ATE316152T1 - Komplexitätsmanagement und analyse genomischer dna - Google Patents

Komplexitätsmanagement und analyse genomischer dna

Info

Publication number
ATE316152T1
ATE316152T1 AT99965737T AT99965737T ATE316152T1 AT E316152 T1 ATE316152 T1 AT E316152T1 AT 99965737 T AT99965737 T AT 99965737T AT 99965737 T AT99965737 T AT 99965737T AT E316152 T1 ATE316152 T1 AT E316152T1
Authority
AT
Austria
Prior art keywords
analysis
genomic dna
sample
invention further
further provides
Prior art date
Application number
AT99965737T
Other languages
English (en)
Inventor
Shoulian Dong
Robert J Lipshutz
David J Lockhart
Original Assignee
Affymetrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc filed Critical Affymetrix Inc
Application granted granted Critical
Publication of ATE316152T1 publication Critical patent/ATE316152T1/de

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855Ligating adaptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99965737T 1998-10-27 1999-10-27 Komplexitätsmanagement und analyse genomischer dna ATE316152T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10586798P 1998-10-27 1998-10-27
US13612599P 1999-05-26 1999-05-26

Publications (1)

Publication Number Publication Date
ATE316152T1 true ATE316152T1 (de) 2006-02-15

Family

ID=26803034

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99965737T ATE316152T1 (de) 1998-10-27 1999-10-27 Komplexitätsmanagement und analyse genomischer dna

Country Status (8)

Country Link
US (3) US6361947B1 (de)
EP (1) EP1124990B1 (de)
JP (1) JP2002528096A (de)
AT (1) ATE316152T1 (de)
AU (1) AU2144000A (de)
CA (1) CA2345441A1 (de)
DE (1) DE69929542T2 (de)
WO (1) WO2000024939A1 (de)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
WO1999023256A1 (en) 1997-10-30 1999-05-14 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing dna
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
CA2372131A1 (en) * 1999-02-22 2000-08-31 Sydney Brenner Polymorphic dna fragments and uses thereof
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20020119448A1 (en) * 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
IL150291A0 (en) * 2000-01-11 2002-12-01 Maxygen Inc Integrated systems and methods for diversity generation and screening
WO2001083813A1 (en) * 2000-05-02 2001-11-08 Centre National De La Recherche Scientifique Identification of genetic markers
US20020055112A1 (en) * 2000-08-26 2002-05-09 Nila Patil Methods for reducing complexity of nucleic acid samples
US20020164634A1 (en) * 2000-08-26 2002-11-07 Perlegen Sciences, Inc. Methods for reducing complexity of nucleic acid samples
US20020137043A1 (en) * 2000-08-26 2002-09-26 Nila Patil Method for reducing complexity of nucleic acid samples
AR031640A1 (es) * 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
WO2002061145A2 (en) * 2001-01-31 2002-08-08 Ambion, Inc. Competitive amplification of fractionated targets from multiple nucleic acid samples
WO2002090599A1 (en) * 2001-05-09 2002-11-14 Genetic Id, Inc. Universal microarray system
US20030009294A1 (en) * 2001-06-07 2003-01-09 Jill Cheng Integrated system for gene expression analysis
US7297778B2 (en) * 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
US6872529B2 (en) * 2001-07-25 2005-03-29 Affymetrix, Inc. Complexity management of genomic DNA
AU2002357249A1 (en) * 2001-12-13 2003-07-09 Blue Heron Biotechnology, Inc. Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins
AU2002357368A1 (en) * 2001-12-19 2003-07-09 Affymetrix, Inc. Array plates and method for constructing array plates
DE10208333A1 (de) * 2002-02-27 2003-09-04 Axaron Bioscience Ag Analyse von Nukleinsäure-Fragmentmischungen
AU2003220254B2 (en) 2002-03-13 2008-09-18 Syngenta Participations, Ag. Nucleic acid detection method
US20070065816A1 (en) * 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US7097976B2 (en) 2002-06-17 2006-08-29 Affymetrix, Inc. Methods of analysis of allelic imbalance
US7108976B2 (en) * 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US9388459B2 (en) 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
US20040072217A1 (en) * 2002-06-17 2004-04-15 Affymetrix, Inc. Methods of analysis of linkage disequilibrium
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
US7482170B2 (en) * 2002-09-30 2009-01-27 Roche Nimblegen, Inc. Parallel loading of arrays
WO2004031351A2 (en) * 2002-10-01 2004-04-15 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
US7459273B2 (en) * 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
DE10246824A1 (de) * 2002-10-08 2004-04-22 Axaron Bioscience Ag Hybridisierungsproben reduzierter Komplexität
WO2004042057A1 (ja) * 2002-11-07 2004-05-21 Daiichi Pure Chemicals Co., Ltd. 遺伝子変異検出法
WO2004067708A2 (en) * 2003-01-17 2004-08-12 Sri International Et Al. Device and method for fragmenting material by hydrodynamic shear
WO2004067779A2 (en) * 2003-01-30 2004-08-12 Applera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
US20090124514A1 (en) * 2003-02-26 2009-05-14 Perlegen Sciences, Inc. Selection probe amplification
US20060183132A1 (en) * 2005-02-14 2006-08-17 Perlegen Sciences, Inc. Selection probe amplification
US20040259125A1 (en) * 2003-02-26 2004-12-23 Omni Genetics, Inc. Methods, systems and apparatus for identifying genetic differences in disease and drug response
EP1613774A2 (de) * 2003-03-10 2006-01-11 Applera Corporation Mit stenose assoziierte genetische polymorphismen, verfahren zum nachweis und verwendungen davon
US20070042382A1 (en) * 2003-03-10 2007-02-22 Applera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
CA2519476A1 (en) * 2003-03-18 2004-09-30 Applera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
EP1613776A1 (de) * 2003-04-02 2006-01-11 Blue Heron Biotechnology, Inc. Fehlerreduktion bei der automatisierten gensynthese
JP2006525814A (ja) 2003-05-23 2006-11-16 コールド スプリング ハーバー ラボラトリー ヌクレオチド配列の実質的表示
EP2327795B1 (de) 2003-06-10 2017-08-09 The Trustees Of Boston University Nachweismethoden für Lungenerkrankungen
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005003304A2 (en) * 2003-06-20 2005-01-13 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050032102A1 (en) * 2003-07-22 2005-02-10 Affymetrix, Inc. Mapping genomic rearrangements
US8114978B2 (en) * 2003-08-05 2012-02-14 Affymetrix, Inc. Methods for genotyping selected polymorphism
US20050100911A1 (en) * 2003-08-06 2005-05-12 Perlegen Sciences, Inc. Methods for enriching populations of nucleic acid samples
DK2322278T3 (en) 2003-10-24 2017-04-10 Aushon Biosystems Inc Apparatus and method for dispensing liquid, semi-solid and solid samples
WO2005054516A2 (en) 2003-11-26 2005-06-16 Advandx, Inc. Peptide nucleic acid probes for analysis of certain staphylococcus species
US20050233354A1 (en) * 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
CA2497324A1 (en) 2004-02-17 2005-08-17 Affymetrix, Inc. Methods for fragmenting and labelling dna
SE0401270D0 (sv) * 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
EP2290073A3 (de) 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
EP1623996A1 (de) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verbessertes Verfahren zur Auswahl eines Proteins von einer Bibliothek
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
CA2524964A1 (en) 2004-10-29 2006-04-29 Affymetrix, Inc. Automated method of manufacturing polymer arrays
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
EP2302055B1 (de) 2004-11-12 2014-08-27 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNAa-inhibitorischen Molekülen verbunden sind
US20060166224A1 (en) * 2005-01-24 2006-07-27 Norviel Vernon A Associations using genotypes and phenotypes
EP3211093A1 (de) 2005-04-14 2017-08-30 The Trustees of Boston University Diagnose für lungenerkrankungen mittels klassenvorhersage
US20060286571A1 (en) 2005-04-28 2006-12-21 Prometheus Laboratories, Inc. Methods of predicting methotrexate efficacy and toxicity
US7452671B2 (en) * 2005-04-29 2008-11-18 Affymetrix, Inc. Methods for genotyping with selective adaptor ligation
DE602006013831D1 (de) * 2005-06-23 2010-06-02 Keygene Nv Verbesserte strategien zur sequenzierung komplexer genome unter verwendung von sequenziertechniken mit hohem durchsatz
DK2302070T3 (da) 2005-06-23 2012-11-26 Keygene Nv Strategier til identifikation og detektion af polymorfismer med højt gennemløb
AU2006266251A1 (en) * 2005-06-30 2007-01-11 Syngenta Participations Ag Methods for screening for gene specific hybridization polymorphisms (GSHPs) and their use in genetic mapping and marker development
US20070003938A1 (en) * 2005-06-30 2007-01-04 Perlegen Sciences, Inc. Hybridization of genomic nucleic acid without complexity reduction
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
WO2007037678A2 (en) 2005-09-29 2007-04-05 Keygene N.V. High throughput screening of mutagenized populations
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0524069D0 (en) * 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
US7634363B2 (en) * 2005-12-07 2009-12-15 Affymetrix, Inc. Methods for high throughput genotyping
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
CN103937899B (zh) 2005-12-22 2017-09-08 凯津公司 用于基于aflp的高通量多态性检测的方法
SG169356A1 (en) 2006-02-08 2011-03-30 Illumina Cambridge Ltd Method for sequencing a polynucleotide template
WO2007103541A2 (en) 2006-03-09 2007-09-13 The Trustees Of Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US7951583B2 (en) * 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US8675199B2 (en) * 2006-03-10 2014-03-18 Plc Diagnostics, Inc. Waveguide-based detection system with scanning light source
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
WO2007107710A1 (en) * 2006-03-17 2007-09-27 Solexa Limited Isothermal methods for creating clonal single molecule arrays
EP3239304B1 (de) 2006-04-04 2020-08-19 Keygene N.V. Nachweis von molekularmarkern mit hohem durchsatz auf der basis von aflp und mit hoher durchsatzsequenzierung
US9328378B2 (en) * 2006-07-31 2016-05-03 Illumina Cambridge Limited Method of library preparation avoiding the formation of adaptor dimers
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
AU2007325931A1 (en) 2006-11-02 2008-06-05 Yale University Assessment of oocyte competence
US8293684B2 (en) * 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
CA2687218A1 (en) * 2007-05-14 2008-11-27 Insight Genetics, Inc. Methods of screening nucleic acids for single nucleotide variations
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
EP2173509A4 (de) * 2007-06-25 2013-11-06 Affymetrix Inc Strukturierte mikrocodes
WO2009012984A1 (en) * 2007-07-26 2009-01-29 Roche Diagnostics Gmbh Target preparation for parallel sequencing of complex genomes
US20090093378A1 (en) * 2007-08-29 2009-04-09 Helen Bignell Method for sequencing a polynucleotide template
US8716190B2 (en) 2007-09-14 2014-05-06 Affymetrix, Inc. Amplification and analysis of selected targets on solid supports
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
WO2009036332A1 (en) 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US8124336B2 (en) * 2007-09-26 2012-02-28 Population Genetics Technologies Ltd Methods and compositions for reducing the complexity of a nucleic acid sample
US12060554B2 (en) 2008-03-10 2024-08-13 Illumina, Inc. Method for selecting and amplifying polynucleotides
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
AU2009224170B2 (en) 2008-03-11 2012-03-29 National Cancer Center Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using SNP array
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
WO2010082815A1 (en) 2009-01-13 2010-07-22 Keygene N.V. Novel genome sequencing strategies
EP3722810A3 (de) 2009-02-11 2021-01-13 Caris MPI, Inc. Molekulare profilierung von tumoren
AU2010226726B8 (en) 2009-03-16 2014-08-14 Pangu Biopharma Limited Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
US20100310576A1 (en) 2009-03-31 2010-12-09 Adams Ryan A COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
EP2248914A1 (de) * 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Die Verwendung von IIB-Restriktionsendonukleasen in Sequenzierungsanwendungen der zweiten Generation
GB0912909D0 (en) * 2009-07-23 2009-08-26 Olink Genomics Ab Probes for specific analysis of nucleic acids
US8445201B2 (en) * 2009-07-31 2013-05-21 Affymetrix, Inc. Hybridization device, methods, and system using mixing beads
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
PT2669387T (pt) 2009-08-25 2016-09-20 Illumina Inc Métodos para selecção e amplificação de polinucleótidos
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
CN102858995B (zh) 2009-09-10 2016-10-26 森特瑞隆技术控股公司 靶向测序方法
EP2494077A4 (de) 2009-10-27 2013-08-21 Caris Mpi Inc Molekulare profilierung für personalisierte medizin
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
WO2011071382A1 (en) 2009-12-10 2011-06-16 Keygene N.V. Polymorfphic whole genome profiling
JP5799484B2 (ja) * 2009-12-14 2015-10-28 トヨタ自動車株式会社 Dnaマイクロアレイにおけるプローブ設計方法、当該方法により設計されたプローブを有するdnaマイクロアレイ
US8835358B2 (en) * 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
EP2513333B1 (de) 2009-12-17 2013-10-02 Keygene N.V. Auf restriktionsenzym basierende vollständige ganzgenomsequenzierung
GB0922377D0 (en) 2009-12-22 2010-02-03 Arab Gulf University The Mutant LDL receptor
CA2797093C (en) 2010-04-26 2019-10-29 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
EP2563381B1 (de) 2010-04-27 2017-08-09 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von isoleucyl-trna-synthetasen
CN103097524B (zh) 2010-04-28 2016-08-03 Atyr医药公司 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
EP2563383B1 (de) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von valyl-trna-synthetasen
AU2011248227B2 (en) 2010-05-03 2016-12-01 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
CN103096925A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
ES2668207T3 (es) 2010-05-03 2018-05-17 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ, インコーポレイテッド p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2568996B1 (de) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Therapeutische, diagnostische und antikörperhaltige zusammensetzungen im zusammenhang mit proteinfragmenten von phenylalanyl-beta-trna-synthetasen
CN103096913B (zh) 2010-05-27 2017-07-18 Atyr 医药公司 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2012039529A1 (en) * 2010-09-20 2012-03-29 Seegene, Inc. Detection of target nucleic acid sequences by exonucleolytic activity using single-labeled immobilized probes on solid phase
CA2823815A1 (en) 2011-01-14 2012-07-19 Keygene N.V. Paired end random sequence based genotyping
AU2011360257B2 (en) 2011-02-24 2015-08-06 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a feline
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
CN103597097B (zh) 2011-06-15 2016-08-17 希尔氏宠物营养品公司 用于诊断和监测猫科动物的甲状腺功能亢进的组合物和方法
AU2012304328B2 (en) 2011-09-09 2017-07-20 The Board Of Trustees Of The Leland Stanford Junior University Methods for obtaining a sequence
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
WO2013095935A1 (en) 2011-12-19 2013-06-27 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating hyperthyroidism in companion animals
EP2802666B1 (de) 2012-01-13 2018-09-19 Data2Bio Genotypisierung durch eine sequenzierung der nächsten generation
EP2814514B1 (de) 2012-02-16 2017-09-13 Atyr Pharma, Inc. Histidyl-trna-synthetasen zur behandlung von autoimmun- und entzündungserkrankungen
CA2865575C (en) 2012-02-27 2024-01-16 Cellular Research, Inc. Compositions and kits for molecular counting
EP2820174B1 (de) 2012-02-27 2019-12-25 The University of North Carolina at Chapel Hill Verfahren und verwendung für molekulare tags
PT2828218T (pt) 2012-03-20 2020-11-11 Univ Washington Through Its Center For Commercialization Métodos para baixar a taxa de erro da sequenciação paralela massiva de adn utilizando sequenciação duplex de consensus
WO2014071070A1 (en) 2012-11-01 2014-05-08 Pacific Biosciences Of California, Inc. Compositions and methods for selection of nucleic acids
CN104937111B (zh) 2012-11-27 2018-05-11 智利天主教教皇大学 用于诊断甲状腺肿瘤的组合物和方法
SG10201705094SA (en) * 2012-12-21 2017-07-28 Univ Nanyang Tech Site-specific induction of bimolecular quadruplex-duplex hybrids and methods of using the same
JP6451633B2 (ja) * 2013-08-21 2019-01-16 富士レビオ株式会社 固相プローブを用いた修飾核酸塩基の測定方法およびそのキット
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
EP3633047B1 (de) 2014-08-19 2022-12-28 Pacific Biosciences of California, Inc. Verfahren zur sequenzierung von nukleinsäuren basierend auf einer anreicherung von nukleinsäuren
US10435685B2 (en) 2014-08-19 2019-10-08 Pacific Biosciences Of California, Inc. Compositions and methods for enrichment of nucleic acids
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
JP6858783B2 (ja) 2015-10-18 2021-04-14 アフィメトリックス インコーポレイテッド 一塩基多型及びインデルの複対立遺伝子遺伝子型決定
CA3006792A1 (en) 2015-12-08 2017-06-15 Twinstrand Biosciences, Inc. Improved adapters, methods, and compositions for duplex sequencing
AU2018366213B2 (en) 2017-11-08 2025-05-15 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
WO2019232067A1 (en) 2018-05-29 2019-12-05 Centrillion Technologies, Inc. Increasing efficiency of photochemical reactions on substrates
BR112021000409A2 (pt) 2018-07-12 2021-04-06 Twinstrand Biosciences, Inc. Métodos e reagentes para caracterizar edição genômica, expansão clonal e aplicações associadas
WO2020109412A1 (en) 2018-11-28 2020-06-04 Keygene N.V. Targeted enrichment by endonuclease protection
EP3888021B1 (de) 2018-11-30 2024-02-21 Caris MPI, Inc. Molekulare profilierung der nächsten generation
CA3127572A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
EP3956476A1 (de) 2019-04-17 2022-02-23 Igenomix S.L. Verbesserte verfahren zur frühdiagnose von uterinen leiomyomen und leiomyosarkomen
CA3163319A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
WO2021116371A1 (en) 2019-12-12 2021-06-17 Keygene N.V. Semi-solid state nucleic acid manipulation
EP4077661A1 (de) 2019-12-20 2022-10-26 Keygene N.V. Herstellung von ngs-bibliotheken unter verwendung von kovalent verschlossenen nukleinsäuremolekül-enden.
WO2022074058A1 (en) 2020-10-06 2022-04-14 Keygene N.V. Targeted sequence addition
WO2022112316A1 (en) 2020-11-24 2022-06-02 Keygene N.V. Targeted enrichment using nanopore selective sequencing
US20240093288A1 (en) 2020-11-25 2024-03-21 Koninklijke Nederlandse Akademie Van Wetenschappen Ribosomal profiling in single cells
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends
EP4689157A1 (de) 2023-04-04 2026-02-11 Keygene N.V. Linker für duplexsequenzierung

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675283A (en) * 1984-07-19 1987-06-23 Massachusetts Institute Of Technology Detection and isolation of homologous, repeated and amplified nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP0224126A3 (de) 1985-11-25 1989-02-01 The University of Calgary Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5093245A (en) 1988-01-26 1992-03-03 Applied Biosystems Labeling by simultaneous ligation and restriction
US5027877A (en) * 1988-04-14 1991-07-02 Bridgestone Corporation Off-the-road heavy duty pneumatic radial tire
US6107023A (en) 1988-06-17 2000-08-22 Genelabs Technologies, Inc. DNA amplification and subtraction techniques
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
ATE142272T1 (de) 1989-01-19 1996-09-15 Behringwerke Ag Nukleinsäure-amplifikation unter verwendung eines einzelprimers
US5508178A (en) 1989-01-19 1996-04-16 Rose; Samuel Nucleic acid amplification using single primer
EP0456721A4 (en) 1989-01-31 1992-06-03 University Of Miami Microdissection and amplification of chromosomal dna
JPH05508305A (ja) 1989-10-16 1993-11-25 ジエネラブス・テクノロジーズ・インコーポレイテツド 非特異的dna増幅
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
WO1992007095A1 (en) 1990-10-15 1992-04-30 Stratagene Arbitrarily primed polymerase chain reaction method for fingerprinting genomes
AU672760B2 (en) 1991-09-24 1996-10-17 Keygene N.V. Selective restriction fragment amplification: a general method for DNA fingerprinting
WO1993014217A1 (en) * 1992-01-10 1993-07-22 Life Technologies, Inc. Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules
EP0675966B1 (de) * 1992-02-19 2004-10-06 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungen von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzierung und manipulieren von nukleinsäuren
US5750335A (en) * 1992-04-24 1998-05-12 Massachusetts Institute Of Technology Screening for genetic variation
US6277606B1 (en) 1993-11-09 2001-08-21 Cold Spring Harbor Laboratory Representational approach to DNA analysis
US5436142A (en) 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5759922A (en) * 1993-08-25 1998-06-02 Micron Technology, Inc. Control of etch profiles during extended overetch
US6207373B1 (en) 1998-02-25 2001-03-27 Nanogen, Inc. Methods for determining nature of repeat units in DNA
US6027877A (en) 1993-11-04 2000-02-22 Gene Check, Inc. Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification
WO1995025538A1 (en) 1994-03-18 1995-09-28 The General Hospital Corporation Cleaved amplified rflp detection methods
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
AU2907695A (en) * 1994-08-08 1996-03-07 Wisconsin Alumni Research Foundation Purification and pharmaceutical compositions containing type g botulinum neurotoxin
US5710000A (en) 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
DE69621507T2 (de) * 1995-03-28 2003-01-09 Japan Science And Technology Corp., Kawaguchi Verfahren zur molekularen Indexierung von Genen unter Verwendung von Restriktionsenzymen
US5972693A (en) * 1995-10-24 1999-10-26 Curagen Corporation Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
EP0779034B1 (de) * 1995-12-12 2003-04-02 Societe Des Produits Nestle S.A. Speiseeis
US5712127A (en) 1996-04-29 1998-01-27 Genescape Inc. Subtractive amplification
DE19620874A1 (de) * 1996-05-23 1997-11-27 Bmw Rolls Royce Gmbh Kraftstoffeinspritzung für eine gestufte Gasturbinen-Brennkammer
US5763239A (en) 1996-06-18 1998-06-09 Diversa Corporation Production and use of normalized DNA libraries
WO1998020165A2 (en) 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
US6060240A (en) 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US6060245A (en) 1996-12-13 2000-05-09 Stratagene Methods and adaptors for generating specific nucleic acid populations
AU6024598A (en) 1997-01-10 1998-08-03 Pioneer Hi-Bred International, Inc. Hybridization-based genetic amplification and analysis
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
ATE296898T1 (de) 1997-03-20 2005-06-15 Affymetrix Inc Iterative resequenzierung
DE69833758T2 (de) * 1997-06-13 2006-08-31 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips
WO1999023256A1 (en) * 1997-10-30 1999-05-14 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing dna
US6033861A (en) 1997-11-19 2000-03-07 Incyte Genetics, Inc. Methods for obtaining nucleic acid containing a mutation
EP1047794A2 (de) * 1998-01-13 2000-11-02 BioChip Technologies GmbH Verfahren zum nachweis von nukleinsäuresequenzen
US6306643B1 (en) * 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (de) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Vorselektion und Isolierung eines Einzelnukleotidpolymorphismus
ES2312337T3 (es) * 1999-03-11 2009-03-01 Zeachem Inc. Proceso para producir etanol.
US6906643B2 (en) * 2003-04-30 2005-06-14 Hewlett-Packard Development Company, L.P. Systems and methods of viewing, modifying, and interacting with “path-enhanced” multimedia

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