ATE314350T1 - Malonsäure derivate, verfahren zu ihrer herstellung, ihre verwendung als inhibitor der faktor xa aktivität und pharmazeutische zusammensetzungen diese enthaltend - Google Patents

Malonsäure derivate, verfahren zu ihrer herstellung, ihre verwendung als inhibitor der faktor xa aktivität und pharmazeutische zusammensetzungen diese enthaltend

Info

Publication number: ATE314350T1
Authority: AT; Austria
Prior art keywords: inhibitor; factor; activity; production; pharmaceutical compositions
Prior art date: 2000-02-26

Application number

AT01907546T

Other languages

English (en)

Inventor

Fahad Al-Obeidi

Armin Walser

Peter Wildgoose

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-26

Filing date

2001-02-21

Publication date

2006-01-15

2001-02-21 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2006-01-15 Application granted granted Critical

2006-01-15 Publication of ATE314350T1 publication Critical patent/ATE314350T1/de

Links

108010074860 Factor Xa Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000002690 malonic acid derivatives Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Crystallography & Structural Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Oncology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)

AT01907546T 2000-02-26 2001-02-21 Malonsäure derivate, verfahren zu ihrer herstellung, ihre verwendung als inhibitor der faktor xa aktivität und pharmazeutische zusammensetzungen diese enthaltend ATE314350T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00104041A EP1127884A1 (de)	2000-02-26	2000-02-26	Neue Malonsäure Derivaie, Verfahren zu ihrer Herstellung, ihre Verwendung als Inhibitor der Faktor XA Aktivtät und pharmazeutische Zusammensetzungen diese enthaltend
PCT/EP2001/001928 WO2001062735A1 (en)	2000-02-26	2001-02-21	Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor xa activity and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
ATE314350T1 true ATE314350T1 (de)	2006-01-15

Family

ID=8167968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01907546T ATE314350T1 (de)	2000-02-26	2001-02-21	Malonsäure derivate, verfahren zu ihrer herstellung, ihre verwendung als inhibitor der faktor xa aktivität und pharmazeutische zusammensetzungen diese enthaltend

Country Status (23)

Country	Link
US (1)	US6794365B2 (de)
EP (2)	EP1127884A1 (de)
JP (1)	JP2003524001A (de)
KR (1)	KR20020079892A (de)
CN (1)	CN1406226A (de)
AR (1)	AR027533A1 (de)
AT (1)	ATE314350T1 (de)
AU (1)	AU2001235486A1 (de)
BR (1)	BR0108694A (de)
CA (1)	CA2400871C (de)
CZ (1)	CZ20022862A3 (de)
DE (1)	DE60116272T2 (de)
ES (1)	ES2254370T3 (de)
HK (1)	HK1052696A1 (de)
HU (1)	HUP0300080A3 (de)
IL (1)	IL151459A0 (de)
MX (1)	MXPA02007398A (de)
NO (1)	NO20024040L (de)
NZ (1)	NZ520982A (de)
PL (1)	PL357183A1 (de)
RU (1)	RU2002125671A (de)
WO (1)	WO2001062735A1 (de)
ZA (1)	ZA200206581B (de)

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US20030224023A1 (en) *	2002-05-29	2003-12-04	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Cosmetic compositions with hydroxy amine salts of malonic acid
US20040185073A1 (en) *	2003-03-17	2004-09-23	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Cosmetic compositions containing salts of malonic acid
US20040185015A1 (en) *	2003-03-17	2004-09-23	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Sunscreen cosmetic compositions storage stabilized with malonate salts
US20040202689A1 (en) *	2003-03-17	2004-10-14	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Terpenoid fragrance components stabilized with malonic acid salts
US20040185074A1 (en) *	2003-03-17	2004-09-23	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Odor control in amine salt containing cosmetic compositions
EP1891044A1 (de) *	2005-03-24	2008-02-27	Warner-Lambert Company LLC	Kristalline formen einer bekannten, als faktor-xa-inhibitor wirkenden pyrrolidinverbindung
US10414839B2 (en)	2010-10-20	2019-09-17	Sirrus, Inc.	Polymers including a methylene beta-ketoester and products formed therefrom
US9249265B1 (en)	2014-09-08	2016-02-02	Sirrus, Inc.	Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US9828324B2 (en)	2010-10-20	2017-11-28	Sirrus, Inc.	Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US9279022B1 (en)	2014-09-08	2016-03-08	Sirrus, Inc.	Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
EP2630191A4 (de)	2010-10-20	2015-05-20	Sirrus Inc	Synthese substantiell verunreinigungsfreier methylen-malonate
CA2853073A1 (en)	2011-10-19	2013-04-25	Bioformix Inc.	Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US9181365B2 (en)	2012-03-30	2015-11-10	Sirrus, Inc.	Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
US10913875B2 (en)	2012-03-30	2021-02-09	Sirrus, Inc.	Composite and laminate articles and polymerizable systems for producing the same
US9234107B2 (en)	2012-03-30	2016-01-12	Sirrus, Inc.	Ink coating formulations and polymerizable systems for producing the same
US10047192B2 (en)	2012-06-01	2018-08-14	Sirrus, Inc.	Optical material and articles formed therefrom
EP2920231B1 (de)	2012-11-16	2020-05-06	Sirrus, Inc.	Kunststoffverbindungssysteme und verfahren
CN105164797B (zh)	2012-11-30	2019-04-19	瑟拉斯公司	用于电子应用的复合组合物
WO2014110388A1 (en)	2013-01-11	2014-07-17	Bioformix Inc.	Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9315597B2 (en)	2014-09-08	2016-04-19	Sirrus, Inc.	Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9416091B1 (en)	2015-02-04	2016-08-16	Sirrus, Inc.	Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US10501400B2 (en)	2015-02-04	2019-12-10	Sirrus, Inc.	Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en)	2015-05-29	2016-05-10	Sirrus, Inc.	Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en)	2015-06-01	2015-12-22	Sirrus, Inc.	Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en)	2016-05-13	2016-12-13	Sirrus, Inc.	High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9617377B1 (en)	2016-06-03	2017-04-11	Sirrus, Inc.	Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en)	2016-06-03	2019-02-05	Sirrus, Inc.	Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US10428177B2 (en)	2016-06-03	2019-10-01	Sirrus, Inc.	Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US9567475B1 (en)	2016-06-03	2017-02-14	Sirrus, Inc.	Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
CN106501472A (zh) *	2016-11-29	2017-03-15	昆明理工大学	一种基于抗凝血生化指数评价三七活血作用的方法
CN112321451B (zh) *	2019-12-13	2022-08-23	福建海西新药创制有限公司	一种用于制备盐酸西那卡塞药物中间体的方法
US11806387B1 (en) *	2022-05-20	2023-11-07	Radius Health, Inc.	Process of making abaloparatide
CN115299636B (zh) *	2022-08-17	2025-02-14	中国烟草总公司郑州烟草研究院	一种卷烟滤嘴用功能吸附丸芯及其制备方法和烟支

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KR920703558A (ko) *	1990-11-15	1992-12-18	원본미기재	메타-치환 페닐알라닌 유도체
WO1994018185A1 (de) *	1993-02-10	1994-08-18	Pentapharm Ag	Piperazide von substituierten phenylalanin-derivativen als thrombin inhibitoren
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WO1996005189A1 (de) *	1994-08-09	1996-02-22	Pentapharm Ag	Neue inhibitoren vom benzamidintyp
SK281432B6 (sk) *	1995-12-20	2001-03-12	Hoechst Marion Roussel, Inc.	Spôsob prípravy n-acetyl-(l)-4-kyanofenylalanínu ac-(l)-phe(4- -cn)-oh a n-acetyl-(l)-p-amidinofenylalanín-cyklohexylglycín- -beta-(3-n-metylpyridínium)-alanínu ac-(l)-paph-chg-palme(3)-nh2
TR199902692T2 (xx) *	1997-05-02	2000-07-21	Akzo Nobel N.V.	Serin proteaz inhibit�rleri.
US6037356A (en) *	1997-11-26	2000-03-14	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
BR9814340B1 (pt)	1997-12-24	2010-07-13		compostos derivados de indol, processo para a preparação dos mesmo e composição farmacêutica.
JP3283485B2 (ja) *	1998-04-10	2002-05-20	日本たばこ産業株式会社	アミジン化合物
DE69924527T2 (de)	1999-01-02	2006-02-09	Sanofi-Aventis Deutschland Gmbh	Arylalkanoylderivate, verfahren zu ihrer herstellung, ihre verwendung und diese enthaltende pharmazeutische zubereitungen
EP1016663A1 (de) *	1999-01-02	2000-07-05	Aventis Pharma Deutschland GmbH	Neue Malonsäure Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung und pharmazeutische Zusammensetzungen sie enthaltend (Inhibierung der Faktor Xa Aktivität)
CA2358578A1 (en) *	1999-01-02	2000-07-13	Aventis Pharma Deutschland Gmbh	Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor xa activity)

2000
- 2000-02-26 EP EP00104041A patent/EP1127884A1/de not_active Withdrawn
2001
- 2001-02-21 CN CN01805589A patent/CN1406226A/zh active Pending
- 2001-02-21 AU AU2001235486A patent/AU2001235486A1/en not_active Abandoned
- 2001-02-21 IL IL15145901A patent/IL151459A0/xx unknown
- 2001-02-21 HK HK03104942.8A patent/HK1052696A1/zh unknown
- 2001-02-21 CZ CZ20022862A patent/CZ20022862A3/cs unknown
- 2001-02-21 WO PCT/EP2001/001928 patent/WO2001062735A1/en not_active Ceased
- 2001-02-21 NZ NZ520982A patent/NZ520982A/en unknown
- 2001-02-21 ES ES01907546T patent/ES2254370T3/es not_active Expired - Lifetime
- 2001-02-21 BR BR0108694-4A patent/BR0108694A/pt not_active Application Discontinuation
- 2001-02-21 DE DE60116272T patent/DE60116272T2/de not_active Expired - Lifetime
- 2001-02-21 CA CA2400871A patent/CA2400871C/en not_active Expired - Fee Related
- 2001-02-21 JP JP2001562517A patent/JP2003524001A/ja active Pending
- 2001-02-21 KR KR1020027011004A patent/KR20020079892A/ko not_active Withdrawn
- 2001-02-21 RU RU2002125671/04A patent/RU2002125671A/ru not_active Application Discontinuation
- 2001-02-21 EP EP01907546A patent/EP1265867B1/de not_active Expired - Lifetime
- 2001-02-21 HU HU0300080A patent/HUP0300080A3/hu unknown
- 2001-02-21 MX MXPA02007398A patent/MXPA02007398A/es active IP Right Grant
- 2001-02-21 AT AT01907546T patent/ATE314350T1/de not_active IP Right Cessation
- 2001-02-21 PL PL01357183A patent/PL357183A1/xx not_active Application Discontinuation
- 2001-02-22 AR ARP010100806A patent/AR027533A1/es not_active Application Discontinuation
- 2001-02-23 US US09/790,641 patent/US6794365B2/en not_active Expired - Lifetime
2002
- 2002-08-16 ZA ZA200206581A patent/ZA200206581B/en unknown
- 2002-08-23 NO NO20024040A patent/NO20024040L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20020079892A (ko)	2002-10-19
NZ520982A (en)	2004-05-28
ES2254370T3 (es)	2006-06-16
EP1127884A1 (de)	2001-08-29
CN1406226A (zh)	2003-03-26
DE60116272T2 (de)	2006-08-17
CZ20022862A3 (cs)	2002-11-13
RU2002125671A (ru)	2004-01-10
DE60116272D1 (de)	2006-02-02
MXPA02007398A (es)	2002-12-09
IL151459A0 (en)	2003-04-10
AU2001235486A1 (en)	2001-09-03
BR0108694A (pt)	2002-12-10
US20020022596A1 (en)	2002-02-21
HUP0300080A2 (hu)	2003-06-28
JP2003524001A (ja)	2003-08-12
WO2001062735A1 (en)	2001-08-30
NO20024040D0 (no)	2002-08-23
HK1052696A1 (zh)	2003-09-26
CA2400871C (en)	2011-04-26
CA2400871A1 (en)	2001-08-30
EP1265867B1 (de)	2005-12-28
HUP0300080A3 (en)	2004-07-28
NO20024040L (no)	2002-09-24
ZA200206581B (en)	2003-07-28
PL357183A1 (en)	2004-07-26
EP1265867A1 (de)	2002-12-18
AR027533A1 (es)	2003-04-02
US6794365B2 (en)	2004-09-21

Legal Events

Date	Code	Title	Description
2006-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60116272D1 (de)	2006-02-02	Malonsäure derivate, verfahren zu ihrer herstellung, ihre verwendung als inhibitor der faktor xa aktivität und pharmazeutische zusammensetzungen diese enthaltend
ATE252562T1 (de)	2003-11-15	Pyrazolcarbonsäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE602004029236D1 (de)	2010-11-04	Cyclische harnstoffderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung als kinaseinhibitoren
ATE388944T1 (de)	2008-03-15	Indanessigsäure-derivate und ihre verwendung als pharmazeutische mittel, zwischenprodukten und verfahren zur herstellung
DE60215851D1 (de)	2006-12-14	N-adamantylmethyl-derivate und zwischenprodukte als pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung
ATE265424T1 (de)	2004-05-15	Acylphenylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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