DK1091975T3 - Ny cyclosporin med forbedret aktivitetsprofil - Google Patents

Ny cyclosporin med forbedret aktivitetsprofil

Info

Publication number: DK1091975T3
Authority: DK; Denmark
Prior art keywords: improved activity; activity profile; new cyclosporine; cyclosporine; new
Prior art date: 1998-07-01

Application number

DK99926684T

Other languages

English (en)

Inventor

Roland M Wenger

Manfred Mutter

Thomas Ruckle

Original Assignee

Debiopharm Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-01

Filing date

1999-06-30

Publication date

2006-04-18

1999-06-30 Application filed by Debiopharm Sa filed Critical Debiopharm Sa

2006-04-18 Application granted granted Critical

2006-04-18 Publication of DK1091975T3 publication Critical patent/DK1091975T3/da

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
108010036949 Cyclosporine Proteins 0.000 title abstract 2
229960001265 ciclosporin Drugs 0.000 title abstract 2
229930182912 cyclosporin Natural products 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK99926684T 1998-07-01 1999-06-30 Ny cyclosporin med forbedret aktivitetsprofil DK1091975T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH140598		1998-07-01

Publications (1)

Publication Number	Publication Date
DK1091975T3 true DK1091975T3 (da)	2006-04-18

Family

ID=4209677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99926684T DK1091975T3 (da)	1998-07-01	1999-06-30	Ny cyclosporin med forbedret aktivitetsprofil

Country Status (14)

Country	Link
US (2)	US6927208B1 (da)
EP (1)	EP1091975B1 (da)
JP (1)	JP4350898B2 (da)
CN (1)	CN1218958C (da)
AT (1)	ATE312843T1 (da)
AU (1)	AU759480B2 (da)
BR (1)	BR9911724A (da)
CA (1)	CA2335903C (da)
DE (1)	DE69928938T2 (da)
DK (1)	DK1091975T3 (da)
ES (1)	ES2255275T3 (da)
MX (1)	MXPA00013019A (da)
PT (1)	PT1091975E (da)
WO (1)	WO2000001715A1 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1091975E (pt)	1998-07-01	2006-05-31	Debiopharm Sa	Nova ciclosporina com um perfil de actividade melhorado
ES2267492T3 (es) *	1999-02-05	2007-03-16	Debiopharm S.A.	Derivados de ciclosporina y procedimiento de preparacion de dichos derivados.
DE60208180T2 (de)	2001-04-20	2006-08-17	Debiopharm S.A.	Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung
JP2006524232A (ja)	2003-03-17	2006-10-26	アルバニーモレキュラーリサーチインコーポレーティッド	新規サイクロスポリン
GB0320638D0 (en) *	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
US20060035821A1 (en) *	2004-08-16	2006-02-16	Hunt Kevin W	Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
JP2008514701A (ja) *	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
EP1804823A4 (en) *	2004-09-29	2010-06-09	Amr Technology Inc	NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
UA88484C2 (ru) *	2004-10-01	2009-10-26	Дебиофарм Са	ПРИМЕНЕНИЕ [D-MeAla]3-[EtVal]4-ЦИКЛОСПОРИНА ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИИ ГЕПАТИТА С И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ ВКЛЮЧАЕТ [D-MeAla]3-[EtVal]4-ЦИКЛОСПОРИН
JP5139065B2 (ja) *	2004-10-01	2013-02-06	スシネキスインク	Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7361636B2 (en)	2004-10-06	2008-04-22	Amr Technology, Inc.	Cyclosporin alkynes and their utility as pharmaceutical agents
SI1853296T1 (sl)	2005-01-10	2012-10-30	Debiopharm Sa	Uporaba cikličnega undekapeptida za pripravo zdravila za dajanje med miokardnimi ishemičnimi dogodki
US8329658B2 (en) *	2005-09-30	2012-12-11	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
BRPI0616476A2 (pt)	2005-09-30	2011-06-21	Scynexis Inc	uso de uma quantidade terapeuticamente eficaz de um derivado de ciclosporina, e, composição farmacêutica
CA2623898C (en)	2005-10-26	2013-12-24	Astellas Pharma Inc.	New cyclic peptide compounds
US7696166B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
ATE502633T1 (de)	2006-05-19	2011-04-15	Scynexis Inc	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
EP2027761A1 (fr) *	2006-06-02	2009-02-25	Claude Annie Perrichon	Gestion des electrons actifs
CN101108178B (zh) *	2006-07-20	2010-09-15	复旦大学	一种亲环素a抑制剂在制备抗艾滋病药物中的应用
BRPI0719189A2 (pt) *	2006-10-12	2018-08-14	Univ Kyushu Nat Univ Corp	uso de ciclosporinas modificadas
US7576057B2 (en)	2006-11-20	2009-08-18	Scynexis, Inc.	Cyclic peptides
JP5801534B2 (ja) *	2007-01-04	2015-10-28	デビオファームインターナショナルソシエテアノニム	ウールリッヒ型先天筋ジストロフィーの処置のための、非免疫抑制性シクロスポリン
US20080255038A1 (en) *	2007-04-11	2008-10-16	Samuel Earl Hopkins	Pharmaceutical compositions
ES2396170T3 (es)	2007-05-02	2013-02-19	Astellas Pharma Inc.	Nuevos compuestos péptídicos ciclicos
WO2009042892A1 (en)	2007-09-26	2009-04-02	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) *	2008-02-08	2009-08-13	Debiopharm Sa	Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
US9090671B2 (en) *	2008-06-06	2015-07-28	Scynexis, Inc.	Macrocyclic peptides
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2376524B1 (en) *	2008-12-31	2017-03-15	Cypralis Limited	Derivatives of cyclosporin a
SG173180A1 (en) *	2009-01-30	2011-09-29	Enanta Pharm Inc	Cyclosporin analogues for preventing or treating hepatitis c infection
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
BR112012010110A2 (pt)	2009-10-30	2019-09-24	Boehringer Ingelheim Int	regimes de dosagem para terapia combinada para hcv compreendendo bi201335, interferon alfa e ribavirina
BR112012014729A2 (pt) *	2009-12-18	2016-03-29	Boehringer Ingelheim Int	terapia combinada contra hcv
WO2011076784A2 (en)	2009-12-21	2011-06-30	Institut National De La Sante Et De La Recherche Medicale (Inserm)	New inhibitors of cyclophilins and uses thereof
WO2012009715A2 (en)	2010-07-16	2012-01-19	S&T Global Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012021796A2 (en)	2010-08-12	2012-02-16	S&T Global, Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US20130267460A1 (en) *	2010-09-16	2013-10-10	The Johns Hopkins University	Methods of Inhibiting Alphavirus Replication and Treating Alphavirus Infection
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
JO3337B1 (ar) *	2010-12-13	2019-03-13	Debiopharm Sa	تركيبات صيدلية تشمل أليسبوريفير
JP6144627B2 (ja)	2010-12-15	2017-06-07	コントラヴィアファーマシューティカルズ、インク．	アミノ酸１および３で修飾されたシクロスポリン類似体分子
CA2811203C (en)	2011-10-21	2015-05-05	Abbvie Inc.	Methods for treating hcv
US8492386B2 (en)	2011-10-21	2013-07-23	Abbvie Inc.	Methods for treating HCV
US8466159B2 (en)	2011-10-21	2013-06-18	Abbvie Inc.	Methods for treating HCV
CN104023726A (zh)	2011-10-21	2014-09-03	艾伯维公司	用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333)
AR090964A1 (es) *	2012-05-09	2014-12-17	Novartis Ag	Proceso para la elaboracion de undecapeptidos ciclicos
EP2705856A1 (en)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Compounds for the treatment of neurodegenerative disorders
US8906853B2 (en)	2012-11-28	2014-12-09	Enanta Pharmaceuticals, Inc.	[N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
SG11201601274QA (en)	2013-08-26	2016-03-30	Enanta Pharm Inc	Cyclosporin analogues for preventing or treating hepatitis c
CN104744570A (zh) *	2013-12-31	2015-07-01	深圳先进技术研究院	一种环孢菌素的合成方法
WO2016073480A1 (en)	2014-11-03	2016-05-12	Enanta Pharmaceuticals, Inc.	Novel cyclosporin analogues for preventing or treating hepatitis c infection
JP7129703B2 (ja)	2016-04-28	2022-09-02	エモリーユニバーシティー	アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
EP4132558A1 (en)	2020-04-06	2023-02-15	Debiopharm International SA	Alisporivir for use in human viral infections

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4210581A (en)	1975-11-04	1980-07-01	Sandoz Ltd.	Organic compounds
CH614931A5 (da)	1975-11-04	1979-12-28	Sandoz Ag
DE2819094A1 (de)	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv)	1978-10-18	1987-02-16	Sandoz Ag	Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en)	1980-02-14	1983-08-02	Sandoz Ltd.	Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0034567B1 (en)	1980-02-14	1984-11-07	Sandoz Ag	A method for the total synthesis of cyclosporins and novel cyclosporins
DE3047662C2 (de)	1980-12-18	1985-02-21	Karl M. Reich Maschinenfabrik GmbH, 7440 Nürtingen	Puffersystem bei Einschlaggeräten
DE3260468D1 (en)	1981-01-09	1984-09-06	Sandoz Ag	Novel cyclosporins
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
CY1915A (en)	1984-10-04	1985-09-27	Sandoz Ag	Cyclosporins
EP0194972B1 (en)	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
US4814323A (en)	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
ES2059558T3 (es)	1987-06-17	1994-11-16	Sandoz Ag	Ciclosporins y su uso como productos farmaceuticos.
KR0148748B1 (ko)	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
ATE148469T1 (de)	1990-11-02	1997-02-15	Sandoz Ag	Zyklosporine
PL324531A1 (en)	1995-07-17	1998-06-08	Chem Ag C	Derivatives of cyclosporin effective against hiv virus
JP3089350B2 (ja)	1995-11-20	2000-09-18	ギルフォードファーマシューティカルズインコーポレイテッド	シクロフィリンロタマーゼ活性の阻害剤
FR2757520B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2757521B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757522B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PT1091975E (pt)	1998-07-01	2006-05-31	Debiopharm Sa	Nova ciclosporina com um perfil de actividade melhorado
GB0320638D0 (en)	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
US7439277B2 (en)	2005-05-19	2008-10-21	Fina Technology, Inc.	In-situ preparation of hydroperoxide functionalized rubber

1999
- 1999-06-30 PT PT99926684T patent/PT1091975E/pt unknown
- 1999-06-30 CA CA002335903A patent/CA2335903C/fr not_active Expired - Lifetime
- 1999-06-30 US US09/720,923 patent/US6927208B1/en not_active Ceased
- 1999-06-30 DK DK99926684T patent/DK1091975T3/da active
- 1999-06-30 MX MXPA00013019A patent/MXPA00013019A/es active IP Right Grant
- 1999-06-30 BR BR9911724-0A patent/BR9911724A/pt not_active Application Discontinuation
- 1999-06-30 JP JP2000558116A patent/JP4350898B2/ja not_active Expired - Lifetime
- 1999-06-30 DE DE69928938T patent/DE69928938T2/de not_active Expired - Lifetime
- 1999-06-30 CN CNB998081558A patent/CN1218958C/zh not_active Expired - Lifetime
- 1999-06-30 ES ES99926684T patent/ES2255275T3/es not_active Expired - Lifetime
- 1999-06-30 AU AU43856/99A patent/AU759480B2/en not_active Expired
- 1999-06-30 EP EP99926684A patent/EP1091975B1/fr not_active Expired - Lifetime
- 1999-06-30 AT AT99926684T patent/ATE312843T1/de active
- 1999-06-30 US US12/123,601 patent/USRE40987E1/en not_active Expired - Lifetime
- 1999-06-30 WO PCT/IB1999/001232 patent/WO2000001715A1/fr not_active Ceased

