|
CA2995542A1
(en)
*
|
1997-09-05 |
1999-03-11 |
Genzyme Corporation |
Methods for generating high titer helper-free preparations of recombinant aav vectors
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
US6995006B2
(en)
|
1997-09-05 |
2006-02-07 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
EP2942393A1
(de)
|
1998-09-04 |
2015-11-11 |
Genzyme Corporation |
Verfahren zur erzeugung helferfreier präparate mit hohem titer aus freigesetzten rekombinanten aav-vektoren
|
|
CA2364934C
(fr)
*
|
1999-02-22 |
2011-10-18 |
Transgene S.A. |
Procede d'obtention d'une preparation virale purifiee
|
|
US6464976B1
(en)
|
1999-09-07 |
2002-10-15 |
Canji, Inc. |
Methods and compositions for reducing immune response
|
|
US6436402B1
(en)
*
|
1999-10-15 |
2002-08-20 |
Merck & Co., Inc. |
Process for making human papillomavirus virus-like particles with improved properties
|
|
EP1681299B1
(de)
|
2000-03-27 |
2009-11-11 |
Genetics Institute, LLC |
Verfahren zur Reinigung stark anionischer Proteine
|
|
EP1404428B1
(de)
*
|
2001-06-05 |
2006-07-19 |
Genetics Institute, LLC |
Verfahren zur reinigung hochanionischer proteine
|
|
US6833238B2
(en)
|
2002-01-04 |
2004-12-21 |
Applera Corporation |
Petal-array support for use with microplates
|
|
US20040018559A1
(en)
*
|
2002-07-26 |
2004-01-29 |
Applera Corporation |
Size-exclusion ion-exchange particles
|
|
CA2529053A1
(en)
*
|
2003-06-18 |
2004-12-29 |
Onyx Pharmaceuticals, Inc. |
Method for purifying virus
|
|
AU2004249802B2
(en)
*
|
2003-06-20 |
2007-06-28 |
Microbix Biosystems Inc. |
Improvements in virus production
|
|
US7479222B2
(en)
*
|
2004-02-05 |
2009-01-20 |
Millipore Corporation |
Porous adsorptive or chromatographic media
|
|
US20050181378A1
(en)
*
|
2004-02-18 |
2005-08-18 |
Applera Corporation |
Polyelectrolyte-coated size-exclusion ion-exchange particles
|
|
US20060160122A1
(en)
*
|
2004-02-18 |
2006-07-20 |
Applera Corporation |
Polyelectrolyte-coated size-exclusion ion-exchange particles
|
|
US20050196856A1
(en)
*
|
2004-02-18 |
2005-09-08 |
Applera Corporation |
Polyelectrolyte-coated size-exclusion ion-exchange particles
|
|
CN1922308A
(zh)
*
|
2004-02-23 |
2007-02-28 |
克鲁塞尔荷兰公司 |
病毒纯化方法
|
|
WO2005114171A2
(en)
*
|
2004-05-20 |
2005-12-01 |
Chiron Srl |
Analysis of liquid chromatography eluates
|
|
US20090104226A1
(en)
|
2004-05-21 |
2009-04-23 |
Novartis Vaccines And Diagnostics Inc. |
Alphavirus Vectors for Respiratory Pathogen Vaccines
|
|
ATE412737T1
(de)
*
|
2005-04-11 |
2008-11-15 |
Crucell Holland Bv |
Virusreinigung mit ultrafiltration
|
|
US20070111309A1
(en)
*
|
2005-10-04 |
2007-05-17 |
Daelli Marcelo G |
Vero cell line adapted to grow in suspension
|
|
PL2007883T3
(pl)
|
2006-04-20 |
2012-07-31 |
Wyeth Llc |
Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej
|
|
EP1878791A1
(de)
*
|
2006-07-11 |
2008-01-16 |
Bia Separations D.O.O. |
Verfahren zur Reinigung von Influenzaviren
|
|
US9422342B2
(en)
|
2006-07-13 |
2016-08-23 |
Institute Of Advanced Study |
Recoding method that removes inhibitory sequences and improves HIV gene expression
|
|
US8481298B2
(en)
|
2006-09-29 |
2013-07-09 |
Ge Healthcare Bio-Sciences Ab |
Separation matrix for viral purification
|
|
WO2008067480A2
(en)
|
2006-11-29 |
2008-06-05 |
Nationwide Children's Hospital |
Myostatin inhibition for enhancing muscle and/or improving muscle function
|
|
US9433922B2
(en)
*
|
2007-08-14 |
2016-09-06 |
Emd Millipore Corporation |
Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
|
|
US20090130738A1
(en)
*
|
2007-11-19 |
2009-05-21 |
Mikhail Kozlov |
Media for membrane ion exchange chromatography
|
|
US9415121B2
(en)
|
2008-12-19 |
2016-08-16 |
Nationwide Children's Hospital |
Delivery of MECP2 polynucleotide using recombinant AAV9
|
|
US11219696B2
(en)
|
2008-12-19 |
2022-01-11 |
Nationwide Children's Hospital |
Delivery of polynucleotides using recombinant AAV9
|
|
WO2010089339A1
(en)
|
2009-02-06 |
2010-08-12 |
Glaxosmithkline Biologicals S.A. |
Purification of virus or viral antigens by density gradient ultracentrifugation
|
|
FR2944292B1
(fr)
*
|
2009-04-08 |
2013-08-23 |
Sanofi Pasteur |
Procede de purification du virus rabique
|
|
EP4786482A2
(de)
|
2009-08-06 |
2026-08-05 |
F. Hoffmann-La Roche AG |
Virusfiltrierungsverfahren
|
|
EP2482825B1
(de)
|
2009-10-02 |
2016-11-23 |
The Trustees of Columbia University in the City of New York |
Diagnostische fisch-reoviren-zusammensetzungen
|
|
US8557253B2
(en)
|
2009-10-07 |
2013-10-15 |
Sanofi Pasteur Sa |
Stabilizing excipient for inactivated whole virus vaccine
|
|
SG184833A1
(en)
|
2010-04-14 |
2012-11-29 |
Emd Millipore Corp |
Methods of producing high titer, high purity virus stocks and methods of use thereof
|
|
WO2012015908A2
(en)
|
2010-07-30 |
2012-02-02 |
Millipore Corporation |
Chromatography media and method
|
|
DE102010046817A1
(de)
|
2010-09-28 |
2012-03-29 |
Sartorius Stedim Biotech Gmbh |
Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium
|
|
CA2816883A1
(en)
|
2010-11-23 |
2012-05-31 |
Presage Biosciences, Inc. |
Therapeutic methods and compositions for solid delivery
|
|
EP3495472B1
(de)
|
2011-04-21 |
2023-11-15 |
Nationwide Children's Hospital, Inc. |
Rekombinante virusprodukte und verfahren zur expressionshemmung von myotilin
|
|
US10196636B2
(en)
|
2011-04-21 |
2019-02-05 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of myotilin
|
|
US20130039888A1
(en)
|
2011-06-08 |
2013-02-14 |
Nationwide Children's Hospital Inc. |
Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders
|
|
CA2842798C
(en)
|
2011-07-25 |
2021-02-23 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of dux4
|
|
US9434928B2
(en)
|
2011-11-23 |
2016-09-06 |
Nationwide Children's Hospital, Inc. |
Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
|
|
CA2880653C
(en)
|
2012-08-01 |
2022-05-17 |
Nationwide Children's Hospital |
Intrathecal delivery of recombinant adeno-associated virus 9
|
|
CA2885216A1
(en)
|
2012-09-17 |
2014-03-20 |
The Research Institute At Nationwide Children's Hospital |
Compositions and methods for treating amyotrophic lateral sclerosis
|
|
MY178616A
(en)
|
2012-09-17 |
2020-10-19 |
Grace W R & Co |
Chromatography media and devices
|
|
JP6320429B2
(ja)
*
|
2013-02-22 |
2018-05-09 |
エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ |
負帯電粒子を用いるウイルス調製物のクロマトグラフィー精製
|
|
US9862945B2
(en)
|
2013-04-20 |
2018-01-09 |
Research Institute At Nationwide Children's Hospital |
Recombinant adeno-associated virus delivery of exon 2-targeted U7SNRNA polynucleotide constructs
|
|
RS63942B1
(sr)
|
2013-08-27 |
2023-02-28 |
Res Inst Nationwide Childrens Hospital |
Proizvodi i postupci za lečenje amiotrofične lateralne skleroze
|
|
US9725719B2
(en)
|
2013-11-05 |
2017-08-08 |
The Research Institute At Nationwide Children's Hospital |
Compositions and methods for inhibiting NF-κB and SOD-1 to treat amyotrophic lateral sclerosis
|
|
IL230970A0
(en)
|
2014-02-13 |
2014-09-30 |
Univ Ramot |
Tilapia virus vaccines
|
|
US10047130B2
(en)
|
2014-03-18 |
2018-08-14 |
Washington University |
Methods and compositions for red-shifted chromophore substitution for optogenetic applications
|
|
CA2957661A1
(en)
|
2014-08-09 |
2016-02-18 |
Kevin FLANIGAN |
Methods and materials for activating an internal ribosome entry site in exon 5 of the dmd gene
|
|
EP3188816B1
(de)
|
2014-09-02 |
2021-06-09 |
EMD Millipore Corporation |
Chromatographie-medum, bestehend aus diskreten porösen bündeln von nanofibrillen
|
|
US10842886B2
(en)
|
2014-10-10 |
2020-11-24 |
Research Institute At Nationwide Children's Hospital |
Guided injections for AAV gene transfer to muscle
|
|
EP3690024A1
(de)
|
2014-11-05 |
2020-08-05 |
The Research Institute at Nationwide Children's Hospital |
Verfahren und materialien zur herstellung rekombinanter viren in eukaryotischen mikroalgen
|
|
US20170298091A1
(en)
|
2014-12-08 |
2017-10-19 |
Emd Millipore Corporation |
Mixed Bed Ion Exchange Adsorber
|
|
US10183072B2
(en)
|
2014-12-15 |
2019-01-22 |
Kimron Veterinary Institute |
Tilapia virus and uses thereof
|
|
MA41451A
(fr)
|
2015-02-04 |
2017-12-12 |
Univ Washington |
Constructions anti-tau
|
|
WO2016135558A2
(en)
|
2015-02-23 |
2016-09-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
US10017832B2
(en)
|
2015-08-25 |
2018-07-10 |
Washington University |
Compositions and methods for site specific recombination at asymmetric sites
|
|
KR102799163B1
(ko)
|
2015-09-17 |
2025-04-21 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
Galgt2 유전자 치료 방법 및 물질
|
|
WO2017064546A1
(en)
|
2015-09-24 |
2017-04-20 |
Crispr Therapeutics Ag |
Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
|
|
EP4279084B1
(de)
|
2015-10-28 |
2025-06-11 |
Vertex Pharmaceuticals Inc. |
Materialien und verfahren zur behandlung von duchenne-muskeldystrophie
|
|
US11866727B2
(en)
|
2015-11-06 |
2024-01-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of glycogen storage disease type 1A
|
|
CN108463211B
(zh)
|
2015-11-16 |
2022-09-27 |
全国儿童医院研究所 |
用于治疗肌联蛋白类肌病和其它肌联蛋白病变的材料和方法
|
|
WO2017093804A2
(en)
|
2015-12-01 |
2017-06-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of alpha-1 antitrypsin deficiency
|
|
CA3009308A1
(en)
|
2015-12-23 |
2017-06-29 |
Chad Albert COWAN |
Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
|
|
US11938193B2
(en)
|
2016-01-08 |
2024-03-26 |
Washington University |
Compositions comprising chemerin and methods of use thereof
|
|
EP3411078A1
(de)
|
2016-02-02 |
2018-12-12 |
Crispr Therapeutics AG |
Materialien und verfahren zur behandlung von schwerer kombinierter immundefizienz (scid) oder omenn-syndrom
|
|
WO2017141109A1
(en)
|
2016-02-18 |
2017-08-24 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
|
WO2017147509A1
(en)
|
2016-02-25 |
2017-08-31 |
Marco Colonna |
Compositions comprising trem2 and methods of use thereof
|
|
JP6966463B2
(ja)
|
2016-02-26 |
2021-11-17 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
組換えウイルス産物及びdux4エクソンスキッピングを誘導するための方法
|
|
US11083799B2
(en)
|
2016-03-16 |
2021-08-10 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hereditary haemochromatosis
|
|
BR112018070249A2
(pt)
|
2016-04-02 |
2019-01-29 |
Research Institute At Nationwide Children's Hospital |
sistema promotor de u6 modificada para expressão específica de tecido
|
|
WO2017181011A1
(en)
|
2016-04-15 |
2017-10-19 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of microrna-29 to treat muscular dystrophy
|
|
CN109121395B
(zh)
|
2016-04-15 |
2022-08-09 |
全国儿童医院研究所 |
腺相关病毒载体递送β-肌聚糖和微RNA-29以及肌营养不良症的治疗
|
|
JP6974349B2
(ja)
|
2016-04-18 |
2021-12-01 |
クリスパー セラピューティクス アクチェンゲゼルシャフト |
ヘモグロビン異常症の処置のための材料及び方法
|
|
WO2017191503A1
(en)
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
|
WO2018002762A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis (als) and other related disorders
|
|
CA3029119A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Materials and methods for treatment of friedreich ataxia and other related disorders
|
|
EP3481857B1
(de)
|
2016-07-06 |
2026-02-11 |
Vertex Pharmaceuticals Incorporated |
Materialien und verfahren zur behandlung von schmerzbedingten erkrankungen
|
|
EP4650364A3
(de)
|
2016-07-06 |
2026-01-21 |
Vertex Pharmaceuticals Incorporated |
Materialien und verfahren zur behandlung von schmerzbedingten erkrankungen
|
|
WO2018007871A1
(en)
|
2016-07-08 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of transthyretin amyloidosis
|
|
WO2018020323A2
(en)
|
2016-07-25 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of fatty acid disorders
|
|
US20190194628A1
(en)
*
|
2016-09-01 |
2019-06-27 |
Takeda Vaccines, Inc. |
Methods for producing virus for vaccine production
|
|
IL322146A
(en)
|
2016-11-17 |
2025-09-01 |
Nationwide Childrens Hospital Inc |
Intrathecal administration of adenovirus encoding methyl-CpG-binding protein 2
|
|
CA3045667A1
(en)
|
2016-12-13 |
2018-06-21 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Methods of exogenous drug activation of chemical-induced signaling complexes expressed in engineered cells in vitro and in vivo
|
|
WO2018154418A1
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
|
WO2018154439A1
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 1 (sca1) and other spinocerebellar ataxia type 1 protein (atxn1) gene related conditions or disorders
|
|
EP3585899A1
(de)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von primärer hyperoxalurie typ 1 (ph1) und anderen mit dem alanin-glyoxylataminotransferase (agxt)-gen assoziierten erkrankungen oder störungen
|
|
WO2018154462A2
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
|
|
AU2018224387B2
(en)
|
2017-02-22 |
2024-08-08 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
|
EP3420076B1
(de)
|
2017-03-06 |
2024-02-21 |
Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. |
Verfahren zur herstellung und charakterisierung eines virusimpfstoffes und einer virenimpfstoffzusammensetzung
|
|
ES2975182T3
(es)
|
2017-03-06 |
2024-07-03 |
Guangzhou Realbenefitspot Pharmaceutical Co Ltd |
Métodos de producción y caracterización de vacunas víricas y composición de vacuna vírica
|
|
CN108524929B
(zh)
*
|
2017-03-06 |
2019-05-07 |
广州瑞贝斯药业有限公司 |
一种狂犬病疫苗的生产方法
|
|
CN110997923B
(zh)
|
2017-03-17 |
2024-01-02 |
全国儿童医院研究所 |
腺相关病毒载体递送肌肉特异性微肌营养不良蛋白以治疗肌营养不良症
|
|
US11338045B2
(en)
|
2017-03-17 |
2022-05-24 |
Newcastle University |
Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
|
|
RU2019133002A
(ru)
|
2017-03-24 |
2021-04-26 |
Зе Юнивёрсити Корт Оф Зе Юнивёрсити Оф Эдинбург |
ЭКСПРЕССИОННЫЕ КАССЕТЫ MeCP2
|
|
BR112019023608A2
(pt)
|
2017-05-12 |
2020-05-26 |
Crispr Therapeutics Ag |
Materiais e métodos para células manipuladas e seus usos em imuno-oncologia
|
|
WO2019011817A1
(en)
|
2017-07-08 |
2019-01-17 |
Genethon |
TREATMENT OF SPINAL AMYOTROPHY
|
|
MA49923A
(fr)
|
2017-10-02 |
2020-06-24 |
Res Inst Nationwide Childrens Hospital |
Système de déciblage de miarn pour interférence spécifique d'un tissu
|
|
US20220080055A9
(en)
|
2017-10-17 |
2022-03-17 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing for hemophilia a
|
|
WO2019078916A1
(en)
|
2017-10-18 |
2019-04-25 |
Research Institute At Nationwide Children's Hospital |
ADENO-ASSOCIATED VIRUS VECTOR ADMINISTRATION OF MUSCLE-SPECIFIC MICRO-DYSTROPHINE TO TREAT MUSCLE DYSTROPHY
|
|
MX2020004035A
(es)
|
2017-10-20 |
2020-11-09 |
Res Inst Nationwide Childrens Hospital |
Métodos y materiales para terapia génica con nt-3.
|
|
MA50849A
(fr)
|
2017-10-26 |
2020-09-02 |
Vertex Pharma |
Substances et procédés pour le traitement d'hémoglobinopathies
|
|
EP4585229A3
(de)
|
2017-11-08 |
2026-01-14 |
Novartis AG |
Mittel und verfahren zur herstellung von viralen vektoren und deren verwendung
|
|
MA50579A
(fr)
|
2017-11-09 |
2020-09-16 |
Crispr Therapeutics Ag |
Systèmes crispr/cas ou crispr/cpf1 à auto-inactivation (sin) et leurs utilisations
|
|
EP3714055A1
(de)
|
2017-11-21 |
2020-09-30 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von autosomal-dominanter retinitis pigmentosa
|
|
CA3084825A1
(en)
|
2017-12-14 |
2019-06-20 |
Crispr Therapeutics Ag |
Novel rna-programmable endonuclease systems and their use in genome editing and other applications
|
|
CA3084633A1
(en)
|
2017-12-21 |
2019-06-27 |
Crispr Therapeutics Ag |
Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp)
|
|
AU2018393050A1
(en)
|
2017-12-21 |
2020-06-18 |
Bayer Healthcare Llc |
Materials and methods for treatment of Usher Syndrome Type 2A
|
|
EP3737762A1
(de)
|
2018-01-12 |
2020-11-18 |
CRISPR Therapeutics AG |
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|
|
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(en)
|
