ATE315222T1 - Vorrichtung und verfahren zum kalibrieren eines abtastsystems für mikroarrays - Google Patents

Vorrichtung und verfahren zum kalibrieren eines abtastsystems für mikroarrays

Info

Publication number
ATE315222T1
ATE315222T1 AT00989657T AT00989657T ATE315222T1 AT E315222 T1 ATE315222 T1 AT E315222T1 AT 00989657 T AT00989657 T AT 00989657T AT 00989657 T AT00989657 T AT 00989657T AT E315222 T1 ATE315222 T1 AT E315222T1
Authority
AT
Austria
Prior art keywords
fluorophore
dilution
detection system
brightness
microarray
Prior art date
Application number
AT00989657T
Other languages
English (en)
Inventor
David Noblett
Original Assignee
Gsi Lumonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gsi Lumonics Inc filed Critical Gsi Lumonics Inc
Application granted granted Critical
Publication of ATE315222T1 publication Critical patent/ATE315222T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Facsimile Scanning Arrangements (AREA)
AT00989657T 1999-11-09 2000-10-12 Vorrichtung und verfahren zum kalibrieren eines abtastsystems für mikroarrays ATE315222T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/437,039 US6471916B1 (en) 1999-11-09 1999-11-09 Apparatus and method for calibration of a microarray scanning system

Publications (1)

Publication Number Publication Date
ATE315222T1 true ATE315222T1 (de) 2006-02-15

Family

ID=23734812

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00989657T ATE315222T1 (de) 1999-11-09 2000-10-12 Vorrichtung und verfahren zum kalibrieren eines abtastsystems für mikroarrays

Country Status (6)

Country Link
US (1) US6471916B1 (de)
EP (1) EP1228354B1 (de)
AT (1) ATE315222T1 (de)
CA (1) CA2390651A1 (de)
DE (1) DE60025400T2 (de)
WO (1) WO2001035074A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3469504B2 (ja) * 1999-06-01 2003-11-25 日立ソフトウエアエンジニアリング株式会社 マイクロアレイチップ及びそのインデックス方法
US6789040B2 (en) 2000-08-22 2004-09-07 Affymetrix, Inc. System, method, and computer software product for specifying a scanning area of a substrate
JP3596868B2 (ja) * 2000-11-24 2004-12-02 キヤノン株式会社 末端標識プローブアレイのプローブの量の評価方法、及び、該標識プローブアレイを用いた標的物質量の評価方法
JP3663125B2 (ja) * 2000-11-28 2005-06-22 日立ソフトウエアエンジニアリング株式会社 蛍光読み取り方法及び蛍光読み取り装置
GB0102357D0 (en) * 2001-01-30 2001-03-14 Randox Lab Ltd Imaging method
JP3695340B2 (ja) * 2001-03-30 2005-09-14 株式会社日立製作所 Ｄｎａ検査方法及びその装置並びに蛍光検出方法
US7183050B2 (en) * 2001-04-18 2007-02-27 Krull Ulrich J Gradient resolved information platform
US6490533B2 (en) * 2001-04-26 2002-12-03 Affymetrix, Inc. System, method, and product for dynamic noise reduction in scanning of biological materials
WO2004010099A2 (en) * 2001-05-16 2004-01-29 Burstein Technologies, Inc. Variable sampling for rendering pixelization of analysis results in optical bio-disc assembly
US6583424B2 (en) * 2001-06-25 2003-06-24 Agilent Technologies Inc. Scanning system with calibrated detection and method
US6673315B2 (en) 2001-06-29 2004-01-06 Biomachines, Inc. Method and apparatus for accessing a site on a biological substrate
US7115232B2 (en) * 2001-07-13 2006-10-03 Hudson Gordon S Fluorescence validation microplate and method of use
US6767733B1 (en) 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
US6929951B2 (en) * 2002-02-28 2005-08-16 Agilent Technologies, Inc. Method and system for molecular array scanner calibration
US6870166B2 (en) * 2002-02-28 2005-03-22 Agilent Technologies, Inc. Maximum sensitivity optical scanning system
WO2003083127A2 (en) * 2002-03-28 2003-10-09 Deutsches Krebsforschungszentrum Method and system for determining absolute mrna quantities
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
US7354389B2 (en) * 2002-05-28 2008-04-08 Autogenomics, Inc. Microarray detector and methods
AU2002257345A1 (en) * 2002-05-29 2003-12-19 Autogenomics, Inc. Integrated micro array system and methods therefor
US7089123B2 (en) * 2002-09-30 2006-08-08 Agilent Technologies, Inc Array scanner control system
US7013220B2 (en) * 2002-09-30 2006-03-14 Agilent Technologies, Inc. Biopolymer array scanner with real-time saturation detection
US20040201844A1 (en) * 2003-02-03 2004-10-14 Affymetrix, Inc., A Corporation Organized Under The Laws Of Delaware System, method and product for providing a stable calibration standard for optical systems
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
US20050030601A1 (en) * 2003-06-12 2005-02-10 Affymetrix, Inc. System and method for scanner instrument calibration using a calibration standard
SE0301897D0 (sv) * 2003-06-27 2003-06-27 Foss Tecator Ab Referece standard and method for calibration
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
US20060024690A1 (en) * 2003-09-19 2006-02-02 Kao H P Normalization of data using controls
DK2322278T3 (en) 2003-10-24 2017-04-10 Aushon Biosystems Inc Apparatus and method for dispensing liquid, semi-solid and solid samples
DE102004022263A1 (de) * 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
US7499166B2 (en) * 2004-05-20 2009-03-03 The Regents Of The University Of California Wide field imager for quantitative analysis of microarrays
US20050287040A1 (en) * 2004-06-29 2005-12-29 Molecular Devices Corporation Fluorescence validation plate
CN1280623C (zh) * 2004-07-16 2006-10-18 北京博奥生物芯片有限责任公司 一种用于荧光仪器校准测量的校准基片及其制备方法
US20060063274A1 (en) * 2004-09-23 2006-03-23 Schremp Donald J Methods for manufacturing and using chemical array calibration devices
JP4577645B2 (ja) * 2004-09-30 2010-11-10 横河電機株式会社 スクリーニング装置
DE102004047593A1 (de) * 2004-09-30 2006-04-13 Carl Zeiss Jena Gmbh Referenzkörper für Fluoreszenzmessungen und Verfahren zur Herstellung desselben
US8173367B2 (en) * 2004-10-18 2012-05-08 Sherri Boucher In situ dilution of external controls for use in microarrays
US8084260B2 (en) * 2004-11-24 2011-12-27 Applied Biosystems, Llc Spectral calibration method and system for multiple instruments
US7324202B2 (en) * 2004-12-07 2008-01-29 Novx Systems Inc. Optical system
WO2006102352A2 (en) * 2005-03-22 2006-09-28 Applera Corporation Normalization of data using controls
KR101637140B1 (ko) 2005-05-09 2016-07-06 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US7858382B2 (en) * 2005-05-27 2010-12-28 Vidar Systems Corporation Sensing apparatus having rotating optical assembly
US7928357B2 (en) * 2005-06-02 2011-04-19 Capitalbio Corporation High speed scanning platform for microarray scanner
WO2006128321A1 (en) * 2005-06-02 2006-12-07 Capitalbio Corporation Laser confocal microarray scanner
US7706419B2 (en) * 2005-06-03 2010-04-27 Capitalbio Corporation Optical systems for microarray scanning
DE102005036149B4 (de) * 2005-07-28 2007-07-12 Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. Anordung für eine schnelle, räumlich und spektral auflösende Fluoreszenzanalyse von Biochips
US7397042B2 (en) 2005-08-24 2008-07-08 Dr. Chip Biotechnology Incorporation Optical detection apparatus and method thereof
US7528374B2 (en) * 2006-03-03 2009-05-05 Vidar Systems Corporation Sensing apparatus having optical assembly that collimates emitted light for detection
