ATE312843T1 - Neues cyclosporin mit verbesserter wirkung - Google Patents

Neues cyclosporin mit verbesserter wirkung

Info

Publication number: ATE312843T1
Authority: AT; Austria
Prior art keywords: improved effects; new cyclosporin; cyclosporin; new; effects
Prior art date: 1998-07-01

Application number

AT99926684T

Other languages

English (en)

Inventor

Roland M Wenger

Manfred Mutter

Thomas Ruckle

Original Assignee

Debiopharm Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-01

Filing date

1999-06-30

Publication date

2005-12-15

1999-06-30 Application filed by Debiopharm Sa filed Critical Debiopharm Sa

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE312843T1 publication Critical patent/ATE312843T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 title abstract 2
108010036949 Cyclosporine Proteins 0.000 title abstract 2
229960001265 ciclosporin Drugs 0.000 title abstract 2
229930182912 cyclosporin Natural products 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT99926684T 1998-07-01 1999-06-30 Neues cyclosporin mit verbesserter wirkung ATE312843T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH140598		1998-07-01
PCT/IB1999/001232 WO2000001715A1 (fr)	1998-07-01	1999-06-30	Nouvelle cyclosporine ayant un profil d'activite ameliore

Publications (1)

Publication Number	Publication Date
ATE312843T1 true ATE312843T1 (de)	2005-12-15

Family

ID=4209677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99926684T ATE312843T1 (de)	1998-07-01	1999-06-30	Neues cyclosporin mit verbesserter wirkung

Country Status (14)

Country	Link
US (2)	USRE40987E1 (de)
EP (1)	EP1091975B1 (de)
JP (1)	JP4350898B2 (de)
CN (1)	CN1218958C (de)
AT (1)	ATE312843T1 (de)
AU (1)	AU759480B2 (de)
BR (1)	BR9911724A (de)
CA (1)	CA2335903C (de)
DE (1)	DE69928938T2 (de)
DK (1)	DK1091975T3 (de)
ES (1)	ES2255275T3 (de)
MX (1)	MXPA00013019A (de)
PT (1)	PT1091975E (de)
WO (1)	WO2000001715A1 (de)

