ATE314460T1 - Antigenpräsentierende zellen, ein verfahren zur deren herstellung und deren verwendung als zelluläre impfstoffen - Google Patents

Antigenpräsentierende zellen, ein verfahren zur deren herstellung und deren verwendung als zelluläre impfstoffen

Info

Publication number
ATE314460T1
ATE314460T1 AT97924012T AT97924012T ATE314460T1 AT E314460 T1 ATE314460 T1 AT E314460T1 AT 97924012 T AT97924012 T AT 97924012T AT 97924012 T AT97924012 T AT 97924012T AT E314460 T1 ATE314460 T1 AT E314460T1
Authority
AT
Austria
Prior art keywords
macrophages
antigen
allogenic
determined
yeast
Prior art date
Application number
AT97924012T
Other languages
English (en)
Inventor
Mohamed Chokri
Jacques Bartholeyns
Jean-Loup Romet-Lemonne
Original Assignee
Idm Immuno Designed Molecules
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idm Immuno Designed Molecules filed Critical Idm Immuno Designed Molecules
Application granted granted Critical
Publication of ATE314460T1 publication Critical patent/ATE314460T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/80—Neurotransmitters; Neurohormones
    • C12N2501/82—Histamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT97924012T 1996-05-21 1997-05-15 Antigenpräsentierende zellen, ein verfahren zur deren herstellung und deren verwendung als zelluläre impfstoffen ATE314460T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96401099A EP0808897A1 (de) 1996-05-21 1996-05-21 Antigenpräsentierende Zellen, ein Verfahren zur deren Herstellung und deren Verwendung als zelluläre Impfstoffen
PCT/EP1997/002703 WO1997044441A1 (en) 1996-05-21 1997-05-15 New antigen presenting cells, a process for preparing the same and their use as cellular vaccines

Publications (1)

Publication Number Publication Date
ATE314460T1 true ATE314460T1 (de) 2006-01-15

Family

ID=8225258

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97924012T ATE314460T1 (de) 1996-05-21 1997-05-15 Antigenpräsentierende zellen, ein verfahren zur deren herstellung und deren verwendung als zelluläre impfstoffen

Country Status (9)

Country Link
US (3) US20020182725A1 (de)
EP (2) EP0808897A1 (de)
JP (1) JP3428025B2 (de)
AT (1) ATE314460T1 (de)
AU (1) AU732536C (de)
DE (1) DE69734989T2 (de)
DK (1) DK0925356T3 (de)
ES (1) ES2256886T3 (de)
WO (1) WO1997044441A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1066370A1 (de) * 1998-03-30 2001-01-10 I.D.M. Immuno-Designed Molecules Stimulierte monocyten-stammende zellen, deren herstellungsverfahren und verwendungen
AU3601299A (en) * 1998-04-09 1999-11-01 I.D.M. Immuno-Designed Molecules Use of monocytes derived cells and antibodies in a synergic way for optimal induction of immunotherapeutic efficiency
US20020168347A1 (en) * 1998-04-09 2002-11-14 Jacques Bartholeyns Use of monocytes derived cells, antigens and antibodies for optimal induction of immunotherapeutic efficiency
JP2002514408A (ja) 1998-05-11 2002-05-21 インセルム（アンスティチュ・ナショナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） 新規アポトーシス小体、それを含有する単球由来細胞、それらの調製方法、及びワクチンとしてのそれらの使用
DE19950262C2 (de) * 1999-10-18 2001-09-13 Martin Foermer Verfahren zur Durchführung eines durchflusszytometrischen Phagozytosetests
EP1259592A1 (de) * 2000-01-11 2002-11-27 Maxygen, Inc. Monozyten abgeleitete dendritische zellen untegruppen
US20020094323A1 (en) 2000-10-12 2002-07-18 Kristoffer Hellstrand Methods and compositions for promoting the maturation of monocytes
US20040072140A1 (en) * 2000-12-07 2004-04-15 Jacques Bartholeyns Dehydrated antigen presenting cells usable for vaccination
FR2819263B1 (fr) * 2001-01-10 2003-04-11 Lco Sante Procede de maturation des cellules dendritiques et d'activation des macrophages avec le ru 41740
DE10135615A1 (de) * 2001-07-21 2003-02-06 Genethor Gmbh Ex vivo Selektion von T-Zellen
WO2003010301A1 (en) * 2001-07-25 2003-02-06 I.D.M. Immuno-Designed Molecules New isolated dendritic cells, a process for preparing the same and their use in pharmaceutical compositions
DK1592441T3 (da) * 2003-02-06 2012-05-14 Aduro Biotech Listeria, hvis indtrængen i ikke-phagocytiske celler er svækket, vacciner omfattende listeria og fremgangsmåder til anvendelse deraf
WO2004084936A2 (en) * 2003-02-06 2004-10-07 Cerus Corporation Modified free-living microbes, vaccine compositions and methods of use thereof
US7695725B2 (en) * 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
DE10339905B4 (de) 2003-08-29 2009-04-23 Kist-Europe Forschungsgesellschaft Mbh Implantierbarer Mikrozellprozessor zur Krankheitsbehandlung
US7842289B2 (en) * 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
JPWO2019244973A1 (ja) * 2018-06-20 2021-07-08 中外製薬株式会社 標的細胞に対する免疫反応を活性化する方法およびその組成物
EP3999081A1 (de) * 2019-07-18 2022-05-25 GPB Scientific, Inc. Geordnete verarbeitung von blutprodukten zur herstellung von therapeutisch aktiven zellen
CN113244383B (zh) * 2021-06-11 2021-09-10 诺赛联合(北京)生物医学科技有限公司 一种dc瘤苗制备方法及其在肿瘤治疗中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3583420B2 (ja) * 1990-10-05 2004-11-04 メダレツクス・インコーポレーテツド 二特異的試薬を用いた標的免疫化
DE69333433T2 (de) * 1992-04-01 2004-12-02 The Rockefeller University Verfahren zur in vitro kultivierung dendritischer vorläuferzellen und deren verwendung zur immunogen herstellung
US5662899A (en) * 1993-05-18 1997-09-02 I.D.M. Immuno-Designed Molecules Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
US6001351A (en) * 1993-05-18 1999-12-14 I.D.M. Immuno-Designed Molecules Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
US6540994B1 (en) * 1997-07-18 2003-04-01 I.D.M. Immuno-Designed Molecules Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
FR2729570A1 (fr) * 1995-01-24 1996-07-26 Idm Immuno Designed Molecules Procede de preparation de macrophages actives, trousses et compositions pour la mise en oeuvre de ce procede

Also Published As

Publication number Publication date
JP3428025B2 (ja) 2003-07-22
US20020192192A1 (en) 2002-12-19
ES2256886T3 (es) 2006-07-16
DE69734989T2 (de) 2006-06-22
EP0925356A1 (de) 1999-06-30
DK0925356T3 (da) 2006-02-13
EP0808897A1 (de) 1997-11-26
US20020182725A1 (en) 2002-12-05
US20020192193A1 (en) 2002-12-19
AU732536B2 (en) 2001-04-26
DE69734989D1 (de) 2006-02-02
WO1997044441A1 (en) 1997-11-27
AU2961597A (en) 1997-12-09
AU732536C (en) 2002-03-21
JP2000503545A (ja) 2000-03-28
EP0925356B1 (de) 2005-12-28

Similar Documents

Publication Publication Date Title
DE69734989D1 (de) Antigenpräsentierende zellen, ein verfahren zur deren herstellung und deren verwendung als zelluläre impfstoffen
Simon Measurement of the cyanophycin granule polypeptide contained in the blue-green alga Anabaena cylindrica
JP4091052B2 (ja) 遠心発酵プロセス
Hoppe Microbial extracellular enzyme activity: a new key parameter in aquatic ecology
EP2132301B1 (de) Systeme und verfahren zur kultivierung gespaltener anaerober mikroben aus der umgebung
Smuckler et al. Studies on carbon tetrachloride intoxication. III. A subcellular defect in protein synthesis
Bruley-Rosset et al. Interleukin-1 synthesis and activity in aged mice
US6387651B1 (en) Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a microwell device
WO1999066066A1 (en) Comparative phenotype analysis
BR0008772B1 (pt) vetor de expressão, célula bacteriana ou fúngica cultivada, processos para expandir in vitro células hematopoiéticas e progenitores de células hematopoiéticas, e para detectar a presença de rna de ligando zalfa11 e de ligando zalfa 11 in vitro em uma amostra biológica.
Langer Biosynthesis of glycosaminoglycans in foraminifera: A review
Imhoff Rhodopseudomonas marina sp. nov., a new marine phototrophic purple bacterium
US4745064A (en) Process for the degradation of s-triazine derivatives in aqueous solutions
EP0460414A3 (en) Culture and detection method for sterile-filterable autonomously replicating biological particles
Leinfelder et al. A highly sensitive cell assay for validation of purification regimes of alginates
Wackett et al. Electron microscopy of nickel-containing methanogenic enzymes: methyl reductase and F420-reducing hydrogenase
Kaznowski Identification of Aeromonas strains of different origin to the genomic species level
Nishioka et al. Analysis of photoenzymatic repair of UV lesions in DNA by single light flashes IX. Excess production of photoreactivating enzyme inE. Coli Bs-1-160 under different growth conditions, and its suppression by adenine
Guerra et al. Biochemical and microbiological tools for the evaluation of environmental quality of a coastal lagoon system in Southern Brazil
Babu et al. Intensity heteromorphisms of human chromosome 15p by DA/DAPI technique
CN112689669B (zh) 用于培养目的微生物的方法及相关设备
Pohlit et al. Growth of cells on solid culture medium: II. Cell physiological data of stationary yeast cells and the initiation of cell cycle in nutrient free buffer solution
O'Brien et al. Induction of mutations in TK6 human lymphoblastoid cells by ethyl methanesulphonate, benzo [a] pyrene and benzidine
CN116731327B (zh) 一种温敏性细胞微载体及其制备方法，以及培养细胞的方法
Kramer et al. Growth regulation in irradiance limited marine Synechococcus sp. WH 7803

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties