ATE315047T1 - Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten. - Google Patents

Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.

Info

Publication number: ATE315047T1
Authority: AT; Austria
Prior art keywords: gal; polypeptide; alpha; fusion proteins; proteins containing
Prior art date: 1997-03-26

Application number

AT98912863T

Other languages

English (en)

Inventor

Jan Holgersson

Jining Liu

Original Assignee

Absorber Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-26

Filing date

1998-03-26

Publication date

2006-02-15

1998-03-26 Application filed by Absorber Ab filed Critical Absorber Ab

2006-02-15 Application granted granted Critical

2006-02-15 Publication of ATE315047T1 publication Critical patent/ATE315047T1/de

Links

QIGJYVCQYDKYDW-SDOYDPJRSA-N alpha-D-galactosyl-(1->3)-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-SDOYDPJRSA-N 0.000 title 1
239000000427 antigen Substances 0.000 title 1
102000036639 antigens Human genes 0.000 title 1
108091007433 antigens Proteins 0.000 title 1
102000037865 fusion proteins Human genes 0.000 title 1
108020001507 fusion proteins Proteins 0.000 title 1
229920001184 polypeptide Polymers 0.000 abstract 7
102000004196 processed proteins & peptides Human genes 0.000 abstract 7
108090000765 processed proteins & peptides Proteins 0.000 abstract 7
239000008280 blood Substances 0.000 abstract 4
210000004369 blood Anatomy 0.000 abstract 4
230000004927 fusion Effects 0.000 abstract 2
102000030902 Galactosyltransferase Human genes 0.000 abstract 1
108060003306 Galactosyltransferase Proteins 0.000 abstract 1
108060003951 Immunoglobulin Proteins 0.000 abstract 1
102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 abstract 1
108010054395 P-selectin ligand protein Proteins 0.000 abstract 1
102000003800 Selectins Human genes 0.000 abstract 1
108090000184 Selectins Proteins 0.000 abstract 1
102000018358 immunoglobulin Human genes 0.000 abstract 1
AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Transplantation (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT98912863T 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten. ATE315047T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9701127A SE9701127D0 (sv)	1997-03-26	1997-03-26	Antigenic fusionprotein carrying GALal, 3GAL epitopes

Publications (1)

Publication Number	Publication Date
ATE315047T1 true ATE315047T1 (de)	2006-02-15

Family

ID=20406335

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98912863T ATE315047T1 (de)	1997-03-26	1998-03-26	Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.

Country Status (12)

Country	Link
US (3)	US6943239B2 (de)
EP (2)	EP1700868A3 (de)
JP (1)	JP4099239B2 (de)
AT (1)	ATE315047T1 (de)
AU (1)	AU751760B2 (de)
BR (1)	BR9804826A (de)
CA (1)	CA2255765A1 (de)
DE (1)	DE69833106T2 (de)
DK (1)	DK0923606T3 (de)
ES (1)	ES2258297T3 (de)
SE (1)	SE9701127D0 (de)
WO (1)	WO1998042750A1 (de)

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US7355017B2 (en) *	2001-07-20	2008-04-08	Absorber Ab	Blood group antigen fusion polypeptides and methods of use thereof
JP2005530493A (ja) *	2002-04-22	2005-10-13	レコファーマアーベー	ムチン融合ポリペプチドワクチン、組成物およびそれらの使用方法
EP1517923A2 (de) *	2002-04-22	2005-03-30	Recopharma AB	Zusammensetzungen und verfahren zur inhibierung der mikrobiellen adhesion
AU2003249641B2 (en)	2002-05-16	2009-08-20	Glycomimetics, Inc.	Compounds and methods for inhibiting selectin-mediated function
JP2006502986A (ja) *	2002-07-03	2006-01-26	グリコミメティクス，インコーポレイテッド	新脈管形成に関与する医学的状態の診断および治療のための組成物および方法
US7638323B2 (en) *	2002-08-09	2009-12-29	Recopharma Ab	Fusion proteins and methods of producing same
US20050076759A1 (en) *	2003-10-08	2005-04-14	Brian Westfall	Linear saw with stab-cut bevel capability
US20040219158A1 (en) *	2003-05-02	2004-11-04	Glycomimetics, Inc.	Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US7459523B2 (en) *	2003-11-12	2008-12-02	Wisconsin Alumni Research Foundation	Equine P-selectin glycoprotein ligand-1 and uses thereof
WO2005051920A2 (en) *	2003-11-19	2005-06-09	Glycomimetics, Inc.	Specific antagonist for both e- and p-selectins
JP2007524658A (ja) *	2003-11-19	2007-08-30	グリコミメティクス，インコーポレイテッド	Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト
CA2571852A1 (en) *	2004-06-23	2006-01-05	Japan Science And Technology Agency	Inhibition of infiltration, and cell killing agent
US8201377B2 (en) *	2004-11-05	2012-06-19	Faus Group, Inc.	Flooring system having multiple alignment points
US20090036386A1 (en) *	2005-05-25	2009-02-05	Glycomimetics, Inc	Heterobifunctional compounds for selectin inhibition
EP1928892B1 (de) *	2005-08-09	2011-10-12	GlycoMimetics, Inc.	Glycomimetische inhibitoren des pa-il-lectins, pa-iil-lectins oder beider lectine aus pseudomonas
CN101287741B (zh) *	2005-09-02	2014-05-07	糖模拟物有限公司	异型双功能全选择素抑制剂
US20070113297A1 (en) *	2005-09-13	2007-05-17	Yongguang Yang	Methods and compositions for inhibition of immune responses
ES2502966T3 (es) *	2006-01-26	2014-10-06	Recopharma Ab	Composiciones y métodos para inhibir la adhesión viral
US20070178447A1 (en) *	2006-01-31	2007-08-02	Bethyl Laboratories, Inc.	Method for decreasing interference in results of immunochemical methods
US20090176717A1 (en) *	2006-06-01	2009-07-09	Glycomimetics, Inc.	Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
JP5298020B2 (ja)	2006-10-12	2013-09-25	グリコミメティクス，インコーポレイテッド	ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換
US7998486B2 (en) *	2006-10-25	2011-08-16	Newlink Genetics Corporation	Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes
EP2457573A1 (de) *	2007-02-09	2012-05-30	GlycoMimetics, Inc.	Verfahren zur Verwendung von Glykomimetika für Hexosen und N-Acetyl-Hexosamine
US8039442B2 (en)	2007-07-18	2011-10-18	Glycomimetics, Inc.	Compounds and methods for treatment of sickle cell disease or complications associated therewith
US8895510B2 (en) *	2008-04-08	2014-11-25	Glycomimetics, Inc.	Pan-selectin inhibitor with enhanced pharmacokinetic activity
EP2318015B1 (de) *	2008-06-13	2013-08-07	GlycoMimetics, Inc.	Behandlung von blutkrebs mit ausgewählten glykomimetischen verbindungen
EP2424544A1 (de)	2009-05-01	2012-03-07	GlycoMimetics, Inc.	Heterobifunktionale inhibitoren von e-selectinen und cxcr4-chemokin-rezeptoren
US9420770B2 (en)	2009-12-01	2016-08-23	Indiana University Research & Technology Corporation	Methods of modulating thrombocytopenia and modified transgenic pigs
US8921328B2 (en)	2010-09-14	2014-12-30	Glycomimetics, Inc.	E-selectin antagonists
JP2014501748A (ja) *	2010-12-21	2014-01-23	リコファーマアーベー	涙代用物
KR102055958B1 (ko)	2011-12-22	2019-12-13	글리코미메틱스, 인크.	E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법
US9867841B2 (en)	2012-12-07	2018-01-16	Glycomimetics, Inc.	Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
CA2968391C (en)	2014-12-03	2022-04-26	Glycomimetics, Inc.	Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US11045485B2 (en)	2016-01-22	2021-06-29	Glycomimetics, Inc.	Glycomimetic inhibitors of PA-IL and PA-IIL lectins
US11291678B2 (en)	2016-03-02	2022-04-05	Glycomimetics, Inc	Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
JP2019524791A (ja)	2016-08-08	2019-09-05	グリコミメティクス，インコーポレイテッド	Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ
KR102607640B1 (ko)	2016-10-07	2023-11-28	글리코미메틱스, 인크.	매우 강력한 다량체성 e-셀렉틴 길항물질
US11197877B2 (en)	2017-03-15	2021-12-14	Glycomimetics. Inc.	Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
JP7275131B2 (ja)	2017-11-30	2023-05-17	グリコミメティクス，インコーポレイテッド	骨髄浸潤リンパ球を動員する方法、およびその使用
BR112020013198A2 (pt)	2017-12-29	2020-12-01	Glycomimetics, Inc.	inibidores heterobifuncionais de e-selectina e galectina-3
KR20200128025A (ko)	2018-03-05	2020-11-11	글리코미메틱스, 인크.	급성 골수성 백혈병 및 관련 병태의 치료 방법
WO2019241386A1 (en) *	2018-06-12	2019-12-19	Rush University Medical Center	Methods for enhanced endothelialization of implanted material
US11845771B2 (en)	2018-12-27	2023-12-19	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (4)

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Publication number	Priority date	Publication date	Assignee	Title
DE122007000078I2 (de) *	1991-06-27	2011-01-13	Bristol Myers Squibb Co	CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung
DE69333346T2 (de)	1992-10-23	2004-10-07	Inst Genetics Llc	Neuartiges p- selectin ligandenprotein
CA2157659C (en)	1993-03-16	2003-10-21	Mauro S. Sandrin	Use of porcine gal .alpha. (1,3) galactosyl transferase in xenograft therapies
GB9517758D0 (en) *	1995-08-31	1995-11-01	Imutran Ltd	Compositions and their uses

1997
- 1997-03-26 SE SE9701127A patent/SE9701127D0/xx unknown
1998
- 1998-03-26 AT AT98912863T patent/ATE315047T1/de not_active IP Right Cessation
- 1998-03-26 BR BR9804826-0A patent/BR9804826A/pt not_active Application Discontinuation
- 1998-03-26 AU AU67551/98A patent/AU751760B2/en not_active Ceased
- 1998-03-26 US US09/194,396 patent/US6943239B2/en not_active Expired - Fee Related
- 1998-03-26 DK DK98912863T patent/DK0923606T3/da active
- 1998-03-26 WO PCT/SE1998/000555 patent/WO1998042750A1/en not_active Ceased
- 1998-03-26 JP JP54556998A patent/JP4099239B2/ja not_active Expired - Fee Related
- 1998-03-26 EP EP06075010A patent/EP1700868A3/de not_active Withdrawn
- 1998-03-26 ES ES98912863T patent/ES2258297T3/es not_active Expired - Lifetime
- 1998-03-26 DE DE69833106T patent/DE69833106T2/de not_active Expired - Lifetime
- 1998-03-26 EP EP98912863A patent/EP0923606B1/de not_active Expired - Lifetime
- 1998-03-26 CA CA002255765A patent/CA2255765A1/en not_active Abandoned
2005
- 2005-06-15 US US11/153,082 patent/US20050255099A1/en not_active Abandoned
2009
- 2009-07-22 US US12/507,626 patent/US20090286963A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2258297T3 (es)	2006-08-16
EP0923606B1 (de)	2006-01-04
WO1998042750A1 (en)	1998-10-01
US20020028205A1 (en)	2002-03-07
EP1700868A3 (de)	2007-12-12
US20050255099A1 (en)	2005-11-17
JP4099239B2 (ja)	2008-06-11
JP2000511782A (ja)	2000-09-12
EP0923606A1 (de)	1999-06-23
US20090286963A1 (en)	2009-11-19
AU6755198A (en)	1998-10-20
US6943239B2 (en)	2005-09-13
BR9804826A (pt)	2000-01-25
DK0923606T3 (da)	2006-05-22
CA2255765A1 (en)	1998-10-01
AU751760B2 (en)	2002-08-29
SE9701127D0 (sv)	1997-03-26
DE69833106T2 (de)	2006-08-31
EP1700868A2 (de)	2006-09-13
DE69833106D1 (de)	2006-03-30

Legal Events

Date

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Description

2007-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0923606

Country of ref document: EP

2011-12-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE315047T1 (de)	2006-02-15	Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.
CA2118010A1 (en)	1993-10-28	Antibodies specific for carcinoma-associated antigens
DK0739413T3 (da)	1999-10-11	Fremgangsmåde til udvælgelse af specifikke bakteriofager
ES2106195T3 (es)	1997-11-01	Anticuerpo igg aglicosilado anti cd3.
EP0699755A3 (de)	1996-06-12	Verfahren zur Herstellung modifizierter Immunoglobulinen mit reduzierter Immunogenität der variablen Domänen einer murinen Antikörpers, Zusammensetzungen die diese enthalten
ATE320448T1 (de)	2006-04-15	Gereinigte primate clta-8 antigene und verwandte reagenzien
RU2003129528A (ru)	2005-04-10	Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела
FI834530L (fi)	1983-12-09	Affinitetsreningsfoerfarande medelst monoklonala anti-kroppar.
KR960022559A (ko)	1996-07-18	슈도모나스 에루지노사 막 단백질로부터 유도된 면역원성 하이브리드 단백질 OprF-Oprl
DE69227041D1 (de)	1998-10-22	Expression und reinigung von rekombinantem, löslichem gewebefaktor
DE59208982D1 (de)	1997-11-27	Verfahren zur Reinigung von IgG-monoklonalen Antikörpern
ZA874558B (en)	1988-10-26	Monoclonal antibodies to unreduced,nonenzymatically-glycated proteins
WO1999003987A3 (fr)	1999-04-08	Epitopes du vrs et anticorps les comportant, utiles dans le diagnostic et la therapie
ES2179824T3 (es)	2003-02-01	Anticuerpos humanizados reactivos contra el antigeno gpiib/iiia.
AU2707992A (en)	1993-04-22	Monoclonal antibodies to hepatitis c virus
NO913037D0 (no)	1991-08-05	Peptider med for alfal-mikroglobulin karakteristiske antigene determinanter.
ATE207935T1 (de)	2001-11-15	Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
WO1999024835A3 (en)	1999-07-22	An immunoassay for procollagen-iii-c-terminal propeptide
SE9000931L (sv)	1991-09-16	Antikroppar mot proteiner
DK329789A (da)	1990-01-05	Monoklonalt antistof
KR100315596B1 (ko)	2002-01-15	인간의 자연형 ＩｇＭ 항체
DE68919553D1 (de)	1995-01-12	Rekombinantes Treponema hyodysenteriae-Antigen und seine Verwendungen.
DK0476059T3 (da)	1996-07-29	Fremgangsmåder til forøgelse af modificeringshastigheden for metastabile bindinger
KR920000941A (ko)	1992-01-29	사람 적혈구 비응집(nonagglutinating)표면항원에 대한 단일클론 항체를 생산하는 방법 및 그의 응용