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|
|
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(fr)
|
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|
|
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(de)
|
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|
|
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(de)
|
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|
|
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(ja)
|
2018-03-19 |
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新規rnaプログラム可能エンドヌクレアーゼ系およびその使用
|
|
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(en)
|
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2019-10-24 |
Casebia Therapeutics Limited Liability Partnership |
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|
|
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(en)
|
2018-04-27 |
2019-10-31 |
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|
|
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(ja)
|
2018-06-08 |
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|
|
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(en)
|
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|
|
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(ja)
|
2018-06-18 |
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(ja)
|
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|
|
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(en)
|
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|
|
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(de)
|
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|
|
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(en)
|
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Expression cassettes for gene therapy vectors
|
|
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(ja)
|
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|
|
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(zh)
|
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|
|
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(es)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(ko)
|
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|
|
US20220145274A1
(en)
|
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Novel high fidelity rna-programmable endonuclease systems and uses thereof
|
|
US20220193259A1
(en)
|
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|
|
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(de)
|
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|
|
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(ja)
|
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|
|
US12173290B2
(en)
|
2019-06-28 |
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Materials and methods for controlling gene editing
|
|
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(zh)
|
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2022-03-11 |
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|
|
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(en)
|
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|
|
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(ja)
|
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|
|
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(en)
|
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|
|
US20230211018A1
(en)
|
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|
|
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(de)
|
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|
|
WO2021168124A1
(en)
|
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|
|
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(zh)
|
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2022-11-22 |
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|
|
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(de)
|
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|
|
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(en)
|
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Genome-editing compositions and methods to modulate faah for treatment of neurological disorders
|
|
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(zh)
|
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|
|
CN114181970B
(zh)
*
|
2020-09-15 |
2023-07-25 |
上海药明巨诺生物医药研发有限公司 |
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|
|
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(ja)
|
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|
|
US20240261434A1
(en)
|
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|
|
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(en)
|
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|
|
RU2748475C1
(ru)
*
|
2020-11-02 |
2021-05-26 |
Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") |
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|
|
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(en)
|
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2022-06-02 |
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Compositions and methods for treating facioscapulohumeral muscular dystrophy (fshd)
|
|
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(de)
|
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|
|
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(en)
|
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2022-08-04 |
Research Institute At Nationwide Children's Hospital |
Materials and methods for the treatment of lysosomal acid lipase deficiency (lal-d)
|
|
US20240093191A1
(en)
|
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2024-03-21 |
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Compositions and methods for treating disease associated with dux4 overexpression
|
|
WO2022170038A1
(en)
|
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Amicus Therapeutics, Inc. |
Adeno-associated virus delivery of cln3 polynucleotide
|
|
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(de)
|
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Produkte und verfahren zur behandlung von dystrophinbasierten myopathien mit crispr-cas9 zur korrektur von dmd-exon-duplikationen
|
|
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(zh)
|
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2024-06-04 |
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|
|
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(en)
|
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2022-10-20 |
Research Institute At Nationwide Children's Hospital |
Recombinant adeno-associated virus encoding methyl-cpg binding protein 2 for treating pitt hopkins syndrome via intrathecal delivery
|
|
US12275941B2
(en)
|
2021-04-15 |
2025-04-15 |
Research Institute At Nationwide Children's Hospital |
Products and methods for inhibition of expression of dynamin-1 variants
|
|
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(en)
|
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2023-11-16 |
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|
|
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(pt)
|
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2024-01-30 |
Sarepta Therapeutics Inc |
Produção de vetores de aav recombinantes para o tratamento de distrofia muscular
|
|
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(de)
|
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2023-03-22 |
Research Institute at Nationwide Children's Hospital |
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|
|
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(de)
|
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2022-12-14 |
Bayer AG |
Programmierbare typ-v-rna-endonukleasesysteme
|
|
MX2023014774A
(es)
|
2021-06-11 |
2024-01-15 |
Bayer Ag |
Nuevos sistemas de endonucleasas programables de arn tipo v.
