ATE314116T1 - Verwendung von roxithromycin zur herstellung eines medikaments zur verbesserung der biologischen und antiviralen aktivität von protease-inhibitoren - Google Patents

Verwendung von roxithromycin zur herstellung eines medikaments zur verbesserung der biologischen und antiviralen aktivität von protease-inhibitoren

Info

Publication number: ATE314116T1
Authority: AT; Austria
Prior art keywords: protease inhibitors; roxithromycin; medication; biological; producing
Prior art date: 1995-08-30

Application number

AT96929058T

Other languages

English (en)

Inventor

Raymond F Schinazi

Jean-Pierre Sommadossi

Original Assignee

Uab Research Foundation

Raymond F Schinazi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-30

Filing date

1996-08-30

Publication date

2006-01-15

1996-08-30 Application filed by Uab Research Foundation, Raymond F Schinazi filed Critical Uab Research Foundation

2006-01-15 Application granted granted Critical

2006-01-15 Publication of ATE314116T1 publication Critical patent/ATE314116T1/de

Links

239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 4
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
230000004071 biological effect Effects 0.000 title 1
229940079593 drug Drugs 0.000 title 1
229960005224 roxithromycin Drugs 0.000 title 1
229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 2
229940122440 HIV protease inhibitor Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
230000004700 cellular uptake Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000004030 hiv protease inhibitor Substances 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Tropical Medicine & Parasitology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
AIDS & HIV (AREA)
Bioinformatics & Cheminformatics (AREA)
Crystallography & Structural Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT96929058T 1995-08-30 1996-08-30 Verwendung von roxithromycin zur herstellung eines medikaments zur verbesserung der biologischen und antiviralen aktivität von protease-inhibitoren ATE314116T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/521,474 US5750493A (en)	1995-08-30	1995-08-30	Method to improve the biological and antiviral activity of protease inhibitors
PCT/US1996/013721 WO1997008180A1 (en)	1995-08-30	1996-08-30	Method to improve the biological and antiviral activity of protease inhibitors

Publications (1)

Publication Number	Publication Date
ATE314116T1 true ATE314116T1 (de)	2006-01-15

Family

ID=24076871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96929058T ATE314116T1 (de)	1995-08-30	1996-08-30	Verwendung von roxithromycin zur herstellung eines medikaments zur verbesserung der biologischen und antiviralen aktivität von protease-inhibitoren

Country Status (11)

Country	Link
US (1)	US5750493A (de)
EP (1)	EP0876387B1 (de)
JP (1)	JP4335311B2 (de)
KR (1)	KR100454663B1 (de)
AT (1)	ATE314116T1 (de)
AU (1)	AU716821B2 (de)
DE (1)	DE69635671T2 (de)
DK (1)	DK0876387T3 (de)
ES (1)	ES2257752T3 (de)
PT (1)	PT876387E (de)
WO (1)	WO1997008180A1 (de)

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ES2140329B1 (es) *	1997-12-04	2000-10-16	Univ Granada	Utilizacion de acido maslinico como inhibidor de proteasas para el tratamiento de la enfermedad causada por los virus de la inmunodeficiencia adquirida.
US6436989B1 (en) *	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
US6734192B1 (en) *	1999-08-23	2004-05-11	Mp-1 Inc.	Treatment of viral infections
ITMI992711A1 (it) *	1999-12-27	2001-06-27	Novartis Ag	Composti organici
NZ521368A (en) *	2000-03-28	2004-05-28	Biochemie Ges M	Granulated particles of an active compound, with a film-forming coating resulting in the masked taste of said active compound
US6566401B2 (en) *	2001-03-30	2003-05-20	The Board Of Trustees Of The Leland Stanford Junior University	N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
EP1265073A3 (de) *	2001-06-05	2003-11-26	Tibotec Pharmaceuticals Ltd.	Verfahren zum Nachweis von der Plasmakonzentration von freien Arzneimitteln
US7271154B2 (en) *	2002-02-15	2007-09-18	Merckle Gmbh	Antibiotic conjugates
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AU2003208751A1 (en) *	2002-02-22	2003-09-09	Tibotec Bvba	Methods for determining the influence of protein binding on antiretroviral activity
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US7553844B2 (en)	2003-02-21	2009-06-30	Jarrow Formulas, Inc.	Methods for treatment of HIV or malaria using combinations of chloroquine and protease inhibitors
WO2005002626A2 (en) *	2003-04-25	2005-01-13	Gilead Sciences, Inc.	Therapeutic phosphonate compounds
US7452901B2 (en) *	2003-04-25	2008-11-18	Gilead Sciences, Inc.	Anti-cancer phosphonate analogs
EA014685B1 (ru) *	2003-04-25	2010-12-30	Джилид Сайэнс, Инк.	Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
US20050261237A1 (en) *	2003-04-25	2005-11-24	Boojamra Constantine G	Nucleoside phosphonate analogs
US20090247488A1 (en) *	2003-04-25	2009-10-01	Carina Cannizzaro	Anti-inflammatory phosphonate compounds
CN101410120A (zh) *	2003-04-25	2009-04-15	吉里德科学公司	抗炎的膦酸酯化合物
US7427636B2 (en) *	2003-04-25	2008-09-23	Gilead Sciences, Inc.	Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
US7407965B2 (en) *	2003-04-25	2008-08-05	Gilead Sciences, Inc.	Phosphonate analogs for treating metabolic diseases
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US7470724B2 (en) *	2003-04-25	2008-12-30	Gilead Sciences, Inc.	Phosphonate compounds having immuno-modulatory activity
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US7427624B2 (en) *	2003-10-24	2008-09-23	Gilead Sciences, Inc.	Purine nucleoside phosphorylase inhibitory phosphonate compounds
EP1678321A1 (de) *	2003-10-24	2006-07-12	Gilead Sciences, Inc.	Verfahren und zusammensetzungen zur identifizierung therapeutischer verbindungen
US7432273B2 (en) *	2003-10-24	2008-10-07	Gilead Sciences, Inc.	Phosphonate analogs of antimetabolites
EP1706405B1 (de) *	2003-12-22	2009-03-04	Gilead Sciences, Inc.	4'-substituierte carbovir- und abacavir-derivate sowie verwandte verbindungen mit hiv- und hcv-antiviraler wirkung
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1995
- 1995-08-30 US US08/521,474 patent/US5750493A/en not_active Expired - Lifetime
1996
- 1996-08-30 AT AT96929058T patent/ATE314116T1/de not_active IP Right Cessation
- 1996-08-30 EP EP96929058A patent/EP0876387B1/de not_active Expired - Lifetime
- 1996-08-30 WO PCT/US1996/013721 patent/WO1997008180A1/en not_active Ceased
- 1996-08-30 ES ES96929058T patent/ES2257752T3/es not_active Expired - Lifetime
- 1996-08-30 KR KR10-1998-0701498A patent/KR100454663B1/ko not_active Expired - Fee Related
- 1996-08-30 DE DE69635671T patent/DE69635671T2/de not_active Expired - Lifetime
- 1996-08-30 JP JP51050297A patent/JP4335311B2/ja not_active Expired - Fee Related
- 1996-08-30 AU AU68601/96A patent/AU716821B2/en not_active Ceased
- 1996-08-30 PT PT96929058T patent/PT876387E/pt unknown
- 1996-08-30 DK DK96929058T patent/DK0876387T3/da active

Also Published As

Publication number	Publication date
KR19990044262A (ko)	1999-06-25
EP0876387A1 (de)	1998-11-11
KR100454663B1 (ko)	2004-12-29
AU716821B2 (en)	2000-03-09
DK0876387T3 (da)	2006-05-29
DE69635671T2 (de)	2006-09-07
AU6860196A (en)	1997-03-19
EP0876387A4 (de)	1999-12-01
JP4335311B2 (ja)	2009-09-30
DE69635671D1 (de)	2006-02-02
PT876387E (pt)	2006-05-31
EP0876387B1 (de)	2005-12-28
WO1997008180A1 (en)	1997-03-06
US5750493A (en)	1998-05-12
ES2257752T3 (es)	2006-08-01
JP2001500471A (ja)	2001-01-16

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2006-12-15

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Publication	Publication Date	Title
ATE314116T1 (de)	2006-01-15	Verwendung von roxithromycin zur herstellung eines medikaments zur verbesserung der biologischen und antiviralen aktivität von protease-inhibitoren
WO2003034803A8 (en)	2003-11-27	Methods for determining toxicity reversing agents
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PT1019040E (pt)	2005-01-31	Inibicao da actividade de p38-quinase por meio de arilureias
ES2133807T3 (es)	1999-09-16	Compuestos de peptidilo y su uso terapeutico como inhibidores de metaloproteasas.
ATE179429T1 (de)	1999-05-15	Cytokine dämpfende substanzen
BRPI0509172A (pt)	2007-08-28	pelo menos uma entidade quìmica, composição farmacêutica, métodos para tratar um paciente, para inibir pelo menos uma enzima que utiliza atp, e para tratar pelo menos uma doença, uso de pelo menos uma entidade quìmica, e, método para a fabricação de um medicamento
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AU2180501A (en)	2001-06-12	Novel DNA polymerase inhibitors, mikanolide and dihydromikanolide
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ATE251462T1 (de)	2003-10-15	Verfahren zur behandlung von narbengewebe
NO951277L (no)	1995-04-03	Desulfatohirudin med höy molekylvekt
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