IT1282994B1 - Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante - Google Patents

Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante

Info

Publication number
IT1282994B1
IT1282994B1 IT96MI000956A ITMI960956A IT1282994B1 IT 1282994 B1 IT1282994 B1 IT 1282994B1 IT 96MI000956 A IT96MI000956 A IT 96MI000956A IT MI960956 A ITMI960956 A IT MI960956A IT 1282994 B1 IT1282994 B1 IT 1282994B1
Authority
IT
Italy
Prior art keywords
polysaccharide
pct
derivatives
high anti
date nov
Prior art date
Application number
IT96MI000956A
Other languages
English (en)
Inventor
Giorgio Zoppetti
Pasqua Oreste
Giovanni Cipolletti
Original Assignee
Inalco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inalco Spa filed Critical Inalco Spa
Publication of ITMI960956A0 publication Critical patent/ITMI960956A0/it
Priority to IT96MI000956A priority Critical patent/IT1282994B1/it
Priority to PCT/EP1997/002379 priority patent/WO1997043317A1/en
Priority to CA002253833A priority patent/CA2253833C/en
Priority to ES97924941T priority patent/ES2167748T3/es
Priority to AT97924941T priority patent/ATE210154T1/de
Priority to EP97924941A priority patent/EP0897393B1/en
Priority to US09/180,406 priority patent/US6162797A/en
Priority to DK97924941T priority patent/DK0897393T3/da
Priority to DE69708862T priority patent/DE69708862T2/de
Priority to AU30265/97A priority patent/AU3026597A/en
Publication of ITMI960956A1 publication Critical patent/ITMI960956A1/it
Application granted granted Critical
Publication of IT1282994B1 publication Critical patent/IT1282994B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT96MI000956A 1996-05-10 1996-05-10 Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante IT1282994B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT96MI000956A IT1282994B1 (it) 1996-05-10 1996-05-10 Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
AT97924941T ATE210154T1 (de) 1996-05-10 1997-05-09 Derivate von k5 polysaccharid mit hoher, blutgerinnungshemmender wirkung
CA002253833A CA2253833C (en) 1996-05-10 1997-05-09 Derivatives of k5 polysaccharide having high anticoagulant activity
ES97924941T ES2167748T3 (es) 1996-05-10 1997-05-09 Derivados del polisacarido k5 con actividad anticoagulante.
PCT/EP1997/002379 WO1997043317A1 (en) 1996-05-10 1997-05-09 Derivatives of k5 polysaccharide having high anticoagulant activity
EP97924941A EP0897393B1 (en) 1996-05-10 1997-05-09 Derivatives of k5 polysaccharide having high anticoagulant activity
US09/180,406 US6162797A (en) 1996-05-10 1997-05-09 Derivatives of K5 polysaccharide having high anticoagulant activity
DK97924941T DK0897393T3 (da) 1996-05-10 1997-05-09 Derivater af K5-polysaccharid med antikoagulerende aktivitet
DE69708862T DE69708862T2 (de) 1996-05-10 1997-05-09 Derivate von k5 polysaccharid mit hoher, blutgerinnungshemmender wirkung
AU30265/97A AU3026597A (en) 1996-05-10 1997-05-09 Derivatives of k5 polysaccharide having high anticoagulant activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI000956A IT1282994B1 (it) 1996-05-10 1996-05-10 Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante

Publications (3)

Publication Number Publication Date
ITMI960956A0 ITMI960956A0 (it) 1996-05-10
ITMI960956A1 ITMI960956A1 (it) 1997-11-10
IT1282994B1 true IT1282994B1 (it) 1998-04-03

Family

ID=11374247

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI000956A IT1282994B1 (it) 1996-05-10 1996-05-10 Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante

Country Status (10)

Country Link
US (1) US6162797A (it)
EP (1) EP0897393B1 (it)
AT (1) ATE210154T1 (it)
AU (1) AU3026597A (it)
CA (1) CA2253833C (it)
DE (1) DE69708862T2 (it)
DK (1) DK0897393T3 (it)
ES (1) ES2167748T3 (it)
IT (1) IT1282994B1 (it)
WO (1) WO1997043317A1 (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294797B1 (it) * 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
US7307159B2 (en) * 2001-05-08 2007-12-11 The Board Of Regents Of The University Of Oklahoma Heparin/heparosan synthase from P. multocida and methods of making and using same
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US8088604B2 (en) 1998-04-02 2012-01-03 The Board Of Regents Of The University Of Oklahoma Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20040197868A1 (en) * 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US8227449B2 (en) 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US20050027117A1 (en) * 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
ITMI20032498A1 (it) * 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
US8580290B2 (en) * 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
US8513407B2 (en) 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
PL375088A1 (en) * 2002-06-18 2005-11-14 Glycores 2000 S.R.L. Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation
ITMI20031618A1 (it) * 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) * 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
CA2869128C (en) 2012-03-30 2022-07-26 The Board Of Regents Of The University Of Oklahoma High molecular weight heparosan polymers and methods of production and use thereof
CN113603732B (zh) * 2021-08-25 2024-02-13 江南大学 一种非动物源硫酸软骨素寡糖及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
GB2254083A (en) * 1991-03-28 1992-09-30 Italfarmaco Spa Anticoagulants from e.coli saccharide
IT1271057B (it) * 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico

Also Published As

Publication number Publication date
DE69708862T2 (de) 2002-08-14
ES2167748T3 (es) 2002-05-16
WO1997043317A1 (en) 1997-11-20
CA2253833A1 (en) 1997-11-20
ATE210154T1 (de) 2001-12-15
US6162797A (en) 2000-12-19
EP0897393B1 (en) 2001-12-05
AU3026597A (en) 1997-12-05
ITMI960956A0 (it) 1996-05-10
EP0897393A1 (en) 1999-02-24
CA2253833C (en) 2006-06-27
DK0897393T3 (da) 2002-04-02
ITMI960956A1 (it) 1997-11-10
DE69708862D1 (de) 2002-01-17

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