|
|
WO2023283962A1
(en)
|
2021-07-16 |
2023-01-19 |
Huigene Therapeutics Co., Ltd. |
Modified aav capsid for gene therapy and methods thereof
|
|
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(en)
|
2021-08-11 |
2023-02-16 |
Solid Biosciences Inc. |
Treatment of muscular dystrophy
|
|
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(de)
|
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2023-03-08 |
Bayer AG |
Neue programmierbare rna-endonuklease-systeme mit verbesserter pam-spezifität und deren verwendung
|
|
JP2024534410A
(ja)
|
2021-09-16 |
2024-09-20 |
ノバルティス アーゲー |
新規転写因子
|
|
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(en)
|
2021-10-07 |
2024-12-05 |
Research Institute At Nationwide Children' S Hospital |
Products and methods for myelin protein zero silencing and treating cmt1b disease
|
|
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(en)
|
2021-10-08 |
2023-04-13 |
Amicus Therapeutics, Inc. |
Biomarkers for lysosomal storage diseases
|
|
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(en)
|
2021-10-15 |
2025-04-29 |
Research Institute At Nationwide Children's Hospital |
Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy
|
|
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(en)
|
2021-11-12 |
2024-06-13 |
Research Institute At Nationwide Children's Hospital |
Materials and methods for slc6a1 gene therapy
|
|
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(en)
|
2021-11-30 |
2023-09-07 |
Research Institute At Nationwide Children's Hospital |
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|
|
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(de)
|
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2023-06-21 |
Genethon |
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|
|
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(de)
|
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2023-06-21 |
Genethon |
Transfererhöhung des gamma-sarcoglycan-gens unter verwendung von modifizierten itr-sequenzen
|
|
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(de)
|
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2023-06-21 |
Genethon |
Calpain-3-gentransfersteigerung unter verwendung von modifizierten itr-sequenzen
|
|
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(de)
|
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2023-06-21 |
Genethon |
Erhöhung des gentransfers von fukutin-verwandtem protein unter verwendung modifizierter itr-sequenzen
|
|
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(de)
|
2021-12-21 |
2024-10-30 |
Research Institute at Nationwide Children's Hospital |
Materialien und verfahren zur behandlung von muskeldystrophie bei gliedmassengürteln
|
|
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(de)
|
2021-12-23 |
2024-10-30 |
Bayer Aktiengesellschaft |
Neuartige programmierbare endonukleasesysteme für kleine v-rna
|
|
WO2023166425A1
(en)
|
2022-03-01 |
2023-09-07 |
Crispr Therapeutics Ag |
Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions
|
|
WO2023168400A2
(en)
|
2022-03-03 |
2023-09-07 |
Research Institute At Nationwide Children's Hospital |
Materials and methods for the treatment of eif2b5 mutations and diseases resulting therefrom
|
|
AU2023250649A1
(en)
|
2022-04-04 |
2024-11-14 |
The Regents Of The University Of California |
Genetic complementation compositions and methods
|
|
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(en)
|
2022-05-06 |
2023-11-09 |
Novartis Ag |
NEW VP2 FUSION POLYPEPTIDES OF RECOMBINANT AAV
|
|
JP2025523399A
(ja)
|
2022-06-08 |
2025-07-23 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
変異型又は病原性kcnq3発現に関連する疾患又は状態を治療するための生成物及び方法
|
|
WO2023237587A1
(en)
|
2022-06-10 |
2023-12-14 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