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20090047673A1 (en) 2006-08-22 2009-02-19 Cary Robert B Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
US8980561B1 (en) 2006-08-22 2015-03-17 Los Alamos National Security, Llc. Nucleic acid detection system and method for detecting influenza
JP5172162B2 (ja) * 2006-08-25 2013-03-27 株式会社日立ハイテクノロジーズ 欠陥検査装置
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
US20080178653A1 (en) * 2007-01-29 2008-07-31 Applera Corporation System and Method for Interpolative Calibration
WO2008096318A2 (en) * 2007-02-09 2008-08-14 Koninklijke Philips Electronics N.V. Identification system
CA2682761C (en) 2007-04-04 2015-10-13 Network Biosystems, Inc. Methods for rapid multiplexed amplification of target nucleic acids
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
CA3138078C (en) 2007-10-02 2024-02-13 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
JP4389991B2 (ja) * 2007-10-26 2009-12-24 ソニー株式会社 微小粒子の光学的測定方法及び光学的測定装置
DE102007055386B4 (de) * 2007-11-20 2015-07-16 Boehringer Ingelheim Vetmedica Gmbh Verfahren zur Kalibrierung eines Sensorelements
WO2009137055A1 (en) * 2008-05-05 2009-11-12 Los Alamos National Security, Llc Nanocrystal-based lateral flow microarrays and low-voltage signal detection systems
EP2279403B1 (de) 2008-05-05 2016-03-16 Los Alamos National Security, LLC Höchst vereinfachte vorbereitung von nukleinsäureproben auf lateralflussbasis und passive strömungssteuerung
DE102008040513B4 (de) * 2008-07-17 2010-08-26 BAM Bundesanstalt für Materialforschung und -prüfung Verwendung einer langwellig emittierenden Cyaninverbindung als NIR-Fluoreszenzstandard und Kit zur Kalibrierung von Photolumineszenzmesssystemen
JP2010101835A (ja) * 2008-10-27 2010-05-06 Toshiba Corp 蛍光基準部材、及び蛍光基準部材を備える蛍光検知装置
PT3299800T (pt) * 2009-03-16 2020-03-04 Alere Tech Gmbh Dispositivo microfluídico
EP2443254A2 (de) 2009-06-15 2012-04-25 NetBio, Inc. Verbesserte verfahren für forensische dna-quantifizierung
EP3859746B1 (de) 2009-10-19 2024-10-16 Labrador Diagnostics LLC Integriertes system zur erfassung und analyse von gesundheitsdaten
WO2012030334A1 (en) * 2010-09-01 2012-03-08 Analogic Corporation Optical system calibration verification
MX349288B (es) 2011-01-21 2017-07-21 Theranos Inc Sistemas y metodos para maximizacion de uso de muestras.
DE102011002080B4 (de) 2011-04-15 2016-05-04 Lre Medical Gmbh Vorrichtung und Verfahren zur Bestimmung der Konzentration von Fluorophoren in einer Probe
CN103608467B (zh) 2011-04-20 2017-07-21 美飒生物技术公司 用于核酸的振荡扩增反应
CA3106132C (en) 2011-05-12 2023-08-29 Ande Corporation Methods and compositions for rapid multiplex amplification of str loci
AU2013202804A1 (en) 2012-06-14 2014-01-16 Gen-Probe Incorporated Use of a fluorescent material to detect failure or deteriorated performance of a fluorometer
WO2014100626A1 (en) * 2012-12-21 2014-06-26 Hutman Diagnostics AG Microarrays
GB201321609D0 (en) 2013-12-06 2014-01-22 Starna Scient Ltd PCR Validation Tubes
DE102013021097A1 (de) * 2013-12-18 2015-06-18 Euroimmun Medizinische Labordiagnostika Ag Kalibriernormal für eine Vorrichtung zur bildlichen Darstellung biologischen Materials
US9233568B1 (en) 2014-06-25 2016-01-12 Xerox Corporation Cross-process direction uniformity for wide format printers
US10191194B2 (en) * 2014-11-05 2019-01-29 Rochester Institute Of Technology Spectral target for macroscopic and microscopic reflectance imaging
EP3286546B1 (de) 2015-04-24 2023-07-19 Mesa Biotech, Inc. Fluidische testkassette
US20170284942A1 (en) * 2016-03-31 2017-10-05 Plexbio Co., Ltd. Method for calibrating fluorescent plate readers
EP3610242B1 (de) * 2017-04-13 2023-09-27 F. Hoffmann-La Roche AG Bestimmung der zielmoleküldichte auf einem fluoreszenzbild
US20220026361A1 (en) * 2018-12-18 2022-01-27 Hewlett-Packard Development Company, L.P. Ordered arrays of microdots
CN119620558B (zh) * 2024-12-19 2026-01-23 浙江创芯集成电路有限公司 一种光学处理设备及其工作方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH568564A5 (de) * 1974-06-10 1975-10-31 Killer W Dr Ag
US3973129A (en) * 1975-01-10 1976-08-03 Bell Telephone Laboratories, Incorporated Fluorimetric apparatus and method for analysis of body fluid
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
AU702267B2 (en) 1994-09-02 1999-02-18 Biometric Imaging, Inc. Calibration method and apparatus for optical scanner
US5585639A (en) * 1995-07-27 1996-12-17 Hewlett-Packard Company Optical scanning apparatus
US5742380A (en) * 1996-12-31 1998-04-21 Ronn Avigdor M Plasma assay spectrometer
US5798206A (en) * 1997-01-10 1998-08-25 New York Blood Center Methods for screening of test compounds for inhibiting binding of a CD4-HIV 1 complex to a chemokine receptor
US5838435A (en) 1997-10-20 1998-11-17 Sandia Corporation Calibration method for spectroscopic systems
US6078390A (en) * 1998-05-04 2000-06-20 General Scanning, Inc. Scanning system and method of operation for automatically setting detection sensitivity
US6245517B1 (en) * 1998-09-29 2001-06-12 The United States Of America As Represented By The Department Of Health And Human Services Ratio-based decisions and the quantitative analysis of cDNA micro-array images
US6251601B1 (en) * 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
US6215894B1 (en) * 1999-02-26 2001-04-10 General Scanning, Incorporated Automatic imaging and analysis of microarray biochips
US6075613A (en) * 1999-02-26 2000-06-13 General Scanning, Inc. Optical scanner calibration device