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USRE40987E1 (en)	1998-07-01	2009-11-17	Debiopharm S.A.	Cyclosporin with improved activity profile
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DE60208180T2 (de)	2001-04-20	2006-08-17	Debiopharm S.A.	Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung
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US20060035821A1 (en) *	2004-08-16	2006-02-16	Hunt Kevin W	Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
WO2006039163A2 (en)	2004-09-29	2006-04-13	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
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SI1802650T1 (sl) *	2004-10-01	2012-03-30	Scynexis Inc	Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
PT1793844E (pt) *	2004-10-01	2011-03-10	Debiopharm Sa	Utilização de [d-meala]3-[etval]4-csa para o tratamento de infecção causada pelo vírus da hepatite c
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
WO2006041631A2 (en) *	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
US8889629B2 (en) *	2005-01-10	2014-11-18	Debiopharm International Sa	Use of a cyclic undecapeptide for the preparation of a medicament for administration during myocardial ischaemic events
CA2623864C (en)	2005-09-30	2014-12-16	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection
CN105169369B (zh)	2005-09-30	2019-10-18	中美华世通生物医药科技（武汉）有限公司	治疗和预防丙型肝炎感染的方法和药物组合物
PL1957518T3 (pl) *	2005-10-26	2016-07-29	Astellas Pharma Inc	Nowe cykliczne związki peptydowe
US7696166B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
EP2023918B1 (de)	2006-05-19	2011-03-23	Scynexis, Inc.	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
KR101089112B1 (ko) *	2006-06-02	2011-12-06	피씨 제스띠옹 에스.아.에스.	활성 전자 관리
CN101108178B (zh) *	2006-07-20	2010-09-15	复旦大学	一种亲环素a抑制剂在制备抗艾滋病药物中的应用
SG175621A1 (en) *	2006-10-12	2011-11-28	Novartis Ag	Use of modified cyclosporins
US7576057B2 (en)	2006-11-20	2009-08-18	Scynexis, Inc.	Cyclic peptides
RU2462262C2 (ru) *	2007-01-04	2012-09-27	Дебиофарм С А	Неиммуносупрессорный циклоспорин для лечения врожденной миопатии ульриха
WO2008127613A1 (en) *	2007-04-11	2008-10-23	Scynexis, Inc.	New pharmaceutical compositions
KR20100017547A (ko) *	2007-05-02	2010-02-16	아스텔라스세이야쿠 가부시키가이샤	신규 시클릭 펩티드 화합물
WO2009042892A1 (en)	2007-09-26	2009-04-02	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) *	2008-02-08	2009-08-13	Debiopharm Sa	Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
JP5820722B2 (ja)	2008-06-06	2015-11-24	スシネキスインク	シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
WO2009148615A1 (en) *	2008-06-06	2009-12-10	Scynexis, Inc.	Cyclosporin analogs and their use in the treatment of hcv infections
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
CA2748389A1 (en) *	2008-12-31	2010-07-08	Scynexis, Inc.	Derivatives of cyclosporin a
EP2391376A4 (de) *	2009-01-30	2012-08-01	Enanta Pharm Inc	Cyclosporin-analoga zur prävention oder behandlung von hepatitis-c-infektionen
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
PH12012500827A1 (en)	2009-10-30	2013-01-07	Boehringer Ingelheim Int	Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
PH12012501216A1 (en) *	2009-12-18	2012-11-05	Boehringer Ingelheim Int	Hcv combination therapy
CN105693597A (zh)	2009-12-21	2016-06-22	国家健康与医学研究院（Inserm）	新的亲环素抑制剂及其用途
CN107007815A (zh)	2010-07-16	2017-08-04	美国科技环球有限公司	新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用
WO2012021796A2 (en)	2010-08-12	2012-02-16	S&T Global, Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012037485A2 (en) *	2010-09-16	2012-03-22	1The Johns Hopkins University	Methods of inhibiting alphavirus replication and treating alphavirus infection
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
JO3337B1 (ar) *	2010-12-13	2019-03-13	Debiopharm Sa	تركيبات صيدلية تشمل أليسبوريفير
LT2651965T (lt)	2010-12-15	2019-01-10	Contravir Pharmaceuticals, Inc.	Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis
US8466159B2 (en)	2011-10-21	2013-06-18	Abbvie Inc.	Methods for treating HCV
SE1450130A1 (sv)	2011-10-21	2014-05-07	Abbvie Inc	Förfaranden för att behandla hcv innefattande minst två direktverkande antivirala agenser, ribavirin men inte interferon
EP2583680A3 (de)	2011-10-21	2013-06-12	Abbvie Inc.	Einzel- (PSI-7977) oder Kombinationsbehandlung in der Verwendung zur Behandlung von HCV
US8492386B2 (en)	2011-10-21	2013-07-23	Abbvie Inc.	Methods for treating HCV
AR090964A1 (es) *	2012-05-09	2014-12-17	Novartis Ag	Proceso para la elaboracion de undecapeptidos ciclicos
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
US8906853B2 (en)	2012-11-28	2014-12-09	Enanta Pharmaceuticals, Inc.	[N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
KR20160045136A (ko)	2013-08-26	2016-04-26	이난타 파마슈티칼스, 인코포레이티드	C형 간염을 예방 또는 치료하기 위한 사이클로스포린 유사체
CN104744570A (zh) *	2013-12-31	2015-07-01	深圳先进技术研究院	一种环孢菌素的合成方法
WO2016073480A1 (en)	2014-11-03	2016-05-12	Enanta Pharmaceuticals, Inc.	Novel cyclosporin analogues for preventing or treating hepatitis c infection
EA201892448A1 (ru)	2016-04-28	2019-06-28	Эмори Юниверсити	Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
EP4132558A1 (de)	2020-04-06	2023-02-15	Debiopharm International SA	Alisporivir zur verwendung bei menschlichen virusinfektionen

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CH614931A5 (de)	1975-11-04	1979-12-28	Sandoz Ag
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DE2819094A1 (de)	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv)	1978-10-18	1987-02-16	Sandoz Ag	Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
ATE43335T1 (de)	1980-02-14	1989-06-15	Sandoz Ag	Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung.
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EP0296122B1 (de)	1987-06-17	1993-09-29	Sandoz Ag	Cyclosporine und deren Benutzung als Arzneimittel
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FR2757522B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
USRE40987E1 (en)	1998-07-01	2009-11-17	Debiopharm S.A.	Cyclosporin with improved activity profile
GB0320638D0 (en)	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
US7439277B2 (en)	2005-05-19	2008-10-21	Fina Technology, Inc.	In-situ preparation of hydroperoxide functionalized rubber

1999
- 1999-06-30 US US12/123,601 patent/USRE40987E1/en not_active Expired - Lifetime
- 1999-06-30 US US09/720,923 patent/US6927208B1/en not_active Ceased
- 1999-06-30 CA CA002335903A patent/CA2335903C/fr not_active Expired - Lifetime
- 1999-06-30 BR BR9911724-0A patent/BR9911724A/pt not_active Application Discontinuation
- 1999-06-30 PT PT99926684T patent/PT1091975E/pt unknown
- 1999-06-30 CN CNB998081558A patent/CN1218958C/zh not_active Expired - Lifetime
- 1999-06-30 DK DK99926684T patent/DK1091975T3/da active
- 1999-06-30 AU AU43856/99A patent/AU759480B2/en not_active Expired
- 1999-06-30 EP EP99926684A patent/EP1091975B1/de not_active Expired - Lifetime
- 1999-06-30 ES ES99926684T patent/ES2255275T3/es not_active Expired - Lifetime
- 1999-06-30 MX MXPA00013019A patent/MXPA00013019A/es active IP Right Grant
- 1999-06-30 WO PCT/IB1999/001232 patent/WO2000001715A1/fr not_active Ceased
- 1999-06-30 AT AT99926684T patent/ATE312843T1/de active
- 1999-06-30 JP JP2000558116A patent/JP4350898B2/ja not_active Expired - Lifetime
- 1999-06-30 DE DE69928938T patent/DE69928938T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU759480B2 (en)	2003-04-17
EP1091975A1 (de)	2001-04-18
ES2255275T3 (es)	2006-06-16
CA2335903A1 (fr)	2000-01-13
CA2335903C (fr)	2009-11-10
DE69928938D1 (de)	2006-01-19
AU4385699A (en)	2000-01-24
US6927208B1 (en)	2005-08-09
DE69928938T2 (de)	2006-08-17
BR9911724A (pt)	2001-03-20
DK1091975T3 (da)	2006-04-18
WO2000001715A1 (fr)	2000-01-13
PT1091975E (pt)	2006-05-31
JP4350898B2 (ja)	2009-10-21
CN1308635A (zh)	2001-08-15
EP1091975B1 (de)	2005-12-14
CN1218958C (zh)	2005-09-14
USRE40987E1 (en)	2009-11-17
MXPA00013019A (es)	2003-07-14
JP2002519434A (ja)	2002-07-02

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2006-09-15

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Publication	Publication Date	Title
ATE312843T1 (de)	2005-12-15	Neues cyclosporin mit verbesserter wirkung
TR199800375A3 (tr)	1999-05-21	Selant kompozisyonlari.
BR9710372B1 (pt)	2013-02-05	composto, e, composiÇço farmacÊutica.
ITTO20000779A0 (it)	2000-08-04	Composizioni farmaceutiche.
ID27415A (id)	2001-04-05	Komposisi farmaseutik
IS4565A (is)	1997-09-22	2-methýl-thíenó-bensódíasepín, samsetning til inntöku
DE69818093D1 (de)	2003-10-16	Langwirkende, injizierbare, formulierungen enthaltend rizinusöl
NO20005913D0 (no)	2000-11-22	Legemiddelsammensetning
SE9802729D0 (sv)	1998-08-13	Novel Compounds
NO20025450L (no)	2002-11-14	Ny farmasöytisk sammensetning
EE200000468A (et)	2002-04-15	Ühendid, nende kasutamine ja farmatseutiline kompositsioon
ID29262A (id)	2001-08-16	Komposisi farmasi
ATE330017T1 (de)	2006-07-15	Kallikrein gen
ID27201A (id)	2001-03-08	Komposisi farmasi
DE59902827D1 (de)	2002-10-31	Azidfreie, gaserzeugende Zusammensetzung
DE60005462D1 (de)	2003-10-30	Tintenzusammensetzungen enthaltend 1,3,5-Trioxan
TR199901017A3 (tr)	1999-12-21	Böcek ilaci terkibi.
ITTO20000385A0 (it)	2000-04-21	Composizione pesticida.
TR199700147A2 (tr)	1997-09-21	Mikrop öldürücü terkip.
EA200300128A1 (ru)	2003-08-28	Фармацевтические композиции, содержащие карбонат лития
ID26215A (id)	2000-12-07	Komposisi farmasi
ITTO20000386A0 (it)	2000-04-21	Composizione pesticida.
ITTO990702A0 (it)	1999-08-09	Composizioni insetticide.
NO20021429D0 (no)	2002-03-21	1,4-dioksacykloalkan-2-oner og 1,4-dioksacykloalken-2-oner
TR199700155A2 (tr)	1997-09-21	Mikrop öldürücü terkip.