|
AU2023303015A1
(en)
|
2022-07-06 |
2025-01-23 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus delivery of cln1 polynucleotide
|
|
WO2024035782A1
(en)
|
2022-08-10 |
2024-02-15 |
Aav Gene Therapeutics, Inc. |
Aav-mediated intramuscular delivery of insulin
|
|
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(en)
|
2022-10-11 |
2024-04-18 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus delivery to treat spinal muscular atrophy with respiratory distress type 1 (smard1) and charcot-marie-tooth type 2s (cmt2s)
|
|
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(de)
|
2022-10-27 |
2025-09-03 |
CARGO Therapeutics, Inc. |
Zusammensetzungen und verfahren für verbesserte immuntherapien
|
|
CN120569476A
(zh)
|
2022-11-30 |
2025-08-29 |
安铂生物公司 |
用于靶向反式剪接的方法和组合物
|
|
US20260209732A1
(en)
|
2022-12-13 |
2026-07-23 |
Bayer Aktiengesellschaft |
Engineered type v rna programmable endonucleases and their uses
|
|
US20260216373A1
(en)
|
2023-01-13 |
2026-07-30 |
Amicus Therapeutics, Inc. |
Gene Therapy Constructs for the Treatment of Pompe Disease
|
|
KR20250138783A
(ko)
|
2023-02-01 |
2025-09-22 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
rAAV 생산 방법
|
|
WO2024168276A2
(en)
|
2023-02-09 |
2024-08-15 |
Cargo Therapeutics, Inc. |
Compositions and methods for immunotherapies
|
|
JP2026516715A
(ja)
|
2023-04-18 |
2026-05-26 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
肢帯型筋ジストロフィーr9及び先天性筋ジストロフィー1cを治療するための遺伝子療法
|
|
WO2024229115A1
(en)
|
2023-05-02 |
2024-11-07 |
Research Institute At Nationwide Children's Hospital |
Treatment of multiple sclerosis using nt-3 gene therapy
|
|
AU2024265705A1
(en)
|
2023-05-02 |
2025-11-20 |
Research Institute At Nationwide Children's Hospital |
Gene therapy for treatment of protein misfolding diseases
|
|
AU2024265701A1
(en)
|
2023-05-02 |
2025-12-04 |
Research Institute At Nationwide Children's Hospital |
A modular system to convert therapeutic microrna expression cassettes from polymerase iii-based to polymerase ii-based promoters
|
|
WO2024254319A1
(en)
|
2023-06-07 |
2024-12-12 |
Research Institute At Nationwide Children's Hospital |
Gene therapy for lysosomal acid lipase deficiency (lal-d)
|
|
EP4727966A1
(de)
|
2023-06-13 |
2026-04-22 |
Research Institute at Nationwide Children's Hospital |
Materialien und verfahren zur behandlung von neurofibromin-1-mutationen und daraus resultierende erkrankungen
|
|
CN116718524B
(zh)
*
|
2023-06-26 |
2025-11-07 |
西安交通大学 |
一种基于细胞膜色谱技术的病毒颗粒检测方法
|
|
WO2025022290A1
(en)
|
2023-07-21 |
2025-01-30 |
Crispr Therapeutics Ag |
Modulating expression of alas1 (5'-aminolevulinate synthase 1) gene
|
|
EP4512403A1
(de)
|
2023-08-22 |
2025-02-26 |
Friedrich-Schiller-Universität Jena |
Neuropeptid b und w-rezeptor als ziel zur behandlung von stimmungsstörungen und/oder chronischem stress
|
|
TW202521691A
(zh)
|
2023-10-06 |
2025-06-01 |
美商藍岩醫療公司 |
經工程化之v型rna可程式核酸內切酶及其用途
|
|
WO2025096498A1
(en)
|
2023-10-30 |
2025-05-08 |
Research Institute At Nationwide Children's Hospital |
Compositions and methods for treating diseases or conditions associated with progerin expression
|
|
US12655424B2
(en)
|
2024-02-05 |
2026-06-16 |
Amber Bio Inc. |
Methods and compositions for trans-splicing utilizing small nuclear RNAs and small nucleolar RNAs
|
|
WO2025179121A1
(en)
|
2024-02-21 |
2025-08-28 |
Research Institute At Nationwide Children's Hospital |
Exon 17-targeted nucleic acids, compositions, and methods for treatment of dystrophin-based myopathies
|
|
WO2025186726A1
(en)
|
2024-03-05 |
2025-09-12 |
Crispr Therapeutics Ag |
Modulating expression of agt (angiotensinogen) gene
|
|
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(en)
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