ATE316093T1 - Glucopyranosid-konjugate von 2-(4-hydroxy-phenyl)-1-(4-(2-amin-1-yl-ethoxy)- enzyl)-1h-indol-5-olen - Google Patents

Glucopyranosid-konjugate von 2-(4-hydroxy-phenyl)-1-(4-(2-amin-1-yl-ethoxy)- enzyl)-1h-indol-5-olen

Info

Publication number
ATE316093T1
ATE316093T1 AT00960064T AT00960064T ATE316093T1 AT E316093 T1 ATE316093 T1 AT E316093T1 AT 00960064 T AT00960064 T AT 00960064T AT 00960064 T AT00960064 T AT 00960064T AT E316093 T1 ATE316093 T1 AT E316093T1
Authority
AT
Austria
Prior art keywords
olene
enzyl
glucopyranoside
indol
conjugates
Prior art date
Application number
AT00960064T
Other languages
English (en)
Inventor
Christopher Paul Miller
Michael David Collini
Bach Dinh Tran
Anita Wai-Yin Chan
Arkadiy Zinoviy Rubezhov
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE316093T1 publication Critical patent/ATE316093T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AT00960064T 1999-09-13 2000-09-11 Glucopyranosid-konjugate von 2-(4-hydroxy-phenyl)-1-(4-(2-amin-1-yl-ethoxy)- enzyl)-1h-indol-5-olen ATE316093T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39424099A 1999-09-13 1999-09-13

Publications (1)

Publication Number Publication Date
ATE316093T1 true ATE316093T1 (de) 2006-02-15

Family

ID=23558135

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00960064T ATE316093T1 (de) 1999-09-13 2000-09-11 Glucopyranosid-konjugate von 2-(4-hydroxy-phenyl)-1-(4-(2-amin-1-yl-ethoxy)- enzyl)-1h-indol-5-olen

Country Status (25)

Country Link
EP (1) EP1212335B1 (de)
JP (1) JP2003509435A (de)
KR (1) KR100653570B1 (de)
CN (1) CN1196708C (de)
AR (1) AR025638A1 (de)
AT (1) ATE316093T1 (de)
AU (1) AU764436B2 (de)
BR (1) BR0013943A (de)
CA (1) CA2382683A1 (de)
CY (1) CY1104970T1 (de)
CZ (1) CZ298862B6 (de)
DE (1) DE60025630T2 (de)
DK (1) DK1212335T3 (de)
EA (1) EA005371B1 (de)
ES (1) ES2254215T3 (de)
HK (1) HK1044777B (de)
HU (1) HUP0202679A3 (de)
IL (2) IL148273A0 (de)
MX (1) MXPA02002654A (de)
NO (1) NO322250B1 (de)
NZ (1) NZ517645A (de)
PL (1) PL354179A1 (de)
TW (1) TWI287018B (de)
WO (1) WO2001019839A1 (de)
ZA (1) ZA200201876B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1406898B1 (de) * 2001-07-19 2005-04-06 Cv Therapeutics, Inc. Substituierte piperazinderivate und ihre verwendung als fettsaüreoxidationsinhibitoren
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP4847333B2 (ja) * 2004-09-06 2011-12-28 キッセイ薬品工業株式会社 排尿障害の予防又は治療薬
CA2758109A1 (en) * 2009-04-13 2010-10-21 Sandoz Ag Processes for the synthesis of bazedoxifene acetate and intermediates thereof
CN101857617A (zh) * 2010-04-28 2010-10-13 中国海洋大学 喹唑啉类糖衍生物及其制备方法和应用
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN104798294B (zh) * 2012-11-22 2018-09-25 艾默生电气公司 电机、定子和压缩机，以及制造它们的方法
CN104151265B (zh) * 2013-05-13 2016-10-05 上海医药工业研究院 醋酸巴多昔芬中间体的制备方法
CN104725334A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 (4-(2-(氮杂环庚烷-1-基)乙氧基)苯基)甲醇的制备方法
CN105085365B (zh) * 2014-05-12 2018-06-19 四川科伦药业股份有限公司 醋酸巴多昔芬及其中间体的制备方法
CN107033062B (zh) * 2017-03-24 2019-10-29 梯尔希（南京）药物研发有限公司 一种巴多昔芬衍生物的制备方法
CN107400087B (zh) * 2017-09-15 2019-12-13 济南美高生物医药科技有限公司 一种1-(2-(4-(氯甲基)苯氧基)乙基)氮杂环庚烷盐酸盐的制备方法
CN111196831B (zh) * 2020-01-20 2023-05-09 山西医科大学 一种呋喃酚葡萄糖醛酸结合物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3821148A1 (de) * 1988-06-23 1989-12-28 Erwin Von Dr Angerer Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
EP0639567A1 (de) * 1992-05-08 1995-02-22 Otsuka Pharmaceutical Factory, Inc. Indol-derivate
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
NZ281431A (en) * 1994-02-22 1997-09-22 Merrell Pharma Inc Alkylamide-substituted indole derivatives
US5567820A (en) * 1994-05-20 1996-10-22 Eli Lilly And Company Glucopyranoside benzothiophenes
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
PT802183E (pt) * 1996-04-19 2002-03-28 American Home Prod Agentes estrogenicos
PT1025077E (pt) * 1997-10-15 2007-05-31 Wyeth Corp Novas ariloxi-alquil-dialquilaminas
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin

Also Published As

Publication number Publication date
EA200200358A1 (ru) 2002-08-29
HK1044777B (en) 2006-04-13
EA005371B1 (ru) 2005-02-24
CZ2002881A3 (cs) 2003-01-15
DK1212335T3 (da) 2006-03-20
JP2003509435A (ja) 2003-03-11
MXPA02002654A (es) 2002-07-30
HUP0202679A2 (hu) 2003-01-28
NO322250B1 (no) 2006-09-04
PL354179A1 (en) 2003-12-29
IL148273A0 (en) 2002-09-12
WO2001019839A1 (en) 2001-03-22
AU764436B2 (en) 2003-08-21
NO20021203D0 (no) 2002-03-12
IL148273A (en) 2007-03-08
NO20021203L (no) 2002-03-12
CY1104970T1 (el) 2010-03-03
ZA200201876B (en) 2003-08-27
HUP0202679A3 (en) 2003-04-28
AR025638A1 (es) 2002-12-04
CN1382151A (zh) 2002-11-27
KR20020027643A (ko) 2002-04-13
CN1196708C (zh) 2005-04-13
TWI287018B (en) 2007-09-21
EP1212335B1 (de) 2006-01-18
BR0013943A (pt) 2002-05-14
CA2382683A1 (en) 2001-03-22
CZ298862B6 (cs) 2008-02-27
HK1044777A1 (en) 2002-11-01
DE60025630T2 (de) 2006-08-10
KR100653570B1 (ko) 2006-12-05
AU7128400A (en) 2001-04-17
ES2254215T3 (es) 2006-06-16
EP1212335A1 (de) 2002-06-12
NZ517645A (en) 2003-09-26
DE60025630D1 (de) 2006-04-06

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