DK1144452T3 - Modificerede antistoffer og antistoffragmenter med foröget aktivitetsvarighed - Google Patents

Modificerede antistoffer og antistoffragmenter med foröget aktivitetsvarighed

Info

Publication number
DK1144452T3
DK1144452T3 DK99962682T DK99962682T DK1144452T3 DK 1144452 T3 DK1144452 T3 DK 1144452T3 DK 99962682 T DK99962682 T DK 99962682T DK 99962682 T DK99962682 T DK 99962682T DK 1144452 T3 DK1144452 T3 DK 1144452T3
Authority
DK
Denmark
Prior art keywords
group
antibodies
human
modified antibodies
antibody fragments
Prior art date
Application number
DK99962682T
Other languages
Danish (da)
English (en)
Inventor
George A Heavner
Robert W Weber
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Application granted granted Critical
Publication of DK1144452T3 publication Critical patent/DK1144452T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK99962682T 1998-11-03 1999-11-02 Modificerede antistoffer og antistoffragmenter med foröget aktivitetsvarighed DK1144452T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18515198A 1998-11-03 1998-11-03

Publications (1)

Publication Number Publication Date
DK1144452T3 true DK1144452T3 (da) 2006-05-29

Family

ID=22679823

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99962682T DK1144452T3 (da) 1998-11-03 1999-11-02 Modificerede antistoffer og antistoffragmenter med foröget aktivitetsvarighed

Country Status (13)

Country Link
EP (1) EP1144452B1 (de)
CN (1) CN1406138A (de)
AT (1) ATE315410T1 (de)
AU (1) AU768295B2 (de)
CA (1) CA2353082A1 (de)
CY (1) CY1105333T1 (de)
DE (1) DE69929467T2 (de)
DK (1) DK1144452T3 (de)
ES (1) ES2257094T3 (de)
MX (1) MXPA01005562A (de)
NZ (1) NZ512055A (de)
PT (1) PT1144452E (de)
WO (1) WO2000026256A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
MXPA05007151A (es) 2002-12-31 2005-09-21 Nektar Therapeutics Al Corp Polimeros terminados en maleimida hidroliticamente estables.
US7074755B2 (en) 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
EP2184606B1 (de) * 2008-11-03 2015-06-24 Helena Laboratories (UK) Ltd. Immunverschiebungs-Elektrophorese
SG10201407757XA (en) 2009-10-23 2015-01-29 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
CA2882757A1 (en) * 2012-08-31 2014-03-06 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor 1 (igf-1)
JP2017518737A (ja) 2014-04-21 2017-07-13 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＳＹＫ標的治療薬のための抗ｐＳＹＫ抗体分子及びその使用
US10647777B2 (en) * 2014-05-28 2020-05-12 Genzyme Corporation Methods of controlling the formation of disulfide bonds in protein solutions
KR102396217B1 (ko) * 2017-09-19 2022-05-09 임문워크 아이엔씨 알부민과의 결합 친화성이 증대된 약학 구조물
TW202237638A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
TW202237639A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 鳥苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
KR20230146032A (ko) 2021-02-15 2023-10-18 다케다 야쿠힌 고교 가부시키가이샤 Tgf-b 신호전달을 조절하기 위한 세포 치료 조성물 및 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006133A1 (en) * 1988-11-25 1990-06-14 Centocor, Inc. Heterobifunctional antibodies having specificity for platelets and thrombolytic agents
CA2051436A1 (en) * 1989-04-03 1990-10-04 Christoph Bode Platelet specific immunoconjugates
WO1996040250A2 (en) * 1995-06-07 1996-12-19 Centocor, Inc. Platelet-specific chimeric immunoglobulin and methods of use therefor
GB9625640D0 (en) * 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
WO1998032466A1 (en) * 1997-01-29 1998-07-30 Polymasc Pharmaceuticals Plc Pegylation process
JP2001512480A (ja) * 1997-02-19 2001-08-21 セントコア，インコーポレイテッド 持続的薬物送達およびそれに有用な組成物
EP0979102A4 (de) * 1997-04-30 2005-11-23 Enzon Inc Einzelsträngige polypeptide modifiziert durch polyalkylenoxid

Also Published As

Publication number Publication date
WO2000026256A3 (en) 2001-11-08
ES2257094T3 (es) 2006-07-16
NZ512055A (en) 2003-11-28
ATE315410T1 (de) 2006-02-15
PT1144452E (pt) 2006-05-31
EP1144452A2 (de) 2001-10-17
EP1144452B1 (de) 2006-01-11
DE69929467T2 (de) 2006-09-28
CY1105333T1 (el) 2010-03-03
AU1907800A (en) 2000-05-22
DE69929467D1 (de) 2006-04-06
CN1406138A (zh) 2003-03-26
MXPA01005562A (es) 2003-08-01
EP1144452A3 (de) 2002-03-13
AU768295B2 (en) 2003-12-04
CA2353082A1 (en) 2000-05-11
WO2000026256A9 (en) 2002-08-22
WO2000026256A2 (en) 2000-05-11

Similar Documents

Publication Publication Date Title
DK1144452T3 (da) Modificerede antistoffer og antistoffragmenter med foröget aktivitetsvarighed
Raman et al. Optogenetic skeletal muscle-powered adaptive biological machines
Muzykantov et al. Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs
McClurg et al. Targeting cartilage degradation in osteoarthritis
CN102281907A (zh) 生物复合材料及其制造方法
Seliktar Extracellular stimulation in tissue engineering
Aramesh et al. Functionalized bead assay to measure three-dimensional traction forces during T-cell activation
FR2794477B1 (fr) Cable de structure d'ouvrage de construction, troncon de gaine d'un tel cable, et procede de pose
Kim et al. Targeted antithrombotic protein micelles
FR2763943B1 (fr) Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
ATE433998T1 (de) Divalent anti-t-zellen immuntoxinen und deren verwendung
Stone et al. Induced remodeling of porcine tendons to human anterior cruciate ligaments by α-GAL epitope removal and partial cross-linking
NZ515603A (en) Method of producing catalytic antibodies in a human
ATE176758T1 (de) Verwendung von antiidiotypischen antikörpern zur vorbeugung einer hyperakuten abstossung von xenotransplantaten
ATE252374T1 (de) Eingekapselte antikörper-produzierende zellen
DE69428278D1 (de) Leukozytadhaesiontest
DE69638145D1 (de) Verfahren zur herbeiführung einer immuntoleranz mit hilfe von immuntoxinen
ATE249243T1 (de) Biotinylierter antikörper mit verminderter positiver nettoladung und toxin, medikament oder chelat
FR2720407B1 (fr) Véhicule aqueux pour micro-organismes non autonomes du règne animal à maintenir vivants hors de leur milieu naturel, notamment spermatozoïdes de bovin.
Smith et al. Cartilage tissue homeostasis
Rizki et al. Basement membrane polarizes lectin binding sites of Drosophila larval fat body cells
Romerosa Chemoenzymatic synthesis: application to the study of carbohydrate recognition
FI971879A7 (fi) Allogeenisten ja ksenogeenisten proteiinien vasta-aineet, niiden käytt ö diagnoosissa ja hoidossa ja menetelmät niiden määrittämiseksi
Marasco et al. Fine structure of Eimer's organ in the coast mole (Scapanus orarius)
Zhadan et al. Ultrastructure of the abdominal sense organ of the scallop Mizuchopecten yessoensis (Jay)