ATE315043T1 - Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen - Google Patents

Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen

Info

Publication number
ATE315043T1
ATE315043T1 AT03291601T AT03291601T ATE315043T1 AT E315043 T1 ATE315043 T1 AT E315043T1 AT 03291601 T AT03291601 T AT 03291601T AT 03291601 T AT03291601 T AT 03291601T AT E315043 T1 ATE315043 T1 AT E315043T1
Authority
AT
Austria
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Application number
AT03291601T
Other languages
English (en)
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of ATE315043T1 publication Critical patent/ATE315043T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT03291601T 2003-06-30 2003-06-30 Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen ATE315043T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03291601A EP1367061B1 (de) 2003-06-30 2003-06-30 Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen

Publications (1)

Publication Number Publication Date
ATE315043T1 true ATE315043T1 (de) 2006-02-15

Family

ID=29414888

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03291601T ATE315043T1 (de) 2003-06-30 2003-06-30 Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen

Country Status (17)

Country Link
US (1) US7179833B2 (de)
EP (1) EP1367061B1 (de)
JP (1) JP4347341B2 (de)
CN (1) CN1802384B (de)
AR (1) AR044944A1 (de)
AT (1) ATE315043T1 (de)
AU (1) AU2004253721B2 (de)
DE (1) DE60303101T2 (de)
DK (1) DK1367061T3 (de)
EA (1) EA008836B1 (de)
ES (1) ES2256689T3 (de)
MY (1) MY139159A (de)
NZ (1) NZ544003A (de)
PL (1) PL211161B1 (de)
SI (1) SI1367061T1 (de)
WO (1) WO2005003153A1 (de)
ZA (1) ZA200510330B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1362864T1 (sl) * 2003-06-30 2007-08-31 Servier Lab Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
EP1380591B1 (de) * 2003-08-29 2005-11-16 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
US7615571B2 (en) * 2004-05-31 2009-11-10 Ipca Laboratories Ltd. Process for manufacture of pure (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl]amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid and its tert. butyl amine salt
CA2584698C (en) 2004-10-20 2014-02-25 Ethicon, Inc. A reinforced absorbable multilayered hemostatic wound dressing and method of making
US9358318B2 (en) 2004-10-20 2016-06-07 Ethicon, Inc. Method of making a reinforced absorbable multilayered hemostatic wound dressing
DK1679072T5 (da) 2005-01-06 2009-04-20 Ipca Lab Ltd Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2008019214A (ja) * 2006-07-13 2008-01-31 Shiono Chemical Co Ltd ペリンドプリルまたはその誘導体の製造方法
RU2433998C1 (ru) * 2010-03-16 2011-11-20 Закрытое акционерное общество "Активный Компонент" Способ получения периндоприла и его фармацевтически приемлемых солей
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
SI9500140A (en) * 1995-04-24 1996-10-31 Genesis Para La Investigacion Novel n-sulfoxy anhydrides, process for the preparation thereof and its use for the preparation of bioactive substances having ace inhibitory action
PT1321471E (pt) * 2003-03-12 2005-07-29 Servier Lab Novo processo de sintese do perindopril e dos seus sais aceitaveis sob o ponto de vista farmaceutico
US20050171165A1 (en) * 2003-11-12 2005-08-04 Bhirud Shekhar B. Process for the preparation of perindopril

Also Published As

Publication number Publication date
MY139159A (en) 2009-08-28
PL211161B1 (pl) 2012-04-30
DE60303101T2 (de) 2006-09-28
JP2007537974A (ja) 2007-12-27
JP4347341B2 (ja) 2009-10-21
US20060178421A1 (en) 2006-08-10
PL380408A1 (pl) 2007-01-22
DE60303101D1 (de) 2006-03-30
ES2256689T3 (es) 2006-07-16
EA008836B1 (ru) 2007-08-31
EP1367061A1 (de) 2003-12-03
AR044944A1 (es) 2005-10-12
DK1367061T3 (da) 2006-05-15
NZ544003A (en) 2009-03-31
CN1802384B (zh) 2010-06-16
EA200501925A1 (ru) 2006-06-30
HK1089188A1 (en) 2006-11-24
SI1367061T1 (sl) 2006-04-30
ZA200510330B (en) 2007-05-30
CN1802384A (zh) 2006-07-12
AU2004253721B2 (en) 2007-12-20
EP1367061B1 (de) 2006-01-04
US7179833B2 (en) 2007-02-20
AU2004253721A1 (en) 2005-01-13
WO2005003153A1 (fr) 2005-01-13

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