ATE267879T1 - Polymerasesignalversuch - Google Patents
PolymerasesignalversuchInfo
- Publication number
- ATE267879T1 ATE267879T1 AT99930259T AT99930259T ATE267879T1 AT E267879 T1 ATE267879 T1 AT E267879T1 AT 99930259 T AT99930259 T AT 99930259T AT 99930259 T AT99930259 T AT 99930259T AT E267879 T1 ATE267879 T1 AT E267879T1
- Authority
- AT
- Austria
- Prior art keywords
- polymorphisms
- nucleic acid
- methods
- mutations
- sequences
- Prior art date
Links
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 230000035772 mutation Effects 0.000 abstract 2
- 238000012300 Sequence Analysis Methods 0.000 abstract 1
- 238000003491 array Methods 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000000819 phase cycle Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Disintegrating Or Milling (AREA)
- Saccharide Compounds (AREA)
- Crushing And Grinding (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/097,791 US6872521B1 (en) | 1998-06-16 | 1998-06-16 | Polymerase signaling assay |
| PCT/US1999/013430 WO1999066076A1 (en) | 1998-06-16 | 1999-06-15 | Polymerase signaling assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267879T1 true ATE267879T1 (de) | 2004-06-15 |
Family
ID=22265149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99930259T ATE267879T1 (de) | 1998-06-16 | 1999-06-15 | Polymerasesignalversuch |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6872521B1 (de) |
| EP (1) | EP1088106B1 (de) |
| JP (1) | JP2002518024A (de) |
| AT (1) | ATE267879T1 (de) |
| AU (1) | AU756666B2 (de) |
| CA (1) | CA2331788A1 (de) |
| DE (1) | DE69917636T2 (de) |
| WO (1) | WO1999066076A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| AU2001270504A1 (en) * | 2000-05-04 | 2001-11-12 | Syngenta Participations Ag | Novel assay for nucleic acid analysis |
| CA2440754A1 (en) | 2001-03-12 | 2002-09-19 | Stephen Quake | Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension |
| KR100434651B1 (ko) * | 2002-05-31 | 2004-06-12 | 김두환 | 분진폭발 시험용 균일 분진운 형성장치 및 방법 |
| CN1318606C (zh) * | 2002-09-19 | 2007-05-30 | 阿普里拉股份有限公司 | 检测靶序列的方法和组合物 |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| US7972783B2 (en) * | 2003-11-24 | 2011-07-05 | Branhaven LLC | Method and markers for determining the genotype of horned/polled cattle |
| EP1716254B1 (de) | 2004-02-19 | 2010-04-07 | Helicos Biosciences Corporation | Verfahren zur analyse von polynukleotidsequenzen |
| EP1593425B1 (de) * | 2004-05-04 | 2006-08-09 | Eppendorf Array Technologies SA | Herstellungsverfahren und Verwendung von Mikro-Array-Trägern zur Detektion mehrfacher Polynukleotidsequenzen mit hoher Empfindlichkeit |
| US7476734B2 (en) | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
| EP1766090B1 (de) | 2004-05-25 | 2011-04-27 | Helicos Biosciences Corporation | Verfahren zur nukleinsäureimmobilisierung |
| US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
| US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| DE102005011350A1 (de) * | 2005-03-11 | 2006-09-14 | Eppendorf Ag | CDNA Microarrays mit Zufallsspacern |
| US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
| US7397546B2 (en) | 2006-03-08 | 2008-07-08 | Helicos Biosciences Corporation | Systems and methods for reducing detected intensity non-uniformity in a laser beam |
| US9114398B2 (en) * | 2006-11-29 | 2015-08-25 | Canon U.S. Life Sciences, Inc. | Device and method for digital multiplex PCR assays |
| EP3733867A1 (de) * | 2011-01-17 | 2020-11-04 | Life Technologies Corporation | Enzymatische ligation von nukleinsäuren |
| US20120196294A1 (en) | 2011-01-17 | 2012-08-02 | Life Technologies Corporation | Workflow for detection of ligands using nucleic acids |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521509A (en) | 1982-11-24 | 1985-06-04 | Research Corporation | Method for degrading DNA |
| GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
| US4981783A (en) | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
| US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
| US5151507A (en) | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
| US4812856A (en) | 1987-10-30 | 1989-03-14 | Microfab Technologies, Inc. | Method and apparatus for dispensing a fluid with dispersed particles therein |
| US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
| WO1989010414A1 (en) | 1988-04-28 | 1989-11-02 | Robert Bruce Wallace | AMPLIFIED SEQUENCE POLYMORPHISMS (ASPs) |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| US5053100A (en) | 1989-09-01 | 1991-10-01 | Microfab Technologies, Inc. | Method of making apparatus for dispensing small amounts of fluids |
| US5518900A (en) | 1993-01-15 | 1996-05-21 | Molecular Tool, Inc. | Method for generating single-stranded DNA molecules |
| US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US5795714A (en) * | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
| JPH08509857A (ja) | 1993-01-07 | 1996-10-22 | シーケノム・インコーポレーテッド | マススペクトロメトリーによるｄｎａ配列決定法 |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| JPH09508003A (ja) | 1993-07-23 | 1997-08-19 | ハイセック，インコーポレイション | 未知の生物をスクリーニングするための方法 |
| AU8126694A (en) | 1993-10-26 | 1995-05-22 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| FR2726286B1 (fr) | 1994-10-28 | 1997-01-17 | Genset Sa | Procede d'amplification d'acides nucleiques en phase solide et trousse de reactifs utile pour la mise en oeuvre de ce procede |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| US5759779A (en) | 1995-08-29 | 1998-06-02 | Dehlinger; Peter J. | Polynucleotide-array assay and methods |
| DE19601385A1 (de) | 1996-01-16 | 1997-07-17 | Mueller Manfred W | Verfahren zur Amplifikation von Nukleinsäure |
| AU2253397A (en) | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
| EP0958378A2 (de) * | 1996-09-24 | 1999-11-24 | Rapigene, Inc. | Zusammensetzungen und verfahren zur verbesserung der hybridisierungsspezifitaet |
| GB9708606D0 (en) | 1997-04-28 | 1997-06-18 | Webster Andrew | Sequencing |
| US6322968B1 (en) * | 1997-11-21 | 2001-11-27 | Orchid Biosciences, Inc. | De novo or “universal” sequencing array |
-
1998
- 1998-06-16 US US09/097,791 patent/US6872521B1/en not_active Expired - Lifetime
-
1999
- 1999-06-15 AT AT99930259T patent/ATE267879T1/de not_active IP Right Cessation
- 1999-06-15 AU AU46836/99A patent/AU756666B2/en not_active Expired
- 1999-06-15 CA CA002331788A patent/CA2331788A1/en not_active Abandoned
- 1999-06-15 JP JP2000554884A patent/JP2002518024A/ja active Pending
- 1999-06-15 DE DE69917636T patent/DE69917636T2/de not_active Expired - Lifetime
- 1999-06-15 EP EP99930259A patent/EP1088106B1/de not_active Expired - Lifetime
- 1999-06-15 WO PCT/US1999/013430 patent/WO1999066076A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1088106A4 (de) | 2002-02-06 |
| DE69917636T2 (de) | 2005-05-19 |
| AU756666B2 (en) | 2003-01-23 |
| AU4683699A (en) | 2000-01-05 |
| US6872521B1 (en) | 2005-03-29 |
| DE69917636D1 (en) | 2004-07-01 |
| WO1999066076A1 (en) | 1999-12-23 |
| EP1088106A1 (de) | 2001-04-04 |
| CA2331788A1 (en) | 1999-12-23 |
| EP1088106B1 (de) | 2004-05-26 |
| JP2002518024A (ja) | 2002-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |