ATE313645T1 - Test zur bestimmung von dimethyl-l-arginine (adma) - Google Patents

Test zur bestimmung von dimethyl-l-arginine (adma)

Info

Publication number: ATE313645T1
Authority: AT; Austria
Prior art keywords: adma; arginine; dimethyl; test; citrulline
Prior art date: 1999-02-05

Application number

AT00908453T

Other languages

English (en)

Inventor

Robert F Balint

Mitchell Wayne Mutz

John P Cooke

Original Assignee

Unither Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-05

Filing date

2000-02-02

Publication date

2006-01-15

2000-02-02 Application filed by Unither Pharma Inc filed Critical Unither Pharma Inc

2006-01-15 Application granted granted Critical

2006-01-15 Publication of ATE313645T1 publication Critical patent/ATE313645T1/de

Links

YDGMGEXADBMOMJ-LURJTMIESA-N N(g)-dimethylarginine Chemical compound CN(C)C(\N)=N\CCC[C@H](N)C(O)=O YDGMGEXADBMOMJ-LURJTMIESA-N 0.000 title abstract 4
YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 title abstract 3
RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 3
RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 3
229960002173 citrulline Drugs 0.000 abstract 3
235000013477 citrulline Nutrition 0.000 abstract 3
101710085388 N(G),N(G)-dimethylarginine dimethylaminohydrolase Proteins 0.000 abstract 1
102100035854 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Human genes 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
238000005341 cation exchange Methods 0.000 abstract 1
230000007071 enzymatic hydrolysis Effects 0.000 abstract 1
238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 1
230000002452 interceptive effect Effects 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
235000018102 proteins Nutrition 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT00908453T 1999-02-05 2000-02-02 Test zur bestimmung von dimethyl-l-arginine (adma) ATE313645T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11883899P	1999-02-05	1999-02-05
PCT/US2000/002712 WO2000046395A1 (en)	1999-02-05	2000-02-02	Assay for asymmetrical dimethyl-l-arginine (adma)

Publications (1)

Publication Number	Publication Date
ATE313645T1 true ATE313645T1 (de)	2006-01-15

Family

ID=22381031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00908453T ATE313645T1 (de)	1999-02-05	2000-02-02	Test zur bestimmung von dimethyl-l-arginine (adma)

Country Status (8)

Country	Link
US (1)	US6358699B1 (de)
EP (1)	EP1070139B1 (de)
AT (1)	ATE313645T1 (de)
AU (1)	AU2979300A (de)
CA (1)	CA2327413A1 (de)
DE (1)	DE60024930T2 (de)
ES (1)	ES2254147T3 (de)
WO (1)	WO2000046395A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6358699B1 (en) *	1999-02-05	2002-03-19	Cooke Pharma	Assay for asymmetrical NG, NG dimethyl-l-arginine
WO2002004465A1 (en) *	2000-07-06	2002-01-17	Fal Diagnostics	Methods and kits for the detection of arginine compounds
DE10040904A1 (de) *	2000-08-18	2002-02-28	Boeger Rainer H	Verfahren und Mittel zum Nachweis einer Wahrscheinlichkeit zukünftigen Fortschreitens von Gefässerkrankungen
US6887642B2 (en) *	2002-04-05	2005-05-03	Kodak Polychrome Graphies Llc	Multi-layer negative working imageable element
CN1656123A (zh) *	2002-05-31	2005-08-17	尤尼特尔药品公司	用于评估心血管疾病危险性的蛋白和方法
US7033602B1 (en)	2002-06-21	2006-04-25	Advanced Cardiovascular Systems, Inc.	Polycationic peptide coatings and methods of coating implantable medical devices
US8506617B1 (en)	2002-06-21	2013-08-13	Advanced Cardiovascular Systems, Inc.	Micronized peptide coated stent
US7056523B1 (en)	2002-06-21	2006-06-06	Advanced Cardiovascular Systems, Inc.	Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine
US7011842B1 (en)	2002-06-21	2006-03-14	Advanced Cardiovascular Systems, Inc.	Polycationic peptide coatings and methods of making the same
US7070798B1 (en)	2002-06-21	2006-07-04	Advanced Cardiovascular Systems, Inc.	Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
US6994867B1 (en)	2002-06-21	2006-02-07	Advanced Cardiovascular Systems, Inc.	Biocompatible carrier containing L-arginine
US7217426B1 (en)	2002-06-21	2007-05-15	Advanced Cardiovascular Systems, Inc.	Coatings containing polycationic peptides for cardiovascular therapy
WO2004046314A2 (en) *	2002-11-15	2004-06-03	The Board Of Trustees Of The Leland Stanford Junior University	Methods for detecting asymmetric dimethylarginine in a biological sample
US7094256B1 (en)	2002-12-16	2006-08-22	Advanced Cardiovascular Systems, Inc.	Coatings for implantable medical device containing polycationic peptides
DE10347682B4 (de) *	2003-10-14	2007-11-29	Kodak Polychrome Graphics Gmbh	Verfahren zur Herstellung zweischichtiger wärmeempfindlicher bebilderbarer Elemente
JP2006081481A (ja) *	2004-09-17	2006-03-30	Kikkoman Corp	非対称ジメチルアルギニン測定法及び非対称ジメチルアルギニン測定キット
GB2439877B (en) *	2005-03-30	2010-04-28	Ucl Business Plc	Assay for measuring asymmetric methylarginine in a biological sample
DE102005056408B4 (de) *	2005-05-28	2007-05-31	Esa Patentverwertungsagentur Sachsen-Anhalt Gmbh	Verfahren zur Bestimmung der Konzentration von asymmetrischem Dimethylarginin (ADMA)
EP3808733A1 (de)	2008-08-07	2021-04-21	IDEXX Laboratories, Inc.	Verfahren zur detektion von symmetrischem demethylarginin
CN102154444B (zh) *	2010-12-30	2013-09-25	北京九强生物技术股份有限公司	测定不对称二甲基精氨酸浓度的方法及诊断试剂盒
CN103845739A (zh) *	2012-12-04	2014-06-11	绍兴科锐捷生物科技有限公司	一种非对称二甲基精氨酸水解酶冻干粉针剂及制备方法
CN103207173B (zh) *	2013-03-13	2015-06-17	北大工学院绍兴技术研究院	一种酶学检测方法
AU2014315063B2 (en)	2013-09-05	2020-07-23	Idexx Laboratories, Inc.	Methods for detecting renal disease
EP2963496B1 (de)	2014-06-30	2017-04-05	Agfa Graphics NV	Lithografiedruckplattenvorläufer mit (Ethylen-, Vinylacetal-) Copolymeren
US10775365B2 (en)	2015-02-20	2020-09-15	Idexx Laboratories, Inc.	Homogenous immunoassay with compensation for background signal
CN105424620A (zh) *	2015-04-30	2016-03-23	北京丹大生物技术有限公司	水解酶法测定不对称二甲基精氨酸及试剂盒
EP3697499A4 (de)	2017-10-19	2021-07-21	IDEXX Laboratories, Inc.	Nachweis von symmetrischem dimethylarginin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7269098A (en)	1997-05-01	1998-11-24	Cooke Pharma, Inc.	Cardiovascular disease risk assessment
US6358699B1 (en) *	1999-02-05	2002-03-19	Cooke Pharma	Assay for asymmetrical NG, NG dimethyl-l-arginine

2000
- 2000-02-01 US US09/495,553 patent/US6358699B1/en not_active Expired - Lifetime
- 2000-02-02 AT AT00908453T patent/ATE313645T1/de not_active IP Right Cessation
- 2000-02-02 WO PCT/US2000/002712 patent/WO2000046395A1/en not_active Ceased
- 2000-02-02 ES ES00908453T patent/ES2254147T3/es not_active Expired - Lifetime
- 2000-02-02 EP EP00908453A patent/EP1070139B1/de not_active Expired - Lifetime
- 2000-02-02 AU AU29793/00A patent/AU2979300A/en not_active Abandoned
- 2000-02-02 CA CA002327413A patent/CA2327413A1/en not_active Abandoned
- 2000-02-02 DE DE60024930T patent/DE60024930T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60024930D1 (de)	2006-01-26
ES2254147T3 (es)	2006-06-16
CA2327413A1 (en)	2000-08-10
WO2000046395A1 (en)	2000-08-10
DE60024930T2 (de)	2006-10-26
AU2979300A (en)	2000-08-25
US6358699B1 (en)	2002-03-19
EP1070139A1 (de)	2001-01-24
EP1070139B1 (de)	2005-12-21

Legal Events

Date	Code	Title	Description
2006-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE313645T1 (de)	2006-01-15	Test zur bestimmung von dimethyl-l-arginine (adma)
EA199900980A1 (ru)	2000-04-24	Улучшенные способы приготовления активированного белка с
ATE367398T1 (de)	2007-08-15	Verfahren zur rückfaltung von proteinen mit freien cysteinresten
BR0111284A (pt)	2003-06-10	Uso de enzimas para reduzir o tempo de maceração e exigências em so2 em um processo de moagem a úmido de milho
Hayashi et al.	1980	Racemization of amino acid residues during alkali-treatment of protein and its adverse effect on pepsin digestibility
ATE242317T1 (de)	2003-06-15	Verfahren zur reinigung von viren mit chromatographie
DK622788D0 (da)	1988-11-08	Analysemetode og testsystem til bestemmelse af den relative maengde af et bestemt haemoglobinderivat i en blodproeve
DE3686050D1 (de)	1992-08-20	Vorrichtung zur kultivierung von zellen in vitro.
WO2000001845A3 (de)	2000-02-17	Verfahren zur frühen diagnose von carcinomen
SG172470A1 (en)	2011-07-28	A method and a system for improved trading derivative contracts and combinations thereof
NO930770L (no)	1993-09-06	Immunologisk fremgangsmaate for bestemmelse av et hemoglobinderivat
WO2005066660A3 (en)	2005-10-06	Processing seismic data representing a physical system
DE3765310D1 (de)	1990-11-08	Vorrichtung zur bestimmung von gaspartialdruecken im blut.
WO2005109203A3 (en)	2006-09-28	Data processing system with trace co-processor
AU5419399A (en)	2000-02-28	Method for determining the immune defences of blood, test kit therefor and use of a suitable system for taking blood samples
ATE138386T1 (de)	1996-06-15	Satz zur spezifischen bestimmung von angiotensin- ii
DE68917613D1 (de)	1994-09-29	Natriumdecylsulfat enthaltende Waschlösung, Testsatz und Verfahren zur Bestimmung eines immunologischen Liganden.
NO994750L (no)	2000-03-31	Anti-Fas-antistoffer
PT1276763E (pt)	2004-06-30	Proteinas anti-congelantes sua producao e utilizacao
EP0821238A3 (de)	1998-09-16	Verfahren und Testsatz zur in vitro Bestätigung der Diagnose von Bauchkrankheit
WO1994025590A3 (en)	1994-12-22	Trichohyalin and transglutaminase-3 and methods of using same
DE69809412D1 (de)	2002-12-19	Reagenz zur guanidinylierung
DE69838553D1 (de)	2007-11-22	Verfahren zur diagnose, prognose und behandlung von glaukom und verwandten erkrankungen
CA2019872A1 (en)	1991-01-08	Method and kit for determining the functional activity of protein s in human plasma
ATE452984T1 (de)	2010-01-15	Verfahren und zusammensetzungen zur extraktion von proteinen aus zellen