ATE316101T1 - Thrombinspaltbare faktor-x-analoga - Google Patents

Thrombinspaltbare faktor-x-analoga

Info

Publication number
ATE316101T1
ATE316101T1 AT03762681T AT03762681T ATE316101T1 AT E316101 T1 ATE316101 T1 AT E316101T1 AT 03762681 T AT03762681 T AT 03762681T AT 03762681 T AT03762681 T AT 03762681T AT E316101 T1 ATE316101 T1 AT E316101T1
Authority
AT
Austria
Prior art keywords
analogues
thrombin
factor
splitting factor
arg
Prior art date
Application number
AT03762681T
Other languages
English (en)
Inventor
Virginie Louvain
Elsa Bianchini
Pierre-Emmanuel Marque
Claire Calmel-Tareau
Martine Aiach
Bonniec Bernard Le
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Application granted granted Critical
Publication of ATE316101T1 publication Critical patent/ATE316101T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT03762681T 2002-07-03 2003-06-30 Thrombinspaltbare faktor-x-analoga ATE316101T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0208299A FR2841904B1 (fr) 2002-07-03 2002-07-03 Analogues de facteurs x clivables par la thrombine

Publications (1)

Publication Number Publication Date
ATE316101T1 true ATE316101T1 (de) 2006-02-15

Family

ID=29725108

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03762681T ATE316101T1 (de) 2002-07-03 2003-06-30 Thrombinspaltbare faktor-x-analoga

Country Status (10)

Country Link
US (1) US8168753B2 (de)
EP (1) EP1539816B1 (de)
JP (1) JP4533137B2 (de)
AT (1) ATE316101T1 (de)
AU (1) AU2003250095B2 (de)
CA (1) CA2491040C (de)
DE (1) DE60303312T2 (de)
ES (1) ES2257693T3 (de)
FR (1) FR2841904B1 (de)
WO (1) WO2004005347A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2831170B1 (fr) 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
EP1728798A1 (de) * 2005-06-01 2006-12-06 ZLB Behring GmbH Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1816201A1 (de) 2006-02-06 2007-08-08 CSL Behring GmbH Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät
EP1820508A1 (de) 2006-02-21 2007-08-22 CSL Behring GmbH Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften
WO2008077616A1 (en) 2006-12-22 2008-07-03 Csl Behring Gmbh Modified coagulation factors with prolonged in vivo half-life
JP5833448B2 (ja) 2008-12-19 2015-12-16 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル セリンプロテアーゼ誘導体および血液凝固疾患の予防または処置における使用
JP6514893B2 (ja) 2011-09-30 2019-05-15 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ 止血を調節するための組成物および方法
AU2013270683A1 (en) 2012-06-08 2014-12-11 Biogen Ma Inc. Chimeric clotting factors
AU2013270682A1 (en) 2012-06-08 2014-12-11 Biogen Ma Inc. Procoagulant compounds
KR102049900B1 (ko) 2012-07-25 2019-11-28 카탈리스트 바이오사이언시즈, 인코포레이티드 변형 인자 x 폴리펩티드 및 이의 용도
HK1215196A1 (zh) 2013-01-31 2016-08-19 辉瑞公司 用於抵消因子xa抑制的组合物和方法
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
CN105008530A (zh) * 2013-03-12 2015-10-28 诺和诺德股份有限公司 凝血酶敏感性凝固因子x分子
CN112195169A (zh) 2013-09-24 2021-01-08 辉瑞大药厂 包含重组人凝血因子Xa蛋白的异质性群体的组合物
WO2016028872A2 (en) 2014-08-19 2016-02-25 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor ix function

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS634615A (ja) * 1986-06-25 1988-01-09 Hitachi Tokyo Electron Co Ltd 半導体装置製造装置
GB9222758D0 (en) * 1992-10-29 1992-12-09 British Bio Technology Proteins and nucleic acids
US5746875A (en) * 1994-09-16 1998-05-05 Applied Materials, Inc. Gas injection slit nozzle for a plasma process reactor
US6043218A (en) * 1996-10-22 2000-03-28 Medical University Of South Carolina Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides
EP0946414B1 (de) * 1996-11-04 2005-06-29 Materials Modification, Inc. Mikrowellenplasma chemischen synthese von ultrafeinen pulvern
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
CH697092A5 (de) * 1998-12-24 2008-04-30 Sulzer Metco Ag Anordnung für eine Plasmaspritzanlage.

Also Published As

Publication number Publication date
ES2257693T3 (es) 2006-08-01
US20060148038A1 (en) 2006-07-06
JP4533137B2 (ja) 2010-09-01
FR2841904B1 (fr) 2004-08-20
FR2841904A1 (fr) 2004-01-09
US8168753B2 (en) 2012-05-01
AU2003250095B2 (en) 2009-04-09
WO2004005347A1 (en) 2004-01-15
CA2491040A1 (en) 2004-01-15
DE60303312T2 (de) 2006-09-21
DE60303312D1 (de) 2006-04-06
EP1539816A1 (de) 2005-06-15
AU2003250095A1 (en) 2004-01-23
JP2006507806A (ja) 2006-03-09
EP1539816B1 (de) 2006-01-18
CA2491040C (en) 2012-05-01

Similar Documents

Publication Publication Date Title
DE60303312D1 (de) Thrombinspaltbare faktor-x-analoga
GEP20063741B (en) Nonaryl-Heterocyclic NMDA/NR2B Antagonists
CO5700784A2 (es) Polipeptidos de virus de papiloma humano y composiciones in- munogenas
DE602004031301D1 (de) Nichtsymmetrisches geliermittel
ATE446313T1 (de) Muteine von tränen-lipocalin
CY1119723T1 (el) Φαρμακοτεχνικες μορφες πεπτιδιου περιεχουσες προπυλενογλυκολη οι οποιες ειναι βελτιστες για παραγωγη και για χρηση σε συσκευες ενεσεων
PT1411908E (pt) Tratamento de infeccoes da unha com no
HUP0100652A1 (hu) X-Faktor analógok módosított proteáz hasítási hellyel
CY1108547T1 (el) Αναλογα σωματοστατινης
ES2190653T3 (es) Productos de reaccion del acido hialuronico y de aminoacidos naturales y su utilizacion en composiciones cosmeticas y farmaceuticas.
ATE425253T1 (de) Tribonektine
SE9802729D0 (sv) Novel Compounds
CY1113116T1 (el) Υποκατεστημενες 4-αμινοκυκλοεξανολες
SE0203825D0 (sv) Novel fused heterocycles and uses thereof
ATE282607T1 (de) Tryptase-inhibitoren
EP1641824A4 (de) Analoga von peptiden der relaxin-superfamilie
DE60027326D1 (de) Maca und geweih zur steigerung des testosteronspiegels
ATE357245T1 (de) Biologisch stabile flüssige zusammensetzung von fviii, vwf oder fviii/vwf-komplex menschlichen ursprungs
CY1109444T1 (el) Φαρμακευτικη συνθεση που περιεχει κυκλικα αναλογα σωματοστατινης
PA8577701A1 (es) Polipeptido t20 pegilado
AR006616A1 (es) Derivados carboxilicos utiles como inhibidores de los receptores de las endotelinas y composiciones farmaceuticas que los contienen
ATE302210T1 (de) Histogranin peptide und deren analgetische verwendung
NO20052216L (no) Smertestillende midler
DE69840637D1 (de) Zusammensetzungen zur steigerung der effizienz von impfstoffen unter verwendung von chemokinen
DE60331541D1 (de) Gaserzeugende Zusammensetzung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties