ATE315410T1 - Modifizierte antikörper und antikörper-fragmente mit verlängerter aktivitätsdauer - Google Patents

Modifizierte antikörper und antikörper-fragmente mit verlängerter aktivitätsdauer

Info

Publication number
ATE315410T1
ATE315410T1 AT99962682T AT99962682T ATE315410T1 AT E315410 T1 ATE315410 T1 AT E315410T1 AT 99962682 T AT99962682 T AT 99962682T AT 99962682 T AT99962682 T AT 99962682T AT E315410 T1 ATE315410 T1 AT E315410T1
Authority
AT
Austria
Prior art keywords
group
antibodies
human
modified antibodies
activity
Prior art date
Application number
AT99962682T
Other languages
English (en)
Inventor
George A Heavner
Robert W Weber
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Application granted granted Critical
Publication of ATE315410T1 publication Critical patent/ATE315410T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99962682T 1998-11-03 1999-11-02 Modifizierte antikörper und antikörper-fragmente mit verlängerter aktivitätsdauer ATE315410T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18515198A 1998-11-03 1998-11-03

Publications (1)

Publication Number Publication Date
ATE315410T1 true ATE315410T1 (de) 2006-02-15

Family

ID=22679823

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99962682T ATE315410T1 (de) 1998-11-03 1999-11-02 Modifizierte antikörper und antikörper-fragmente mit verlängerter aktivitätsdauer

Country Status (13)

Country Link
EP (1) EP1144452B1 (de)
CN (1) CN1406138A (de)
AT (1) ATE315410T1 (de)
AU (1) AU768295B2 (de)
CA (1) CA2353082A1 (de)
CY (1) CY1105333T1 (de)
DE (1) DE69929467T2 (de)
DK (1) DK1144452T3 (de)
ES (1) ES2257094T3 (de)
MX (1) MXPA01005562A (de)
NZ (1) NZ512055A (de)
PT (1) PT1144452E (de)
WO (1) WO2000026256A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
MXPA05007151A (es) 2002-12-31 2005-09-21 Nektar Therapeutics Al Corp Polimeros terminados en maleimida hidroliticamente estables.
US7074755B2 (en) 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
EP2184606B1 (de) * 2008-11-03 2015-06-24 Helena Laboratories (UK) Ltd. Immunverschiebungs-Elektrophorese
SG10201407757XA (en) 2009-10-23 2015-01-29 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
CA2882757A1 (en) * 2012-08-31 2014-03-06 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor 1 (igf-1)
JP2017518737A (ja) 2014-04-21 2017-07-13 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＳＹＫ標的治療薬のための抗ｐＳＹＫ抗体分子及びその使用
US10647777B2 (en) * 2014-05-28 2020-05-12 Genzyme Corporation Methods of controlling the formation of disulfide bonds in protein solutions
KR102396217B1 (ko) * 2017-09-19 2022-05-09 임문워크 아이엔씨 알부민과의 결합 친화성이 증대된 약학 구조물
TW202237638A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
TW202237639A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 鳥苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
KR20230146032A (ko) 2021-02-15 2023-10-18 다케다 야쿠힌 고교 가부시키가이샤 Tgf-b 신호전달을 조절하기 위한 세포 치료 조성물 및 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006133A1 (en) * 1988-11-25 1990-06-14 Centocor, Inc. Heterobifunctional antibodies having specificity for platelets and thrombolytic agents
CA2051436A1 (en) * 1989-04-03 1990-10-04 Christoph Bode Platelet specific immunoconjugates
WO1996040250A2 (en) * 1995-06-07 1996-12-19 Centocor, Inc. Platelet-specific chimeric immunoglobulin and methods of use therefor
GB9625640D0 (en) * 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
WO1998032466A1 (en) * 1997-01-29 1998-07-30 Polymasc Pharmaceuticals Plc Pegylation process
JP2001512480A (ja) * 1997-02-19 2001-08-21 セントコア，インコーポレイテッド 持続的薬物送達およびそれに有用な組成物
EP0979102A4 (de) * 1997-04-30 2005-11-23 Enzon Inc Einzelsträngige polypeptide modifiziert durch polyalkylenoxid

Also Published As

Publication number Publication date
WO2000026256A3 (en) 2001-11-08
ES2257094T3 (es) 2006-07-16
DK1144452T3 (da) 2006-05-29
NZ512055A (en) 2003-11-28
PT1144452E (pt) 2006-05-31
EP1144452A2 (de) 2001-10-17
EP1144452B1 (de) 2006-01-11
DE69929467T2 (de) 2006-09-28
CY1105333T1 (el) 2010-03-03
AU1907800A (en) 2000-05-22
DE69929467D1 (de) 2006-04-06
CN1406138A (zh) 2003-03-26
MXPA01005562A (es) 2003-08-01
EP1144452A3 (de) 2002-03-13
AU768295B2 (en) 2003-12-04
CA2353082A1 (en) 2000-05-11
WO2000026256A9 (en) 2002-08-22
WO2000026256A2 (en) 2000-05-11

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