ATE315095T1 - Adenovirenvektoren zur transduktion der chondrozyten - Google Patents
Adenovirenvektoren zur transduktion der chondrozytenInfo
- Publication number
- ATE315095T1 ATE315095T1 AT01974977T AT01974977T ATE315095T1 AT E315095 T1 ATE315095 T1 AT E315095T1 AT 01974977 T AT01974977 T AT 01974977T AT 01974977 T AT01974977 T AT 01974977T AT E315095 T1 ATE315095 T1 AT E315095T1
- Authority
- AT
- Austria
- Prior art keywords
- chondrocytes
- transduction
- adenovirus vectors
- nucleic acid
- delivery vehicle
- Prior art date
Links
- 241000701161 unidentified adenovirus Species 0.000 title abstract 4
- 210000001612 chondrocyte Anatomy 0.000 title abstract 3
- 230000026683 transduction Effects 0.000 title 1
- 238000010361 transduction Methods 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
- 101710145505 Fiber protein Proteins 0.000 abstract 2
- 238000001476 gene delivery Methods 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 208000015100 cartilage disease Diseases 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000002463 transducing effect Effects 0.000 abstract 1
- 230000010415 tropism Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00202835 | 2000-08-10 | ||
| US22491100P | 2000-08-11 | 2000-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE315095T1 true ATE315095T1 (de) | 2006-02-15 |
Family
ID=26072592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01974977T ATE315095T1 (de) | 2000-08-10 | 2001-08-09 | Adenovirenvektoren zur transduktion der chondrozyten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6803234B2 (de) |
| EP (1) | EP1307573B1 (de) |
| AT (1) | ATE315095T1 (de) |
| AU (1) | AU9434801A (de) |
| CA (1) | CA2418977C (de) |
| DE (1) | DE60116513T2 (de) |
| ES (1) | ES2256302T3 (de) |
| WO (1) | WO2002012523A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| US20060238702A1 (en) | 1999-04-30 | 2006-10-26 | Advanced Medical Optics, Inc. | Ophthalmic lens combinations |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| EP1157999A1 (de) * | 2000-05-24 | 2001-11-28 | Introgene B.V. | Verfahren und Mitteln zur Verbesserung der Haut-Transplantation mittels Genabgabe-Vehikel mit Tropismus für primären Fibroblasten, sowie andere Verwendungsmöglichkeiten für diesen |
| ATE315095T1 (de) * | 2000-08-10 | 2006-02-15 | Crucell Holland Bv | Adenovirenvektoren zur transduktion der chondrozyten |
| US7763069B2 (en) | 2002-01-14 | 2010-07-27 | Abbott Medical Optics Inc. | Accommodating intraocular lens with outer support structure |
| US7662180B2 (en) | 2002-12-05 | 2010-02-16 | Abbott Medical Optics Inc. | Accommodating intraocular lens and method of manufacture thereof |
| US7897384B2 (en) | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US8257963B2 (en) * | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
| US7927599B2 (en) * | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US20050131535A1 (en) | 2003-12-15 | 2005-06-16 | Randall Woods | Intraocular lens implant having posterior bendable optic |
| CN100361710C (zh) * | 2004-06-07 | 2008-01-16 | 成都康弘生物科技有限公司 | 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用 |
| WO2006061824A2 (en) * | 2004-12-06 | 2006-06-15 | Prochon Biotech Limited | Chondrocyte-based implant for the delivery of therapeutic agents |
| AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
| US9636213B2 (en) | 2005-09-30 | 2017-05-02 | Abbott Medical Optics Inc. | Deformable intraocular lenses and lens systems |
| US20080161914A1 (en) | 2006-12-29 | 2008-07-03 | Advanced Medical Optics, Inc. | Pre-stressed haptic for accommodating intraocular lens |
| US8685107B2 (en) | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
| US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