Also Published As

Publication number Publication date
EP1228354B1 (de) 2006-01-04
WO2001035074A1 (en) 2001-05-17
DE60025400D1 (de) 2006-03-30
WO2001035074A9 (en) 2002-08-01
EP1228354A1 (de) 2002-08-07
US6471916B1 (en) 2002-10-29
DE60025400T2 (de) 2006-08-31
CA2390651A1 (en) 2001-05-17

Similar Documents

Publication Publication Date Title
ATE315222T1 (de) Vorrichtung und verfahren zum kalibrieren eines abtastsystems für mikroarrays
PT1095270E (pt) Dispositivo de rastreio e metodo de rastreio de um teste de imunoensaio
ATE219340T1 (de) Vorrichtung zur ermittlung der oberflächenform von biologischem gewebe
CA2455118A1 (en) Nanoparticle imaging system and method
KR960705500A (ko) 생체 기질에서 글루코스 농도 분석 방법 및 장치(process and device for detemining the glucose concentration in a biological matrix)
HK1040768A1 (zh) 便携式產品鑒定裝置
DK0619321T3 (da) Fremgangsmåde og apparat til undersøgelse af polynukleotid- eller aminosyresekvenser
TW200951430A (en) Method of determining defects in a substrate and apparatus for exposing a substrate in a lithographic process
ATE215993T1 (de) Nachweis von nukleinsäuren mit breitem dynamikbereich unter verwendung von aggregat- primer-reihen
ATE390627T1 (de) Verfahren und vorrichtung zur oberflächenplasmonenmikroskopie
DE50008446D1 (de) Vorrichtung und verfahren zur echtheitsprüfung von banknoten
ATE363655T1 (de) Vorrichtungen und methoden zur bestimmung von konzentrationen von analyten
ATE215694T1 (de) Verfahren zur charakterisierung von proben unter verwendung statistischer zwischendaten
RU2008129064A (ru) Детектор и способ обнаружения
DE69931365D1 (de) Quantitative methode zum nachweis der nukleotidkonzentration
DE50106782D1 (de) Vorrichtung und verfahren zur erfassung von papierbögen
TWI266872B (en) Unevenness defect inspection method and device of pattern
ATE492650T1 (de) Verfahren und vorrichtung zur detektion von markierungselementen in einer probe
DE50305336D1 (de) Verfahren zur Erkennung und Kompensation der Unterdosierung von Teststreifen
KR100499176B1 (ko) 반도체 기판의 오염 측정 방법 및 이를 수행하기 위한 장치
ATE225971T1 (de) Verfahren zur überprüfung des zustandes einer vorrichtung zur prüfung von blattgut
SE9902871D0 (sv) A method and an arrangement for inspection of and measuring at an object
CN119959292A (zh) 一种摩擦感度试验结果的量化判定方法
RU2000133029A (ru) Способ радиолокационного обнаружения и измерения координат объектов
JPH10185818A (ja) 液面上浮遊物質の光計測装置および光計測方法

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties