学	一种亲环素a抑制剂在制备抗艾滋病药物中的应用
KR20090083902A (ko) *	2006-10-12	2009-08-04	노파르티스 아게	개질된 사이클로스포린의 용도
WO2008069917A2 (en)	2006-11-20	2008-06-12	Scynexis, Inc.	Novel cyclic peptides
CN101616683A (zh) *	2007-01-04	2009-12-30	德比奥法姆股份有限公司	用于治疗Ullrich先天性肌营养不良的非免疫抑制性环孢霉素
WO2008127613A1 (en) *	2007-04-11	2008-10-23	Scynexis, Inc.	New pharmaceutical compositions
EP2150269B1 (de) *	2007-05-02	2012-11-21	Astellas Pharma Inc.	Neue zyklische peptidverbindungen
US8394763B2 (en)	2007-09-26	2013-03-12	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) *	2008-02-08	2009-08-13	Debiopharm Sa	Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
JP5820722B2 (ja) *	2008-06-06	2015-11-24	スシネキスインク	シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
US8536114B2 (en)	2008-12-31	2013-09-17	Scynexis, Inc.	Macrocycles
RU2492181C2 (ru) *	2009-01-30	2013-09-10	Энанта Фармасьютикалс, Инк.	Аналоги циклоспорина для предупреждения или лечения инфекции гепатита с
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
KR20120106942A (ko)	2009-10-30	2012-09-27	베링거 인겔하임 인터내셔날 게엠베하	Ｂｉ２０１３３５, 인터페론 알파 및 리바비린을 포함하는 ｈｃｖ 병용 치료요법을 위한 투여 용법
MX2012007076A (es) *	2009-12-18	2012-07-20	Boehringer Ingelheim Int	Terapia combinada de hcv.
JP5947724B2 (ja)	2009-12-21	2016-07-06	アンスティチュナショナルドゥラサンテエドゥラルシェルシュメディカル	シクロフィリンの新しいインヒビター及びその使用
US9217015B2 (en)	2010-07-16	2015-12-22	S&T Global Inc.	Cyclosporin derivatives for the treatment and prevention of a viral infection
CN103153330B (zh)	2010-08-12	2017-08-18	美国科技环球有限公司	新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
US20130267460A1 (en) *	2010-09-16	2013-10-10	The Johns Hopkins University	Methods of Inhibiting Alphavirus Replication and Treating Alphavirus Infection
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
JO3337B1 (ar) *	2010-12-13	2019-03-13	Debiopharm Sa	تركيبات صيدلية تشمل أليسبوريفير
AU2011342284C1 (en)	2010-12-15	2017-07-13	Contravir Pharmaceuticals, Inc.	Cyclosporine analogue molecules modified at amino acid 1 and 3
US8466159B2 (en)	2011-10-21	2013-06-18	Abbvie Inc.	Methods for treating HCV
DE112012003510T5 (de)	2011-10-21	2015-03-19	Abbvie Inc.	Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon
CN104023726A (zh)	2011-10-21	2014-09-03	艾伯维公司	用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333)
US8492386B2 (en)	2011-10-21	2013-07-23	Abbvie Inc.	Methods for treating HCV
AR090964A1 (es) *	2012-05-09	2014-12-17	Novartis Ag	Proceso para la elaboracion de undecapeptidos ciclicos
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
US8906853B2 (en)	2012-11-28	2014-12-09	Enanta Pharmaceuticals, Inc.	[N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
HK1223843A1 (zh)	2013-08-26	2017-08-11	Enanta Pharmaceuticals, Inc.	用於預防或治療丙型肝炎的環孢菌素類似物
CN104744570A (zh) *	2013-12-31	2015-07-01	深圳先进技术研究院	一种环孢菌素的合成方法
US9669095B2 (en)	2014-11-03	2017-06-06	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis C infection
JP7129703B2 (ja)	2016-04-28	2022-09-02	エモリーユニバーシティー	アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
EP4132558A1 (de)	2020-04-06	2023-02-15	Debiopharm International SA	Alisporivir zur verwendung bei menschlichen virusinfektionen

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CH614931A5 (de)	1975-11-04	1979-12-28	Sandoz Ag
US4210581A (en)	1975-11-04	1980-07-01	Sandoz Ltd.	Organic compounds
DE2819094A1 (de)	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv)	1978-10-18	1987-02-16	Sandoz Ag	Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
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EP0098457B1 (de)	1980-02-14	1987-08-05	Sandoz Ag	(1S,2R,3R)- und (1R,2S,3S)-Nitrilo-1-carbonyl-3-methyl-2-oxy-heptane und -hept-5-enen verwendbar für Totalsynthese von Cyclosporinen und Verfahren zu ihrer Herstellung
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FI111730B (fi)	1990-11-02	2003-09-15	Novartis Ag	Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi
CN1141317C (zh)	1995-07-17	2004-03-10	碳化学公司	有抗人体免疫缺损病毒作用的环孢菌素衍生物
JP3089350B2 (ja)	1995-11-20	2000-09-18	ギルフォードファーマシューティカルズインコーポレイテッド	シクロフィリンロタマーゼ活性の阻害剤
FR2757520B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2757521B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757522B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PT1091975E (pt)	1998-07-01	2006-05-31	Debiopharm Sa	Nova ciclosporina com um perfil de actividade melhorado
GB0320638D0 (en)	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
US7439277B2 (en)	2005-05-19	2008-10-21	Fina Technology, Inc.	In-situ preparation of hydroperoxide functionalized rubber