| US8034108B2 (en) | 2008-03-28 | 2011-10-11 | Abbott Medical Optics Inc. | Intraocular lens having a haptic that includes a cap |
| CA2766654C (en) | 2009-06-26 | 2017-10-10 | Abbott Medical Optics Inc. | Accommodating intraocular lenses |
| EP2461768B1 (de) | 2009-08-03 | 2020-02-19 | Johnson & Johnson Surgical Vision, Inc. | Intraokularlinse für akkommodatives sehvermögen |
| US9452211B2 (en) | 2011-11-28 | 2016-09-27 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
| US9084674B2 (en) | 2012-05-02 | 2015-07-21 | Abbott Medical Optics Inc. | Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity |
| CA3115891A1 (en) | 2013-03-14 | 2014-09-25 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
| DK3198009T3 (da) | 2014-09-24 | 2021-11-22 | Salk Inst For Biological Studi | Onkolytiske tumorvira og anvendelsesfremgangsmåder |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| EP3390645B1 (de) | 2016-02-23 | 2022-09-14 | Salk Institute for Biological Studies | Exogene genexpression eines therapeutischen adenovirus mit geringem einfluss auf die virale kinetik |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| CN110062630A (zh) | 2016-12-12 | 2019-07-26 | 萨克生物研究学院 | 肿瘤靶向合成腺病毒及其用途 |
| WO2019048708A1 (en) | 2017-09-11 | 2019-03-14 | Amo Groningen B.V. | METHODS AND APPARATUSES FOR INCREASING POSITION STABILITY OF INTRAOCULAR LENSES |
| CA3096099A1 (en) | 2018-04-09 | 2019-10-17 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions with enhanced replication properties |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| JP2002525065A (ja) * | 1998-09-11 | 2002-08-13 | ジェンベク、インコーポレイティッド | 選択的にターゲッティングされるアデノウイルス |
| JP4683727B2 (ja) * | 1999-03-04 | 2011-05-18 | クルーセル ホランド ベスローテン フェンノートシャップ | 線維芽細胞様またはマクロファージ様細胞の形質導入のための手段と方法 |
| US6869936B1 (en) * | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
| US6315992B1 (en) * | 1999-06-30 | 2001-11-13 | Tissuegene Co. | Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1 |
| US6445314B1 (en) * | 2000-03-01 | 2002-09-03 | Cisco Technology Inc. | System and method for the decoding of variable length codes |
| US6939540B1 (en) * | 2000-07-31 | 2005-09-06 | Cornell Research Foundation, Inc. | Method of enhancing bone density |
| ATE315095T1 (de) * | 2000-08-10 | 2006-02-15 | Crucell Holland Bv | Adenovirenvektoren zur transduktion der chondrozyten |
-
2001
- 2001-08-09 AT AT01974977T patent/ATE315095T1/de active
- 2001-08-09 WO PCT/NL2001/000595 patent/WO2002012523A2/en not_active Ceased
- 2001-08-09 DE DE60116513T patent/DE60116513T2/de not_active Expired - Lifetime
- 2001-08-09 CA CA2418977A patent/CA2418977C/en not_active Expired - Lifetime
- 2001-08-09 EP EP01974977A patent/EP1307573B1/de not_active Expired - Lifetime
- 2001-08-09 ES ES01974977T patent/ES2256302T3/es not_active Expired - Lifetime
- 2001-08-09 AU AU9434801A patent/AU9434801A/xx not_active Withdrawn
- 2001-08-10 US US09/928,262 patent/US6803234B2/en not_active Expired - Lifetime
-
2004
- 2004-02-17 US US10/779,915 patent/US20040142472A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6803234B2 (en) | 2004-10-12 |
| US20040142472A1 (en) | 2004-07-22 |
| WO2002012523A2 (en) | 2002-02-14 |
| CA2418977A1 (en) | 2002-02-14 |
| US20020115218A1 (en) | 2002-08-22 |
| CA2418977C (en) | 2011-01-18 |
| WO2002012523A3 (en) | 2002-04-25 |
| EP1307573B1 (de) | 2006-01-04 |
| EP1307573A2 (de) | 2003-05-07 |
| ES2256302T3 (es) | 2006-07-16 |
| DE60116513D1 (de) | 2006-03-30 |
| DE60116513T2 (de) | 2006-09-21 |
| AU9434801A (en) | 2002-02-18 |
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| UEP | Publication of translation of european patent specification |
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