ATE314372T1 - Therapeutische verbindungen - Google Patents
Therapeutische verbindungenInfo
- Publication number
- ATE314372T1 ATE314372T1 AT99903533T AT99903533T ATE314372T1 AT E314372 T1 ATE314372 T1 AT E314372T1 AT 99903533 T AT99903533 T AT 99903533T AT 99903533 T AT99903533 T AT 99903533T AT E314372 T1 ATE314372 T1 AT E314372T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- derivatives
- opioid
- morphine
- relates
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 230000001225 therapeutic effect Effects 0.000 title 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 4
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 2
- 229960005181 morphine Drugs 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 abstract 1
- 229960001736 buprenorphine Drugs 0.000 abstract 1
- 229960004126 codeine Drugs 0.000 abstract 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP1530A AUPP153098A0 (en) | 1998-01-29 | 1998-01-29 | Therapeutic compounds |
| AUPP3114A AUPP311498A0 (en) | 1998-04-21 | 1998-04-21 | Therapeutic compounds |
| AUPP5046A AUPP504698A0 (en) | 1998-08-04 | 1998-08-04 | Therapeutic compounds |
| PCT/AU1999/000062 WO1999038869A1 (en) | 1998-01-29 | 1999-01-29 | Therapeutic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE314372T1 true ATE314372T1 (de) | 2006-01-15 |
Family
ID=27158064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99903533T ATE314372T1 (de) | 1998-01-29 | 1999-01-29 | Therapeutische verbindungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6784186B1 (de) |
| EP (1) | EP1053238B1 (de) |
| JP (1) | JP2002501923A (de) |
| AT (1) | ATE314372T1 (de) |
| CA (1) | CA2319627A1 (de) |
| DE (1) | DE69929173T2 (de) |
| WO (1) | WO1999038869A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| CN1507448A (zh) * | 2001-03-02 | 2004-06-23 | ���ŷ� | N-丁-3-烯基降丁丙诺啡及其作为止痛药的用途 |
| AU2002322169B2 (en) * | 2001-08-10 | 2008-10-30 | Monash University | Derivatives of morphine-like opioid compounds |
| US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20060014697A1 (en) | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US7375082B2 (en) * | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| US7338939B2 (en) * | 2003-09-30 | 2008-03-04 | New River Pharmaceuticals Inc. | Abuse-resistant hydrocodone compounds |
| US20070066537A1 (en) * | 2002-02-22 | 2007-03-22 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| CA2474306A1 (en) * | 2002-01-25 | 2003-08-07 | Regents Of The University Of Minnesota | Selective analgesic agents |
| US7700561B2 (en) * | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
| CA2477038A1 (en) * | 2002-02-22 | 2003-09-04 | New River Pharmaceuticals | Use of peptide-drug conjugation to reduce inter-subject variability of drug serum levels |
| US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
| JP4878732B2 (ja) | 2002-02-22 | 2012-02-15 | シャイア エルエルシー | 規制物質の濫用を防ぐための新規な持続放出製薬化合物 |
| US7659253B2 (en) | 2002-02-22 | 2010-02-09 | Shire Llc | Abuse-resistant amphetamine prodrugs |
| AU2002951965A0 (en) * | 2002-10-09 | 2002-10-24 | Monash University | Amidine compounds |
| US20040204862A1 (en) * | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
| BRPI0410792B8 (pt) * | 2003-05-29 | 2021-05-25 | New River Pharmaceuticals Inc | compostos de anfetamina resistentes à dependencia |
| MXPA06003619A (es) * | 2003-09-30 | 2008-01-14 | New River Pharmaceuticals Inc | Composiciones farmaceuticas para prevencion de sobredosis o abuso. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3341538A (en) | 1965-06-18 | 1967-09-12 | Geigy Chem Corp | Certain 2, 6-methano-3-benzazocines |
| JPS491567A (de) * | 1972-05-08 | 1974-01-08 | ||
| DE2245141A1 (de) * | 1972-09-14 | 1974-03-21 | Boehringer Sohn Ingelheim | Neue n-(heteroarylmethyl)-desoxynormorphine und -norcodeine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| JPS4972261A (de) * | 1972-11-18 | 1974-07-12 | ||
| FR2296420A1 (fr) * | 1975-01-02 | 1976-07-30 | Esteve Labor Dr | Nouveaux derives de morphine doues de proprietes antitussives et analgesiques |
| US4108857A (en) * | 1975-08-18 | 1978-08-22 | Sterling Drug Inc. | Imidazolylmethyl methanobenzazocines |
| NL7804509A (nl) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan. |
| US4806556A (en) * | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US5977326A (en) * | 1991-08-06 | 1999-11-02 | Salford Ultrafine Chemicals And Research Limited | Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
| EP0635019B1 (de) | 1992-04-06 | 1999-05-26 | Biosite Diagnostics Inc. | Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden |
| AU685752B2 (en) * | 1992-06-30 | 1998-01-29 | Arqule, Inc. | Aminimide-containing molecules and materials as molecular recognition agents |
| CA2179983A1 (en) | 1993-12-28 | 1995-07-06 | Joseph C. Hogan, Jr. | Modular design and synthesis of aminimide containing molecules |
-
1999
- 1999-01-29 AT AT99903533T patent/ATE314372T1/de not_active IP Right Cessation
- 1999-01-29 DE DE69929173T patent/DE69929173T2/de not_active Expired - Fee Related
- 1999-01-29 JP JP2000529336A patent/JP2002501923A/ja active Pending
- 1999-01-29 WO PCT/AU1999/000062 patent/WO1999038869A1/en not_active Ceased
- 1999-01-29 US US09/582,059 patent/US6784186B1/en not_active Expired - Fee Related
- 1999-01-29 CA CA002319627A patent/CA2319627A1/en not_active Abandoned
- 1999-01-29 EP EP99903533A patent/EP1053238B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1053238A4 (de) | 2003-09-03 |
| EP1053238B1 (de) | 2005-12-28 |
| US6784186B1 (en) | 2004-08-31 |
| JP2002501923A (ja) | 2002-01-22 |
| DE69929173D1 (de) | 2006-02-02 |
| WO1999038869A1 (en) | 1999-08-05 |
| DE69929173T2 (de) | 2006-08-24 |
| CA2319627A1 (en) | 1999-08-05 |
| EP1053238A1 (de) | 2000-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |