ATE313530T1 - Neuer pyridon-derivat der eine affinität für den angiotensin-ii-rezeptor hat - Google Patents

Neuer pyridon-derivat der eine affinität für den angiotensin-ii-rezeptor hat

Info

Publication number: ATE313530T1
Authority: AT; Austria
Prior art keywords: radical; angiotensin; affinity; receptor; pyridone derivative
Prior art date: 1992-02-07

Application number

AT93905369T

Other languages

English (en)

Inventor

Michel Fortin

Jean-Luc Haesslein

Bertrand Heckmann

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-07

Filing date

1993-02-05

Publication date

2006-01-15

1993-02-05 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2006-01-15 Application granted granted Critical

2006-01-15 Publication of ATE313530T1 publication Critical patent/ATE313530T1/de

Links

102000008873 Angiotensin II receptor Human genes 0.000 title 1
108050000824 Angiotensin II receptor Proteins 0.000 title 1
UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 nitro, sulpho, formyl Chemical group 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000003396 thiol group Chemical class [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Pyrane Compounds (AREA)

AT93905369T 1992-02-07 1993-02-05 Neuer pyridon-derivat der eine affinität für den angiotensin-ii-rezeptor hat ATE313530T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9201390A FR2687674B1 (fr)	1992-02-07	1992-02-07	Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
PCT/FR1993/000118 WO1993016049A1 (fr)	1992-02-07	1993-02-05	Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number	Publication Date
ATE313530T1 true ATE313530T1 (de)	2006-01-15

Family

ID=9426432

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93905369T ATE313530T1 (de)	1992-02-07	1993-02-05	Neuer pyridon-derivat der eine affinität für den angiotensin-ii-rezeptor hat

Country Status (13)

Country	Link
EP (1)	EP0579819B1 (de)
JP (1)	JPH06506956A (de)
KR (1)	KR100273181B1 (de)
AT (1)	ATE313530T1 (de)
AU (1)	AU667880B2 (de)
CA (1)	CA2106758A1 (de)
DE (1)	DE69333944T2 (de)
ES (1)	ES2251714T3 (de)
FR (1)	FR2687674B1 (de)
HU (1)	HUT68756A (de)
RU (1)	RU2124004C1 (de)
WO (1)	WO1993016049A1 (de)
ZA (1)	ZA93810B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5866601A (en) *	1995-02-27	1999-02-02	Gilead Sciences, Inc.	Carbocyclic compounds
CN100409844C (zh)	1995-02-27	2008-08-13	吉里德科学公司	神经氨酸苷酶抑制剂
HUP9801766A3 (en) *	1995-05-19	2000-09-28	Biota Scient Managemant Pty Lt	6-carboxamido dihydropyran derivatives, process for producing them and medicaments containing the same
US5763483A (en) *	1995-12-29	1998-06-09	Gilead Sciences, Inc.	Carbocyclic compounds
US6518438B2 (en)	1996-08-23	2003-02-11	Gilead Sciences, Inc.	Preparation of cyclohexene carboxylate derivatives
US5859284A (en) *	1996-08-23	1999-01-12	Gilead Sciences, Inc.	Preparation of carbocyclic compounds
US5994377A (en) *	1996-10-21	1999-11-30	Gilead Sciences, Inc.	Piperidine compounds
TW477783B (en) *	1997-12-12	2002-03-01	Gilead Sciences Inc	Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
JP4556241B2 (ja) *	2003-02-05	2010-10-06	日本曹達株式会社	新規６−フルオロアルキル−２（１ｈ）−ピリジノン、６−フルオロアルキルピリジン化合物及びその製造方法
SE0302487D0 (sv) *	2003-09-18	2003-09-18	Astrazeneca Ab	Novel compounds
EP1749828A1 (de)	2005-08-04	2007-02-07	Farmaprojects S.L.	Verfahren zur Herstellung eines Angiotensin-II-Antagonisten
EP2542076B1 (de) *	2010-03-04	2021-01-13	Merck Sharp & Dohme Corp.	Hemmer der catechol-o-methyl-transferase und ihre verwendung bei der behandlung psychotischer störungen

Family Cites Families (20)

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US4046769A (en) *	1976-10-29	1977-09-06	Warner-Lambert Company	4,10-Dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-2-carboxylic acids and esters
JPS56115784A (en) *	1980-02-15	1981-09-11	Tanabe Seiyaku Co Ltd	Novel pyridinecarboxamide derivative and its preparation
ZA813029B (en) *	1980-05-12	1982-05-26	Rohm & Haas	Novel substituted oxonicotinates,their use as plant growth regulators and plant growth regulating compositions containing them
GB8412208D0 (en) *	1984-05-12	1984-06-20	Pfizer Ltd	Quinolone inotropic agents
US4886744A (en) *	1985-04-25	1989-12-12	Polaroid Corporation	Fluorescent conjugates and biological diagnostic assay system
ES2004489A4 (es) *	1987-01-07	1989-01-16	Monsanto Co	Gametocidas de piridina.
US4747871A (en) *	1987-01-07	1988-05-31	Monsanto Company	2,6-bis(trifluoromethyl)-3-hydroxycarbonyl pyridine, salts and gametocides
US4751073A (en) *	1987-06-03	1988-06-14	Olin Corporation	Selected 2,2,6,6-tetraalkyl-4-piperidinyl derivatives and their use as light stabilizers
CA1338238C (en) *	1988-01-07	1996-04-09	David John Carini	Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
DE3826846A1 (de) *	1988-08-06	1990-02-08	Goedecke Ag	Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5077142A (en) *	1989-04-20	1991-12-31	Ricoh Company, Ltd.	Electroluminescent devices
DK0403159T3 (da) *	1989-06-14	2000-08-14	Smithkline Beecham Corp	Imidazolylalkensyrer
SG52709A1 (en) *	1989-06-30	1998-09-28	Du Pont	Substituted imidazoles
CA2036618C (en) *	1990-02-22	2002-10-29	Akira Morimoto	Fused thiophene derivatives, their production and use
CA2037630C (en) *	1990-03-07	2001-07-03	Akira Morimoto	Nitrogen-containing heterocylic compounds, their production and use
GB9005518D0 (en) *	1990-03-12	1990-05-09	Wellcome Found	Heterocyclic compounds
CA2051705A1 (en) *	1990-06-19	1991-12-20	Kiyoaki Katano	Pyridine derivatives having angiotensin ii antagonism
ATE128128T1 (de) *	1990-06-29	1995-10-15	Upjohn Co	Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one.
IL98319A (en) *	1990-07-05	1997-04-15	Roussel Uclaf	Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
GB9102803D0 (en) *	1991-02-11	1991-03-27	Ici Plc	Pyridine compounds

1992
- 1992-02-07 FR FR9201390A patent/FR2687674B1/fr not_active Expired - Fee Related
1993
- 1993-02-05 CA CA002106758A patent/CA2106758A1/fr not_active Abandoned
- 1993-02-05 RU RU93058177A patent/RU2124004C1/ru active
- 1993-02-05 WO PCT/FR1993/000118 patent/WO1993016049A1/fr not_active Ceased
- 1993-02-05 ZA ZA93810A patent/ZA93810B/xx unknown
- 1993-02-05 HU HU9303144A patent/HUT68756A/hu unknown
- 1993-02-05 AT AT93905369T patent/ATE313530T1/de not_active IP Right Cessation
- 1993-02-05 DE DE69333944T patent/DE69333944T2/de not_active Expired - Fee Related
- 1993-02-05 EP EP93905369A patent/EP0579819B1/de not_active Expired - Lifetime
- 1993-02-05 JP JP5513829A patent/JPH06506956A/ja active Pending
- 1993-02-05 KR KR1019930703012A patent/KR100273181B1/ko not_active Expired - Fee Related
- 1993-02-05 AU AU36341/93A patent/AU667880B2/en not_active Ceased
- 1993-02-05 ES ES93905369T patent/ES2251714T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
RU2124004C1 (ru)	1998-12-27
FR2687674B1 (fr)	1995-05-19
DE69333944D1 (de)	2006-01-26
AU667880B2 (en)	1996-04-18
WO1993016049A1 (fr)	1993-08-19
ZA93810B (en)	1994-02-07
EP0579819A1 (de)	1994-01-26
DE69333944T2 (de)	2006-08-10
ES2251714T3 (es)	2006-05-01
KR100273181B1 (ko)	2000-12-01
CA2106758A1 (fr)	1993-08-08
JPH06506956A (ja)	1994-08-04
HUT68756A (en)	1995-07-28
AU3634193A (en)	1993-09-03
EP0579819B1 (de)	2005-12-21
FR2687674A1 (fr)	1993-08-27
HU9303144D0 (en)	1994-01-28

Legal Events

Date	Code	Title	Description
2006-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE313530T1 (de)	2006-01-15	Neuer pyridon-derivat der eine affinität für den angiotensin-ii-rezeptor hat
UA26427A (uk)	1999-08-30	Похідhі ксаhтиhу у вигляді суміші ізомерів або іhдивідуальhих ізомерів, що мають властивість аhтагоhіста адеhозиhу
ES2077138T3 (es)	1995-11-16	Derivados de aminocumarano, su produccion y su uso.
ATE74134T1 (de)	1992-04-15	Rapamycin-vorlaeufer.
ES2173090T3 (es)	2002-10-16	Derivados biciclicos de la piridina, su procedimiento de preparacion, los productos intermedios obtenidos, su aplicacion como medicamentos y sus composiciones farmaceuticas que los contienen.
HUT62602A (en)	1993-05-28	Process for producing pharmaceutically active hydrazine derivatives
FI875202L (fi)	1987-11-25	Steroider med en spiranring i 17-staellning, foerfarande foer framstaellning av dessa och anvaendning av dessa.
ES2177952T3 (es)	2002-12-16	Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica.
ES8105320A1 (es)	1981-05-16	Un procedimiento para la preparacion de tienamicinas.
ES2101513T3 (es)	1997-07-01	Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen.
FR2336935A1 (fr)	1977-07-29	Nouvelles pyrimidones, leur procede de preparation et leur application
ES2054062T3 (es)	1994-08-01	N-cicloalquilalquilo benzilaminas alfa, alfa y substituidos, su procedimiento de preparacion, su utilizacion como medicamento y sus intermedios de sintesis.
MX9301045A (es)	1993-09-01	Procedimiento para preparar antagonistas receptores de fibrinogeno.
ES432613A1 (es)	1976-12-01	Procedimiento para preparar esteres de acidos pirimidintio-notiolfosforicos.
GB1447462A (en)	1976-08-25	Alpha-thiolincosaminides and the preparation thereof
IL73721A (en)	1990-04-29	(4-and/or 6-substituted o-acyl)glycosylamides,ureas and carbamates,their preparation and pharmaceutical compositions containing them
ES8100278A1 (es)	1980-11-01	Un procedimiento para la preparacion de derivados de 5-triazina
SE8303913L (sv)	1984-01-09	Heterocykliska foreningar
ES470738A1 (es)	1979-01-16	Procedimiento para la obtencion de nuevos derivados de ni- trosourea
FR2559765B1 (fr)	1986-06-13	Nouveaux derives de la phenyl-3 propene-2 amine, leur preparation et les medicaments qui les contiennent
FI904663A0 (fi)	1990-09-21	Nya substituerade alkylpiperidiner och deras anvaendning som inhibitorer i kolesterolsyntes.
FR2369312A1 (fr)	1978-05-26	Ethers oligomeres bromes et leur application comme ignifugeants
MY130090A (en)	2007-05-31	Disubstituted ureas and thioureas
GB1481147A (en)	1977-07-27	3-methyl-pyrazole-5-carboxylates
DE68904491D1 (de)	1993-03-04	Verwendung von adenosinderivaten zur herstellung von arzneimitteln mit immunstimulierender wirkung.