ATE312843T1 - Neues cyclosporin mit verbesserter wirkung - Google Patents

Neues cyclosporin mit verbesserter wirkung

Info

Publication number: ATE312843T1
Authority: AT; Austria
Prior art keywords: improved effects; new cyclosporin; cyclosporin; new; effects
Prior art date: 1998-07-01

Application number

AT99926684T

Other languages

English (en)

Inventor

Roland M Wenger

Manfred Mutter

Thomas Ruckle

Original Assignee

Debiopharm Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-01

Filing date

1999-06-30

Publication date

2005-12-15

1999-06-30 Application filed by Debiopharm Sa filed Critical Debiopharm Sa

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE312843T1 publication Critical patent/ATE312843T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 title abstract 2
108010036949 Cyclosporine Proteins 0.000 title abstract 2
229960001265 ciclosporin Drugs 0.000 title abstract 2
229930182912 cyclosporin Natural products 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT99926684T 1998-07-01 1999-06-30 Neues cyclosporin mit verbesserter wirkung ATE312843T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH140598		1998-07-01
PCT/IB1999/001232 WO2000001715A1 (fr)	1998-07-01	1999-06-30	Nouvelle cyclosporine ayant un profil d'activite ameliore

Publications (1)

Publication Number	Publication Date
ATE312843T1 true ATE312843T1 (de)	2005-12-15

Family

ID=4209677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99926684T ATE312843T1 (de)	1998-07-01	1999-06-30	Neues cyclosporin mit verbesserter wirkung

Country Status (14)

Country	Link
US (2)	USRE40987E1 (de)
EP (1)	EP1091975B1 (de)
JP (1)	JP4350898B2 (de)
CN (1)	CN1218958C (de)
AT (1)	ATE312843T1 (de)
AU (1)	AU759480B2 (de)
BR (1)	BR9911724A (de)
CA (1)	CA2335903C (de)
DE (1)	DE69928938T2 (de)
DK (1)	DK1091975T3 (de)
ES (1)	ES2255275T3 (de)
MX (1)	MXPA00013019A (de)
PT (1)	PT1091975E (de)
WO (1)	WO2000001715A1 (de)

