ATE218551T1 - Tetracyclische verbindungen - Google Patents
Tetracyclische verbindungenInfo
- Publication number
- ATE218551T1 ATE218551T1 AT94927786T AT94927786T ATE218551T1 AT E218551 T1 ATE218551 T1 AT E218551T1 AT 94927786 T AT94927786 T AT 94927786T AT 94927786 T AT94927786 T AT 94927786T AT E218551 T1 ATE218551 T1 AT E218551T1
- Authority
- AT
- Austria
- Prior art keywords
- tetracyclic compounds
- immunosuppressant
- remedy
- chem
- useful
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24136093 | 1993-09-28 | ||
| PCT/JP1994/001591 WO1995009153A1 (en) | 1993-09-28 | 1994-09-28 | Novel tetracyclic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218551T1 true ATE218551T1 (de) | 2002-06-15 |
Family
ID=17073136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94927786T ATE218551T1 (de) | 1993-09-28 | 1994-09-28 | Tetracyclische verbindungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5646283A (de) |
| EP (1) | EP0721942B1 (de) |
| AT (1) | ATE218551T1 (de) |
| AU (1) | AU7707094A (de) |
| CA (1) | CA2150235A1 (de) |
| DE (1) | DE69430752T2 (de) |
| ES (1) | ES2177583T3 (de) |
| WO (1) | WO1995009153A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981541A (en) * | 1996-09-23 | 1999-11-09 | Rutgers, The State University Of New Jersey | Substituted heterocycles as anti-tumor agents |
| US6841561B1 (en) | 1999-10-01 | 2005-01-11 | Institute Of Molecular And Cell Biology | Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases |
| AU7622000A (en) * | 1999-10-01 | 2001-05-10 | Institute Of Molecular And Cell Biology | Compounds for the treatment of viral-mediated diseases |
| US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| WO2003041653A2 (en) * | 2001-11-14 | 2003-05-22 | Rutgers, The State University | Cytotoxic agents |
| CA2467774C (en) | 2001-11-14 | 2011-09-20 | Rutgers, The State University | Solubilized topoisomerase poisons |
| JP4789414B2 (ja) * | 2001-11-14 | 2011-10-12 | ラトガーズ，ザ ステイト ユニバーシティ | 可溶化トポイソメラーゼ毒性剤 |
| DE60225943T2 (de) * | 2001-11-14 | 2009-01-29 | Rutgers, The State University | Topoisomerase-giftmittel |
| US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| AU2003265406A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
| JP4774212B2 (ja) * | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | トポイソメラーゼ−ターゲッティング剤 |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| WO2009038731A2 (en) * | 2007-09-17 | 2009-03-26 | The Trustees Of Columbia University In The City Of New York | Synthesis of resveratrol-based natural products |
| WO2010102219A1 (en) | 2009-03-06 | 2010-09-10 | Rutgers, The State University Of New Jersey | Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| WO2011103442A2 (en) * | 2010-02-18 | 2011-08-25 | The Trustees Of Columbia University In The City Of New York | Synthesis of the potent immunosuppressant agents dalesconol a and b |
| AU2014352920A1 (en) | 2013-11-22 | 2016-06-23 | Genzyme Corporation | Novel methods for treating neurodegenerative diseases |
| WO2017176648A1 (en) | 2016-04-04 | 2017-10-12 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0233661A (ja) * | 1988-07-22 | 1990-02-02 | Sharp Corp | 住所自動入力機能付文字処理装置 |
| US4918077A (en) * | 1989-01-25 | 1990-04-17 | E. I. Du Pont De Nemours & Co., Inc. | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents |
| US5135934A (en) * | 1990-07-06 | 1992-08-04 | Du Pont Merck Pharmaceutical Company | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
| EP0601191B1 (de) * | 1992-04-24 | 1998-07-22 | Kyowa Hakko Kogyo Kabushiki Kaisha | Neue tetracyclische verbindungen |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
-
1994
- 1994-09-28 CA CA002150235A patent/CA2150235A1/en not_active Abandoned
- 1994-09-28 US US08/436,370 patent/US5646283A/en not_active Expired - Fee Related
- 1994-09-28 DE DE69430752T patent/DE69430752T2/de not_active Expired - Fee Related
- 1994-09-28 WO PCT/JP1994/001591 patent/WO1995009153A1/ja not_active Ceased
- 1994-09-28 ES ES94927786T patent/ES2177583T3/es not_active Expired - Lifetime
- 1994-09-28 AT AT94927786T patent/ATE218551T1/de not_active IP Right Cessation
- 1994-09-28 AU AU77070/94A patent/AU7707094A/en not_active Abandoned
- 1994-09-28 EP EP94927786A patent/EP0721942B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU7707094A (en) | 1995-04-18 |
| DE69430752T2 (de) | 2002-10-17 |
| DE69430752D1 (de) | 2002-07-11 |
| WO1995009153A1 (en) | 1995-04-06 |
| CA2150235A1 (en) | 1995-04-06 |
| EP0721942A4 (de) | 1997-03-05 |
| US5646283A (en) | 1997-07-08 |
| ES2177583T3 (es) | 2002-12-16 |
| EP0721942A1 (de) | 1996-07-17 |
| EP0721942B1 (de) | 2002-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |