ATE316794T1 - Pharmazeutische zusammensetzungen enthaltend lysostaphin allein oder in kombination mit einem antibiotikum zur behandlung von staphylokokkeninfektionen - Google Patents

Pharmazeutische zusammensetzungen enthaltend lysostaphin allein oder in kombination mit einem antibiotikum zur behandlung von staphylokokkeninfektionen

Info

Publication number
ATE316794T1
ATE316794T1 AT98935954T AT98935954T ATE316794T1 AT E316794 T1 ATE316794 T1 AT E316794T1 AT 98935954 T AT98935954 T AT 98935954T AT 98935954 T AT98935954 T AT 98935954T AT E316794 T1 ATE316794 T1 AT E316794T1
Authority
AT
Austria
Prior art keywords
antibiotic
treatment
combination
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT98935954T
Other languages
English (en)
Inventor
Beth P Goldstein
Michael W Climo
Richard P Novick
Gordon L Archer
Original Assignee
Ambi Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambi Inc filed Critical Ambi Inc
Application granted granted Critical
Publication of ATE316794T1 publication Critical patent/ATE316794T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24075—Lysostaphin (3.4.24.75)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98935954T 1997-07-23 1998-07-21 Pharmazeutische zusammensetzungen enthaltend lysostaphin allein oder in kombination mit einem antibiotikum zur behandlung von staphylokokkeninfektionen ATE316794T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5347097P 1997-07-23 1997-07-23

Publications (1)

Publication Number Publication Date
ATE316794T1 true ATE316794T1 (de) 2006-02-15

Family

ID=21984478

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98935954T ATE316794T1 (de) 1997-07-23 1998-07-21 Pharmazeutische zusammensetzungen enthaltend lysostaphin allein oder in kombination mit einem antibiotikum zur behandlung von staphylokokkeninfektionen

Country Status (20)

Country Link
US (1) US20020006406A1 (de)
EP (1) EP1001804B1 (de)
JP (1) JP2001510805A (de)
KR (1) KR20010022237A (de)
CN (1) CN1269727A (de)
AT (1) ATE316794T1 (de)
AU (1) AU754806B2 (de)
BR (1) BR9811535A (de)
CA (1) CA2297083C (de)
DE (1) DE69833377T2 (de)
HU (1) HUP0002662A3 (de)
IL (1) IL134056A0 (de)
NO (1) NO320884B1 (de)
NZ (1) NZ502359A (de)
PL (1) PL338178A1 (de)
RU (1) RU2234940C2 (de)
SK (1) SK732000A3 (de)
TW (1) TWI235656B (de)
WO (1) WO1999004809A1 (de)
ZA (1) ZA986593B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399098B1 (en) 1997-10-31 2002-06-04 New Horizons Diagnostics Corp Composition for treating dental caries caused by streptococcus mutans
US6277399B1 (en) 1997-10-31 2001-08-21 New Horizon Diagnostics Corporation Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections
US6432444B1 (en) 1997-10-31 2002-08-13 New Horizons Diagnostics Corp Use of bacterial phage associated lysing enzymes for treating dermatological infections
US6406692B1 (en) 1997-10-31 2002-06-18 New Horizons Diagnostics Corp Composition for treatment of an ocular bacterial infection
US7232576B2 (en) 1997-10-31 2007-06-19 New Horizons Diagnostics Corp Throat lozenge for the treatment of Streptococcus Group A
US6056954A (en) 1997-10-31 2000-05-02 New Horizons Diagnostics Corp Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses
US6428784B1 (en) 1997-10-31 2002-08-06 New Horizons Diagnostics Corp Vaginal suppository for treating group B Streptococcus infection
US6423299B1 (en) 1997-10-31 2002-07-23 Vincent Fischetti Composition for treatment of a bacterial infection of an upper respiratory tract
US6399097B1 (en) 1997-10-31 2002-06-04 New Horizons Diagnostics Corporation Composition for treatment of a bacterial infection of the digestive tract
US6569830B1 (en) * 1999-03-05 2003-05-27 Ambi, Inc. Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
US20020127215A1 (en) * 1999-09-14 2002-09-12 Lawrence Loomis Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
US7063837B2 (en) 1999-09-14 2006-06-20 New Horizons Diagnostics Corp Syrup composition containing phage associated lytic enzymes
WO2001082945A2 (en) * 2000-04-28 2001-11-08 New Horizons Diagnostic Corporation The use of bacterial phage associated lysing enzymes for treating various illnesses
US6395504B1 (en) 2000-09-01 2002-05-28 New Horizons Diagnostics Corp. Use of phage associated lytic enzymes for the rapid detection of bacterial contaminants
US7572439B2 (en) * 2002-03-26 2009-08-11 Biosynexus Incorporated Enzyme disruption of bacterial biofilms
JP2006514636A (ja) * 2002-12-02 2006-05-11 バイオシネクサス インコーポレーテッド 抗ブドウ球菌療法およびワクチンの標的としての壁テイコイン酸
AU2003296937A1 (en) * 2002-12-10 2004-06-30 Biosynexus Incorporated Topical anti-infective formulations
US20100221237A1 (en) * 2003-03-26 2010-09-02 Biosynexus Incorporated Enzyme disruption of bacterial biofilms
EP1850867A1 (de) * 2005-01-10 2007-11-07 Nabi Biopharmaceuticals Verfahren zur behandlung einer infektion mit staphylococcus aureus
EP1885403B1 (de) 2005-04-12 2013-05-08 Nektar Therapeutics Poly(ethylenglykol)-Konjugate von Lysostaphin
ATE470451T1 (de) 2006-03-31 2010-06-15 Univ St Andrews Antimikrobielle zusammensetzungen mit einem kationischen peptid und glycylglycin- endopeptidase
MX2008014150A (es) * 2006-05-05 2009-02-04 Gangagen Inc Actividades antimicrobianas derivadas de fago.
WO2009114520A2 (en) * 2008-03-10 2009-09-17 Pharmain Corporation Compositions for treatment with metallopeptidases, methods of making and using the same
US20090304673A1 (en) * 2008-06-10 2009-12-10 Bernd Buchberger Method of Treatment of Inflammatory Diseases
RU2377011C1 (ru) * 2008-06-23 2009-12-27 Федеральное Государственное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Аграрный Университет Имени Н.И. Вавилова" Способ лечения хронического остеомиелита у животных
CN105579053B (zh) 2013-08-06 2021-08-31 达特茅斯学院理事会 非糖基化溶葡球菌素变体蛋白
RU2572341C2 (ru) * 2013-09-20 2016-01-10 Федеральное государственное бюджетное учреждение Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе Российской академии медицинских наук (ФГБУ "НИИНА" РАМН) АНТИБИОТИК ИНА 5812, ШТАММ-ПРОДУЦЕНТ Streptomyces roseoflavus ИНА-Ас-5812 И СПОСОБ ПОЛУЧЕНИЯ АНТИБИОТИКА
CN109819650A (zh) * 2017-09-25 2019-05-28 春布里泽·格奥尔基·格奥尔基耶维奇 具有抗病毒和抗细菌活性的热稳定组合物及其用途
US11565024B2 (en) 2017-11-16 2023-01-31 Georgia Tech Research Corporation Lysostaphin containing synthetic hydrogel carriers for bone repair
CN110917339B (zh) * 2019-12-27 2023-07-07 遵义医学院附属医院 一种溶葡萄球菌酶凝胶剂及其在mrsa感染创面中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278378A (en) * 1962-04-19 1966-10-11 Schindler Charles Alvin Staphylococcus-derived antibiotic
US4931390A (en) * 1986-04-16 1990-06-05 Public Health Research Institute Of The City Of New York, Inc. Expression of the cloned lysostaphin gene
US5858962A (en) * 1987-05-11 1999-01-12 Ambi Inc. Composition for treating mastitis and other staphylococcal infections
AU623864B2 (en) * 1988-08-29 1992-05-28 Applied Microbiology, Inc Method of treating mastitis and other staphylococcal infections

Also Published As

Publication number Publication date
TWI235656B (en) 2005-07-11
CA2297083A1 (en) 1999-02-04
PL338178A1 (en) 2000-10-09
IL134056A0 (en) 2001-04-30
DE69833377D1 (de) 2006-04-13
EP1001804B1 (de) 2006-02-01
SK732000A3 (en) 2001-03-12
DE69833377T2 (de) 2006-11-16
HUP0002662A3 (en) 2003-08-28
BR9811535A (pt) 2000-08-29
JP2001510805A (ja) 2001-08-07
HUP0002662A2 (hu) 2000-12-28
CN1269727A (zh) 2000-10-11
NO20000314L (no) 2000-03-16
ZA986593B (en) 1999-02-04
NZ502359A (en) 2005-02-25
AU754806B2 (en) 2002-11-28
NO320884B1 (no) 2006-02-06
AU8509598A (en) 1999-02-16
HU0002662D0 (en) 2000-08-28
WO1999004809A1 (en) 1999-02-04
US20020006406A1 (en) 2002-01-17
KR20010022237A (ko) 2001-03-15
RU2234940C2 (ru) 2004-08-27
EP1001804A1 (de) 2000-05-24
NO20000314D0 (no) 2000-01-21
CA2297083C (en) 2007-10-30

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