Also Published As

Publication number	Publication date
AU4385699A (en)	2000-01-24
US6927208B1 (en)	2005-08-09
EP1091975B1 (fr)	2005-12-14
CN1218958C (zh)	2005-09-14
WO2000001715A1 (fr)	2000-01-13
CA2335903A1 (fr)	2000-01-13
DE69928938T2 (de)	2006-08-17
DE69928938D1 (de)	2006-01-19
JP4350898B2 (ja)	2009-10-21
EP1091975A1 (fr)	2001-04-18
AU759480B2 (en)	2003-04-17
USRE40987E1 (en)	2009-11-17
CN1308635A (zh)	2001-08-15
MXPA00013019A (es)	2003-07-14
ATE312843T1 (de)	2005-12-15
PT1091975E (pt)	2006-05-31
ES2255275T3 (es)	2006-06-16
CA2335903C (fr)	2009-11-10
JP2002519434A (ja)	2002-07-02
BR9911724A (pt)	2001-03-20

Publication	Publication Date	Title
PT1091975E (pt)	2006-05-31	Nova ciclosporina com um perfil de actividade melhorado
BR9710372B1 (pt)	2013-02-05	composto, e, composiÇço farmacÊutica.
ATE264863T1 (de)	2004-05-15	28-epirapaloge
DK1104425T3 (da)	2003-06-23	Hidtil ukendte thiazolopyrimidinforbindelser
BR9807848B1 (pt)	2013-11-05	Composto de arilsulfonamidas e análogos, bem como composição farmacêutica e uso dos mesmos.
MA25688A1 (fr)	2003-04-01	2-thio-3, 5-dicyano-4-aryl-6-aminopyridines substituees et leur utilisation.
CY1108610T1 (el)	2014-04-09	Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
TR200100054T2 (tr)	2001-06-21	Paroksetin metansülfonat
HUP0103265A3 (en)	2002-09-30	Cyclic prosaposin-derived peptides, pharmaceutical compositions comprising thereof and their use
DE60120712D1 (en)	2006-07-27	Kallikrein gen
DE69938935D1 (de)	2008-07-31	Zyklische conotoxin-peptide
DE60112671D1 (de)	2005-09-22	Gebogener, elastischer Zahnregulierungsring
BG106316A (en)	2002-08-30	Ambroxol-containing lozenge
GB0028130D0 (en)	2001-01-03	Polypeptide and uses thereof
ATE305517T1 (de)	2005-10-15	Neurotrypsin
PE20399A1 (es)	1999-03-05	Muteina ob
ITMI20000293A0 (it)	2000-02-18	Derivati del 3,9-diazabiciclo [3.3.1]nonano ad attivita' analgesica
DE50004023D1 (de)	2003-11-13	1,4-dioxacycloalkan-2-one und 1,4-dioxacycloalken-2-one
WO2001037780A8 (en)	2001-11-08	Urotensin-ii analogs
HUP0104623A3 (en)	2002-08-28	Cyclosporin solution, pharmaceutical composition comprising thereof and its use
MXPA03001986A (es)	2004-03-19	Composiciones antitromboticas.
ATE250340T1 (de)	2003-10-15	7-methylthiooxomethyl- und 7- methylthiodioxomethyl-paclitaxele
MXPA04005226A (es)	2004-10-11	1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion.
BR9611904A (pt)	1999-04-06	Dioxidos de ditiazol
TR200103662T2 (tr)	2002-05-21	Yeni kalpainler ve bunların kullanılması