1999
- 1999-06-30 PT PT99926684T patent/PT1091975E/pt unknown
- 1999-06-30 WO PCT/IB1999/001232 patent/WO2000001715A1/fr not_active Ceased
- 1999-06-30 US US09/720,923 patent/US6927208B1/en not_active Ceased
- 1999-06-30 ES ES99926684T patent/ES2255275T3/es not_active Expired - Lifetime
- 1999-06-30 BR BR9911724-0A patent/BR9911724A/pt not_active Application Discontinuation
- 1999-06-30 CA CA002335903A patent/CA2335903C/fr not_active Expired - Lifetime
- 1999-06-30 AT AT99926684T patent/ATE312843T1/de active
- 1999-06-30 EP EP99926684A patent/EP1091975B1/de not_active Expired - Lifetime
- 1999-06-30 DE DE69928938T patent/DE69928938T2/de not_active Expired - Lifetime
- 1999-06-30 JP JP2000558116A patent/JP4350898B2/ja not_active Expired - Lifetime
- 1999-06-30 DK DK99926684T patent/DK1091975T3/da active
- 1999-06-30 AU AU43856/99A patent/AU759480B2/en not_active Expired
- 1999-06-30 MX MXPA00013019A patent/MXPA00013019A/es active IP Right Grant
- 1999-06-30 CN CNB998081558A patent/CN1218958C/zh not_active Expired - Lifetime
- 1999-06-30 US US12/123,601 patent/USRE40987E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69928938D1 (de)	2006-01-19
CN1218958C (zh)	2005-09-14
AU759480B2 (en)	2003-04-17
USRE40987E1 (en)	2009-11-17
EP1091975A1 (de)	2001-04-18
US6927208B1 (en)	2005-08-09
MXPA00013019A (es)	2003-07-14
DK1091975T3 (da)	2006-04-18
BR9911724A (pt)	2001-03-20
WO2000001715A1 (fr)	2000-01-13
CA2335903C (fr)	2009-11-10
DE69928938T2 (de)	2006-08-17
JP2002519434A (ja)	2002-07-02
AU4385699A (en)	2000-01-24
ES2255275T3 (es)	2006-06-16
EP1091975B1 (de)	2005-12-14
PT1091975E (pt)	2006-05-31
JP4350898B2 (ja)	2009-10-21
CN1308635A (zh)	2001-08-15
CA2335903A1 (fr)	2000-01-13

Legal Events

Date

Code

Title

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2006-09-15

UEP

Publication of translation of european patent specification

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Publication	Publication Date	Title
DE69928938D1 (de)	2006-01-19	Neues cyclosporin mit verbesserter wirkung
ITTO20000779A0 (it)	2000-08-04	Composizioni farmaceutiche.
DE69818093D1 (de)	2003-10-16	Langwirkende, injizierbare, formulierungen enthaltend rizinusöl
ID27415A (id)	2001-04-05	Komposisi farmaseutik
IS4565A (is)	1997-09-22	2-methýl-thíenó-bensódíasepín, samsetning til inntöku
NO20005913L (no)	2001-01-22	Legemiddelsammensetning
SE9802729D0 (sv)	1998-08-13	Novel Compounds
NO20025450L (no)	2002-11-14	Ny farmasöytisk sammensetning
EE200000468A (et)	2002-04-15	Ühendid, nende kasutamine ja farmatseutiline kompositsioon
FR2712491B1 (fr)	1996-12-27	Compositions antisudorales.
MXPA01002531A (es)	2003-07-14	Composicion cosmetica.
ATE330017T1 (de)	2006-07-15	Kallikrein gen
ID27201A (id)	2001-03-08	Komposisi farmasi
DE59902827D1 (de)	2002-10-31	Azidfreie, gaserzeugende Zusammensetzung
DE19981910T1 (de)	2001-01-18	Gasbildende Zusammensetzung
DE60005462D1 (de)	2003-10-30	Tintenzusammensetzungen enthaltend 1,3,5-Trioxan
TR199901017A3 (tr)	1999-12-21	Böcek ilaci terkibi.
ITTO20000385A0 (it)	2000-04-21	Composizione pesticida.
ATE385805T1 (de)	2008-03-15	Neue peptide
BR9802803A (pt)	2000-03-21	ação e composições farmacêuticas contendo os mesmos.
TR199700147A2 (tr)	1997-09-21	Mikrop öldürücü terkip.
BR9916537B1 (pt)	2010-11-16	composição de fragráncia, e, produto.
ID26215A (id)	2000-12-07	Komposisi farmasi
ITTO20000386A0 (it)	2000-04-21	Composizione pesticida.
NO20021429D0 (no)	2002-03-21	1,4-dioksacykloalkan-2-oner og 1,4-dioksacykloalken-2-oner