PL1934236T3 - Heterobifunkcjonalne inhibitory pan-selektyny - Google Patents

Heterobifunkcjonalne inhibitory pan-selektyny

Info

Publication number
PL1934236T3
PL1934236T3 PL06814078T PL06814078T PL1934236T3 PL 1934236 T3 PL1934236 T3 PL 1934236T3 PL 06814078 T PL06814078 T PL 06814078T PL 06814078 T PL06814078 T PL 06814078T PL 1934236 T3 PL1934236 T3 PL 1934236T3
Authority
PL
Poland
Prior art keywords
selectin inhibitors
heterobifunctional
pan
heterobifunctional pan
selectin
Prior art date
Application number
PL06814078T
Other languages
English (en)
Inventor
John L Magnani
John T Patton Jr
Arun K Sarkar
Sergei A Svarovsky
Beat Ernst
Original Assignee
Glycomimetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc filed Critical Glycomimetics Inc
Publication of PL1934236T3 publication Critical patent/PL1934236T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biochemistry (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Biotechnology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
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PL06814078T 2005-09-02 2006-09-01 Heterobifunkcjonalne inhibitory pan-selektyny PL1934236T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71399405P 2005-09-02 2005-09-02
EP06814078A EP1934236B1 (en) 2005-09-02 2006-09-01 Heterobifunctional pan-selectin inhibitors
PCT/US2006/034274 WO2007028050A1 (en) 2005-09-02 2006-09-01 Heterobifunctional pan-selectin inhibitors

Publications (1)

Publication Number Publication Date
PL1934236T3 true PL1934236T3 (pl) 2013-04-30

Family

ID=37603124

Family Applications (2)

Application Number Title Priority Date Filing Date
PL10011660T PL2264043T3 (pl) 2005-09-02 2006-09-01 Heterobifunkcyjne inhibitory pan-selektyny
PL06814078T PL1934236T3 (pl) 2005-09-02 2006-09-01 Heterobifunkcjonalne inhibitory pan-selektyny

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL10011660T PL2264043T3 (pl) 2005-09-02 2006-09-01 Heterobifunkcyjne inhibitory pan-selektyny

Country Status (15)

Country Link
US (6) US7728117B2 (pl)
EP (2) EP2264043B1 (pl)
JP (2) JP5209476B2 (pl)
CN (2) CN103626813B (pl)
AU (1) AU2006284578B2 (pl)
CA (1) CA2670130A1 (pl)
CY (1) CY1119721T1 (pl)
DK (2) DK1934236T3 (pl)
ES (2) ES2397850T3 (pl)
HU (1) HUE038246T2 (pl)
LT (1) LT2264043T (pl)
PL (2) PL2264043T3 (pl)
PT (2) PT2264043T (pl)
SI (2) SI1934236T1 (pl)
WO (1) WO2007028050A1 (pl)

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US7728117B2 (en) 2005-09-02 2010-06-01 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
EP2074132B1 (en) * 2006-10-12 2013-05-15 GlycoMimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
EP2457573A1 (en) * 2007-02-09 2012-05-30 GlycoMimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and N-Acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US9486497B2 (en) 2007-12-10 2016-11-08 The University Of Queensland Treatment of immunocompromised conditions
WO2009126556A1 (en) * 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
CA2727788A1 (en) * 2008-06-13 2009-12-17 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
US8410066B2 (en) 2009-05-01 2013-04-02 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
WO2012061662A1 (en) * 2010-11-03 2012-05-10 Glycomimetics, Inc. Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors
SI2794626T1 (en) 2011-12-22 2018-02-28 Glycomimetics, Inc. E-SELECTINE ANTAGONIST COMPOUNDS
US20140059130A1 (en) * 2012-08-22 2014-02-27 Mainsoft R&D Ltd. System and method for updating connections in social networks
LT2928476T (lt) 2012-12-07 2018-05-25 Glycomimetics, Inc. Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai
JP2016531871A (ja) * 2013-09-30 2016-10-13 グリコミメティクス， インコーポレイテッド 粘膜炎を治療および／または予防するための方法および組成物
HUE045542T2 (hu) 2014-12-03 2019-12-30 Glycomimetics Inc E-szelektinek és CXCR4 kemokin receptorok heterobifunkcionális inhibitorai
WO2016164394A1 (en) 2015-04-08 2016-10-13 Glycomimetics, Inc. 2-halo-galactose-containing selectin antagonists
US20160331775A1 (en) * 2015-05-14 2016-11-17 The Regents Of The University Of Michigan E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk
WO2016196221A1 (en) 2015-05-29 2016-12-08 Nike Innovate C.V. System for operating multiple transceiver modules concurrently
CA2950088A1 (en) * 2015-12-02 2017-06-02 Glycomimetics, Inc. Heterobifunctional compounds having a triazole linker and e and/or p selectin binding affinity
CN108367072B (zh) 2015-12-07 2022-12-27 默克专利股份有限公司 含抗-pd-l1抗体avelumab的水性药物制剂
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US20200316100A1 (en) 2016-05-24 2020-10-08 GycoMimetics, Inc. Haloalkyl fucose-containing selectin antagonists
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
CA3037850A1 (en) 2016-10-07 2018-04-12 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
US11707474B2 (en) 2018-03-05 2023-07-25 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
EP3893936A2 (en) 2018-12-10 2021-10-20 GlycoMimetics, Inc. Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
WO2020150263A1 (en) 2019-01-14 2020-07-23 Magnani John L Selectin or galectin antagonists for treating cytokine release syndrome and crs-induced neurotoxicity
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BR112021021244A2 (pt) 2019-04-24 2021-12-21 Glycomimetics Inc Inibidores glicomiméticos multiméricos ligados à galactose de receptores de e-selectinas, galectina-3 e/ou quimiocina cxcr4
CN114341368A (zh) 2019-07-12 2022-04-12 糖模拟物有限公司 使用基因表达作为多种肿瘤类型的e-选择素抑制剂功效和临床结果的指标的方法
JP2022542288A (ja) 2019-07-31 2022-09-30 グリコミメティクス， インコーポレイテッド 再構成骨髄枯渇宿主の生存を高めるためのｅ－セレクチンアンタゴニストの使用
WO2021195465A1 (en) * 2020-03-27 2021-09-30 Magnani John L Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin
EP4157285A1 (en) 2020-05-31 2023-04-05 GlycoMimetics, Inc. Compounds and methods for reduction of cancer cell burden and protection of normal hematopoiesis
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CN116113637A (zh) * 2020-09-17 2023-05-12 糖模拟物有限公司 E-选择素靶向剂
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