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AU759480B2 (en)	1998-07-01	2003-04-17	Debiopharm S.A.	Novel cyclosporin with improved activity profile
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US6995139B2 (en)	2001-04-20	2006-02-07	Debiopharm S.A.	Cyclic undecapeptide pro-drugs and uses thereof
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GB0320638D0 (en)	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
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JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008514702A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
DK1793844T3 (da) *	2004-10-01	2011-03-21	Debiopharm Sa	Anvendelse af [D-MeAla]3-[EtVal]4-cyklosporin til behandling af hepatitis C-infektion
SI1802650T1 (sl) *	2004-10-01	2012-03-30	Scynexis Inc	Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
JP2008515886A (ja)	2004-10-06	2008-05-15	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
JP2008526816A (ja) *	2005-01-10	2008-07-24	デビオファームソシエテアノニム	心筋虚血状態の間の投与のための薬剤の製造のための環状ウンデカペプチドの使用
EP1931696B1 (de)	2005-09-30	2011-02-16	Scynexis, Inc.	Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion
JP5517454B2 (ja)	2005-09-30	2014-06-11	スシネキスインク	Ｃ型肝炎感染の治療及び予防のための方法及び医薬組成物
PT1957518E (pt) *	2005-10-26	2016-02-26	Astellas Pharma Inc	Novos compostos peptídicos cíclicos
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US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
EP2023918B1 (de)	2006-05-19	2011-03-23	Scynexis, Inc.	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
CN101502196A (zh) *	2006-06-02	2009-08-05	克洛德·安妮·佩里西恩	激活电子的管理
CN101108178B (zh) *	2006-07-20	2010-09-15	复旦大学	一种亲环素a抑制剂在制备抗艾滋病药物中的应用
CA2665415A1 (en) *	2006-10-12	2008-04-17	Novartis Ag	Use of modified cyclosporins
WO2008069917A2 (en) *	2006-11-20	2008-06-12	Scynexis, Inc.	Novel cyclic peptides
US8450281B2 (en)	2007-01-04	2013-05-28	Debiopharm S.A.	Non-immunosuppressive cyclosporin for treatment of Ullrich congenital muscular dystrophy
WO2008127613A1 (en) *	2007-04-11	2008-10-23	Scynexis, Inc.	New pharmaceutical compositions
KR20100017547A (ko) *	2007-05-02	2010-02-16	아스텔라스세이야쿠 가부시키가이샤	신규 시클릭 펩티드 화합물
US8394763B2 (en)	2007-09-26	2013-03-12	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) *	2008-02-08	2009-08-13	Debiopharm Sa	Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
CN102083852A (zh)	2008-06-06	2011-06-01	西尼克斯公司	环孢菌素类似物及其在治疗hcv感染中的应用
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2376524B1 (de)	2008-12-31	2017-03-15	Cypralis Limited	Derivate von cyclosporin a
KR20110111321A (ko) *	2009-01-30	2011-10-10	이난타 파마슈티칼스, 인코포레이티드	Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
EA201200650A1 (ru)	2009-10-30	2012-12-28	Бёрингер Ингельхайм Интернациональ Гмбх	Курсы комбинированного лечения вируса гепатита с, включающие bi201335, интерферон-альфа и рибавирин
PH12012501216A1 (en) *	2009-12-18	2012-11-05	Boehringer Ingelheim Int	Hcv combination therapy
EP2516387B1 (de)	2009-12-21	2018-02-21	Institut National de la Sante et de la Recherche Medicale (INSERM)	Hemmer für cyclophiline zur prävention und/oder verwendung in der behandlung von viruskrankheiten oder infektionen
WO2012009715A2 (en)	2010-07-16	2012-01-19	S&T Global Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9573978B2 (en)	2010-08-12	2017-02-21	S&T Global, Inc.	Cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012037485A2 (en) *	2010-09-16	2012-03-22	1The Johns Hopkins University	Methods of inhibiting alphavirus replication and treating alphavirus infection
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
JO3337B1 (ar) *	2010-12-13	2019-03-13	Debiopharm Sa	تركيبات صيدلية تشمل أليسبوريفير
BR112013014890B1 (pt)	2010-12-15	2023-10-24	Contravir Pharmaceuticals, Inc	Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos
EP2583677A3 (de)	2011-10-21	2013-07-03	Abbvie Inc.	Verfahren zur Behandlung von HCV mit wenigstens zwei direkt angreifenden viralen Mitteln, Ribavirin aber nicht Interferon.
US8492386B2 (en)	2011-10-21	2013-07-23	Abbvie Inc.	Methods for treating HCV
US8466159B2 (en)	2011-10-21	2013-06-18	Abbvie Inc.	Methods for treating HCV
DE202012012955U1 (de)	2011-10-21	2014-07-14	Abbvie Inc.	Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV
AR090964A1 (es) *	2012-05-09	2014-12-17	Novartis Ag	Proceso para la elaboracion de undecapeptidos ciclicos
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
WO2014085623A1 (en)	2012-11-28	2014-06-05	Enanta Pharmaceuticals, Inc.	Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
JP2016538317A (ja)	2013-08-26	2016-12-08	エナンタファーマシューティカルズインコーポレイテッド	Ｃ型肝炎を防止または治療するための新規シクロスポリン類似体
CN104744570A (zh) *	2013-12-31	2015-07-01	深圳先进技术研究院	一种环孢菌素的合成方法
US9669095B2 (en)	2014-11-03	2017-06-06	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis C infection
EA201892448A1 (ru)	2016-04-28	2019-06-28	Эмори Юниверсити	Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
WO2021205338A1 (en)	2020-04-06	2021-10-14	Debiopharm International Sa	Alisporivir for use in human viral infections

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AU759480B2 (en)	1998-07-01	2003-04-17	Debiopharm S.A.	Novel cyclosporin with improved activity profile
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US7439277B2 (en)	2005-05-19	2008-10-21	Fina Technology, Inc.	In-situ preparation of hydroperoxide functionalized rubber

1999
- 1999-06-30 AU AU43856/99A patent/AU759480B2/en not_active Expired
- 1999-06-30 ES ES99926684T patent/ES2255275T3/es not_active Expired - Lifetime
- 1999-06-30 CN CNB998081558A patent/CN1218958C/zh not_active Expired - Lifetime
- 1999-06-30 PT PT99926684T patent/PT1091975E/pt unknown
- 1999-06-30 AT AT99926684T patent/ATE312843T1/de active
- 1999-06-30 BR BR9911724-0A patent/BR9911724A/pt not_active Application Discontinuation
- 1999-06-30 DE DE69928938T patent/DE69928938T2/de not_active Expired - Lifetime
- 1999-06-30 DK DK99926684T patent/DK1091975T3/da active
- 1999-06-30 MX MXPA00013019A patent/MXPA00013019A/es active IP Right Grant
- 1999-06-30 JP JP2000558116A patent/JP4350898B2/ja not_active Expired - Lifetime
- 1999-06-30 EP EP99926684A patent/EP1091975B1/de not_active Expired - Lifetime
- 1999-06-30 US US12/123,601 patent/USRE40987E1/en not_active Expired - Lifetime
- 1999-06-30 WO PCT/IB1999/001232 patent/WO2000001715A1/fr not_active Ceased
- 1999-06-30 US US09/720,923 patent/US6927208B1/en not_active Ceased
- 1999-06-30 CA CA002335903A patent/CA2335903C/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1308635A (zh)	2001-08-15
CN1218958C (zh)	2005-09-14
JP2002519434A (ja)	2002-07-02
BR9911724A (pt)	2001-03-20
US6927208B1 (en)	2005-08-09
AU4385699A (en)	2000-01-24
JP4350898B2 (ja)	2009-10-21
ES2255275T3 (es)	2006-06-16
DK1091975T3 (da)	2006-04-18
CA2335903A1 (fr)	2000-01-13
CA2335903C (fr)	2009-11-10
MXPA00013019A (es)	2003-07-14
EP1091975A1 (de)	2001-04-18
USRE40987E1 (en)	2009-11-17
DE69928938T2 (de)	2006-08-17
WO2000001715A1 (fr)	2000-01-13
EP1091975B1 (de)	2005-12-14
AU759480B2 (en)	2003-04-17
PT1091975E (pt)	2006-05-31
DE69928938D1 (de)	2006-01-19

Legal Events

Date

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2006-09-15

UEP

Publication of translation of european patent specification

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Publication	Publication Date	Title
ATE312843T1 (de)	2005-12-15	Neues cyclosporin mit verbesserter wirkung
BR9710372B1 (pt)	2013-02-05	composto, e, composiÇço farmacÊutica.
ITTO20000779A0 (it)	2000-08-04	Composizioni farmaceutiche.
ID27415A (id)	2001-04-05	Komposisi farmaseutik
IS1903B (is)	2003-11-20	2-methýl-thíenó-bensódíasepín, samsetning til inntöku
DE69818093D1 (de)	2003-10-16	Langwirkende, injizierbare, formulierungen enthaltend rizinusöl
NO20005913D0 (no)	2000-11-22	Legemiddelsammensetning
FI991485A0 (fi)	1999-06-30	Uusi farmaseuttinen koostumus
SE9802729D0 (sv)	1998-08-13	Novel Compounds
BR0106649B1 (pt)	2011-11-29	composição fertilizante contendo enxofre.
ID29262A (id)	2001-08-16	Komposisi farmasi
FR2712491B1 (fr)	1996-12-27	Compositions antisudorales.
ATE330017T1 (de)	2006-07-15	Kallikrein gen
ID27201A (id)	2001-03-08	Komposisi farmasi
DE60005462D1 (de)	2003-10-30	Tintenzusammensetzungen enthaltend 1,3,5-Trioxan
TR199901017A3 (tr)	1999-12-21	Böcek ilaci terkibi.
ITTO20000385A0 (it)	2000-04-21	Composizione pesticida.
TR199700147A2 (tr)	1997-09-21	Mikrop öldürücü terkip.
EA200300128A1 (ru)	2003-08-28	Фармацевтические композиции, содержащие карбонат лития
ID26215A (id)	2000-12-07	Komposisi farmasi
ITTO20000386A0 (it)	2000-04-21	Composizione pesticida.
ITTO990702A0 (it)	1999-08-09	Composizioni insetticide.
NO20021429D0 (no)	2002-03-21	1,4-dioksacykloalkan-2-oner og 1,4-dioksacykloalken-2-oner
TR199801835A3 (tr)	1999-04-21	Antimikrobiyal kompozisyonlar.
TR199700155A2 (tr)	1997-09-21	Mikrop öldürücü terkip.