ATE315049T1 - Hochsulfatierte derivate von k5-polysacchariden und ihre herstellung - Google Patents

Hochsulfatierte derivate von k5-polysacchariden und ihre herstellung

Info

Publication number: ATE315049T1
Authority: AT; Austria
Prior art keywords: polysaccharides; production; sulphated derivatives; highly sulphated; highly
Prior art date: 2001-02-27

Application number

AT02702593T

Other languages

English (en)

Inventor

Giorgio Zoppetti

Pasqua Oreste

Original Assignee

Giorgio Zoppetti

Pasqua Oreste

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-27

Filing date

2002-02-26

Publication date

2006-02-15

2002-02-26 Application filed by Giorgio Zoppetti, Pasqua Oreste filed Critical Giorgio Zoppetti

2006-02-15 Application granted granted Critical

2006-02-15 Publication of ATE315049T1 publication Critical patent/ATE315049T1/de

Links

150000004676 glycans Chemical class 0.000 title abstract 3
229920001282 polysaccharide Polymers 0.000 title abstract 3
239000005017 polysaccharide Substances 0.000 title abstract 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
241000588724 Escherichia coli Species 0.000 abstract 1
238000003381 deacetylation reaction Methods 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000012264 purified product Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
230000019635 sulfation Effects 0.000 abstract 1
238000005670 sulfation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)

AT02702593T 2001-02-27 2002-02-26 Hochsulfatierte derivate von k5-polysacchariden und ihre herstellung ATE315049T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2001MI000397A ITMI20010397A1 (it)	2001-02-27	2001-02-27	Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione

Publications (1)

Publication Number	Publication Date
ATE315049T1 true ATE315049T1 (de)	2006-02-15

Family

ID=11447035

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02702593T ATE315049T1 (de)	2001-02-27	2002-02-26	Hochsulfatierte derivate von k5-polysacchariden und ihre herstellung

Country Status (12)

Country	Link
US (3)	US6992183B2 (de)
EP (1)	EP1366082B1 (de)
JP (1)	JP2004529227A (de)
CN (2)	CN1916030B (de)
AT (1)	ATE315049T1 (de)
AU (1)	AU2002236118B2 (de)
CA (1)	CA2439337C (de)
DE (1)	DE60208528T2 (de)
DK (1)	DK1366082T3 (de)
ES (1)	ES2254645T3 (de)
IT (1)	ITMI20010397A1 (de)
WO (1)	WO2002068477A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20032498A1 (it)	2003-12-17	2005-06-18	Pasqua Anna Oreste	Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) *	2001-02-27	2002-08-27	Giorgio Zoppetti	Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
ITMI20011633A1 (it)	2001-07-27	2003-01-27	San Raffaele Centro Fond	Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
MXPA04012805A (es) *	2002-06-18	2005-08-19	Glycores 2000 Srl	Polisacarido sulfatado en exceso de bajo peso molecular.
US8513407B2 (en) *	2002-06-18	2013-08-20	Glycores 2000 S.R.L.	Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
CN101942040B (zh) *	2010-09-16	2012-06-06	山东海科化工集团有限公司	肝素钠中多硫酸软骨素的去除方法
US11889986B2 (en)	2010-12-09	2024-02-06	Endochoice, Inc.	Flexible electronic circuit board for a multi-camera endoscope
WO2012116048A1 (en) *	2011-02-22	2012-08-30	Rensselaer Polytechnic Institute	Single step heparosan n-deacetylation and depolymerization for making bioengineered heparin
CN102321563B (zh)	2011-10-24	2013-04-03	江南大学	一株拟无枝酸菌及利用其全细胞转化制备香草醛的方法
CN104448021B (zh) *	2014-12-10	2016-06-29	江南大学	一种具有免疫调节活性的磷酸化k5多糖的制备方法
CN105399849B (zh) *	2015-12-07	2018-04-10	天津科技大学	一种硫酸酯化灰树花水不溶性多糖及应用
CN105483187A (zh) *	2015-12-09	2016-04-13	中国药科大学	一种硫酸化多糖的抗肿瘤作用
CA3126805A1 (en)	2019-01-15	2020-07-23	Optimvia, Llc	Engineered aryl sulfate-dependent enzymes
AU2020310172A1 (en)	2019-07-09	2022-03-03	Optimvia Llc	Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1141483B (it) *	1980-04-18	1986-10-01	Crinos Industria Farmaco	Resina poliamminica per la separazione selettiva di eparina da altri glucosamminoglicani e procedimento per la sua preparazione
DE3787996T2 (de) *	1986-05-16	1994-03-03	Italfarmaco Spa	Heparine, frei von E.D.T.A., Fraktionen und Fragmente von Heparin, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, welche diese enthalten.
GB2254083A (en) *	1991-03-28	1992-09-30	Italfarmaco Spa	Anticoagulants from e.coli saccharide
IT1271057B (it) *	1994-11-04	1997-05-26	Inalco Spa	Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1282994B1 (it) *	1996-05-10	1998-04-03	Inalco Spa	Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
IT1289613B1 (it) *	1997-02-07	1998-10-15	Inalco Spa	Polisaccaridi batterici o-solfatati
IT1290814B1 (it) *	1997-03-24	1998-12-11	Istituto Scient Di Chimica E B	Glicosaminoglicani aventi elevata attivita' antitrombotica
US6329351B1 (en) *	1997-08-28	2001-12-11	Istituto Scientifico Di Chimica E Biochimica “G. Ronzoni”	Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk
ITMI991465A1 (it) *	1999-07-02	2001-01-02	Inalco Spa	Processo per la preparazione dei polisaccaridi k4 e k5 da escherichiacoli
IT1318432B1 (it) *	2000-03-30	2003-08-25	Inalco Spa	Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US20020062019A1 (en) *	2000-03-30	2002-05-23	Pasqua Oreste	Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US20050027117A1 (en) *	2000-12-18	2005-02-03	Pasqua Oreste	Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
ITMI20032498A1 (it) *	2003-12-17	2005-06-18	Pasqua Anna Oreste	Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) *	2001-02-27	2002-08-27	Giorgio Zoppetti	Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
ITMI20011633A1 (it) *	2001-07-27	2003-01-27	San Raffaele Centro Fond	Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
ITMI20012200A1 (it) *	2001-10-22	2003-04-22	Ibsa Inst Biochimique Sa	Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti
MXPA04012805A (es) *	2002-06-18	2005-08-19	Glycores 2000 Srl	Polisacarido sulfatado en exceso de bajo peso molecular.
ITMI20032614A1 (it) *	2003-12-30	2005-06-30	Altergon Sa	Nuova composizione comprendente cs

2001
- 2001-02-27 IT IT2001MI000397A patent/ITMI20010397A1/it unknown
2002
- 2002-02-26 ES ES02702593T patent/ES2254645T3/es not_active Expired - Lifetime
- 2002-02-26 WO PCT/IB2002/000561 patent/WO2002068477A1/en not_active Ceased
- 2002-02-26 CA CA2439337A patent/CA2439337C/en not_active Expired - Fee Related
- 2002-02-26 DE DE60208528T patent/DE60208528T2/de not_active Expired - Lifetime
- 2002-02-26 CN CN2006101275613A patent/CN1916030B/zh not_active Expired - Fee Related
- 2002-02-26 US US10/469,037 patent/US6992183B2/en not_active Expired - Fee Related
- 2002-02-26 AU AU2002236118A patent/AU2002236118B2/en not_active Ceased
- 2002-02-26 AT AT02702593T patent/ATE315049T1/de not_active IP Right Cessation
- 2002-02-26 CN CNB028088875A patent/CN1284800C/zh not_active Expired - Fee Related
- 2002-02-26 DK DK02702593T patent/DK1366082T3/da active
- 2002-02-26 JP JP2002567987A patent/JP2004529227A/ja active Pending
- 2002-02-26 EP EP02702593A patent/EP1366082B1/de not_active Expired - Lifetime
2004
- 2004-07-30 US US10/902,285 patent/US20050004358A1/en not_active Abandoned
2007
- 2007-11-19 US US11/984,482 patent/US20080146793A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2439337C (en)	2011-04-26
CN1284800C (zh)	2006-11-15
ES2254645T3 (es)	2006-06-16
EP1366082A1 (de)	2003-12-03
CN1916030B (zh)	2010-05-12
AU2002236118B2 (en)	2007-05-10
EP1366082B1 (de)	2006-01-04
JP2004529227A (ja)	2004-09-24
DK1366082T3 (da)	2006-03-06
DE60208528D1 (de)	2006-03-30
US20040077848A1 (en)	2004-04-22
US6992183B2 (en)	2006-01-31
US20050004358A1 (en)	2005-01-06
CA2439337A1 (en)	2002-09-06
US20080146793A1 (en)	2008-06-19
WO2002068477A1 (en)	2002-09-06
DE60208528T2 (de)	2006-08-17
CN1529715A (zh)	2004-09-15
ITMI20010397A1 (it)	2002-08-27
CN1916030A (zh)	2007-02-21

Legal Events

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2006-09-15

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Publication of translation of european patent specification

Ref document number: 1366082

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2009-11-15

REN

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Publication	Publication Date	Title
DE60208528D1 (de)	2006-03-30	Hochsulfatierte derivate von k5-polysacchariden und ihre herstellung
ATE426805T1 (de)	2009-04-15	Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
DK0944643T3 (da)	2003-05-05	Oxyiminopregnancarbolactoner.
CY1111543T1 (el)	2015-08-05	Νεες ενωσεις
NO20030411D0 (no)	2003-01-27	Farmasöytiske sammensetninger for behandlingen av smertefulle, inflammatoriske og ulceröse tilstander av fuktige epiteloverflater slik sommukositt, stomatitt og Behcets syndrom
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JO2707B1 (ar)	2014-03-15	مشتقات ثيوفين جليكوسايد جديدة, طرق تحضيرها, والادوية المحتوية على هذه المركبات واستخدامها
KR960705815A (ko)	1996-11-08	신규한 피라진 카복스아미드 유도체, 이의 제조방법 및 약제에 있어서의 이의 용도(Novel pyrazine carboxamide derivatives, their production and their use in medicaments)
MXPA04000891A (es)	2004-05-21	Nuevos derivados de acido vinilcarboxilico y su uso como antidiabeticos.
IT1282994B1 (it)	1998-04-03	Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
NZ624749A (en)	2015-07-31	A sulfated polysaccharide compound and the preparation and use thereof
ECSP055584A (es)	2005-07-06	Proceso para la preparación de fibrinógeno
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DE60219653D1 (de)	2007-05-31	Pharmazeutische zusammensetzung mit chito-oligomeren
MX9200396A (es)	1992-08-01	Derivados de benciloxifenilo, procedimiento para su preparacion y composicion farmaceutica que los contiene.
ATE478662T1 (de)	2010-09-15	Arzneilösungen enthaltend modafinilverbindungen
YU13699A (sh)	1999-12-27	Primena 1-hidroksi-2-piridona za dobijanje leka za lečenje infekcija kože
GEP20053590B (en)	2005-07-25	Phenyl Heterocyclyl Ether Derivatives as Serotonin Re-Uptake Inhibitors
ATE444739T1 (de)	2009-10-15	Polymerzusammensetzung sowie diese enthaltende darreichungsformen
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ES2058282T3 (es)	1994-11-01	Derivados de fenol, su produccion y uso.
NO20050247L (no)	2005-03-16	Lavmolekylaert oversulfatert polysakkarid
UY27229A1 (es)	2002-07-31	Composición
ATE388169T1 (de)	2008-03-15	Niedermolekulare polysaccharide mit antithrombotischer wirkung
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